Intervention Review

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Vitamin C for preventing and treating pneumonia

  1. Harri Hemilä*,
  2. Pekka Louhiala

Editorial Group: Cochrane Acute Respiratory Infections Group

Published Online: 8 AUG 2013

DOI: 10.1002/14651858.CD005532.pub3


How to Cite

Hemilä H, Louhiala P. Vitamin C for preventing and treating pneumonia. Cochrane Database of Systematic Reviews 2013, Issue 8. Art. No.: CD005532. DOI: 10.1002/14651858.CD005532.pub3.

Author Information

  1. University of Helsinki, Department of Public Health, POB 41, Helsinki, Finland

*Harri Hemilä, Department of Public Health, POB 41, University of Helsinki, Mannerheimintie 172, Helsinki, FIN-00014, Finland. harri.hemila@helsinki.fi.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 8 AUG 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Glazebrook 1942 {published data only}
  • Glazebrook AJ, Thomson S. The administration of vitamin C in a large institution and its effect on general health and resistance to infection. Journal of Hygiene 1942;42:1-19. [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199803/; PUBMED: 20475613]
Hunt 1994 {published data only}
  • Hunt C, Chakravorty NK, Annan G, Habibzadeh N, Schorah CJ. The clinical effects of vitamin C supplementation in elderly hospitalised patients with acute respiratory infections. International Journal for Vitamin and Nutrition Research 1994;64(3):212-9. [http://www.mv.helsinki.fi/home/hemila/CP/Hunt1994.pdf; PUBMED: 7814237]
Kimbarowski 1967 {published data only}
  • Kimbarowski JA, Mokrow NJ. Colored precipitation reaction of the urine according to Kimbarowski as an index of the effect of ascorbic acid during treatment of viral influenza [Farbige Ausfällungsreaktion des Harns nach Kimbarowski, als index der Wirkung von Ascorbinsäure bei Behandlung der Virusgrippe]. Deutsche Gesundheitswesen 1967;22(51):2413-8. [translation http://www.mv.helsinki.fi/home/hemila/T4.pdf; PUBMED: 5614915]
Mochalkin 1970 {published data only}
  • Mochalkin NI. Ascorbic acid in the complex therapy of acute pneumonia. Voenno-Meditsinskii Zhurnal 1970;9(Sep):17-21. [translation http://www.mv.helsinki.fi/home/hemila/T5.pdf; PUBMED: 5515787]
Pitt 1979 {published data only}
Tanaka 2000 {published data only}

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Cook 2007 {published data only}
  • Cook NR, Albert CM, Gaziano JM, Zaharris E, MacFadyen J, Danielson E, et al. A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: results from the Women's Antioxidant Cardiovascular Study. Archives of Internal Medicine 2007;167(15):1610-8. [DOI: 10.1001/archinte.167.15.1610; PUBMED: 17698683]
Dahlberg 1944 {published data only}
  • Dahlberg G, Engel A, Rydin H. The value of ascorbic acid as a prophylactic against common colds. Acta Medica Scandinavica 1944;119:540-61. [http://www.mv.helsinki.fi/home/hemila/CC/Dahlberg1944.pdf]
Hunt 1984 {published data only}
  • Hunt C, Chakravorty NK, Annan G. The clinical and biochemical effects of vitamin C supplementation in short-stay hospitalised geriatric patients. International Journal for Vitamin and Nutrition Research 1984;54(1):65-74. [http://www.mv.helsinki.fi/home/hemila/CP/Hunt1984.pdf; PUBMED: 6376396]
Kahn 2011 {published data only}
Mahalanabis 2006a {published data only}
  • Mahalanabis D, Basak M, Paul D, Gupta S, Shaikh S, Wahed MA, et al. Antioxidant vitamins E and C as adjunct therapy of severe acute lower-respiratory infection in infants and young children: a randomized controlled trial. European Journal of Clinical Nutrition 2006;60(5):673–80. [DOI: 10.1038/sj.ejcn.1602368; PUBMED: 16391588]
Mahalanabis 2006b {published data only}
  • Mahalanabis D, Jana S, Shaikh S, Gupta S, Chakrabarti ML, Moitra P, et al. Vitamin E and vitamin C supplementation does not improve the clinical course of measles with pneumonia in children: a controlled trial. Journal of Tropical Pediatrics 2006;52(4):302-3. [DOI: 10.1093/tropej/fmi100; PUBMED: 16291830]
Mochalkin 1975 {published data only}
  • Mochalkin NI. Vitamin C requirement in patients with acute pneumonia during treatment with antibiotics [Russian]. Vrachebnoe Delo 1975;9:88-92. [http://www.mv.helsinki.fi/home/hemila/CP/Mochalkin1975.pdf; PUBMED: 1210310]
Nathens 2002 {published data only}
  • Nathens AB, Neff MJ, Jurkovich GJ, Klotz P, Farver K, Ruzinski JT, et al. Randomized, prospective trial of antioxidant supplementation in critically ill surgical patients. Annals of Surgery 2002;236(6):814-22. [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1422648/; PUBMED: 12454520]
Scheunert 1949 {published data only}
  • Scheunert A. Adult requirements for vitamin C [Der Tagesbedarf des Erwachsenen an vitamin C]. International Zeitschrift fur Vitaminforschung 1949;20:374-86. [http://www.mv.helsinki.fi/home/hemila/CC/Scheunert1949.pdf]
Sesso 2008 {published data only}
Wahed 2008 {published data only}
  • Wahed MA, Islam MA, Khondakar P, Haque MA. Effect of micronutrients on morbidity and duration of hospital stay in childhood pneumonia. Mymensingh Medical Journal 2008;17(Suppl 2):77-83. [PUBMED: 18946457]

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Akaike 2001
Albaum 1996
  • Albaum MN, Hill LC, Murphy M, Li YH, Fuhrman CR, Britton CA, et al. Interobserver reliability of the chest radiograph in community-acquired pneumonia. Chest 1996;110(2):343-50. [PUBMED: 8697831]
Anderson 1973
  • Anderson TW, Reid DBW, Beaton GH. Vitamin C and the common cold [correction of the trial data in: 1972;107(6):503-8]. Canadian Medical Association Journal 1973;108(2):133. [PUBMED: 4684621]
Ashton 1999
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Campbell 1975
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Elwood 1976
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Goetzl 1974
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Hamilton 2000
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Hemilä 1997a
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Hemilä 1999a
Hemilä 1999b
Hemilä 2003
Hemilä 2004a
Hemilä 2004b
Hemilä 2006
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Hemilä 2007a
Hemilä 2008
Hemilä 2009a
Hemilä 2011a
  • Hemilä H, Kaprio J. Subgroup analysis of large trials can guide further research: a case study of vitamin E and pneumonia. Clinical Epidemiology 2011;3:51-9. [DOI: 10.2147/CLEP.S16114; PUBMED: 21386974]
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Hess 1920
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Hochwald 1937
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Hopstaken 2004
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Klenner 1951
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Levine 1996
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Luberoff 1978
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References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Hemilä 1997c
Hemilä 2007b
  • Hemilä H, Louhiala P. Vitamin C for preventing and treating pneumonia. Cochrane Database of Systematic Reviews 2007, Issue 2. [DOI: 10.1002/14651858.CD005532.pub2]
Hemilä 2009b
  • Hemilä H, Louhiala P. Vitamin C for preventing and treating pneumonia. Cochrane Database of Systematic Reviews 2009, Issue 3. [DOI: 10.1002/14651858.CD005532.pub2]
Hemilä 2011b
  • Hemilä H, Louhiala P. Vitamin C for preventing and treating pneumonia. Cochrane Database of Systematic Reviews 2011, Issue 7. [DOI: 10.1002/14651858.CD005532.pub2]