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Lamotrigine for chronic neuropathic pain and fibromyalgia in adults

  1. Philip J Wiffen*,
  2. Sheena Derry,
  3. R Andrew Moore

Editorial Group: Cochrane Pain, Palliative and Supportive Care Group

Published Online: 3 DEC 2013

Assessed as up-to-date: 26 NOV 2013

DOI: 10.1002/14651858.CD006044.pub4


How to Cite

Wiffen PJ, Derry S, Moore RA. Lamotrigine for chronic neuropathic pain and fibromyalgia in adults. Cochrane Database of Systematic Reviews 2013, Issue 12. Art. No.: CD006044. DOI: 10.1002/14651858.CD006044.pub4.

Author Information

  1. University of Oxford, Pain Research and Nuffield Department of Clinical Neurosciences (Nuffield Division of Anaesthetics), Oxford, Oxfordshire, UK

*Philip J Wiffen, Pain Research and Nuffield Department of Clinical Neurosciences (Nuffield Division of Anaesthetics), University of Oxford, Pain Research Unit, Churchill Hospital, Oxford, Oxfordshire, OX3 7LE, UK. phil.wiffen@ndcn.ox.ac.uk.

Publication History

  1. Publication Status: Stable (no update expected for reasons given in 'What's new')
  2. Published Online: 3 DEC 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Eisenberg 2001 {published data only}
  • Eisenberg E, Lurie Y, Breker C, Daoud D, Ishay A. Lamotrigine reduces painful diabetic neuropathy: a randomized, controlled study. Neurology 2001;57(3):505-9.
  • Lurie Y, Brecker C, Daoud D, Ishay A, Eisenberg E. Lamotrigine in the treatment of painful diabetic neuropathy: a randomized placebo controlled study. Progress in Pain Research and Management 2000;16:857-62.
Finnerup 2002a {published data only}
Jose 2007 {published data only}
  • Jose VM, Bhansali A, Hota D, Pandhi P. Randomized double-blind study comparing the efficacy and safety of lamotrigine and amitriptyline in painful diabetic neuropathy. Diabetic Medicine 2007; Vol. 24:377-83. [DOI: 10.1111/j.1464-5491.2007.02093.x]
McCleane 1999 {published data only}
Rao 2008 {published data only}
  • Rao RD, Flynn PJ, Sloan JA, Wong GY, Novotny P, Johnson DB, et al. Efficacy of lamotrigine in the management of chemotherapy-induced peripheral neuropathy: a phase 3 randomized, double-blind, placebo-controlled trial, N01C3. Cancer 2008; Vol. 112:2802-8. [DOI: 10.1002/cncr.23482]
Silver 2007 {published data only}
  • NPP30010. A multicenter, randomized, double-blind, placebo-controlled, parallel group study to evaluate the safety and efficacy of lamotrigine in subjects with neuropathic pain and inadequate pain relief with gabapentin, tricyclic antidepressants or non-narcotic analgesics. www.gsk-clinicalstudyregister.com/ (Accessed 7 August 2013) 2005.
  • Silver M, Blum D, Grainger J, Hammer AE, Quessy S. Double-blind, placebo-controlled trial of lamotrigine in combination with other medications for neuropathic pain. Journal of Pain and Symptom Management 2007; Vol. 34:446-54. [DOI: 10.1016/j.jpainsymman.2006.12.015]
Simpson 2000 {published data only}
Simpson 2003 {published data only}
  • Simpson DM, McArthur JC, Olney R, Clifford D, So Y, Ross D, et al. Lamotrigine HIV Neuropathy Study Team. Lamotrigine for HIV-associated painful sensory neuropathies: a placebo-controlled trial. Neurology 2003;60(9):1508-14.
Vestergaard 2001 {published data only}
Vinik 2007a {published data only}
  • Vinik AI, Tuchman M, Safirstein B, Corder C, Kirby L, Wilks K, et al. Lamotrigine for treatment of pain associated with diabetic neuropathy: results of two randomized, double-blind, placebo-controlled studies. Pain 2007; Vol. 128:169-79. [DOI: 10.1016/j.pain.2006.09.040]
Vinik 2007b {published data only}
Zakrzewska 1997 {published data only}

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Bonicalzi 1997 {published data only}
Breuer 2007 {published data only}
  • Breuer B, Pappagallo M, Knotkova H, Guleyupoglu N, Wallenstein S, Portenoy RK. A randomized, double-blind, placebo-controlled, two-period, crossover, pilot trial of lamotrigine in patients with central pain due to multiple sclerosis. Clinical Therapeutics 2007; Vol. 29:2022-30. [DOI: 10.1016/j.clinthera.2007.09.023]
Carrieri 1998 {published data only}
Devulder 2000 {published data only}
Di Vadi 1998 {published data only}
Eisenberg 1998 {published data only}
Eisenberg 2003 {published data only}
Eisenberg 2005 {published data only}
  • Eisenberg E, Shifrin A, Krivoy N. Lamotrigine for neuropathic pain. Expert Review of Neurotherapeutics 2005; Vol. 5:729-35. [DOI: 10.1586/14737175.5.6.729]
Lunardi 1997 {published data only}
  • Lunardi G, Leandri M, Albano C, Cultrera S, Fracassi M, Rubino V, et al. Clinical effectiveness of lamotrigine and plasma levels in essential and symptomatic trigeminal neuralgia. Neurology 1997;48(6):1714-7.
Petersen 2003 {published data only}
  • Petersen KL, Maloney A, Hoke F, Dahl JB, Rowbotham MC. A randomized study of the effect of oral lamotrigine and hydromorphone on pain and hyperalgesia following heat/capsaicin sensitization. Journal of Pain 2003;4(7):400-6.
Sandner-Kiesling 2002 {published data only}
Shaikh 2011 {published data only}

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
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Khaliq 2013
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Moore 2009b
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Moore 2010a
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Moore 2010d
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Moore 2011a
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Moore 2011b
  • Moore RA, Straube S, Paine J, Derry S, McQuay HJ. Minimum efficacy criteria for comparisons between treatments using individual patient meta-analysis of acute pain trials: examples of etoricoxib, paracetamol, ibuprofen, and ibuprofen/paracetamol combinations after third molar extraction. Pain 2011;152(5):982-9. [DOI: doi:10.1016/j.pain.2010.11.030]
Moore 2011c
Moore 2012a
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Moore 2013a
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Moore 2013b
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Wiffen 2011b
Wiffen 2013a
  • Wiffen PJ, Derry S, Moore RA, Aldington D, Cole P, Rice ASC, et al. Antiepileptic drugs for neuropathic pain and fibromyalgia. Cochrane Database of Systematic Reviews 2013, Issue 6. [DOI: 10.1002/14651858.CD010567]
Wiffen 2013b
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References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Wiffen 2007
Wiffen 2011a