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Antiamoebic drugs for treating amoebic colitis

  1. Maria Liza M Gonzales1,*,
  2. Leonila F Dans2,
  3. Elizabeth G Martinez1

Editorial Group: Cochrane Infectious Diseases Group

Published Online: 15 APR 2009

Assessed as up-to-date: 4 DEC 2008

DOI: 10.1002/14651858.CD006085.pub2

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Additional Information

How to Cite

Gonzales MLM, Dans LF, Martinez EG. Antiamoebic drugs for treating amoebic colitis. Cochrane Database of Systematic Reviews 2009, Issue 2. Art. No.: CD006085. DOI: 10.1002/14651858.CD006085.pub2.

Author Information

  1. 1

    College of Medicine-Philippine General Hospital, University of the Philippines, Department of Pediatrics, Manila, National Capital Region, Philippines

  2. 2

    Philippine General Hospital, University of the Philippines, Departments of Pediatrics and Clinical Epidemiology, Manila, National Capital Region, Philippines

*Maria Liza M Gonzales, Department of Pediatrics, College of Medicine-Philippine General Hospital, University of the Philippines, Taft Avenue, Manila, National Capital Region, 1000, Philippines. lizmgonzales@yahoo.com.

Publication History

  1. Publication Status: New
  2. Published Online: 15 APR 2009

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Asrani 1995 {published data only}
  • Asrani CH, Damle SS, Ghotge VV, Gokhale AS, Jalgaonkar M, Pai Kakode PR, et al. Efficacy and safety of metronidazole versus a combination of metronidazole and diiodohydroxyquinoline for the treatment of patients with intestinal amebiasis: a Primary Care Physician Research Group Study. Current Therapeutic Research 1995;56(7):678-83.
Awal 1979 {published data only}
  • Awal ARMA, Ali S. Tinidazole in the treatment of symptomatic intestinal amoebiasis. Current Therapeutic Research 1979;26(6):962-6.
Batra 1972 {published data only}
  • Batra SK, Ajmani NK, Chuttani HK. Evaluation of 1-methyl-2-(4'-fluorophenyl)-5-nitroimidazole. Journal of Tropical Medicine and Hygiene 1972;75(2):40-1.
Botero 1974 {published data only}
  • Botero D. Double blind study with a new nitroimidazole derivative, Ro 7-0207, versus metronidazole in symptomatic intestinal amebiasis. American Journal of Tropical Medicine and Hygiene 1974;23(5):1000-1.
Botero 1977 {published data only}
  • Botero D, Perez A. Treatment of intestinal amoebiasis and vaginal trichomoniasis with panidazole and its comparison with metronidazole. Transactions of the Royal Society of Tropical Medicine and Hygiene 1977;71(6):508-11.
Chunge 1989 {published data only}
  • Chunge CN, Estambale BB, Pamba HO, Chitayi PM, Munanga PN, Kang'ethe S. Comparison of four nitroimidazole compounds for treatment of symptomatic amoebiasis in Kenya. East African Medical Journal 1989;66(11):724-7.
Davila 2002 {published data only}
  • Davila-Gutierrez C, Vasquez C, Trujillo-Hernandez B, Huerta M. Nitazoxanide compared with quinfamide and mebendazole in the treatment of helminthic infections and intestinal protozoa in children. American Journal of Tropical Medicine and Hygiene 2002;66(3):251-4.
Donckaster 1964 {published data only}
  • Donckaster R, Atias A, Faiguenbaum J, Jarpa A, Sapunar J, Cuello E. Chronic intestinal amebiasis. Therapeutic trial of antibiotics, chemotherapeutics and placebos [Amibiasis intestinal cronica. Ensayo terapeutico con antibioticos, quimioterapicos y placebo]. Boletin Chileno de Parasitologia 1964;19:46-54.
Huggins 1982 {published data only}
  • Huggins D. Double-blind clinical trial with WIN 40.014 in the treatment of intestinal chronic amebiasis [Ensaio clinico duplo-cego com o WIN 40.014 no tratamento da amebiase intestinal cronica]. Folha Medica 1982;85 Suppl 1:869-70.
Joshi 1975 {published data only}
  • Joshi HD, Shah BM. A comparative study of tinidazole and metronidazole in treatment of amoebiasis. The Indian Practitioner 1975:295-302.
Kapadia 1968 {published data only}
  • Kapadia RM, Pathak HY, Apte SP. Chlorhydroxyquinoline and di-iodohydroxyquinoline in amoebiasis: a comparative study. Journal of the Indian Medical Association 1968;51(3):125-7.
Karabay 1999 {published data only}
  • Karabay O, Godekmerden A. Comparison of therapeutic efficacies of the single dose secnidazole versus 10-day metronidazole in acute amebiasis [Akut intestinal amebiyaz tedavisinde tek doz seknidazol ile 10 gunluk metronidazolun etkinliklerinin karsilastirilmasi]. Klimik Dergisi 1999;12(2):82-4.
Mansour-Ghanaei 2003 {published data only}
  • Mansour-Ghanaei F, Dehbashi N, Yazdanparast K, Shafaghi A. Efficacy of Saccharomyces boulardii with antibiotics in acute amoebiasis. World Journal of Gastroenterology 2003;9(8):1832-3.
Mathur 1976 {published data only}
  • Mathur SN, Itigi A, Rao PD, Krishnaveni, Rai V. Evaluation of tinidazole in treatment of amoebiasis. Indian Medical Gazette 1976:361-4.
Misra 1974 {published data only}
Misra 1977 {published data only}
  • Misra NP, Gupta RC. A comparison of a short course of single daily dosage therapy of tinidazole with metronidazole in intestinal amoebiasis. Journal of International Medical Research 1977;5(6):434-7.
Misra 1978 {published data only}
Mohammed 1998 {published data only}
  • Mohammed KA, Strak SK, Jawad AM, Al-Sadoon IO, Mahdi NK. Effectiveness of praziquantel in treatment of intestinal amoebiasis and giardiasis. Eastern Mediterranean Health Journal 1998;4(1):161-3.
Naoemar 1973 {published data only}
  • Naoemar SA, Rukmono B. Clinical trial of Ro 7-0207, a nitroimidazole derivative in amoebic dysentery. Southeast Asian Journal of Tropical Medicine and Public Health 1973;4(3):417-20.
Nnochiri 1967 {published data only}
  • Nnochiri E. Oral chemotherapy in amoebic dysentery - potentiating effect of chloroquine on the action of diloxanide furoate. Journal of Tropical Medicine and Hygiene 1967;70(9):224-8.
Padilla 2000 {published data only}
  • Padilla N, Diaz R, Munoz M. Efficacy and safety of quinfamide versus secnidazole in the management of amoebic non-dysenteric colitis in children. Clinical Drug Investigation 2000;20(2):89-93.
Pamba 1990 {published data only}
  • Pamba HO, Estambale BB, Chunge CN, Donno L. Comparative study of aminosidine, etophamide and nimorazole, alone or in combination, in the treatment of intestinal amoebiasis in Kenya. European Journal of Clinical Pharmacology 1990;39(4):353-7.
Panggabean 1980 {published data only}
  • Panggabean A, Sutjipto A, Aldy D, Sutanto AH, Siregar H. Tinidazole versus ornidazole in amebic dysentery in children (a double blind trial). Paediatrica Indonesiana 1980;20(11-12):229-35.
Pehrson 1983 {published data only}
  • Pehrson P, Bengtsson E. Treatment of non-invasive amoebiasis. A comparison between tinidazole alone and in combination with diloxanide furoate. Transactions of the Royal Society of Tropical Medicine and Hygiene 1983;77(6):845-6.
Pehrson 1984 {published data only}
  • Pehrson P, Bengtsson E. Treatment of non-invasive amoebiasis - a comparison between tinidazole and metronidazole. Annals of Tropical Medicine and Parasitology 1984;78(5):505-8.
Prasad 1985 {published data only}
  • Prasad R, Jagota SC, Mathur PP, Taneja V. Drug trial of 'Dependal' - M suspension against metronidazole suspension in amoebiasis and giardiasis. Indian Medical Gazette 1985;119(7):219-23.
Pudjiadi 1973 {published data only}
  • Pudjiadi SH, Sunoto, Suharjono, Kadri N. A new oral amoebicid (RO 7-0207) in the treatment of intestinal amoebiasis. Paediatrica Indonesiana 1973;13(4):113-9.
Rossignol 2001 {published data only}
  • Rossignol JF, Ayoub A, Ayers MS. Treatment of diarrhea caused by Giardia intestinalis and Entamoeba histolytica or E. dispar: a randomized, double-blind, placebo-controlled study of nitazoxanide. Journal of Infectious Diseases 2001;184(3):381-4.
Rossignol 2007 {published data only}
Rubidge 1970 {published data only}
  • Rubidge CJ, Scragg JN, Powell SJ. Treatment of children with acute amoebic dysentery. Comparative trial of metronidazole against a combination of dehydroemetine, tetracycline, and diloxanide furoate. Archives of Disease in Childhood 1970;45(240):196-7.
Salles 1999 {published data only}
  • Salles JMC, Bechara C, Tavares AM, Martins M, Sobrinho JG, Dietrich-Neto F, et al. Comparative study of the efficacy and tolerability of secnidazole suspension (single dose) and tinidazole suspension (two days dosage) in the treatment of amebiasis in children. Brazilian Journal of Infectious Diseases 1999;3(2):80-8.
Singh 1977 {published data only}
  • Singh G, Kumar S. Short course of single daily dosage treatment with tinidazole and metronidazole in intestinal amoebiasis: a comparative study. Current Medical Research and Opinion 1977;5(2):157-60.
Sitepu 1982 {published data only}
  • Sitepu N, Lubis CP, Sutanto AH, Siregar H. Minute treatment with tinidazole and ornidazole in children with amebic dysentery. Paediatrica Indonesiana 1982;22(7-8):132-5.
Soedin 1985 {published data only}
  • Soedin K, Alfien Syukran OK, Fadillah A, Sidabutar P. Comparison between the efficacy of a single dose of secnidazole with a 5-day course of tetracycline and clioquinol in the treatment of acute intestinal amoebiasis. Pharmatherapeutica 1985;4(4):251-4.
Swami 1977 {published data only}
Toppare 1994 {published data only}
  • Toppare MF, Kitapci F, Senses DA, Yalcinkaya F, Safa Kaya I, Dilmen U. Ornidazole and secnidazole in the treatment of symptomatic intestinal amoebiasis in childhood. Tropical Doctor 1994;24(4):183-4.
Tripathi 1986 {published data only}
  • Tripathi BM, Misra NP, Tiwari A. A double-blind trial of GO 10213 and metronidazole in intestinal amoebiasis. Current Therapeutic Research 1986;39(2):178-82.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Abd-Rabbo 1969 {published data only}
Abdallah 1969 {published data only}
  • Abdallah A, Gad-el-Mawla N, el-Kordy MI. Erythromycin stearate in intestinal amoebiasis. Journal of the Egyptian Medical Association 1969;52(2):168-73.
Achar 1967 {published data only}
  • Achar ST, Rama Row GV. Clinical trials with dehydroemetine and paromomycin in acute amoebic dysentery in children. Journal of the Indian Medical Association 1967;49(8):370-2.
Ali Ata 1967 {published data only}
  • Ali Ata AH, el-Raziky ES. Trials of BT 436 in amoebiasis. Zeitschrift für Tropenmedizin und Parasitologie 1967;18(3):321-6.
Alterio 1968 {published data only}
  • Alterio DL. Clinico-parastilogological evaluation of an anti-ameba therapeutic activity of a new non-absorbable erythromycin stearate preparation [Avaliacao clinico-parasitologica da atividade terapeutica antiamebiana de uma nova preparacao de estearato de eritromicina nao absorvivel]. Hospital (Rio de Janeiro, Brazil) 1968;73(4):1207-13.
Amato Neto 1968 {published data only}
  • Amato Neto V, Wanderley RA. Use of an erythromycin stearate preparation, of regulated intestinal release in the treatment of intestinal amebiasis [Observacoes preliminares sobre o emprego de preparacao de estearato de eritromicina, de liberacao intestinal regulada, no tratamento da amebiase intestinal]. Hospital (Rio de Janeiro, Brazil) 1968;73(2):583-9.
Apt 1976 {published data only}
  • Apt W, Perez C, Gabor M, Doren G. Treatment of chronic amebiasis with nitrimidazole [Tratamiento de la amibiasis intestinal cronica con nimorazol]. Revista Medica de Chile 1976;104(11):791-3.
Apt 1983 {published data only}
  • Apt W, Perez C, Miranda C, Gabor M, Doren G. Treatment of intestinal amebiasis and giardiasis with ornidazole [Tratamiento de la amebiasis intestinal y giardiasis con ornidazole]. Revista Medica de Chile 1983;111(11):1130-3.
Arredondo 1993 {published data only}
  • Arredondo-Cortes E, Gonzalez-Gonzales JA, Bosques-Padilla F, Elizondo Riojos G, Barragan-Villareal. A randomized controlled trial of medical treatment vs medical treatment plus puncture in amoebic liver abscess [abstract]. Gut 1993;34(3):S43.
Atias 1972 {published data only}
  • Atias A, Sapunar J, Parodi V, Perez C, Gabor M, Stagno S, et al. Treatment of chronic intestinal amebiasis with teclozan [Tratamiento de la amibiasis intestinal cronica con teclozan]. Boletin Chileno de Parasitologia 1972;27:119-21.
Bakshi 1978 {published data only}
  • Bakshi JS, Ghiara JM, Nanivadekar AS. How does tinidazole compare with metronidazole? A summary report of Indian trials in amoebiasis and giardiasis. Drugs 1978;15 Suppl 1:133-42.
Banerjee 1976 {published data only}
  • Banerjee RN, Singh J, Basu AK. Metronidazole in the treatment of amoebiasis. The Indian Practitioner 1976:208-16.
Baranski 1966 {published data only}
  • Baranski MC. Treatment of chronic intestinal amebiasis with the compound of diiodohydroxyquinoline, tetracycline and chloroquine [Tratamento da amebiase intestinal cronica pela associacao de diiohidroxiquinoleina, tetraciclina e cloroquina]. Revista Brasileira de Medicina 1966;23(11):774-8.
Barroso 1969 {published data only}
  • Barroso E, Ruiloba J. Treatment of intestinal amebiasis with eticlordifene [Tratamento de la amebiasis intestinal con eticlordifene]. Revista de Investigacion Clinica 1969;21(2):195-203.
Bassily 1987 {published data only}
  • Bassily S, Farid Z, El-Masry NA, Mikhail EM. Treatment of intestinal E. histolytica and G. lamblia with metronidazole, tinidazole and ornidazole: a comparative study. Journal of Tropical Medicine and Hygiene 1987;90(1):9-12.
Belkind 2004 {published data only}
  • Belkind-Valdovinos U, Belkind-Gerson J, Sanchez-Francia D, Espinoza-Ruiz MM, Lazcano-Ponce E. Evaluation of nitazoxanide in single dose and for three days in intestinal parasitism [Evaluacion de la nitazoxanida en dosis unica y por tres dias en parasitosis intestinal]. Salud Publica de Mexico 2004;46(3):333-40.
Bezjak 1964 {published data only}
  • Bezjak B, Breitenfeld V. Mexaform in the treatment of amoebiasis [Mexaform in der amobiasis-therapie]. Munchener Medizinische Wochenschrift 1964;106(42):1946-6.
Bhatia 1998 {published data only}
  • Bhatia S, Karnad DR, Oak JL. Randomized double-blind trial of metronidazole versus secnidazole in amebic liver abscess. Indian Journal of Gastroenterology 1998;17(2):53-4.
Biagi 1966 {published data only}
  • Biagi FF, Lopez RM, Gonzalez C, Gutierrez M. Chemoprophylaxis of amebiasis using clefamide in an open community [Quimoprofilaxis de la amibiasis con clefamida en una comunidad abierta]. Gaceta Medica de Mexico Sao Paolo 1966;96(2):183-90.
  • Biagi FF, Lopez RM, Gonzalez C, Gutierrez M. Chemoprophylaxis of amebiasis using clefamide in an open community [Quimoprofilaxis de la amibiasis con clefamida en una comunidad abierta]. Revista do Instituto de Medicina Tropical de São Paulo 1966;8(5):235-40.
Biagi 1978 {published data only}
  • Biagi F, Munoz J, Gonzalez C. Treatment of amoebiasis with drugs acting on intestinal lumen and tissue [Tratamiento de la amibiasis con medicamentos de accion luminal y tisular]. Prensa Medica Mexicana 1978;43(1-2):59-60.
Blanc 1965 {published data only}
  • Blanc F, Denjean B, Felix H, Nosny Y, Pene P, Renaud R. Trial treatment of amoebiasis by oral adminsitration of 2-dehydroemetine [Essai de traitement de l'amibiase par l'administration orale de la 2-dehydroemetine]. Academie Nationale de Medecine La Presse Medicale 1965;149(16-17):360-5.
  • Blanc F, Denjean B, Felix H, Nosny Y, Pene P, Reynaud R, Sankale M. Treatment of amoebiasis with oral 2-dehydroemetine [Le traitement de l'amibiase par la 2-dehydroemetine orale]. La Presse Medicale 1966;74(2):51-4.
Blessman 2002 {published data only}
Blessman 2003a {published data only}
  • Blessman J, Binh HD, Hung DM, Tannich E, Burchard G. Treatment of amoebic liver abscess with metronidazole alone or in combination with ultrasound-guided needle aspiration: a comparative, prospective and randomized study. Tropical Medicine and International Health 2003;8(11):1030-4.
    Direct Link:
Botero 1967 {published data only}
Campos 1969 {published data only}
  • Campos R. Treatment of intestinal amebiasis using erythromycin stearate under controlled release [Tratamento de amebiase intestinal pelo estearato de eritromicina de liberacao regulada]. Revista Brasileira de Medicina 1969;26(2):113-4.
Cardoso Salles 1970 {published data only}
  • Cardoso Salles JM, Gundim Leitao E. Treatment of intestinal amebiasis using ethyl chlordiphene. Comparative study [Tratamento da amebiase intestinal com eticlordifene. Estudo comparativo]. Hospital (Rio de Janeiro, Brazil) 1970;77(6):2073-80.
Cariry 1969 {published data only}
  • Cariry NA, da Silva MA. Treatment of intestinal amoebiasis with teclozan (Falmonox). Comparative study of therapeutic schemes [Tratamento da amebiase intestinal com teclozan (Falmonox). Estudo comparativo de esquemas terapeuticos]. Hospital (Rio de Janeiro, Brazil) 1969;76(3):1033-7.
Chari 1970 {published data only}
  • Chari MV, Gadiyar BN. A new drug (MK-910) in the therapy of intestinal and hepatic amebiasis. First results of clinical trial. American Journal of Tropical Medicine and Hygiene 1970;19(6):926-8.
Chaudhuri 1966 {published data only}
  • Chaudhuri RN, Saha TK. Combined therapy of amoebic dysentery. Bulletin of the Calcutta School of Tropical Medicine 1966;14(1):22.
Cho 1972 {published data only}
  • Cho KM, Cha HY, Soh CT. Clinical trials of R-0207 against Entamoeba histolytica infections (double blind trials versus metronidazole). Yonsei Reports on Tropical Medicine 1972;3:123-33.
Cohen 1975 {published data only}
  • Cohen HG, Reynolds TB. Comparison of metronidazole and chloroquine for the treatment of amoebic liver abscess. A controlled trial. Gastroenterology 1975;69(1):35-41.
da Cunha 1977 {published data only}
  • da Cunha AS, da SIlva EF, de Mello SM. Clinical trial with the imidazol compound R.P. 14539 in intestinal amebiasis [Avaliacao terapeutico do composto imidazolico R.P. 14539 na amebiase intestinal]. Revista do Instituto de Medicina Tropical de São Paulo 1977;19(5):342-8.
Datta 1974 {published data only}
  • Datta DV, Singh SA, Chhuttani PN. Treatment of amoebic liver abscess with emetine hydrochloride, niridazole, and metronidazole. A controlled clinical trial. American Journal of Tropical Medicine and Hygiene 1974;23(4):586-9.
de Carvalho 1965 {published data only}
  • de Carvalho HT, Coura LC, da Silva JR. Treatment of intestinal amebiasis - preliminary results of a trial with a new drug, Bayer 2456 (amebicide) [Tratamento da amebiase intestinal - resultados preliminares de ensaio com um novo medicamento, o Bayer 2456 (amoebacide)]. Revista Brasileira de Medicina 1965;22(9):562-6.
de la Rey 1989 {published data only}
  • de la Rey Nel J, Simjee AE, Patel A. Indication for aspiration of amoebic liver abscess. South African Medical Journal. Suid-Afrikaanse Tydskrif Vir Geneeskunde 1989;75(8):373-6.
de Oliveira 1969 {published data only}
  • da Oliveira CA. Therapeutic experience in the use of erythromycin stearate in chronic intestinal amebiasis [Experiencia terapeutica com estearato de eritromicina de liberacao regulada, na amebiase intestinal cronica]. Hospital (Rio de Janeiro, Brazil) 1969;76(1):175-8.
Delgado 1971 {published data only}
  • Delgado y Garnia R, Chavez-Esgueda JM. Etofamide in the treatment of children with acute intestinal amebiasis [Etofamida en el tratamiento de ninos con amibiasis intestinal aguda]. Prensa Medica Mexicana 1971;36(7-8):358-61.
Devic 1974 {published data only}
  • Devic J, Dosen H. Our initial experiences in the treatment of the intestinal amebiasis with 2-dehydroemetine. Medicinski Pregled 1974;27(1-2):79-83.
Dhariwal 1963 {published data only}
  • Dhariwal RK, Verma NP, Nioguy C, Pal SK, Singh SS, Chatterjee AK, et al. Clinical trial with entamide furoate in acute amebic dysentery. Indian Journal of Medical Science 1963;17:825-6.
Donckaster 1957 {published data only}
  • Donckaster R, Sapunar J, Donoso A. Treatment of chronic intestinal amebiasis with tetracycline and chloroquine with bismuth glycoarsanilate and parasitological control by the combined telemann and polvinyl alcohol method [Ensayo terapeutico de la amibiasis intestinal cronica con tetraciclina y chloroquina glicolilarsanilato de bismuto y control parasitologico con los metodos de telemann y alcohol polivinilico combinados]. Boletin Chileno de Parasitologia 1957;12(2):24-9.
dos Santos 1969 {published data only}
  • dos Santos Moraise ML. Clinico-pathological results using erythromycin stearate in the treatment of intestianl amebiasis [Resultados clinico-parasitologicos obtidos com o uso do estearato de eritromicina de liberacao regulada no tratamento da amebiase intestinal]. Hospital (Rio de Janeiro, Brazil) 1969;75(4):1367-74.
Doshi 1968 {published data only}
  • Doshi JC, Doshi MJ, Vaidya AB, Mehta JM, Sheth UK. Niridazole in amebic dysentery and hepatic amebiasis. American Journal of Tropical Medicine and Hygiene 1968;17(5):702-8.
el Mofti 1965 {published data only}
  • el Mofti A, Ayadi A. Trial of a new amoebicidal agent (choro-hydroxyquinoline). Journal of the Egyptian Medical Association 1965;48(2):142-6.
Esquivel 1979 {published data only}
  • Esquivel Lopez A, Gonzales Espinola G, Garcia Garduno JR, Guarner Dalias V. Various considerations in the treatment of amoebic liver abscess [Algunas consideraciones en el tratamiento del absceso hepatico amibiano]. Revista De Gastroenterologia De Mexico 1979;44(2):51-6.
Ey 1977 {published data only}
  • Ey JL. Treatment of amoebiasis with metronidazole and entamide furoate. Ethiopian Medical Journal 1977;15:101-5.
Felix 1966 {published data only}
  • Felix H, Freyria J, Maillard A. 2-dehydro-emetine administered per os in the treatment of amoebiasis. Therapeutical tests [La 2-dehydro-emetine administree par voie orale dans le traitement de l'amibiase. Essais therapeutiques]. Le Journal de Medecine de Lyon 1966;47(104):1211-6.
  • Felix H, Freyria J, Maillard A. Recent developments. 2-dehydro-emetine administered orally in the treatment of amoebiasis. Therapeutic trials (50 personal cases) [La 2-dehydro-emetine administree par voie orale dans le traitement de l'amibiase. Essais therapeutiques (a propos de 50 cas personnels)]. Archives Francaises des Maladies de l'Appareil Digestif 1966;55(10):909-14.
Freeman 1990 {published data only}
  • Freeman O, Akamaguna A, Jarikre LN. Amoebic liver abscess: the effect of aspiration on the resolution or healing time. Annals of Tropical Medicine and Parasitology 1990;84(3):281-7.
Gilman 1980 {published data only}
  • Gilman R, Islam M, Paschi S, Goleburn J, Ahmad F. Comparison of conventional and immunofluorescent techniques for the detection of Entamoeba histolytica in rectal biopsies. Gastroenterology 1980;78(3):435-9.
Gorbea 1989 {published data only}
  • Gorbea Robles MC, Eternod JG, Velasquez FG, Cupido JD. Comparative study in intestinal amebiasis and giardasis in infants and pre-school: efficacy and tolerance of secnidazole vs metronidazole and etofamide [Estudio comparativo en amebiasis y giardiasis intestinal del lactante y pre-escolar: eficacia y tolerancia del secnidazole vs metronidazol y etofamida]. Investigacion Medicina Inst 1989;16:79-82.
Hatchuel 1975 {published data only}
Hoekenga 1951 {published data only}
  • Hoekenga MT. A comparison of aureomycin and carbarsone in the treatment of intestinal amebiasis. American Journal of Tropical Medicine and Hygiene 1951;31(4):423-5.
Holz 1965 {published data only}
  • Holz J. Comparison of natural and synthetical emetine as amebicide in children. Paediatrica Indonesiana 1965;5(3):793-801.
Huggins 1965 {published data only}
  • Huggins D. Treatment of amebiasis. Results obtained with diloxanide furoate [Tratamento da amebiase. Resultados obtidos com o furoato de diloxanida]. Revista do Instituto de Medicina Tropical de São Paulo 1965;7(2):110-1.
Huggins 1969 {published data only}
  • Huggins D. Clinical trial of a new salt: ethyl chordiphene, in the treatment of chronic intestinal amebiasis [Ensaio clinico com um novo sal: etil clordifene, no tratamento da amebiase intestinal cronica]. Anais da Escola Nacional de Saude Publica e de Medicina Tropical 1969;3(1):93-5.
Huggins 1974 {published data only}
  • Huggins D. Chemoprophylaxis of amebiasis: clinical trial with a new drug etophamide, in an open community [Quimoprofilaxia da amebiase, ensaio clinico com uma nova substancia-etofamida, em uma comunidade aberta]. Anais do Instituto de Higiene e Medicina Tropical 1974;2(1-4):545-51.
  • Huggins D. Clinical and chemoprophilatical trial with a new drug used against amebiasis in an open community [Ensaio clinico e quimoprofilatico com etofamida, uma substancia amebicida numa comunidade aberta]. Revista Brasiliera de Clinica e Terapeutica 1974;3(7):279-84.
Huggins 1977 {published data only}
  • Huggins D. Clinical test with teclozan in the treatment of amebic dysentery with a dose of 24 hours [Ensaio clinico com teclozan no tratamento da colite amebiana nao desinterica na dose de 24 horas]. Anais do Instituto de Higiene e Medicina Tropical 1977-1978;5(1-4):329-31.
Huggins 1980 {published data only}
  • Huggins D. Clinical trial of etophamide in the treatment of chronic intestinal amebiasis. G.E.N 1980;34(1):51-4.
Huggins 1981 {published data only}
  • Huggins D. Clinical trials with RO 7-0207, ornidazole, in the treatment of chronic intestinal amebiasis [Ensaio clinico com Ro 7-0207, ornidazol, no tratamento da amebiase intestinal cronica]. Folha Medica 1981;82(4):445-6.
Irusen 1992 {published data only}
  • Irusen EM, Jackson TF, Simjee AE. Asymptomatic intestinal colonization by pathogenic Entamoeba histolytica in amebic liver abscess: prevalence, response to therapy, and pathogenic potential. Clinical Infectious Diseases 1992;14(4):889-93.
Islam 1975 {published data only}
Islam 1978a {published data only}
Islam 1978b {published data only}
Jain 1990 {published data only}
  • Jain NK, Madan A, Sharma TN, Sharma DK, Mandhana RG. Hepatopulmonary amoebiasis. Efficacy of various treatment regimens containing dehydroemetine and/or metronidazole. Journal of the Association of Physicians of India 1990;38(4):269-71.
Jayawickrema 1975 {published data only}
  • Jayawickrema US, Lionel ND. Comparison of metronidazole with emetine and chloroquine in the treatment of hepatic amoebiasis - a controlled double blind study. Ceylon Medical Journal 1975;20(2):99-102.
Kaur 1972 {published data only}
  • Kaur J, Mathur TN. Comparative drug trials in symptomatic and asymptomatic non-dysenteric amoebic colitis. Indian Journal of Medical Research 1972;60(10):1547-53.
Khalil 1987 {published data only}
  • Khalil HM, Fawzy AF, Sarwat MA. Trials of furazol and some other drugs in intestinal amoebiasis. Journal of the Egyptian Society of Parasitology 1987;17(2):417-25.
Khokhani 1977 {published data only}
  • Khokhani RC, Garud AD, Deodhar KP, Sureka SB, Kulkarni M, Damle VB. Comparative study of tinidazole and metronidazole in amoebic liver abscess. Current Medical Research and Opinion 1977;5(2):161-3.
Khokhani 1978 {published data only}
Konar 1963 {published data only}
  • Konar NR, Mandal AK. Clinical trial of dehydroemetine in amoebiasis. Journal of the Indian Medical Association 1963;41(11):529-34.
Krishnaiah 2003 {published data only}
  • Krishnaiah YSR, Muzib YI, Bhaskar P, Satyanarayana V, Latha K. Pharmacokinetic evaluation of guar gum-based colon-targeted drug delivery systems of tinidazole in healthy human volunteers. Drug Delivery 2003;10(4):263-8.
Kurt 2008 {published data only}
  • Kurt O, Girginkardesler N, Balcioglu IC, Ozbilgin A, Ok UZ. A comparison of metronidazole and single-dose ornidazole for the treatment of dientamoebiasis. Clinical Microbiology and Infections 2008;14:601-4.
    Direct Link:
Laham 1951 {published data only}
  • Laham E. Clinical trial of bismuth glycolyl arsenilate in intestinal amebiasis [Essai clinique du glycolyl arsenilate de bismuth dans l'amibiase intestinale]. Revue Medicale du Moyen-Orient 1951;8(1):96-9.
Levy 1967 {published data only}
  • Levy A, Martinez AA, de Castro ML. Sustained release erythromycin stearate in the therapy of intestinal amebiasis [Estearatao de eritromicina de liberacao regulada no tratamento da amebiase intestinal]. Revista Brasileira de Medicina 1967;24(6):413-5.
Martinez 1969 {published data only}
  • Martinez AA, Levy A. Efficiency of the combination erythromycin-hexocylium in the treatment of dysentery syndromes [Eficacia da associacao eritromicina-hexociclio no tratamento de sindromes disentericas]. Revista Brasileira de Medicina 1969;26(12):759-62.
Masters 1979 {published data only}
  • Masters DK, Hopkins AD. Therapeutic trials of four amoebicide regimens in rural Zaire. Journal of Tropical Medicine and Hygiene 1979;82(5):99-101.
Mathur 1974 {published data only}
  • Mathur TN, Kaur J. Non-dysenteric amoebic colitis treated with two grammes of metronidazole given as a single dose for two days. Indian Journal of Medical Research 1974;62(8):1208-11.
McAuley 1992 {published data only}
Mendis 1984 {published data only}
  • Mendis S, Dharmasena BD, Jayatissa SK. Comparison of tinidazole with metronidazole in the treatment of hepatic amoebiasis: a controlled double blind study. Ceylon Medical Journal 1984;29(2):97-100.
Misra 1976a {published data only}
  • Misra NP, Laiq SM. Tinidazole in intestinal amoebiasis. Antiseptic 1976;73(7):371-3.
Misra 1976b {published data only}
  • Misra NP, Laiq SM. Tinidazole in intestinal amoebiasis. Journal of the Association of Physicians of India 1976;24(4):231-5.
Morales 1975 {published data only}
  • Morales-Mareles P, Suarez-Sanchez F, Boom RA. Random double blind comparison of intravenous metronidazole and intramuscular emetine in acute amebic liver abscess [Tratamiento doble ciego al azar con metronidazole i.v. o emetina i.m. en el absceso hepatico amibiano agudo]. Prensa Medica Mexicana 1975;40(3-4):124-6.
Murray 1980 {published data only}
Muzzafar 2006 {published data only}
  • Muzaffar J, Madan K, Sharma MP, Kar P. Randomized, single-blind, placebo-controlled multicenter trial to compare the efficacy and safety of metronidazole and satranidazole in patients with amebic liver abscess. Digestive Disease Science 2006;51(12):2270-3.
Nahrevanian 2008 {published data only}
  • Nahrevanian H, Assmar M. Cryptosporidiosis in immunocompromised patients in the Islamic Republic of Iran. Journal of Microbiology Immunology and Infection 2008;41:74-7.
Naik 1968 {published data only}
  • Naik BK, Saboo RM. Quixalin. A drug trial. Journal of the Association of Physicians of India 1968;16(5):313-6.
Nanavati 1965 {published data only}
  • Nanavati MB, Damany SJ, Joshi HD. Clinical trial of deydroemetine (Ro 1-9334) in amoebiasis. Indian Practitioner 1965;18:259-63.
Nel 1985 {published data only}
  • Nel JR, Patel A, Ramidal K, Simjee AE, Englebrecht HE, Dingle C, et al. Does aspiration influence the course of amoebic liver abscess? [abstract]. South African Medical Journal 1985:68528.
Nel 1986 {published data only}
  • Nel JD, Simjee AE, Patel A. Indications for aspiration of amoebic liver abscess (ALA) [abstract]. South African Medical Journal. Suid-Afrikaanse Tydskrif Vir Geneeskunde 1986:7050.
O'Holohan 1972 {published data only}
  • O'Holohan DR, Hugoe-Matthews JH. Single-dose and short course regimens of metronidazole in the treatment of amoebiasis in Malaysia. Annals of Tropical Medicine and Parasitology 1972;66(2):181-6.
Okeniyi 2007 {published data only}
  • Okeniyi JA, Ogunlesi T A, Oyelami OA, Adeyemi L A. Effectiveness of dried Carica papaya seeds against human intestinal parasitosis: a pilot study. Journal of Medicine and Food 2007;10(1):194-6.
Olaeta 1996 {published data only}
  • Olaeta Elizalde R, Perez Huacuja R, Najera Ruano A. Comparison of quinfamide versus etofamide in the Mexican population with intestinal amebiasis [Comparacion quinfamida vs etofamida en poblacion Mexicana con amibiasis intestinal]. Acta Gastroenterologica Latinoamericana 1996;26(5):277-80.
Omrani 1995 {published data only}
  • Omrani G, Rastegar-Lari A, Khamse M. Effect of single dose of secnidazole in treatment of intestinal amoebiasis. Journal of the Pakistan Medical Association 1995;45(6):159.
Orozco 1975 {published data only}
  • Orozco Garcia O, Perez Nava J, Gonzalez Diaz R. Clinical evaluation of nimorazole in amebic liver abscess (author's transl)]. Prensa Medica Mexicana 1975;40(11-12):378-82.
Padilla 1995 {published data only}
  • Padilla N, Figueroa R, Rivera MR, Guerrero S. Comparative study in quinfamide and etofamide in the treatment of asymptomatic amoebic infection [Estudio comparativo entre quinfamida y etofamida en el tratamiento de lainfección amibiana asintomática]. Revista Mexicana de Pediatría 1995;62(1):5-7.
Padilla 1998 {published data only}
  • Padilla-Raygoza N, Alarcon-Ginori A, Figueroa-Ferrari RC, Munoz-Rodriguez M. Comparison of the effect of quinfamide and nitazoxanide in the treatment of nondysenteric intestinal amebiasis in children [Comparacion del efecto de la quinfamida y de la nitazoxanida en el tratamento de la amibiasis intestinal no disenterica en ninos]. Revista Mexicana de Pediatria 1998;65(5):196-9.
Padilla 2002 {published data only}
  • Padilla N, Diaz R, Alarcon A, Barreda R. Antiamoebic chemoprophylaxis using quinfamide in children: a comparative study. Scientific World Journal 2002;2:1070-8.
Pimparkar 1966 {published data only}
  • Pimparkar BD, Raghavan P, Satoskar RS. A clinical trial of 1-dichloroacetyl-4-methylpiperidine (R.D. 7098) a new anti-amoebic drug. Transactions of the Royal Society of Tropical Medicine and Hygiene 1966;60(2):237-40.
Populaire 1980 {published data only}
  • Populaire P, Decouvelaere B, Renard A, Pasquier P. Study of seric concentrations and urinary excretion of secnidazole after oral administration in man. Comparison with tinidazole [Etude des taux seriques et de l'elimination urinaire du secnidazole apres adminsitration orale chez l'homme comparaison avec le tinidazole]. Pathologie et Biologie 1980;28(9):621-4.
Powell 1965a {published data only}
  • Powell SJ, MacLeod I, Wilmot AJ, Elsdon-Dew R. The treatment of acute amoebic dysentery: trials of dehydroemetine, of dehydroemetine-bismuth-iodide, and of dehydroemetine and dehydroemetine-bismuth-iodide in combination. Annals of Tropical Medicine and Parasitology 1965;59:205-7.
Powell 1965b {published data only}
  • Powell SJ, Wilmot AJ, Macleod IN, Elsdon-Dew R. A comparative trial of dehydroemetine, emetine hydrochloride and chloroquine in the treatment of amoebic liver abscess. Annals of Tropical Medicine and Parasitology 1965;59(4):496-9.
Powell 1965c {published data only}
  • Powell SJ, Wilmot AJ, Macleod IN, Elsdon-Dew R. Dehydroemetine in the treatment of amoebic liver abscess. Annals of Tropical Medicine and Parasitology 1965;59(2):208-9.
Powell 1965d {published data only}
  • Powell SJ, MacLeod I, Wilmot AJ, Elsdon-Dew R. Further drug trials in acute amoebic dysentery: demethylchlortetracycline, methacycline, ampicilllin and chlorhydroxyquinoline. Transactions of the Royal Society of Tropical Medicine and Hygiene 1965;59(6):709-11.
Powell 1966a {published data only}
  • Powell SJ, MacLeod I, Wilmot AJ, Elsdon-Dew R. Ambilhar in amoebic dysentery and amoebic liver abscess. Lancet 1966;i:20-2.
Powell 1966b {published data only}
  • Powell SJ, MacLeod I, Wilmot AJ, Elsdon-Dew R. Late release oral dehydroemetine in acute amoebic dysentery. Journal of Tropical Medicine and Hygiene 1966;69:153-4.
Powell 1966c {published data only}
  • Powell SJ, Wilmot AJ, MacLeod I, Elsdon-Dew R. The effect of a nitro-thiazole dericative, Ciba 32,644-Ba, in amebic dysentery and amebic liver abscess. American Journal of Tropical Medicine and Hygiene 1966;15(3):300-2.
Powell 1967 {published data only}
  • Powell SJ, Wilmot AJ, Macleod IN, Elsdon-Dew R. A comparative trial of dehydroemetine and emetine hydrochloride in identical dosage in amoebic liver abscess. Annals of Tropical Medicine and Parasitology 1967;61(1):26-8.
Powell 1968 {published data only}
  • Powell SJ. Metronidazole in the treatment of amoebic dysentery. Indian Practitioner 1968:696-700.
Powell 1969a {published data only}
  • Powell SJ, Wilmot AJ, Elsdon-Dew R. Single and low dosage regimens of metronidazole in amoebic dysentery and amoebic liver abscess. Annals of Tropical Medicine and Parasitology 1969;63(2):139-42.
Powell 1969b {published data only}
  • Powell SJ, Wilmot AJ, Elsdon-Dew R. The use of niridazole alone and in combination with other amoebicides in amoebic dysentery and amoebic liver abscess. Annals of the New York Academy of Science 1969;160(2):749-54.
    Direct Link:
Powell 1969c {published data only}
Powell 1971a {published data only}
Powell 1971b {published data only}
Powell 1972a {published data only}
  • Powell SJ, Elsdon-Dew R. Some new nitroimidazole derivatives. Clinical trials in amebic liver abscess. American Journal of Tropical Medicine and Hygiene 1972;21(5):518-20.
Powell 1972b {published data only}
  • Powell SJ. Latest developments in the treatment of amebiasis. Advances in Pharmacology and Chemotherapy 1972;10:91-103.
Powell 1973 {published data only}
  • Powell SJ, Rubidge CJ, Elsdon-Dew R. Clinical trials of benzoyl metronidazole suspension in amoebic dysentery and amoebic liver abscess. South African Medical Journal 1973;47(12):507-8.
Prakash 1974 {published data only}
  • Prakash C, Bansal BC, Bansal MR. A comparative study of tinidazole and metronidazole in symptomatic intestinal amoebiasis. Journal of the Association of Physicians of India 1974;22(7):527-9.
Qureshi 1994 {published data only}
  • Qureshi H, Baqai B, Zuberi SJ, Ahmed W, Qureshi SA. Efficacy of secnidazole in the treatment of intestinal amoebiasis. Journal of the Pakistan Medical Association 1994;44(4):93-4.
Qureshi 1997 {published data only}
  • Qureshi H, Ali A, Baqai R, Ahmed A. Efficacy of a combined diloxanide furoate-metronidazole preparation in the treatment of amoebiasis and giardiasis. Journal of International Medical Research 1997;25(3):167-70.
Rodrigues 1968 {published data only}
  • Rodrigues LD, Jafferian PA, Villela MdeP, de Mello EB. Comparative study on 3 amebicides: teclozine, clefamide and a combination of clefamide and iodo-chloro-oxyquinolines and streptomycin [Estudo comparativo de tres amebicidas: o teclozine, a clefamida e a associacao de clefamida com iodo-cloro-oxiquinoleina e estreptomicina]. Hospital (Rio de Janeiro, Brazil) 1968;74(5):1563-73.
Ruas 1973 {published data only}
  • Ruas A, Correia MH, Valle JC do, Ribeiro JA. RO 7-0207 in amoebic liver abscess. Comparative study of the effects of RO 7-0207 and metronidazole. Central African Journal of Medicine 1973;19(6):128-32.
Ruchko 1978 {published data only}
  • Ruchko AF. Clinical and treatment characteristics of amebiasis in children in a hot climate. Pediatriia, Akusherstvo i Ginekologiia 1978, (5):28-9.
Saha 1966 {published data only}
  • Saha TK, Chaudhuri RN. Clinical trial of furoxone in amoebic dysentery. Bulletin of the Calcutta School of Tropical Medicine 1966;14(1):22.
Saha 1970 {published data only}
  • Saha TK, Mandal JN. Niridazole in amoebic dysentery. Journal of the Indian Medical Association 1970;55(4):127-9.
Salem 1964 {published data only}
  • Salem HH, Rabbo HA. Clinical trials with dehydroemetine dihydrochloride in the treatment of acute amoebiasis. Journal of Tropical Medicine and Hygiene 1964;67:137-41.
Salem 1967 {published data only}
Sandia 1977 {published data only}
  • Sandia OG, Dobbins Filho J, Leite IC, Harris PB. Comparative therapeutic trial of ornidazole and metronidazole in chronic amebiasis [Ensaio terapeutico comparativo entre ornidazole e metronidazol em amebiase cronica]. Revista do Instituto de Medicina Tropical de São Paulo 1977;19(1):52-6.
Sangiuolo 1969 {published data only}
  • Sangiuolo F. Antimicrobial and antispastic effect of a combination of canulase and iodochloroxyquinoline (Septo-canulase) in various acute and chronic enteropathies [Sull'azione antimicrobica ed antispastica di una associazione di canulase con iodoclorossichinolina (Septo-canulase) in alcune enteropatie acute e croniche]. Rassegna Internazionale di Clinica e Terapia 1969;49(19):1231-50.
Sankale 1966 {published data only}
  • Sankale M, Moulanier M. Treatment of amebiasis with oral dehydroemetine [Le traitement de l'amibiase par la dehydroemetine orale]. Therapie 1966;21(3):733-41.
Sankale 1969 {published data only}
  • Sankale M, Satge P, Lariviere M, Moulanier M, Bourgeade A, Debroise C, et al. Efficacy of niridazole in amoebic dysentery. Annals of the New York Academy of Science 1969;160(2):755-63.
    Direct Link:
Sankale 1974 {published data only}
  • Sankale M, Coly D, Niang I. Treatment of amoebiasis with a drinkable suspension of metronidazole [Traitement de l'amibiase par une suspension buvable de metronidazole]. Therapie 1974;29:411-5.
Satpathy 1988 {published data only}
  • Satpathy BK, Acharya SK, Satpathy S. Comparative study of intravenous metronidazole and intramuscular dehydroemetine in amoebic liver abscess. Journal of the Indian Medical Association 1988;86(2):38-40.
Schapiro 1967 {published data only}
Scragg 1968 {published data only}
  • Scragg JN, Powell SJ. Emetine hydrochloride and dehydroemetine combined with chloroquine in the treatment of children with amoebic liver abscess. Archives of Disease in Childhood 1968;43(227):121-3.
Scragg 1970 {published data only}
Segal 1967 {published data only}
  • Segal J. Clinico-paracytological and therapeutic study with a new preparation of erythromycin stearate of controlled release (A-16535) [Estudo clinico-parasitologico e terapeutico com uma nova preparacao de estearato de eritromicina de liberacao regulada (A-16535)]. Revista Brasileira de Medicina 1967;24(8):626-32.
Sharma 1989 {published data only}
Shrotriya 1985 {published data only}
  • Shrotriya V, Dabral SB, Maheshwari BB, Gupta SC, Maheshwari BB. A controlled trial of Diarex and tinidazole in chronic intestinal amoebiasis. Medicine and Surgery 1985;25(1):8-9,16.
Simjee 1985 {published data only}
  • Simjee AE, Gathiram V, Jackson TF, Khan BF. A comparative trial of metronidazole v. tinidazole in the treatment of amoebic liver abscess. South African Medical Journal. Suid-Afrikaanse Tydskrif Vir Geneeskunde 1985;68(13):923-4.
Simon 1967 {published data only}
  • Simon M, Shookhoff HB, Terner H, Weingarten B, Parker JG. Paromomycin in the treatment of intestinal amebiasis; a short course of therapy. American Journal of Gastroenterology 1967;48(6):504-11.
Sinuhaji 1986 {published data only}
  • Sinuhaji AB, Lubis CP, Daulay HRM, Lubis IT, Jufri A, Sutanto AH. A double-blind trial between metronidazole and secnidazole in acute amebic dysetnery in children (Preliminary Report). Paediatrica Indonesiana 1986;26:9-14.
Sladden 1964 {published data only}
  • Sladden DL, Taylor E, Livingstone DJ. A clinical trial of a new compound (dehydroemetine bismuth iodide, Ro 4,3076) in amoebic dysentery. The Central African Journal of Medicine 1964;10(11):412-3.
Soh 1980 {published data only}
  • Soh CT, Cho MJ, Choi HJ, Hur JD. Double blind test of ornidazole versus tinidazole against amoebic liver abscess. Yonsei Reports on Tropical Medicine 1980;11(1):43-50.
Spellberg 1969 {published data only}
Spillman 1976 {published data only}
  • Spillman R, Ayala SC, Sanchez CE. Double blind test of metronidazole and tinidazole in the treatment of asymptomatic Entamoeba histolytica and Entamoeba hartmanni carriers. American Journal of Tropical Medicine and Hygiene 1976;25(4):549-51.
Sutrisno 1978 {published data only}
  • Sutrisno D, Ismail D, Sebodo T, Ismangun, Noerhajati S. Nitrimidazine (Naxogin) in the treatment of children with intestinal amoebiasis. Paediatrica Indonesiana 1978;18(7-8):217-23.
Tandon 1997 {published data only}
  • Tandon A, Jain AK, Dixit VK, Agarwal AK, Gupta JP. Needle aspiration in large amoebic liver abscess. Tropical Gastroenterology: Official Journal of the Digestive Diseases Foundation 1997;18(1):19-21.
Thoren 1990a {published data only}
  • Thoren K, Hakansson C, Bergstrom T, Johnaisson G, Norkrans G. Treatment of asymptomatic amebiasis in homosexual men. Clinical trials with metronidazole, tinidazole, and diloxanide furoate. Sexually Transmitted Diseases 1990;17(2):72-4.
Thoren 1990b {published data only}
  • Thoren K, Hakansson C, Bergstrom T, Johnaisson G, Norkrans G. Treatment of asymptomatic amoebiasis in homosexual men: clinical trials with metronidazole, tinidazole and diloxanide furoate [abstract]. Genitourinary Medicine 1990;66(5):411.
Tjaij 1969 {published data only}
  • Tjaij JK, Raid N, Irawati T, Siregar D, Kwo IT, Tan BE. Mexaform and entobex therapy in amebic dysentery. Paediatrica Indonesiana 1969;9(5):210-4.
Tjaij 1970 {published data only}
  • Tjaij JK, Raid N, Sutanto AH. Clinical trials of oral dehydro-emetine tablets (Ro 1-9334/10) in amebic dysentery in children. Paediatrica Indonesiana 1970;10(4):139-48.
Vaidya 1983 {published data only}
  • Vaidya AB, Ray DK, Mankodi NA, Paul T, Sheth UK. Phase I tolerability and antiamoebic activity studies with 1-methylsulphonyl-3-(1-methyl-5-nitro-2-imidazolyl)-2-imidazolidinone (Go 10213): a new antiprotozoal agent. British Journal of Clinical Pharmacology 1983;16(5):517-22.
Vakil 1967 {published data only}
  • Vakil BJ, Shah SC, Moses JM. The comparative value of dehydroemetine and emetine in amebiasis. Journal of the Association of Physicians of India 1967;15(5):223-8.
Vakil 1971 {published data only}
  • Vakil BJ, Dalal AJ, Mehta AJ, Mody NC. Clinical evaluation of oral dehydroemetine in amoebiasis. Journal of the Association of Physicians of India 1971;19(5):403-8.
Vakil 1974 {published data only}
  • Vakil BJ, Dalal NJ. Comparative evaluation of amoebicidal drugs. Progress in Drug Research 1974;18:353-64.
Valencia 1973 {published data only}
  • Valencia-Parparcen J. Erythromycin in the treatment of intestinal amebiasis and other processes of the digestive tract [La eritromicina en el tratamiento de la amibiasis intestinal y otros procesos del tubo digestivo]. G.E.N 1973;28(1):29-37.
Vanijanonta 1985 {published data only}
  • Vanijanonta S, Bunnag D, Looareesuwan S, Harinasuta T. Low dose tinidazole in the treatment of amoebic liver abscess. Southeast Asia Journal of Tropical Medicine and Public Health 1985;16(2):253-6.
Viswanathan 1968 {published data only}
  • Viswanathan M, Krishnaswami CV. Therapeutic trials with oral dehydroemetine in intestinal amoebiasis. Journal of the Indian Medical Association 1968;51(8):381-3.
Wang 1971a {published data only}
  • Wang LT, Sung JL. Trials of metronidazole in amebic dysentery and amebic liver abscess. Taiwan Yi Xue Hue Za Zhi 1971;70(7):405-8.
Wang 1971b {published data only}
  • Wang LT, Yang SP. Studies on oxytetracycline resistant amebic dysentery. Taiwan Yi Xue Hue Za Zhi 1971;70(3):131-4.
Watson 1975 {published data only}
Welch 1978 {published data only}
  • Welch JS, Rowsell BJ, Freeman C. Treatment of intestinal amoebiasis and giardiasis. Efficacy of metronidazole and tinidazole compared. Medical Journal of Australia 1978;1(9):469-71.
Widjaya 1991 {published data only}
  • Widjaya P, Bilic A, Babic Z, Ljubicic N, Bakula B, Pilas V. Amoebic liver abscess: ultrasonographic characteristics and results of different therapeutic approaches. Acta Medica Iugoslavica 1991;45(1):15-21.
Wilmot 1962 {published data only}
Wolfe 1973 {published data only}
Wolfensberger 1968 {published data only}
  • Wolfensberger HR. Amoebiasis: clinical trials of dehydroemetine late-release tablets (Ro 1-9334/20) compared with parenteral dehydroemetine and niridazole. Transactions of the Royal Society of Tropical Medicine and Hygiene 1968;62(6):831-7.
Zuberi 1973 {published data only}

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Guevara 1980 {published data only}
  • Guevara L. Evaluation of the tolerance and efficiency of quinfamide, a new intraluminal amebicide, in man (one day treatment). Double blind study. Revista de Gastroenterologia de Mexico 1980;45(2):93-7.
Soedin 1989 {published data only}
  • Soedin K, Lelo A. A single dose of secnidazole vs a 5-day regimen of the combination tetracycline/clioquinol in the treatment of intestinal ameobiasis. Proceedings of the 16th International Congress of Chemotherapy; 1989 Jun 12; Jerusalem, Israel. Amsterdam: Excerpta Medica, 1989:43-8.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
AAP 2006
  • American Academy of Pediatrics. Amebiasis. In: Pickering LK, Baker CJ, Long SS, McMillan JA, et al. editor(s). Red Book: 2006 Report of the Committee on Infectious Diseases. 27th Edition. Elk Grove Village, IL: American Academy of Pediatrics, 2006:204-6.
Abd-Alla 2002
  • Abd-Alla MD, Ravdin JI. Diagnosis of amoebic colitis by antigen capture ELISA in patients presenting with acute diarrhoea in Cairo, Egypt. Tropical Medicine and International Health 2002;7(4):365-70.
    Direct Link:
Adams 1977
Barwick 2002
  • Barwick RS, Uzicanin A, Lareau S, Malakmadze N, Imnadze P, Iosava M, et al. Outbreak of amebiasis in Tbilisi, Republic of Georgia, 1998. American Journal of Tropical Medicine and Hygiene 2002;67(6):623-31.
Blessman 2003b
  • Blessman J, Ali IKM, Ton Nu PA, Dinh BT, Ngo Viet TQ, Van AL, et al. Longitudinal study of intestinal Entamoeba histolytica infections in asymptomatic adult carriers. Journal of Clinical Microbiology 2003;41(10):4745-50.
Braga 1996
  • Braga LL, Lima AAM, Sears CL, Newman RD, Wuhib T, Paiva CA, et al. Seroepidemiology of Entamoeba histolytica in a slum in Northeastern Brazil. American Journal of Tropical Medicine and Hygiene 1996;55(6):693-7.
Braga 1998
  • Braga LL, Mendonca Y, Paiva CA, Sales A, Cavalcante ALM, Mann BJ. Seropositivity for and intestinal colonization with Entamoeba histolytica and Entamoeba dispar in individuals in Northeastern Brazil. Journal of Clinical Microbiology 1998;36(10):3044-5.
Brooks 1985
Chen 2004
  • Chen HT, Hsu YH, Chang YZ. Fulminant amebic colitis: recommended treatment to improve survival. Tzu Chi Medical Journal 2004;16:1-8.
Dans 2006
  • Dans L, Martinez E. Amoebic dysentery. Clinical Evidence 2006;15:1007-13.
Ellyson 1986
Gathiram 1985
Gathiram 1987
  • Gathiram V, Jackson TFHG. A longitudinal study of asymptomatic carriers of pathogenic zymodemes of Entamoeba histolytica. South African Medical Journal 1987;72:669-72.
Gatti 2002
  • Gatti S, Swierczynski G, Robinson F, Anselmi M, Corrales J, Moreira J, et al. Amebic infections due to the Entamoeba histolytica-Entamoeba dispar complex: a study of the incidence in a remote rural area of Ecuador. American Journal of Tropical Medicine and Hygiene 2002;67(1):123-7.
Gonzalez-Ruiz 1994
  • Gonzalez-Ruiz A, Haque R, Aguirre A, Castanon G, Hall A, Guhl F, et al. Value of microscopy in the diagnosis of dysentery associated with invasive Entamoeba histolytica. Journal of Clinical Pathology 1994;47(3):236-9.
Haque 1995
  • Haque R, Neville LM, Hahn P, Petri WA Jr. Rapid diagnosis of Entamoeba infection by using Entamoeba and Entameoba histolytica stool antigen detection kits. Journal of Clinical Microbiology 1995;33(10):2558-61.
Haque 1997
Haque 1998
  • Haque R, Ali IKM, Akther S, Petri WA Jr. Comparison of PCR, isoenzyme analysis, and antigen detection for diagnosis of Entamoeba histolytica infection. Journal of Clinical Microbiology 1998;36(2):449-52.
Haque 1999
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