Low molecular weight heparin for prevention of central venous catheterization-related thrombosis in children

  • Protocol
  • Intervention

Authors

  • Prakeshkumar S Shah,

    Corresponding author
    1. University of Toronto, Department of Paediatrics and Department of Health Policy, Management and Evaluation, Rm 775A, Toronto, Ontario, Canada
    • Prakeshkumar S Shah, Department of Paediatrics and Department of Health Policy, Management and Evaluation, Rm 775A, University of Toronto, 600 University Avenue, Toronto, Ontario, M5G 1XB, Canada. pshah@mtsinai.on.ca.

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  • Niketa Shah

    1. New Jersey Hospital, Department of Pediatrics, Jersey City, New Jersey, USA
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Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

The primary objective of this review is to determine the prophylactic effect of LMWH on the incidence of CVC-related thrombosis in children.

Secondary objectives are to determine the effect of LMWH on:

(1) occlusion of CVC (defined as inability to infuse fluids through the catheter due to blockage);
(2) number of days of CVC patency;
(3) episodes of catheter-related sepsis (defined as symptoms and signs suggestive of sepsis accompanied by positive blood cultures obtained from a normally sterile site different to a central line, and from the line or catheter tip, each growing the same micro-organism)
(4) abnormality of coagulation profile;
(5) allergic reactions to LMWH;
(6) bleeding complications;
(7) osteoporosis with long-term use;
(8) mortality during therapy.