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Vitamin A supplementation for postpartum women

  1. Julicristie M Oliveira-Menegozzo1,*,
  2. Denise P Bergamaschi2,
  3. Philippa Middleton3,
  4. Christine E East4

Editorial Group: Cochrane Pregnancy and Childbirth Group

Published Online: 6 OCT 2010

Assessed as up-to-date: 26 AUG 2010

DOI: 10.1002/14651858.CD005944.pub2

How to Cite

Oliveira-Menegozzo JM, Bergamaschi DP, Middleton P, East CE. Vitamin A supplementation for postpartum women. Cochrane Database of Systematic Reviews 2010, Issue 10. Art. No.: CD005944. DOI: 10.1002/14651858.CD005944.pub2.

Author Information

  1. 1

    School of Public Health, University of Sao Paulo, Department of Nutrition, São Paulo, SP, Brazil

  2. 2

    University of Sao Paulo, Departamento de Epidemiologia-Estatistica, Sao Paulo, Brazil

  3. 3

    The University of Adelaide, ARCH: Australian Research Centre for Health of Women and Babies, Discipline of Obstetrics and Gynaecology, Adelaide, South Australia, Australia

  4. 4

    Pregnancy Research Centre, Department of Perinatal Medicine, Royal Women's Hospital, Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria, Australia

*Julicristie M Oliveira-Menegozzo, Department of Nutrition, School of Public Health, University of Sao Paulo, Av Dr Arnaldo, 715, São Paulo, SP, Cep 01246-904, Brazil. julicristie@yahoo.com. cristie@usp.br.

Publication History

  1. Publication Status: New
  2. Published Online: 6 OCT 2010

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[Figure 1]
Figure 1. Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
[Figure 2]
Figure 2. Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Supplement (vitamin A as retinyl, water miscible or beta-carotene) versus control (placebo, no treatment), Outcome 1 Maternal mortality to six months.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Supplement (vitamin A as retinyl, water miscible or beta-carotene) versus control (placebo, no treatment), Outcome 2 Maternal fever at 3 months postpartum.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Supplement (vitamin A as retinyl, water miscible or beta-carotene) versus control (placebo, no treatment), Outcome 3 Maternal respiratory tract infection at 3 months postpartum.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Supplement (vitamin A as retinyl, water miscible or beta-carotene) versus control (placebo, no treatment), Outcome 4 Maternal diarrhoea at 3 months postpartum.
[Analysis 1.5]
Analysis 1.5. Comparison 1 Supplement (vitamin A as retinyl, water miscible or beta-carotene) versus control (placebo, no treatment), Outcome 5 Maternal adverse effects of supplementation.
[Analysis 1.6]
Analysis 1.6. Comparison 1 Supplement (vitamin A as retinyl, water miscible or beta-carotene) versus control (placebo, no treatment), Outcome 6 Maternal serum retinol (μmol/L) at 1.5 months postpartum.
[Analysis 1.7]
Analysis 1.7. Comparison 1 Supplement (vitamin A as retinyl, water miscible or beta-carotene) versus control (placebo, no treatment), Outcome 7 Maternal serum retinol (mcmol/L) at 3 - 3.5 months postpartum.
[Analysis 1.8]
Analysis 1.8. Comparison 1 Supplement (vitamin A as retinyl, water miscible or beta-carotene) versus control (placebo, no treatment), Outcome 8 Maternal serum retinol (mcmol/L) at 6 - 6.5 months postpartum.
[Analysis 1.9]
Analysis 1.9. Comparison 1 Supplement (vitamin A as retinyl, water miscible or beta-carotene) versus control (placebo, no treatment), Outcome 9 Maternal serum retinol (mcmol/L) at 9 months postpartum.
[Analysis 1.10]
Analysis 1.10. Comparison 1 Supplement (vitamin A as retinyl, water miscible or beta-carotene) versus control (placebo, no treatment), Outcome 10 Maternal low hepatic vitamin A stores 3 months postpartum (MRDR ≥ 0.06).
[Analysis 1.11]
Analysis 1.11. Comparison 1 Supplement (vitamin A as retinyl, water miscible or beta-carotene) versus control (placebo, no treatment), Outcome 11 Maternal low hepatic vitamin A stores 5 - 6 months postpartum (MRDR ≥ 0.06).
[Analysis 1.12]
Analysis 1.12. Comparison 1 Supplement (vitamin A as retinyl, water miscible or beta-carotene) versus control (placebo, no treatment), Outcome 12 Maternal low hepatic vitamin A stores 9 months postpartum (MRDR ≥ 0.06).
[Analysis 1.13]
Analysis 1.13. Comparison 1 Supplement (vitamin A as retinyl, water miscible or beta-carotene) versus control (placebo, no treatment), Outcome 13 Maternal low hepatic vitamin A stores 3 months postpartum (RDR > 20%).
[Analysis 1.14]
Analysis 1.14. Comparison 1 Supplement (vitamin A as retinyl, water miscible or beta-carotene) versus control (placebo, no treatment), Outcome 14 Maternal low hepatic vitamin A stores 6 months postpartum (RDR > 20%).
[Analysis 1.15]
Analysis 1.15. Comparison 1 Supplement (vitamin A as retinyl, water miscible or beta-carotene) versus control (placebo, no treatment), Outcome 15 Breast milk retinol (mcmol/L) at 3 - 3.5 months postpartum.
[Analysis 1.16]
Analysis 1.16. Comparison 1 Supplement (vitamin A as retinyl, water miscible or beta-carotene) versus control (placebo, no treatment), Outcome 16 Breast milk retinol (mcmol/L) at 6 - 6.5 months postpartum.
[Analysis 1.17]
Analysis 1.17. Comparison 1 Supplement (vitamin A as retinyl, water miscible or beta-carotene) versus control (placebo, no treatment), Outcome 17 Breast milk retinol (mcmol/L) at 8 - 9 months postpartum.
[Analysis 1.18]
Analysis 1.18. Comparison 1 Supplement (vitamin A as retinyl, water miscible or beta-carotene) versus control (placebo, no treatment), Outcome 18 Breast milk retinol (< 1.05 mcmol/L) at 3 months postpartum.
[Analysis 1.19]
Analysis 1.19. Comparison 1 Supplement (vitamin A as retinyl, water miscible or beta-carotene) versus control (placebo, no treatment), Outcome 19 Breast milk retinol (< 1.05 mcmol/L) at 6 months postpartum.
[Analysis 1.20]
Analysis 1.20. Comparison 1 Supplement (vitamin A as retinyl, water miscible or beta-carotene) versus control (placebo, no treatment), Outcome 20 Breast milk retinol (< 1.05 mcmol/L) at 8-9 months postpartum.
[Analysis 1.21]
Analysis 1.21. Comparison 1 Supplement (vitamin A as retinyl, water miscible or beta-carotene) versus control (placebo, no treatment), Outcome 21 Breast milk retinol (< 0.28 mcmol/g of fat) at 3 months postpartum.
[Analysis 1.22]
Analysis 1.22. Comparison 1 Supplement (vitamin A as retinyl, water miscible or beta-carotene) versus control (placebo, no treatment), Outcome 22 Breast milk retinol (< 0.28 mcmol/g of fat) at 6 months postpartum.
[Analysis 1.23]
Analysis 1.23. Comparison 1 Supplement (vitamin A as retinyl, water miscible or beta-carotene) versus control (placebo, no treatment), Outcome 23 Breast milk retinol (< 0.28 mcmol/g of fat) at 9 months postpartum.
[Analysis 1.24]
Analysis 1.24. Comparison 1 Supplement (vitamin A as retinyl, water miscible or beta-carotene) versus control (placebo, no treatment), Outcome 24 Maternal abnormal conjunctival impression cytology 3 months postpartum.
[Analysis 1.25]
Analysis 1.25. Comparison 1 Supplement (vitamin A as retinyl, water miscible or beta-carotene) versus control (placebo, no treatment), Outcome 25 Maternal abnormal conjunctival impression cytology 6 months postpartum.
[Analysis 1.26]
Analysis 1.26. Comparison 1 Supplement (vitamin A as retinyl, water miscible or beta-carotene) versus control (placebo, no treatment), Outcome 26 Infant mortality.
[Analysis 1.27]
Analysis 1.27. Comparison 1 Supplement (vitamin A as retinyl, water miscible or beta-carotene) versus control (placebo, no treatment), Outcome 27 Infant diarrhoea (one or more episodes) to 12 months.
[Analysis 1.28]
Analysis 1.28. Comparison 1 Supplement (vitamin A as retinyl, water miscible or beta-carotene) versus control (placebo, no treatment), Outcome 28 Infant diarrhoea episodes and duration.
[Analysis 1.29]
Analysis 1.29. Comparison 1 Supplement (vitamin A as retinyl, water miscible or beta-carotene) versus control (placebo, no treatment), Outcome 29 Infant gastroenteritis to 3 months.
[Analysis 1.30]
Analysis 1.30. Comparison 1 Supplement (vitamin A as retinyl, water miscible or beta-carotene) versus control (placebo, no treatment), Outcome 30 Infant acute respiratory infection (one or more episodes) to 12 months.
[Analysis 1.31]
Analysis 1.31. Comparison 1 Supplement (vitamin A as retinyl, water miscible or beta-carotene) versus control (placebo, no treatment), Outcome 31 Infant upper respiratory tract infection to 3 months.
[Analysis 1.32]
Analysis 1.32. Comparison 1 Supplement (vitamin A as retinyl, water miscible or beta-carotene) versus control (placebo, no treatment), Outcome 32 Infant acute respiratory tract infection episodes and duration.
[Analysis 1.33]
Analysis 1.33. Comparison 1 Supplement (vitamin A as retinyl, water miscible or beta-carotene) versus control (placebo, no treatment), Outcome 33 Infant febrile illness episodes.
[Analysis 1.34]
Analysis 1.34. Comparison 1 Supplement (vitamin A as retinyl, water miscible or beta-carotene) versus control (placebo, no treatment), Outcome 34 Infant adverse effects of supplementation.
[Analysis 1.35]
Analysis 1.35. Comparison 1 Supplement (vitamin A as retinyl, water miscible or beta-carotene) versus control (placebo, no treatment), Outcome 35 Infant serum retinol (µmol/L) at 2 - 3.5 months postpartum.
[Analysis 1.36]
Analysis 1.36. Comparison 1 Supplement (vitamin A as retinyl, water miscible or beta-carotene) versus control (placebo, no treatment), Outcome 36 Infant serum retinol (µmol/L) at 5 - 6 months postpartum.
[Analysis 1.37]
Analysis 1.37. Comparison 1 Supplement (vitamin A as retinyl, water miscible or beta-carotene) versus control (placebo, no treatment), Outcome 37 Infant low hepatic vitamin A stores 1.5 months postpartum (MRDR ≥ 0.06).
[Analysis 1.38]
Analysis 1.38. Comparison 1 Supplement (vitamin A as retinyl, water miscible or beta-carotene) versus control (placebo, no treatment), Outcome 38 Infant low hepatic vitamin A stores at 5 - 6.5 months postpartum.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Supplement (vitamin A as retinyl) high dose versus low dose, Outcome 1 Infant mortality.
[Analysis 2.2]
Analysis 2.2. Comparison 2 Supplement (vitamin A as retinyl) high dose versus low dose, Outcome 2 Maternal serum retinol (ɥmol/L).
[Analysis 2.3]
Analysis 2.3. Comparison 2 Supplement (vitamin A as retinyl) high dose versus low dose, Outcome 3 Breast milk retinol (< 1.05 ɥmol/L).
[Analysis 2.4]
Analysis 2.4. Comparison 2 Supplement (vitamin A as retinyl) high dose versus low dose, Outcome 4 Infant serum retinol (ɥmol/L ) at 2 months postpartum.