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Nutritional supplements for people being treated for active tuberculosis

  1. David Sinclair1,*,
  2. Katharine Abba1,
  3. Liesl Grobler2,
  4. Thambu D Sudarsanam3

Editorial Group: Cochrane Infectious Diseases Group

Published Online: 9 NOV 2011

Assessed as up-to-date: 1 JUL 2011

DOI: 10.1002/14651858.CD006086.pub3


How to Cite

Sinclair D, Abba K, Grobler L, Sudarsanam TD. Nutritional supplements for people being treated for active tuberculosis. Cochrane Database of Systematic Reviews 2011, Issue 11. Art. No.: CD006086. DOI: 10.1002/14651858.CD006086.pub3.

Author Information

  1. 1

    Liverpool School of Tropical Medicine, International Health Group, Liverpool, UK

  2. 2

    Cape Town, Western Province, South Africa

  3. 3

    Christian Medical College, Medicine Unit 2, Vellore, Tamil Nadu, India

*David Sinclair, International Health Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK. sinclad@liverpool.ac.uk.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 9 NOV 2011

SEARCH

[Figure 1]
Figure 1. Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
[Figure 2]
Figure 2. Study flowchart (PRISMA template)
[Analysis 1.1]
Analysis 1.1. Comparison 1 Macronutrient supplementation, Outcome 1 Death (1 year of follow-up).
[Analysis 1.2]
Analysis 1.2. Comparison 1 Macronutrient supplementation, Outcome 2 Cured (at 6 months).
[Analysis 1.3]
Analysis 1.3. Comparison 1 Macronutrient supplementation, Outcome 3 Treatment completion.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Macronutrient supplementation, Outcome 4 Sputum negative at 8 weeks.
[Analysis 1.5]
Analysis 1.5. Comparison 1 Macronutrient supplementation, Outcome 5 Mean weight gain.
[Analysis 1.6]
Analysis 1.6. Comparison 1 Macronutrient supplementation, Outcome 6 Change in maximum grip strength (kg).
[Analysis 1.7]
Analysis 1.7. Comparison 1 Macronutrient supplementation, Outcome 7 Change in quality of life score.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Daily meal versus routine care, Outcome 1 Treatment completion.
[Analysis 2.2]
Analysis 2.2. Comparison 2 Daily meal versus routine care, Outcome 2 Cough clearance.
[Analysis 2.3]
Analysis 2.3. Comparison 2 Daily meal versus routine care, Outcome 3 Sputum clearance.
[Analysis 2.4]
Analysis 2.4. Comparison 2 Daily meal versus routine care, Outcome 4 Mean weight gain.
[Analysis 3.1]
Analysis 3.1. Comparison 3 High energy oral supplements and dietary advice vs dietary advice alone, Outcome 1 Death.
[Analysis 3.2]
Analysis 3.2. Comparison 3 High energy oral supplements and dietary advice vs dietary advice alone, Outcome 2 Treatment completion rate.
[Analysis 3.3]
Analysis 3.3. Comparison 3 High energy oral supplements and dietary advice vs dietary advice alone, Outcome 3 Sputum conversion rate at 8 weeks.
[Analysis 3.4]
Analysis 3.4. Comparison 3 High energy oral supplements and dietary advice vs dietary advice alone, Outcome 4 Change in body weight (kg).
[Analysis 3.5]
Analysis 3.5. Comparison 3 High energy oral supplements and dietary advice vs dietary advice alone, Outcome 5 Change in total lean mass (kg).
[Analysis 3.6]
Analysis 3.6. Comparison 3 High energy oral supplements and dietary advice vs dietary advice alone, Outcome 6 Change in total fat mass (kg).
[Analysis 3.7]
Analysis 3.7. Comparison 3 High energy oral supplements and dietary advice vs dietary advice alone, Outcome 7 Change in maximum grip strength (kg).
[Analysis 3.8]
Analysis 3.8. Comparison 3 High energy oral supplements and dietary advice vs dietary advice alone, Outcome 8 Change in overall health score.
[Analysis 3.9]
Analysis 3.9. Comparison 3 High energy oral supplements and dietary advice vs dietary advice alone, Outcome 9 Change in quality of life score.
[Analysis 3.10]
Analysis 3.10. Comparison 3 High energy oral supplements and dietary advice vs dietary advice alone, Outcome 10 Change in physical function score.
[Analysis 4.1]
Analysis 4.1. Comparison 4 Monthly ration, Outcome 1 Death (at 6 months).
[Analysis 4.2]
Analysis 4.2. Comparison 4 Monthly ration, Outcome 2 Cured (at 6 months).
[Analysis 4.3]
Analysis 4.3. Comparison 4 Monthly ration, Outcome 3 Treatment failure (before 6 months).
[Analysis 5.1]
Analysis 5.1. Comparison 5 High cholesterol (850 mg/day) vs low cholesterol (250 mg/day) diet, Outcome 1 Sputum-culture positive.
[Analysis 6.1]
Analysis 6.1. Comparison 6 Multivitamin and trace element tablets vs placebo, Outcome 1 Death during follow-up (subgrouped by HIV status).
[Analysis 6.2]
Analysis 6.2. Comparison 6 Multivitamin and trace element tablets vs placebo, Outcome 2 Sputum-smear or sputum-culture positive at 1 month.
[Analysis 6.3]
Analysis 6.3. Comparison 6 Multivitamin and trace element tablets vs placebo, Outcome 3 Sputum-smear or sputum-culture positive at 2 months.
[Analysis 6.4]
Analysis 6.4. Comparison 6 Multivitamin and trace element tablets vs placebo, Outcome 4 Mean weight gain.
[Analysis 6.5]
Analysis 6.5. Comparison 6 Multivitamin and trace element tablets vs placebo, Outcome 5 Mean change in handgrip strength.
[Analysis 7.1]
Analysis 7.1. Comparison 7 Vitamin A vs placebo, Outcome 1 Mean serum retinol (normal range > 20 µg/l).
[Analysis 7.2]
Analysis 7.2. Comparison 7 Vitamin A vs placebo, Outcome 2 Death.
[Analysis 7.3]
Analysis 7.3. Comparison 7 Vitamin A vs placebo, Outcome 3 Treatment completion.
[Analysis 7.4]
Analysis 7.4. Comparison 7 Vitamin A vs placebo, Outcome 4 Symptomatic at 6 weeks.
[Analysis 7.5]
Analysis 7.5. Comparison 7 Vitamin A vs placebo, Outcome 5 Sputum smear/culture positive during follow up.
[Analysis 7.6]
Analysis 7.6. Comparison 7 Vitamin A vs placebo, Outcome 6 BMI (kg/m2).
[Analysis 7.7]
Analysis 7.7. Comparison 7 Vitamin A vs placebo, Outcome 7 Body fat (%).
[Analysis 8.1]
Analysis 8.1. Comparison 8 Zinc vs placebo, Outcome 1 Serum zinc levels (normal range > 10.7 µmol/L).
[Analysis 8.2]
Analysis 8.2. Comparison 8 Zinc vs placebo, Outcome 2 Death by 6/8 months.
[Analysis 8.3]
Analysis 8.3. Comparison 8 Zinc vs placebo, Outcome 3 Death by 6/8 months (subgrouped by HIV status).
[Analysis 8.4]
Analysis 8.4. Comparison 8 Zinc vs placebo, Outcome 4 Treatment completion at 6 months.
[Analysis 8.5]
Analysis 8.5. Comparison 8 Zinc vs placebo, Outcome 5 Sputum smear/culture positive during follow-up.
[Analysis 8.6]
Analysis 8.6. Comparison 8 Zinc vs placebo, Outcome 6 Weight change (kg).
[Analysis 8.7]
Analysis 8.7. Comparison 8 Zinc vs placebo, Outcome 7 BMI (kg/m2).
[Analysis 8.8]
Analysis 8.8. Comparison 8 Zinc vs placebo, Outcome 8 Body fat (%).
[Analysis 9.1]
Analysis 9.1. Comparison 9 Zinc + Vitamin A vs placebo, Outcome 1 Serum retinol (normal range > 70 µmol/l).
[Analysis 9.2]
Analysis 9.2. Comparison 9 Zinc + Vitamin A vs placebo, Outcome 2 Serum zinc level (normal range > 10.7 µmol/l).
[Analysis 9.3]
Analysis 9.3. Comparison 9 Zinc + Vitamin A vs placebo, Outcome 3 Death by 6 months.
[Analysis 9.4]
Analysis 9.4. Comparison 9 Zinc + Vitamin A vs placebo, Outcome 4 Treatment completion at 6 months.
[Analysis 9.5]
Analysis 9.5. Comparison 9 Zinc + Vitamin A vs placebo, Outcome 5 Sputum smear/culture positive during follow-up.
[Analysis 9.6]
Analysis 9.6. Comparison 9 Zinc + Vitamin A vs placebo, Outcome 6 Karnofsky score.
[Analysis 9.7]
Analysis 9.7. Comparison 9 Zinc + Vitamin A vs placebo, Outcome 7 BMI (kg/m²).
[Analysis 9.8]
Analysis 9.8. Comparison 9 Zinc + Vitamin A vs placebo, Outcome 8 Body weight (kg).
[Analysis 9.9]
Analysis 9.9. Comparison 9 Zinc + Vitamin A vs placebo, Outcome 9 Mid upper arm circumference (cm).
[Analysis 9.10]
Analysis 9.10. Comparison 9 Zinc + Vitamin A vs placebo, Outcome 10 Biceps skinfold thickness (mm).
[Analysis 9.11]
Analysis 9.11. Comparison 9 Zinc + Vitamin A vs placebo, Outcome 11 Triceps skinfold thickness (mm).
[Analysis 9.12]
Analysis 9.12. Comparison 9 Zinc + Vitamin A vs placebo, Outcome 12 Subscapular skinfold thickness (mm).
[Analysis 9.13]
Analysis 9.13. Comparison 9 Zinc + Vitamin A vs placebo, Outcome 13 Suprailiac skinfold thickness (mm).
[Analysis 9.14]
Analysis 9.14. Comparison 9 Zinc + Vitamin A vs placebo, Outcome 14 Body fat (%).
[Analysis 9.15]
Analysis 9.15. Comparison 9 Zinc + Vitamin A vs placebo, Outcome 15 Fat mass (kg).
[Analysis 10.1]
Analysis 10.1. Comparison 10 Vitamin D vs placebo or no supplements, Outcome 1 Death by 12 months.
[Analysis 10.2]
Analysis 10.2. Comparison 10 Vitamin D vs placebo or no supplements, Outcome 2 TB score.
[Analysis 10.3]
Analysis 10.3. Comparison 10 Vitamin D vs placebo or no supplements, Outcome 3 Sputum-smear positive.
[Analysis 10.4]
Analysis 10.4. Comparison 10 Vitamin D vs placebo or no supplements, Outcome 4 Body Mass Index.
[Analysis 10.5]
Analysis 10.5. Comparison 10 Vitamin D vs placebo or no supplements, Outcome 5 Body weight (kg).
[Analysis 11.1]
Analysis 11.1. Comparison 11 Vitamin E plus selenium vs placebo, Outcome 1 Sputum-smear positive at follow up.
[Analysis 12.1]
Analysis 12.1. Comparison 12 Arginine vs placebo, Outcome 1 Death during treatment.
[Analysis 12.2]
Analysis 12.2. Comparison 12 Arginine vs placebo, Outcome 2 Sputum-smear positive at week 8.
[Analysis 12.3]
Analysis 12.3. Comparison 12 Arginine vs placebo, Outcome 3 Cough at week 2 (HIV-negative participants only).
[Analysis 12.4]
Analysis 12.4. Comparison 12 Arginine vs placebo, Outcome 4 Cough at week 8.