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Lactose avoidance for young children with acute diarrhoea

  1. Stephen MacGillivray1,*,
  2. Tom Fahey2,
  3. William McGuire3

Editorial Group: Cochrane Infectious Diseases Group

Published Online: 31 OCT 2013

Assessed as up-to-date: 14 MAY 2013

DOI: 10.1002/14651858.CD005433.pub2


How to Cite

MacGillivray S, Fahey T, McGuire W. Lactose avoidance for young children with acute diarrhoea. Cochrane Database of Systematic Reviews 2013, Issue 10. Art. No.: CD005433. DOI: 10.1002/14651858.CD005433.pub2.

Author Information

  1. 1

    University of Dundee, Social Dimensions of Health Institute, Dundee, Tayside, UK

  2. 2

    Royal College of Surgeons in Ireland Medical School, Department of Family Medicine and General Practice, Dublin, Ireland

  3. 3

    Hull York Medical School & Centre for Reviews and Dissemination, University of York, York, Y010 5DD, UK

*Stephen MacGillivray, Social Dimensions of Health Institute, University of Dundee, Airlie Place, Dundee, Tayside, DD1 4HN, UK. s.a.macgillivray@dundee.ac.uk.

Publication History

  1. Publication Status: New
  2. Published Online: 31 OCT 2013

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[Figure 1]
Figure 1. Study flow diagram.
[Figure 2]
Figure 2. Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included trials.
[Figure 3]
Figure 3. Risk of bias summary: review authors' judgements about each risk of bias item for each included trial.
[Figure 4]
Figure 4. Funnel plot of comparison: 1 Lactose-free versus lactose-containing milk, milk products, or foodstuffs; outcome: 1.1 Duration of diarrhoea (hrs).
[Figure 5]
Figure 5. Funnel plot of comparison: 1 Lactose-free versus lactose-containing milk, milk products, or foodstuffs; outcome: 1.2 Treatment failure.
[Figure 6]
Figure 6. Funnel plot of comparison: 4 Diluted versus undiluted lactose-containing milk, milk products, or foodstuffs; outcome: 4.2 Treatment failure.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Lactose-free versus lactose-containing milk, milk products, or foodstuffs, Outcome 1 Duration of diarrhoea (hours).
[Analysis 1.2]
Analysis 1.2. Comparison 1 Lactose-free versus lactose-containing milk, milk products, or foodstuffs, Outcome 2 Treatment failure.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Lactose-free versus lactose-containing milk, milk products, or foodstuffs, Outcome 3 Need for hospitalization.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Lactose-free versus lactose-containing milk, milk products, or foodstuffs, Outcome 4 Duration of hospital stay (days).
[Analysis 1.5]
Analysis 1.5. Comparison 1 Lactose-free versus lactose-containing milk, milk products, or foodstuffs, Outcome 5 Stool volume (g/kg body weight/day).
[Analysis 1.6]
Analysis 1.6. Comparison 1 Lactose-free versus lactose-containing milk, milk products, or foodstuffs, Outcome 6 Weight change (at discharge or recovery).
[Analysis 2.1]
Analysis 2.1. Comparison 2 Subgroup analyses (other differences in feed type): Lactose-free versus lactose-containing, Outcome 1 Duration of diarrhoea (feed type).
[Analysis 2.2]
Analysis 2.2. Comparison 2 Subgroup analyses (other differences in feed type): Lactose-free versus lactose-containing, Outcome 2 Treatment failure (feed type).
[Analysis 3.1]
Analysis 3.1. Comparison 3 Sensitivity analyses (low risk of bias): Lactose-free versus lactose-containing, Outcome 1 Duration of diarrhoea (sequence generation).
[Analysis 3.2]
Analysis 3.2. Comparison 3 Sensitivity analyses (low risk of bias): Lactose-free versus lactose-containing, Outcome 2 Duration of diarrhoea (allocation concealment).
[Analysis 3.3]
Analysis 3.3. Comparison 3 Sensitivity analyses (low risk of bias): Lactose-free versus lactose-containing, Outcome 3 Duration of diarrhoea (blinding of participants and personnel).
[Analysis 3.4]
Analysis 3.4. Comparison 3 Sensitivity analyses (low risk of bias): Lactose-free versus lactose-containing, Outcome 4 Duration of diarrhoea (blinding of outcome assessment).
[Analysis 3.5]
Analysis 3.5. Comparison 3 Sensitivity analyses (low risk of bias): Lactose-free versus lactose-containing, Outcome 5 Duration of diarrhoea (complete outcome assessment).
[Analysis 3.6]
Analysis 3.6. Comparison 3 Sensitivity analyses (low risk of bias): Lactose-free versus lactose-containing, Outcome 6 Treatment failure (sequence generation).
[Analysis 3.7]
Analysis 3.7. Comparison 3 Sensitivity analyses (low risk of bias): Lactose-free versus lactose-containing, Outcome 7 Treatment failure (allocation concealment).
[Analysis 3.8]
Analysis 3.8. Comparison 3 Sensitivity analyses (low risk of bias): Lactose-free versus lactose-containing, Outcome 8 Treatment failure (blinding of participants and personnel).
[Analysis 3.9]
Analysis 3.9. Comparison 3 Sensitivity analyses (low risk of bias): Lactose-free versus lactose-containing, Outcome 9 Treatment failure (blinding of outcome assessment).
[Analysis 3.10]
Analysis 3.10. Comparison 3 Sensitivity analyses (low risk of bias): Lactose-free versus lactose-containing, Outcome 10 Treatment failure (complete outcome assessment).
[Analysis 4.1]
Analysis 4.1. Comparison 4 Diluted versus undiluted lactose-containing milk, milk products, or foodstuffs, Outcome 1 Duration of diarrhoea (hrs).
[Analysis 4.2]
Analysis 4.2. Comparison 4 Diluted versus undiluted lactose-containing milk, milk products, or foodstuffs, Outcome 2 Treatment failure.
[Analysis 4.3]
Analysis 4.3. Comparison 4 Diluted versus undiluted lactose-containing milk, milk products, or foodstuffs, Outcome 3 Duration of hospital stay (days).
[Analysis 4.4]
Analysis 4.4. Comparison 4 Diluted versus undiluted lactose-containing milk, milk products, or foodstuffs, Outcome 4 Stool volume (g/kg/day or g/day).
[Analysis 4.5]
Analysis 4.5. Comparison 4 Diluted versus undiluted lactose-containing milk, milk products, or foodstuffs, Outcome 5 Number of stools per day.
[Analysis 4.6]
Analysis 4.6. Comparison 4 Diluted versus undiluted lactose-containing milk, milk products, or foodstuffs, Outcome 6 Weight change (at discharge or recovery).