Intervention Review

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Prophylactic antibiotics for transcervical intrauterine procedures

  1. Jadsada Thinkhamrop1,*,
  2. Malinee Laopaiboon2,
  3. Pisake Lumbiganon1

Editorial Group: Cochrane Gynaecology and Fertility Group

Published Online: 31 MAY 2013

Assessed as up-to-date: 10 AUG 2012

DOI: 10.1002/14651858.CD005637.pub3


How to Cite

Thinkhamrop J, Laopaiboon M, Lumbiganon P. Prophylactic antibiotics for transcervical intrauterine procedures. Cochrane Database of Systematic Reviews 2013, Issue 5. Art. No.: CD005637. DOI: 10.1002/14651858.CD005637.pub3.

Author Information

  1. 1

    Khon Kaen University, Department of Obstetrics and Gynaecology, Faculty of Medicine, Khon Kaen, Thailand

  2. 2

    Khon Kaen University, Department of Biostatistics and Demography, Faculty of Public Health, Khon Kaen, Thailand

*Jadsada Thinkhamrop, Department of Obstetrics and Gynaecology, Faculty of Medicine, Khon Kaen University, Faculty of Medicine, 123 Mittraparb Highway, Khon Kaen, 40002, Thailand. jadsada@kku.ac.th.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 31 MAY 2013

SEARCH

 
Characteristics of excluded studies [ordered by study ID]

StudyReason for exclusion

Bhattacharya 1995The study reported on the outcome bacteraemia following hysteroscopic surgery; this is not relevant to this review's objective which is to assess the effect of antibiotic prophylaxis on infectious morbidity.

Brook 2006This is a randomised controlled trial to assess the rate of bacterial contamination on the transfer catheter tip during embryo transfer and the success rate for a clinical pregnancy. The study's outcomes of interest are not relevant to this review's objective which is to assess the effect of antibiotic prophylaxis on infectious morbidity.

Kasius 2011There were 2 participating hospitals. They enrolled subjects for the intervention arm from one hospital and the control arm from another hospital. This is a therefore a quasi-randomised trial.

Makris 2000There were 2 groups in the study. The authors did not mention how they separated participants into the 2 groups. We cannot confirm from the publication that this was a randomised trial. We sent a letter to the first author to clarify this issue, however we had not received any information at the time of completing the review. The authors mentioned in the article that this was a follow-up study in women given antibiotics or not after endometrial curettage for menorrhagia. It seems to us that this is not a randomised controlled trial.

Marchino 1994This was a 1-arm clinical trial; there was no control group in the study

McCausland 1993There were 2 groups in the study. The authors did not mention how they separated participants into the 2 groups. We cannot confirm from the publication that this was a randomised trial. We sent a letter to the first author to clarify this issue, however we had not received any information at the time of completing the review. There were 200 women who did not receive prophylactic antibiotics and 500 women who received prophylactic antibiotics. There was a large difference between the numbers of participants in the 2 groups. It seems to us that this could not be a randomised controlled trial.

N'Gbesso 2003This was a clinical controlled trial where even and odd enrolment numbers were used to assign the participants to receive the intervention or not

Peikrishvili 2004The study reported on the outcome of interest which was rate of pregnancy loss during IVF cycles according to the prescription of antibiotics or not; this is not relevant to this review's objective which is to assess the effect of antibiotic prophylaxis on infectious morbidity

Pittaway 1983The study reported on acute pelvic inflammatory disease after hysterosalpingogram in the first group without antibiotic prophylaxis, who were recruited between 1 October 1980 and 1 September 1981, and the second group, who were recruited between 1 October 1981 and 1 October 1982, and received antibiotic prophylaxis. This study is therefore a non-concurrent controlled trial.

Primi 2004This was a randomised controlled trial to assess the success rate of implantation on assisted hatching and immunosuppressive/antibiotic treatment. The study's outcome of interest was not relevant to this review's objective which is to assess the effect of antibiotic prophylaxis on infectious morbidity.