Adjunctive antithyroid drugs in radioiodine therapy for hyperthyroidism

  • Protocol
  • Intervention

Authors


Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

The main objectives of the review are:

  • to determine the safety and effects of therapy when antithyroid drugs, carbimazole, methimazole, or propylthiouracil are used before administering radioiodine for treating hyperthyroidism as compared to radioiodine without antithyroid drugs.

  • to determine the safety and effects of therapy when antithyroid drugs, carbimazole, methimazole, or propylthiouracil are used after administering radioiodine for treating hyperthyroidism as compared to radioiodine without antithyroid drugs.

  • to determine the safety and effects of therapy when antithyroid drugs, carbimazole, methimazole, or propylthiouracil are used both before and after administering radioiodine for treating hyperthyroidism as compared to radioiodine without antithyroid drugs, and to antithyroid drugs with radioiodine when antithyroid drugs are given only before, or only after administering radioiodine.

The main outcomes of interest are cure, occurrence of thyrotoxic crisis and adverse cardiovascular events(as defined below) following therapy.