This is the protocol for a review and there is no abstract. The objectives are as follows:
The primary objective of this systematic review is to assess the effects of maintenance of blood glucose within defined target levels, relative to usual care or defined higher target levels, on mortality and morbidity in adult patients receiving intensive care.
As secondary objectives, we will examine whether these effects are modified by target glucose levels; underlying conditions; dose and route of insulin; glucose level, nutrition, co-medication; and structure of the protocol. We will also investigate the robustness of our estimates by performing sensitivity analyses according to risk of bias and methods of glucose measurement.