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Artesunate versus quinine for treating severe malaria

  1. David Sinclair1,*,
  2. Sarah Donegan1,
  3. Rachel Isba1,
  4. David G Lalloo2

Editorial Group: Cochrane Infectious Diseases Group

Published Online: 13 JUN 2012

Assessed as up-to-date: 31 JAN 2011

DOI: 10.1002/14651858.CD005967.pub4


How to Cite

Sinclair D, Donegan S, Isba R, Lalloo DG. Artesunate versus quinine for treating severe malaria. Cochrane Database of Systematic Reviews 2012, Issue 6. Art. No.: CD005967. DOI: 10.1002/14651858.CD005967.pub4.

Author Information

  1. 1

    Liverpool School of Tropical Medicine, International Health Group, Liverpool, UK

  2. 2

    Liverpool School of Tropical Medicine, Clinical Research Group, Liverpool, Merseyside, UK

*David Sinclair, International Health Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK. sinclad@liverpool.ac.uk.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 13 JUN 2012

SEARCH

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Anh 1989 {unpublished data only}
  • Anh TK. Efficacy of qinghaosu in Plasmodium falciparum malaria. World Health Organization report [M20/181/38].
  • Anh TK, Kim NV, Bich NN, Huong N.ng, Phuong N.V, et al. Randomized comparative study of artesunate intravenously and quinine in loading dose IV on severe and complicated malaria. Unpublished report.
Anh 1995 {published data only}
  • Anh TK. Standard dose quinine & IV artesunate in treatment of severe and complicated falciparum malaria [WHO/Geneva/TDCRC/CRH]. Malaria Symposium & Workshop, Vungtau 1992.
  • Anh TK, Binh TQ, Kim NV, et al. Comparative study of intravenous artesunate followed by oral mefloquine versus intravenous quinine in the treatment of severe and complicated malaria in Vietnam. Symposium on Tropical Medicine, Sanya, China. Institute Guangzhou University of TCM, 1995; Vol. 12:8-9.
  • Anh TK, Binh TQ, Kim NV, et al. Comparative study of intravenous artesunate followed by oral mefloquine versus intravenous quinine in the treatment of severe and complicated malaria in Viet Nam. Unpublished report 1995.
Cao 1997 {published data only}
  • Cao XT, Bethell DB, Pham TP, Ta TT, Tran TN, Nguyen TT, et al. Comparison of artemisinin suppositories, intramuscular artesunate and intravenous quinine for the treatment of severe childhood malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene 1997;91(3):335-42.
Dondorp 2005 {published data only}
Dondorp 2010 {published data only}
  • Dondorp AM, Fanello CI, Hendriksen IC, Gomes E, Seni A, Chhaganlal KD, et al. Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial. Lancet 2010;376(9753):1647-57.
Eltahir 2010 {published data only}
  • Eltahir HG, Omer AA, Mohamed AA, Adam I. Comparison of artesunate and quinine in the treatment of Sudanese children with severe Plasmodium falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene 2010;104(10):684-6.
Hien 1992 {published data only}
  • Hien TT, Arnold K, Vinh H, Cuong BM, Phu NH, Chau TT, et al. Comparison of artemisinin suppositories with intravenous artesunate and intravenous quinine in the treatment of cerebral malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene 1992;86(6):582-3.
  • Vinh H, Arnold K, Cuong B, Phu N, Chau T, Hao N. Treatment of cerebral malaria comparing artemisinin suppositories with intravenous artesunate and intravenous quinine. XIIIth International Congress for Tropical Medicine and Malaria; Pattaya, Thailand. 1992:9.
Newton 2003 {published data only}
  • Newton PN, Angus BJ, Chierakul W, Dondorp A, Ruangveerayuth R, Silamut K, et al. Randomized comparison of artesunate and quinine in the treatment of severe falciparum malaria. Clinical Infectious Diseases 2003;37(1):7-16.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Aguwa 2010 {published data only}
  • Aguwa CN, Ukwe CV, Adibe MO. A comparative study of quinine and artemether in the treatment of severe malaria in Nigerian children [Tropical Journal of Pharmaceutical Research]. 2010 9;1:11-17.
Awad 2003 {published data only}
  • Awad MI, Alkadru AM, Behrens RH, Baraka OZ, Eltayeb IB. Descriptive study on the efficacy and safety of artesunate suppository in combination with other antimalarials in the treatment of severe malaria in Sudan. American Journal of Tropical Medicine and Hygiene 2003;68(2):153-8.
Barnes 2004 {published data only}
  • Barnes KI, Mwenechanya J, Tembo M, McIlleron H, Folb PI, Ribeiro I, et al. Efficacy of rectal artesunate compared with parenteral quinine in initial treatment of moderately severe malaria in African children and adults: a randomised study. Lancet 2004;363(9421):1598-605.
Bounyasong 2001 {published data only}
  • Bounyasong S. Randomized trial of artesunate and mefloquine in comparison with quinine sulfate to treat P. falciparum malaria pregnant women. Journal of Medical Association of Thailand 2001;84(9):1288-99.
Haroon 2005 {published data only}
  • Haroon N, Amichandwala K, Solu M. Comparative efficacy of quinine and artesunate in the treatment of severe malaria: A randomized controlled trial. JK Science 2005;7(1):32-5.
Krudsood 2003 {published data only}
  • Krudsood S, Wilairatana P, Vannaphan S, Treeprasertsuk S, Silachamroon U, Phomrattanaprapin W, et al. Clinical experience with intravenous quinine, intramuscular artemether and intravenous artesunate for the treatment of severe malaria in Thailand. Southeast Asian Journal of Tropical Medicine and Public Health 2003;34(1):54-61.
Li 1990 {published data only}
  • Li G, Guo X, Fu L. A randomised comparative study of artesunate versus quinine dihydrochloride in the treatment of falciparum malaria. Clinical Trials on Qinghaosu and its Derivatives; Guangzhou, China. 1990; Vol. 1:50-8.
McGready 2001a {published data only}
  • McGready R, Cho T, Samuel, Villegas L, Brockman A, van Vugt M, et al. Randomized comparison of quinine-clindamycin versus artesunate in the treatment of falciparum malaria in pregnancy. Transactions of the Royal Society of Tropical Medicine and Hygiene 2001;95(6):651-6.
McGready 2001b {published data only}
  • McGready R, Cho T, Keo NK, Thwai KL, Villegas L, Looareesuwan S, et al. Artemisinin antimalarials in pregnancy: a prospective treatment study of 539 episodes of multidrug-resistant Plasmodium falciparum. Clinical Infectious Diseases 2001;33(12):2009-16.
Mohanty 2004 {published data only}
  • Mohanty AK, Rath BK, Mohanty R, Samal AK, Mishra K. Randomized control trial of quinine and artesunate in complicated malaria. Indian Journal of Pediatrics 2004;71(4):291-5.
Newton 2001 {published data only}
  • Newton PN, Chierakul W, Ruangveerayuth R, Silamut K, Teerapong P, Krudsood S, et al. A comparison of artesunate alone with combined artesunate and quinine in the parenteral treatment of acute falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene 2001;95(5):519-23.
Osanuga 2009 {published data only}
  • Osonuga OA, Osonuga IO. Parasitaemia changes in the course of treatment of severe malaria patients with artemether and quinine (A preliminary study). Macedonian Journal of Medical Sciences 2009;2(4):319-323.
Phu 2010 {published data only}
  • Phu NH, Tuan PQ, Day N, Mai NT, Chau TT, Chuong LV, et al. Randomized controlled trial of artesunate or artemether in Vietnamese adults with severe falciparum malaria. Malaria 2010;9(97):doi: 10.1186/1475-2875-9-97.
Pukrittayakamee 2004 {published data only}
  • Pukrittayakamee S, Chotivanich K, Chantra A, Clemens R, Looareesuwan S, White NJ. Activities of artesunate and primaquine against asexual- and sexual-stage parasites in falciparum malaria. Antimicrobial Agents and Chemotherapy 2004;48(4):1329-34.
Win 1992 {published data only}
  • Win K, Than M, Thwe Y. Comparison of combinations of parenteral artemisinin derivatives plus oral mefloquine with intravenous quinine plus oral tetracycline for treating cerebral malaria. Bulletin of the World Health Organization 1992;70(6):777-82.
Zhao 2001 {published data only}
  • Zhao J. Artesunate for 321 patients with falciparum malaria in the Republic of Mali. Chinese Journal of New Drugs and Clinical Remedies 2001;20(4):275-7.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Adjuik 2004
Afolabi 2004
  • Afolabi BB, Okoromah CAN. Intramuscular arteether for treating severe malaria. Cochrane Database of Systematic Reviews 2004, Issue 4. Art. No.: CD004391. [DOI: 10.1002/14651858.CD004391.Pub2]
Alkadi 2007
Altman 1996
AQMSG 2001
  • The Artemether-Quinine Meta-analysis Study Group. A meta-analysis using individual patient data of trials comparing artemether with quinine in the treatment of severe falciparum malaria. Transactions of the Royal Society of Tropical Medicine 2001;95(6):637-50.
Brewer 1994
  • Brewer T, Grate SJ, Peggins JO, Weina PJ, Petras JM, Levine BS, et al. Fatal neurotoxicity of arteether and artemether. American Journal of Tropical Medicine and Hygiene 1994;51(3):251-9.
Doolan 2009
Genovese 2000
  • Genovese RF, Newman DB, Brewer TG. Behavioural and neural toxicity of the artemisinin antimalarial, arteether, but not artesunate and artelinate in rats. Pharmacology, Biochemistry, and Behaviour 2000;67(1):37-44.
Gilles 2000
  • Gilles HM. Management of severe malaria: a practical handbook. 2nd Edition. Geneva: World Health Organization, 2000.
Hien 2004
  • Hien TT, Davis TM, Chuong LV, Ilett KF, Sinh DX, Phu NH, et al. Comparative pharmacokinetics of intramuscular artesunate and artemether in patients with severe falciparum malaria. Antimicrobial Agents and Chemotherapy 2004;48(11):4234-9.
Higgins 2008
  • Higgins JPT, Altman DG (editors). Chapter 8:  Assessing risk of bias in included studies. In: Higgins JPT, Green S (editors), Cochrane Handbook of Systematic Reviews of Intervention. Version 5.0.0 (updated February 2008). The Cochrane Collaboration, 2008. Available from www.cochrane-handbook.org. John Wiley & Sons Ltd.
Jaffar 1997
  • Jaffar S, Van Hensbroek M, Palmer A, Schneider G, Greenwood B. Predictors of a fatal outcome following childhood cerebral malaria. American Journal of Tropical Medicine and Hygiene 1997;57(1):20-4.
Karbwang 1997
  • Karbwang J, Na-Bangchang K, Congpuong K, Molunto P, Thanavibul A. Pharmacokinetics and bioavailability of oral and intramuscular artemether. European Journal of Clinical Pharmacology 1997;52:307-10.
Kissinger 2000
  • Kissinger E, Hien T, Hung N, Nam N, Tuyen N, Dinh B, et al. Clinical and neurophysiological study of the effects of multiple doses of artemisinin on brain-stem function in Vietnamese patients. American Journal of Tropical Medicine and Hygiene 2000;63(1-2):48-55.
Kyu 2009
  • Kyu HH, Fernandez E. Artemisinin derivatives versus quinine for cerebral malaria inAfrican children: a systematic review. Bulletin of the World Health Organization 2009;87:896-904.
Lesi 2004
Li 2004
  • Li Q, Lugt CB, Looareesuwan S, Krudsood S, Wilairatana P, Vannaphan S, et al. Pharmacokinetic investigation of the therapeutic potential of artemotil (ß-arteether) in Thai patients with severe Plasmodium falciparum malaria. Am J Trop Med Hyg 2004;71(6):723-731.
Looareesuwan 2002
  • Looareesuwan S, Oosterhuis B, Schilizzi BM, Sollie FAE, Wilairatana P, Krudsood S, et al. Dose-finding and efficacy study for i.m. artemotil (beta-arteether)and comparison with i.m. artemether in acute uncomplicated P. falciparum malaria. British Journal of Clinical Pharmacology 2002;53(5):492-500.
Lubell 2009
Lubell 2011
  • Lubell Y, Riewpaiboon A, Dondorp AM, von Seidlein L, Mokuolu OA, Nansumba M, et al. Cost-effectiveness of parenteral artesunate for treating children with severe malaria in sub-Saharan Africa.. Bulletin of the World Health Organization 2011;89(7):504-12.
McIntosh 2000
  • McIntosh HM, Olliaro P. Artemisinin derivatives for treating severe malaria. Cochrane Database of Systematic Reviews 2000, Issue 2. [DOI: 10.1002/14651858.CD000527]
Mithwani 2003
  • Mithwani S, Aarons L, Kokwaro GO, Majid O, Muchohi S, Edwards G, et al. Population pharmacokinetics of artemether and dihydroartemisinin following single intramuscular dosing of artemether in African children with severe falciparum malaria. British Journal of Clinical Pharmacology 2003;57(2):146-52.
Murphy 1997
  • Murphy SA, Mberu E, Muhia D, English M, Crawley J, Waruiru C, et al. The disposition of intramuscular artemether in children with cerebral malaria; a preliminary study. Transactions of the Royal Society of Tropical Medicine and Hygiene 1997;91(3):331-4.
Nealon 2002
  • Nealon C, Dzeing A, Müller-Römer U, Planche T, Sinou V, Kombila M, et al. Intramuscular bioavailability and clinical efficacy of artesunate in gabonese children with severe malaria. Antimicrobial Agents and Chemotherapy 2002;46(12):3933-9.
Nontprasert 1998
  • Nontprasert N, Nosten-Bertrand M, Pukrittayakamee S, Vanijanonta S, Angus BJ, White N. Assessment of the neurotoxicity of parenteral artemisinin derivatives in mice. American Journal of Tropical Medicine and Hygiene 1998;59(4):519-22.
Nontprasert 2000
  • Nontprasert A, Pukrittayakamee S, Nosten-Bertrand M, Vanijanonta S, White NJ. Studies of the neurotoxicity of oral artemisinin derivatives in mice. American Journal of Tropical Medicine and Hygiene 2000;62(3):409-12.
Nontprasert 2002
  • Nontprasert A, Pukrittayakamee S, Prakongpan S, Supanaranond W, Looareesuwan S, White NJ. Assessment of neurotoxicity of oral dihydroartemisinin in mice. Transactions of the Royal Society of Tropical Medicine and Hygiene 2002;96(1):99-101.
Nosten 2007
  • Nosten F, White NJ. Artemisinin-based combination treatment of falciparum malaria. American Journal of Tropical Medicine and Hygiene 2007;77 (6 Suppl):181-92.
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Ribeiro 1998
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ter Kuile 1993
  • ter Kuile F, White NJ, Holloway P, Pasvol G, Krishna S. Plasmodium falciparum: in vitro studies of the pharmacodynamic properties of drugs used for the treatment of severe malaria. Experimental Parasitology 1993;76(1):85-95.
Toovey 2004
  • Toovey S, Jamieson A. Audiometric changes associated with the treatment of uncomplicated falciparum malaria with co-artemether. Transactions of the Royal Society of Tropical Medicine and Hygiene 2004;98(5):261-7.
van Der Torn 1996
  • van der Torn M, Thuma PE, Mabeza GF, Biemba G, Moyo VM, McLaren CE, et al. Loading dose of quinine in African children with cerebral malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene 1998;92(3):325-31.
White 1983
  • White NJ, Warrell DA, Chanthavanich P, Looareesuwan S, Warrell MJ, Krishna S, et al. Severe hypoglycemia and hyperinsulinemia in falciparum malaria. New England Journal of Medicine 1983;309(2):61-6.
White 1983b
  • White NJ, Looareesawan S, Warrell DA, Warrell MJ, Chanthavanich P, Bunnag D, et al. Quinine Loading Dose in Severe Malaria. American Journal of Tropical Medicine and Hygiene 1983;32:1-5.
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