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Pharmacotherapy augmentation strategies in treatment-resistant anxiety disorders

  • Review
  • Intervention




A large proportion of patients with anxiety disorders fail to respond to first-line medication interventions, despite evidence of the effectiveness of these agents.


To assess the effects of medication versus placebo augmentation in the treatment of patients with anxiety disorders who have failed to respond adequately to first-line drug therapies.

Search methods

The Cochrane Depression, Anxiety & Neurosis Group (CCDAN) specialised registers (CCDANCTR-Studies and CCDANCTR-References) were searched on 3/8/2005, , MEDLINE (January 1966 to July 2005) and PsycINFO (1966 to 2005, Part A). Unpublished trials were identified through the Controlled Trials database and the National Institute of Health's Computer Retrieval of Information on Scientific Projects (CRISP) service (1972 to 2005). Additional studies in any language were sought in reference lists of retrieved articles.

Selection criteria

All randomised controlled trials (RCTs) of the medication augmentation of pharmacotherapy for treatment resistant anxiety disorders.

Data collection and analysis

Two raters independently assessed RCTs for inclusion in the review, collated trial data, and assessed trial quality. Investigators were contacted to obtain missing data. Summary statistics were stratified by class of augmentation agent and anxiety disorder. Overall effect estimates were calculated using a random-effects model, heterogeneity was assessed and subgroup/sensitivity analyses were undertaken.

Main results

Twenty eight short-term (average of seven weeks) randomised controlled trials (740 participants) were included in the review, 20 of which investigated augmentation of medication for treatment-resistant obsessive compulsive disorder (OCD). Summary statistics for responder status from nine trials demonstrate overall superiority of a variety of medication agents to placebo (relative risk of non-response (RR) 3.16, 95% CI 1.08 to 9.23). Similarly, symptom severity was significantly reduced in the medication groups, relative to placebo (number of trials (N) = 14, standardised mean difference (SMD) -0.87, 95% CI -1.37 to -0.36). There is no evidence of a difference between medication and placebo in total dropout rate, or in the number of dropouts due to adverse events.

Authors' conclusions

Medication augmentation can be an effective and well-tolerated short-term treatment strategy for non-responders to first-line pharmacotherapy of anxiety disorders. However, any conclusions must be tentative in view of methodological and clinical heterogeneity, and the fact that much of the relevant database is based on antipsychotic augmentation trials in OCD patients resistant to serotonin reuptake inhibitors (SRIs). Additional data are needed to address several areas, including the efficacy of augmentation over the longer-term, and the value of medication augmentation in comparison to other strategies (eg switching medication, adding psychotherapy).








在3/8/2005當日搜尋The Cochrane Depression, Anxiety & Neurosis Group (CCDAN) specialised registers (CCDANCTRStudies and CCDANCTRReferences) 及PsycINFO (1966 to 2005, Part A). 由Controlled Trials資料庫和 National Institute of Health's Computer Retrieval of Information on Scientific Projects (CRISP) service (1972 to 2005)上搜尋未發表試驗.由搜尋到的文章文獻清單中尋找是否有其他語言的研究。






28個短期(平均七週)隨機控制試驗(740個受試者)被納入這篇回顧,其中的20個試驗在研究頑抗型強迫症的藥物增強治療。九篇統計結果顯示:許多的藥物組有反應的受試者比率明顯優於安慰劑組(無反應的RR 3.16, 95% CI 1.08 – 9.23)。同樣地,藥物組的症狀嚴重度明顯比安慰劑組輕(共14個試驗, 標準平均差 −0.87, 95% CI −1.37, −0.36)。沒有證據顯示藥物組及安慰劑組在整體退出率,或者在因副作用退出的個案數上有差異。





此翻譯計畫由臺灣國家衛生研究院(National Health Research Institutes, Taiwan)統籌。



Plain language summary

Medication augmentation for treatment-resistant anxiety disorders

Anxiety disorders are highly prevalent and result in substantial socio-economic and personal costs. A significant proportion of patients with anxiety disorders fail to respond to first-line medication interventions. This was a systematic review of 28 short-term randomised controlled trials of medication augmentation for the treatment of such individuals (740 participants). A significantly larger proportion of patients responded to medication (31.8%) than to placebo (13.6%), (nine trials, 250 participants). Symptom severity was also significantly reduced (14 trials, 337 participants). A substantial proportion of the efficacy evidence base was for the augmentation with antipsychotics of serotonin reuptake inhibitors for obsessive compulsive disorder.