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Nutritional supplements for people being treated for active tuberculosis

  1. David Sinclair1,*,
  2. Katharine Abba1,
  3. Liesl Grobler2,
  4. Thambu D Sudarsanam3

Editorial Group: Cochrane Infectious Diseases Group

Published Online: 9 NOV 2011

Assessed as up-to-date: 1 JUL 2011

DOI: 10.1002/14651858.CD006086.pub3


How to Cite

Sinclair D, Abba K, Grobler L, Sudarsanam TD. Nutritional supplements for people being treated for active tuberculosis. Cochrane Database of Systematic Reviews 2011, Issue 11. Art. No.: CD006086. DOI: 10.1002/14651858.CD006086.pub3.

Author Information

  1. 1

    Liverpool School of Tropical Medicine, International Health Group, Liverpool, UK

  2. 2

    Cape Town, Western Province, South Africa

  3. 3

    Christian Medical College, Medicine Unit 2, Vellore, Tamil Nadu, India

*David Sinclair, International Health Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK. sinclad@liverpool.ac.uk.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 9 NOV 2011

SEARCH

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Armijos 2010 {published data only}
Hanekom 1997 {published data only}
Jahnavi 2010 {published data only}
  • Jahnavi G, Sudha CH. Randomised controlled trial of food supplements in patients with newly diagnosed tuberculosis and wasting. Singapore Medical Journal 2010;51(12):957-62.
Karyadi 2002 {published data only}
  • Karyadi E, West CE, Schultink W, Nelwan RH, Gross R, Amin Z, et al. A double-blind, placebo-controlled study of vitamin A and zinc supplementation in persons with tuberculosis in Indonesia: effects on clinical response and nutritional status. American Journal of Clinical Nutrition 2002;75(4):720-7.
Lawson 2010 {published data only}
Martineau 2011 {published data only}
  • Martineau AR, Timms PM, Bothamley GH, Hanifa Y, Islam K, Claxton AP, et al. High-dose vitamin D3 during intensive-phase antimicrobial treatment for pulmonary tuberculosis: a double-blind randomised controlled trial. Lancet 2011;377(9761):242-250.
Martins 2009 {published data only}
  • Martins N, Morris P, Kelly PM. Food incentives to improve completion of tuberculosis treatment: randomised controlled trial in Dili, Timor-Leste. BMJ 2009;229:b4248.
Mehta 2010 {unpublished data only}
  • Mehta S, Mugusi FM, Bosch RJ, Aboud A, Chatterjee A, Finkelstein JL, et al. A Randomized Trial of Multivitamin Supplementation in Children withTuberculosis in Tanzania. clinicaltrials.gov/ct2/show/NCT00145184 unpublished.
Morcos 1998 {published data only}
  • Morcos MM, Gabr AA, Samual S, Kamel M, Baz ME, Beshry ME, et al. Vitamin D administration to tuberculous children and its value. Bollettino Chimico Farmaceutico 1998;137(5):157-64.
Nursyam 2006 {published data only}
  • Nursyam EW, Amin Z, Rumende CA. The effects of vitamin D as supplementary treatment in patients with moderately advanced pulmonary tuberculosis lesion. Acta Medica Indonesiana 2006;38(1):3-5.
Pakasi 2010 {published data only}
  • Pakasi TA, Karyadi E, Suratih NMD, Salean M, Darmawidjaja N, Bor H, et al. Zinc and vitamin A supplementation fails to reduce sputum conversion time in severely malnourished pulmonary tuberculosis patients in Indonesia. Nutrition Journal 2010;9(1):41.
Paton 2004 {published data only}
  • Paton NI, Chua YK, Earnest A, Chee CB. Randomized controlled trial of nutritional supplementation in patients with newly diagnosed tuberculosis and wasting. American Journal of Clinical Nutrition 2004;80(2):460-5.
Praygod 2011 {published data only}
  • Praygod G, Range N, Faurholt-Jepsen D, Jeremiah K, Faurholt-Jepsen M, Aabye MG, et al. The effect of energy-protein supplementation on weight, body composition and handgrip strength among pulmonary tuberculosis HIV-co-infected patients: randomised controlled trial in Mwanza, Tanzania. The British Journal of Nutrition 2011;1(1):1-9 ePub.
Praygod 2011a {published data only}
  • Praygod G, Range N, Faurholt-Jepsen D, Jeremiah K, Faurholt-Jepsen M, Aabye MG, et al. Daily multi-micronutrient supplementation during tuberculosis treatment increases weight and grip strength among HIV-uninfected but not HIV-infected patients in Mwanza, Tanzania. The Journal of Nutrition 2011;141(4):685-91.
Pérez-Guzmán 2005 {published data only}
  • Pérez-Guzmán C, Vargas MH, Quiñonez F, Bazavilvazo N, Aguilar A. A cholesterol-rich diet accelerates bacteriologic sterilization in pulmonary tuberculosis. Chest 2005;127(2):643-51.
Range 2005 {published data only}
  • Range N, Andersen AB, Magnussen P, Mugomela A, Friis H. The effect of micronutrient supplementation on treatment outcome in patients with pulmonary tuberculosis: a randomized controlled trial in Mwanza, Tanzania. Tropical Medicine and International Health 2005;10(9):826-32.
  • Range N, Changalucha J, Krarup H, Magnussen P, Andersen AB, Friis H. The effect of multi-vitamin/mineral supplementation on mortality during treatment of pulmonary tuberculosis: a randomised two-by-two factorial trial in Mwanza, Tanzania. British Journal of Nutrition 2006;95(4):762-70.
Schön 2003 {published data only}
  • Schön T, Elias D, Moges F, Melese E, Tessema T, Stendahl O, et al. Arginine as an adjuvant to chemotherapy improves clinical outcomes in active tuberculosis. European Respiratory Journal 2003;21(3):483-8.
Semba 2007 {published data only}
  • Semba RD, Kumwenda J, Zijlstra E, Ricks MO, van Lettow M, Whalen C, et al. Micronutrient supplements and mortality of HIV-infected adults with pulmonary TB: a controlled clinical trial. International Journal of Tuberculosis and Lung Disease 2007;11(8):854-9.
Seyedrezazadeh 2006 {published data only}
  • Seyedrezazadeh E, Ostadrahimi A, Mohboob S, Asadi Y, Ghaemmagami J, Pourmogaddam M. Effect of vitamin E and selenium supplementation on oxidative stress status in pulmonary tuberculosis patients. Respirology 2008;13(2):294-8.
  • Seyedrezazadeh E, Ostradrahimi AR, Mahboob SA, Assadi Y, Ansarin K, Sakoori P, Pourmoghaddam M. Vitamin E-Selenium supplement and clinical responses of active pulmonary tuberculosis. Tanaffos 2006;5(2):49-55.
Sudarsanam 2010 {published data only}
Villamor 2008 {published and unpublished data}
  • Villamor E, Mugusi F, Urassa W, Bosch R J, Saathoff E, Matsumoto K, et al. A trial of the effect of micronutrient supplementation on treatment outcome, T cell counts, morbidity, and mortality in adults with pulmonary tuberculosis. Journal of Infectious Diseases 2008;197(11):1499-505.
Visser 2011 {published data only}
  • Visser ME, Grewal HMS, Swart EC, Dhansay MA, Walzl G, Swanevelder S, et al. The effect of vitamin A and zinc supplementation on treatment outcomes in pulmonary tuberculosis: a randomized controlled trial. Am J Clin Nutr 2011;93:93-100.
Wejse 2008 {published and unpublished data}
  • Wejse C, Gomes VF, Rabna P, Gustafson P, Aaby P, Lisse IM, et al. Vitamin D as supplementary treatment for tuberculosis - a double-blind randomised placebo-controlled trial. American Journal of Respiratory and Critical Care Medicine 2009;179:843-50.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Gwinup 1981 {published data only}
Martineau 2009 {published data only}
  • Martineau AR, Nanzer AM, Satkunam KR, Packe GE, Rainbow SJ, Maunsell ZJ, et al. Influence of a single oral dose of vitamin D(2) on serum 25-hydroxyvitamin D concentrations in tuberculosis patients. The International Journal of Tuberculosis and Lung Disease 2009;13(1):119-25.
Mbala 1998 {published data only}
Narang 1984 {published data only}
  • Narang NK, Gupta RC, Jain MK. Role of vitamin D in pulmonary tuberculosis. Journal of the Association of Physicians of India 1984;32(2):185-8.
Oluboyede 1978 {published data only}
  • Oluboyede OA, Onadeko BO. Observation on haematological patterns in pulmonary tuberculosis in Nigerians. Journal of Tropical Medicine and Hygiene 1978;81(5):91-5.
Ramakrishnan 1961 {published data only}
  • Ramakrishnan CV, Rajendran K, Jacob PG, Fox W, Radhakrishnan S. The role of diet in the treatment of pulmonary tuberculosis. An evaluation in a controlled chemotherapy study in home and sanatorium patients in South India. Bulletin of the World Health Organization 1961;25:339-59.
Shi 2001 {published data only}
  • Shi XY, Xiao JQ, YI JY, Zhu YQ, Deng CS. Influence of partial parenteral nutrition with fat emulsion on nutritional status in patients with abdominal tuberculosis. Journal of Clinical Internal Medicine 2001;18(2):120-1.

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Chandra 2004 {published data only}

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
ISRCTN16469166 {unpublished data only}
  • ISRCTN16469166. Nutrition and wasting in tuberculosis (TB): Can nutritional supplementation in TB patients improve body weight gain, body composition and treatment outcome?. www.controlled-trials.com/ISRCTN16469166/ISRCTN16469166 (accessed 10 October 2007).
NCT00366470 {unpublished data only}
  • NCT00366470. A clinical trial to study the effect of the addition of vitamin D to conventional treatment in new pulmonary tuberculosis patients. clinicaltrials.gov/ct2/show/NCT00366470 (accessed 10 October 2007).
NCT00507000 {unpublished data only}
  • NCT00507000. Role of oral vitamin D as an adjunct therapy in category I pulmonary tuberculosis along with assessment of immunological parameters. clinicaltrials.gov/ct2/show/NCT00507000 (accessed 10 October 2007).
NCT00698386 {unpublished data only}
  • NCT00698386. Efficacy of Oral Zinc Administration as an Adjunct Therapy in New Pulmonary Tuberculosis (Category I) Patients. ClinicalTrials.gov Accessed on July 21, 2011.
NCT00788320 {unpublished data only}
  • NCT00788320. Antimicrobial Peptide LL-37 (Cathelicidin) Production in Active Tuberculosis Disease: Role of Vitamin D Supplementation. ClinicalTrials.gov Accessed on July 21, 2011.
NCT00801606 {unpublished data only}
  • NCT00801606. Micronutrient Supplementation in Conjunction With Standard Anti-TuberculosisTherapy in Paediatric (6 Months-15 Years) New Pulmonary Tuberculosis Patients. ClinicalTrials.gov Accessed on July 21, 2011.
NCT00918086 {unpublished data only}
  • NCT00918086. Impact of Vitamin D Supplementationon Host Immunity to Mycobacterium Tuberculosisand Response to Treatment: Building Translational Research Capacity in Nutrition and Infectious Diseases in the Republic of Georgia. ClinicalTrials.gov Accessed on July 21, 2011.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Aaron 2004
Arthur 2003
  • Arthur JR, McKenziey RC, Beckett GJ. Selenium in the Immune System. The Journal of Nutrition 2003;133(5):1457S-1459S. (2003).
Barry 2009
  • Barry CE, Boshoff HI, Dartois V, Dick T, Ehrt S, Flynn J, et al. The spectrum of latent tuberculosis:rethinking the biology and intervention strategies. Nature Reviews 2009;7:845-55.
Cegielski 2004
  • Cegielski JP, McMurray DN. The relationship between malnutrition and tuberculosis, evidence from studies in humans and experimental animals. International Journal of Tuberculosis and Lung Disease 2004;8(3):286-98.
Chandra 1996
  • Chandra RK. Nutrition, immunity and infection: from basic knowledge of dietary manipulation of immune responses to practical application of ameliorating suffering and improving survival. Proceedings of the National Academy of Sciences of the United States of America 1996;93(25):14304-7.
Corbett 2003
  • Corbett EL, Watt CJ, Walker N, Maher D, Williams BG, Raviglione MC, et al. The growing burden of tuberculosis: global trends and interactions with the HIV epidemic. Archives of Internal Medicine 2003;163(9):1009-21.
Davies 1985
Harries 2006
Higgins 2005
  • Higgins J, Green S, editors. Highly sensitive search strategies for identifying reports of randomized controlled trials in MEDLINE. Cochrane Handbook for Systematic Reviews of Interventions 4.2.5 [updated May 2005]; Appendix 5b. www.cochrane.org/resources/handbook/hbook.htm (accessed 1 March 2006).
Irlam 2010
Kamolratanakul 1999
  • Kamolratanakul P, Sawert H, Kongsin S, Lertmaharit S, Sriwongsa J, Na-Songkhla S, et al. Economic impact of tuberculosis at the household level. International Journal of Tuberculosis and Lung Disease 1999;3(7):596-602.
Lounis 2001
Louw 1992
Lutge 2009
Macallan 1999
Mahlungulu 2007
Meyers 2006
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Nnoaham 2008
Plit 1998
  • Plit Ml, Theron AJ, Fickl H, Van Rensburg CE, Pendel S, Anderson R. Influence of antimicrobial chemotherapy and smoking status on plasma concentrations of vitamin C, vitamin E, beta-carotene, acute phase reactants, iron and lipid peroxides in patients with pulmonary tuberculosis. International Journal of Tuberculosis and Lung Disease 1998;2(7):590-9.
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Saunders 2007
Schluger 1998
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Stephenson 2001
Taneja 1990
  • Taneja DP. Observations of serum zinc in patients with pulmonary tuberculosis. Journal of the Indian Medical Association 1990;88(10):280-1.
van Lettow 2003
Wesje 2008b
  • Wesje C, Gustafson P, Nielson J, Gomes VF, Aaby P, Anderson PL, et al. A clinical scoring system for monitoring tuberculosis in a low-resource setting. Scandinavian Journal of Infectious Diseases 2008;40:111-20.
WFP 2007
  • Ba M, Strauss A. Getting Started: WFP food assistance in the context of tuberculosis care and treatment. WFP, 2007.
WHO 2009
  • WHO. Global Tuberculosis Control: A short update on the 2009 report. Geneva: WHO, 2009.
WHO 2010
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WHO 2010b
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Wintergerst 2007
Wyss 2001
Zachariah 2002
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Zumla 2000