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Early developmental intervention programs post hospital discharge to prevent motor and cognitive impairments in preterm infants

  • Protocol
  • Intervention

Authors

  • AJ Spittle,

  • J Orton,

  • R Boyd


Ms Alicia Spittle, Physiotherapist, Neonatal Neurology, Murdoch Children's Research Institute, 9th Floor, Neonatal Unit, Royal Women's Hospital, 123 Grattan Street, Carlton, Melbourne, 3153, AUSTRALIA. alicia_spittle@iprimus.com.au.

Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

PRIMARY OBJECTIVE
To determine the effect of early developmental intervention programs post hopsital discharge for preterm or low birth weight infants on cognitive and motor development compared with standard medical follow-up at (12 months and 24 months), preschool (3 - <5 years) and school ages (6 - 18 years).

SECONDARY OBJECTIVE
To perform subgroup analysis to determine:

  • the effect of gestational age, birthweight and brain injury on cognitive and motor outcome in response to intervention compared to standard follow-up

  • the effect of interventions that commence as an inpatient compared to commencing post hospital discharge compared to standard follow-up

SUBGROUPS
Population subgroups:

  • Gestational age: extremely preterm (< 28 weeks), very preterm (< 32 weeks) or preterm (< 37 weeks)

  • Birth weight: extremely low birth weight (< 1000 grams), very low birth weight (< 1500 grams), low birth weight (< 2500 grams)

  • Prognosis: high-risk of adverse neurological outcome vs low-risk of adverse neurological outcome. High-risk of adverse neurological outcome includes infants with grade III or grade IV intraventricular haemorrhage and/or periventricular leukomalacia diagnosed prior to the commencement of intervention

Intervention subgroups:

  • Commencement of program: inpatient or outpatient

  • Main focus of intervention: parent-infant relationship, infant development or parent-infant relationship/infant development

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