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Pregabalin add-on for drug-resistant partial epilepsy

  1. Jennifer Pulman1,*,
  2. Karla Hemming2,
  3. Anthony G Marson1

Editorial Group: Cochrane Epilepsy Group

Published Online: 12 MAR 2014

Assessed as up-to-date: 3 MAR 2014

DOI: 10.1002/14651858.CD005612.pub3


How to Cite

Pulman J, Hemming K, Marson AG. Pregabalin add-on for drug-resistant partial epilepsy. Cochrane Database of Systematic Reviews 2014, Issue 3. Art. No.: CD005612. DOI: 10.1002/14651858.CD005612.pub3.

Author Information

  1. 1

    Institute of Translational Medicine, University of Liverpool, Department of Molecular and Clinical Pharmacology, Liverpool, Merseyside, UK

  2. 2

    University of Birmingham, Public Health, Epidemiology and Biostatistics, Birmingham, UK

*Jennifer Pulman, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Clinical Sciences Centre for Research and Education, Lower Lane, Fazakerley, Liverpool, Merseyside, L9 7LJ, UK. jennifer.pulman@liv.ac.uk.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 12 MAR 2014

SEARCH

[Figure 1]
Figure 1. Study flow diagram. Date of search 9 January 2014.
[Figure 2]
Figure 2. 'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages across all included studies
[Figure 3]
Figure 3. Forest plot of comparison: 1 Pregabalin versus placebo: 50% seizure reduction - ITT, outcome: 1.1 50% responders, ITT.
[Figure 4]
Figure 4. Forest plot of comparison: 1 Pregabalin versus placebo: 50% seizure reduction - ITT, outcome: 1.2 50% responders (Random-effects).
[Analysis 1.1]
Analysis 1.1. Comparison 1 Pregabalin versus placebo: 50% seizure reduction - ITT, Outcome 1 50% responders, ITT.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Pregabalin versus placebo: 50% seizure reduction - ITT, Outcome 2 50% responders (Random-effects).
[Analysis 1.3]
Analysis 1.3. Comparison 1 Pregabalin versus placebo: 50% seizure reduction - ITT, Outcome 3 50% responders, Best-Case Analysis.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Pregabalin versus placebo: 50% seizure reduction - ITT, Outcome 4 50% responders, Best-Case Analysis Random-effects.
[Analysis 1.5]
Analysis 1.5. Comparison 1 Pregabalin versus placebo: 50% seizure reduction - ITT, Outcome 5 50% responders, Worst-Case Analysis.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Pregabalin versus placebo: seizure freedom - ITT, Outcome 1 Seizure freedom post titration.
[Analysis 3.1]
Analysis 3.1. Comparison 3 Pregabalin versus placebo: treatment withdrawal (any reason) - ITT, Outcome 1 Treatment withdrawal any reason.
[Analysis 4.1]
Analysis 4.1. Comparison 4 Pregabalin versus placebo: treatment withdrawal (adverse events) - ITT, Outcome 1 Treatment withdrawal for adverse events.
[Analysis 5.1]
Analysis 5.1. Comparison 5 Pregabalin versus placebo: adverse effects, Outcome 1 Ataxia.
[Analysis 5.2]
Analysis 5.2. Comparison 5 Pregabalin versus placebo: adverse effects, Outcome 2 Fatigue.
[Analysis 5.3]
Analysis 5.3. Comparison 5 Pregabalin versus placebo: adverse effects, Outcome 3 Dizziness.
[Analysis 5.4]
Analysis 5.4. Comparison 5 Pregabalin versus placebo: adverse effects, Outcome 4 Nausea.
[Analysis 5.5]
Analysis 5.5. Comparison 5 Pregabalin versus placebo: adverse effects, Outcome 5 Somnolence.
[Analysis 5.6]
Analysis 5.6. Comparison 5 Pregabalin versus placebo: adverse effects, Outcome 6 Weight gain.
[Analysis 5.7]
Analysis 5.7. Comparison 5 Pregabalin versus placebo: adverse effects, Outcome 7 Headache.
[Analysis 6.1]
Analysis 6.1. Comparison 6 Pregabalin versus Lamotrigine, Outcome 1 50% responders, ITT.
[Analysis 6.2]
Analysis 6.2. Comparison 6 Pregabalin versus Lamotrigine, Outcome 2 Seizure freedom.
[Analysis 6.3]
Analysis 6.3. Comparison 6 Pregabalin versus Lamotrigine, Outcome 3 Treatment withdrawal (any reason).
[Analysis 6.4]
Analysis 6.4. Comparison 6 Pregabalin versus Lamotrigine, Outcome 4 Treatment withdrawal (adverse events).
[Analysis 6.5]
Analysis 6.5. Comparison 6 Pregabalin versus Lamotrigine, Outcome 5 Adverse events.
[Analysis 6.6]
Analysis 6.6. Comparison 6 Pregabalin versus Lamotrigine, Outcome 6 50% responders, Best- and Worst-Case Analysis.