Intervention Review

Chinese herbal medicines for hyperthyroidism

  1. Xiaoxi Zeng2,
  2. Yong Yuan3,
  3. Taixiang Wu1,*,
  4. Liu Yan3,
  5. Han Su4

Editorial Group: Cochrane Metabolic and Endocrine Disorders Group

Published Online: 18 APR 2007

Assessed as up-to-date: 29 JUL 2006

DOI: 10.1002/14651858.CD005450.pub2

How to Cite

Zeng X, Yuan Y, Wu T, Yan L, Su H. Chinese herbal medicines for hyperthyroidism. Cochrane Database of Systematic Reviews 2007, Issue 2. Art. No.: CD005450. DOI: 10.1002/14651858.CD005450.pub2.

Author Information

  1. 1

    West China Hospital, Sichuan University, Chinese Cochrane Centre, Chinese EBM Centre, Chengdu, Sichuan, China

  2. 2

    Sichuan University, West China Hospital, Chengdu, Sichuan, China

  3. 3

    Sichuan University, West China Medical Center, Chengdu, Sichuan, China

  4. 4

    West China Hospital, Sichuan University, Clinical Epidemiology, Chengdu, Sichuan, China

*Taixiang Wu, Chinese Cochrane Centre, Chinese EBM Centre, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, Sichuan, 610041, China. txwutx@hotmail.com. txwutx@public.cd.sc.cn.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 18 APR 2007

SEARCH

 

Abstract

  1. Top of page
  2. Abstract
  3. Plain language summary
  4. 摘要

Background

Hyperthyroidism is a disease in which excessive amounts of thyroid hormones circulate in the blood. Patients, among other things suffer from tachycardia, warm moist skin and raised body temperature. The treatment of hyperthyroidism includes symptom relief and therapy with antithyroid medications, radioiodine and thyroidectomy. Medicinal herbs are used alone or in combination with antithyroid agents to treat hyperthyroidism in China and some other countries.

Objectives

To assess the effects of Chinese herbal medicines for treating hyperthyroidism.

Search methods

Studies were obtained from computerised searches of MEDLINE, EMBASE, The Cochrane Library, the Chinese Biomedical Database.

Selection criteria

Randomised controlled trials comparing the effects of Chinese herbal medicines alone with Chinese herbal medicines combined with antithyroid drugs, radioiodine or both.

Data collection and analysis

Three authors interviewed authors of all potentially relevant studies by telephone to verify randomisation procedures. One author entered data into a data extraction form and another author verified the results of this procedure.

Main results

Thirteen relevant trials with 1770 participants were included. All of them were of low quality. Fifty-two studies still need to be assessed because the original authors could not be interviewed. None of these trials analysed mortality, health related quality of life, economic outcomes or compliance. Compared to antithyroid drugs alone the results showed that Chinese herbal medicines combined with antithyroid drugs may offer benefits in lowering relapse rates, reducing the incidence of adverse effects, relieving symptoms, improving thyroid antibody status and thyroid function. Two trials investigated Chinese herbal medicine versus radioiodine and reported improvements in anxiety, tachycardia and heat intolerance. However, thyroid function - with the exception of restored thyroid stimulating hormone (TSH) - was not significantly altered.

Authors' conclusions

The results suggest that traditional Chinese herbal medicines added to other routine treatment have a therapeutic potential for people with hyperthyroidism. However, due to methodological limitations, we could not identify a well-designed trial to provide strong evidence for Chinese traditional herbal medicine in the treatment of hyperthyroidism. Thus, we currently cannot recommend any single preparation or formulation for clinical use.

 

Plain language summary

  1. Top of page
  2. Abstract
  3. Plain language summary
  4. 摘要

Chinese herbal medicines for hyperthyroidism

Hyperthyroidism is a common illness in which excessive amounts of thyroid hormones circulate in the blood. Affected people, among other things suffer from increased heart beats, warm moist skin and raised body temperature. A large number of Chinese herbal medicines are used to treat this condition in China. Thirteen relevant trials with 1770 participants were analysed. All of them were of low quality. None of these trials analysed mortality, health related quality of life, economic outcomes or compliance with treatments. Some of these herbs may show benefits in improving symptoms, thyroid function and adverse effects. Unfortunately, we were unable to find reliable evidence to recommend a specific herbal preparation from 103 investigated formulations.

 

摘要

  1. Top of page
  2. Abstract
  3. Plain language summary
  4. 摘要

背景

治療甲狀腺高能症之中藥

甲狀腺高能症是一種在血液循環中甲狀腺素過量所造成的疾病。患者,除其他症狀外,有心搏過速,溫暖和濕潤的皮膚及高體溫。甲狀腺高能症的治療,包括減輕症狀和抗甲狀腺藥物治療,放射性碘治療和甲狀腺切除術。在中國和其他一些國家,中藥材也有被單獨使用或與抗甲狀腺藥物結合來治療甲狀腺高能症。

目標

評估中藥在治療甲狀腺高能症的效果。

搜尋策略

收錄的研究是用電腦搜尋MEDLINE, EMBASE, The Cochrane Library, Chinese Biomedical Database等資料庫所得到的。

選擇標準

有做單獨使用中藥與中藥結合抗甲狀腺藥物,放射性碘或兩者之作用比較的隨機對照試驗,才被收錄。

資料收集與分析

三位作者以電話採訪與所有可能有關之研究的作者來驗證隨機程序。一位作者將數據輸入數據摘錄表,另一位作者負責驗證此過程的結果。

主要結論

本回顧收錄13個相關試驗,共有1770位受試者。所有這些試驗的方法學品質都低。因為原著作者無法接受採訪,所以有52個研究仍需被評估。這些試驗均無分析死亡率,與健康有關的生活品質,經濟成果或醫囑順從性。結果顯示,與單獨使用抗甲狀腺藥物相比較,中藥結合抗甲狀腺藥物治療可提供降低復發率,減少不良作用發生率,緩解症狀,改善甲狀腺抗體狀態和甲狀腺功能的利益。有兩項試驗研究中藥與放射性碘的的差異,報告顯示中藥治療可改善焦慮,心搏過速和熱失耐。然而,除甲促素恢復正常外,甲狀腺功能並無明顯改變。

作者結論

結果建議,將傳統的中藥添加到其他常規治療對甲狀腺高能症的人有潛在的治療效果。然而,由於方法學上的限制,我們無法確認有哪一個設計良好的試驗,可提供強力證據證明中國傳統中藥可治療甲狀腺高能症。因此,我們目前不推薦任何一種製劑或配方在臨床上使用。

翻譯人

本摘要由慈濟醫院李哲全翻譯。

此翻譯計畫由臺灣國家衛生研究院(National Health Research Institutes, Taiwan)統籌。

總結

中藥可以提供在甲狀腺高能症治療上一個額外的選擇,但目前沒有一個單一的製劑可被建議。甲狀腺高能症是一種過量的甲狀腺激素在血液中循環的常見疾病。受影響的人,除其他症狀外,有心搏過速,溫暖和濕潤的皮膚及高體溫。在中國已有很多中藥被用來治療這種情況。共有包括1770位受試者在內的13個相關試驗被分析。所有這些試驗的方法學品質都低。這些試驗均無分析死亡率,與健康有關的生活品質,經濟成果或醫囑順從性。其中一些草藥可能顯示出改善症狀,甲狀腺功能和不良作用的利益。很遺憾地,我們從103個被調查的配方中,無法找到可靠的證據來建議一個特定的中藥製劑。