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Carbamazepine for chronic neuropathic pain and fibromyalgia in adults

  1. Philip J Wiffen1,*,
  2. Sheena Derry1,
  3. R Andrew Moore1,
  4. Eija A Kalso2,3

Editorial Group: Cochrane Pain, Palliative and Supportive Care Group

Published Online: 10 APR 2014

Assessed as up-to-date: 7 FEB 2014

DOI: 10.1002/14651858.CD005451.pub3


How to Cite

Wiffen PJ, Derry S, Moore RA, Kalso EA. Carbamazepine for chronic neuropathic pain and fibromyalgia in adults. Cochrane Database of Systematic Reviews 2014, Issue 4. Art. No.: CD005451. DOI: 10.1002/14651858.CD005451.pub3.

Author Information

  1. 1

    University of Oxford, Pain Research and Nuffield Department of Clinical Neurosciences, Oxford, Oxfordshire, UK

  2. 2

    Helsinki University Central Hospital, Department of Anaesthesia, Intensive Care Medicine, Emergency Medicine and Pain Medicine, Helsinki, Finland

  3. 3

    University of Helsinki, Institute of Clinical Medicine, Helsinki, Finland

*Philip J Wiffen, Pain Research and Nuffield Department of Clinical Neurosciences, University of Oxford, Pain Research Unit, Churchill Hospital, Oxford, Oxfordshire, OX3 7LE, UK. phil.wiffen@ndcn.ox.ac.uk.

Publication History

  1. Publication Status: Stable (no update expected for reasons given in 'What's new')
  2. Published Online: 10 APR 2014

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[Figure 1]
Figure 1. Study flow diagram.
[Figure 2]
Figure 2. Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
[Figure 3]
Figure 3. Methodological quality summary: review authors' judgements about each methodological quality item for each included study.
[Figure 4]
Figure 4. Four studies showing percentage improvement (any definition) with carbamazepine (any dose) and placebo. Size of the study is proportional to the size of the symbol (inset scale). Yellow symbols = trigeminal neuralgia , blue = painful diabetic neuropathy, red = post stroke pain
[Figure 5]
Figure 5. Forest plot of comparison: 1 Carbamazepine in neuropathic pain, outcome: 1.1 Any pain improvement.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Carbamazepine in neuropathic pain, Outcome 1 Any pain improvement.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Carbamazepine in neuropathic pain, Outcome 2 At least 1 adverse event.