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Intervention Review

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Topical cystic fibrosis transmembrane conductance regulator gene replacement for cystic fibrosis-related lung disease

  1. Tim WR Lee1,*,
  2. Kevin W Southern2

Editorial Group: Cochrane Cystic Fibrosis and Genetic Disorders Group

Published Online: 26 NOV 2013

Assessed as up-to-date: 19 SEP 2013

DOI: 10.1002/14651858.CD005599.pub4


How to Cite

Lee TWR, Southern KW. Topical cystic fibrosis transmembrane conductance regulator gene replacement for cystic fibrosis-related lung disease. Cochrane Database of Systematic Reviews 2013, Issue 11. Art. No.: CD005599. DOI: 10.1002/14651858.CD005599.pub4.

Author Information

  1. 1

    A Floor, Clarendon Wing, Leeds General Infirmary, Leeds Regional Paediatric Cystic Fibrosis Centre, Leeds, West Yorkshire, UK

  2. 2

    University of Liverpool, Department of Women's and Children's Health, Liverpool, Merseyside, UK

*Tim WR Lee, Leeds Regional Paediatric Cystic Fibrosis Centre, A Floor, Clarendon Wing, Leeds General Infirmary, Great George Street, Leeds, West Yorkshire, LS1 3EX, UK. timlee@doctors.org.uk.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 26 NOV 2013

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This is not the most recent version of the article. View current version (17 JUN 2016)

[Analysis 1.1]
Analysis 1.1. Comparison 1 CFTR gene replacement therapy versus placebo, Outcome 1 Respiratory exacerbations (episodes).
[Analysis 1.2]
Analysis 1.2. Comparison 1 CFTR gene replacement therapy versus placebo, Outcome 2 Change in FEV1 (L) from baseline.
[Analysis 1.3]
Analysis 1.3. Comparison 1 CFTR gene replacement therapy versus placebo, Outcome 3 Change in FEV1 % predicted from baseline.
[Analysis 1.4]
Analysis 1.4. Comparison 1 CFTR gene replacement therapy versus placebo, Outcome 4 Change in FVC.
[Analysis 1.5]
Analysis 1.5. Comparison 1 CFTR gene replacement therapy versus placebo, Outcome 5 Number of inpatient episodes.
[Analysis 1.6]
Analysis 1.6. Comparison 1 CFTR gene replacement therapy versus placebo, Outcome 6 Adverse events.
[Analysis 1.7]
Analysis 1.7. Comparison 1 CFTR gene replacement therapy versus placebo, Outcome 7 Lower airway potential difference change from baseline.
[Analysis 1.8]
Analysis 1.8. Comparison 1 CFTR gene replacement therapy versus placebo, Outcome 8 Lower airway potential difference change from baseline (amiloride and low chloride).
[Analysis 1.9]
Analysis 1.9. Comparison 1 CFTR gene replacement therapy versus placebo, Outcome 9 Measurement of CFTR protein expression (SPQ chloride efflux).
[Analysis 1.10]
Analysis 1.10. Comparison 1 CFTR gene replacement therapy versus placebo, Outcome 10 Change in validated computerised tomogram (CT) score.