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Sertraline versus other antidepressive agents for depression

  1. Andrea Cipriani1,*,
  2. Teresa La Ferla2,
  3. Toshi A Furukawa3,
  4. Alessandra Signoretti1,
  5. Atsuo Nakagawa4,
  6. Rachel Churchill5,
  7. Hugh McGuire6,
  8. Corrado Barbui1

Editorial Group: Cochrane Common Mental Disorders Group

Published Online: 14 APR 2010

Assessed as up-to-date: 30 JUN 2008

DOI: 10.1002/14651858.CD006117.pub4


How to Cite

Cipriani A, La Ferla T, Furukawa TA, Signoretti A, Nakagawa A, Churchill R, McGuire H, Barbui C. Sertraline versus other antidepressive agents for depression. Cochrane Database of Systematic Reviews 2010, Issue 4. Art. No.: CD006117. DOI: 10.1002/14651858.CD006117.pub4.

Author Information

  1. 1

    University of Verona, Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, Verona, Italy

  2. 2

    University of Perugia, Department of Clinical and Experimental Medicine, Section of Psychiatry, Perugia, Italy

  3. 3

    Nagoya City University Graduate School of Medical Sciences, Department of Psychiatry & Cognitive-Behavioral Medicine, Nagoya, Aichi, Japan

  4. 4

    Keio University School of Medicine, Department of Psychiatry, Tokyo, Japan

  5. 5

    University of Bristol, Academic Unit of Psychiatry, Community Based Medicine, Bristol, Avon, UK

  6. 6

    National Collaborating Centre for Women's and Children's Health, London, UK

*Andrea Cipriani, Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Policlinico "G.B.Rossi", Piazzale L.A. Scuro, 10, Verona, 37134, Italy. andrea.cipriani@univr.it. andrea.cipriani@psych.ox.ac.uk.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 14 APR 2010

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Aberg-Wistedt 2000 {published data only}
  • Aberg-Wistedt A, Agren H, Ekselius L, Bengtson F, Akerblad AC. Sertraline versus paroxetine in major depression: clinical outcome after six months of continuous therapy. Journal of Clinical Psychopharmacology 2000;20:645-52.
  • Khoury A, Aberg Wistedt A, Stain Malmgren R. Effect of sertraline and paroxetine treatment on depression scores and peripheral indices of serotonergic function in major depression. 11th European College of Neuropsychopharmacology Congress. Paris, France. 31st October 4th November 1998. Utrecht: ECNP, 1998.
Aguglia 1993 {unpublished data only}
  • Aguglia E, Casacchia M, Cassano GB, Faravelli C, Ferrari G, Giordano P, Pancheri P, Ravizza L, Trabucchi M, Bolino F, Scarpato A, Berardi D, Provenzano G, Brugnoli R, Rozzini R. Double-blind study of the efficacy and safety of sertraline versus fluoxetine in major depression. International Clinical Psychopharmacology 1993;8:197-202.
Alexopoulos 2004 {unpublished data only}
  • Alexopoulos G, Gordon J, Zhang D. A placebo-controlled trial of escitalopram and sertraline in the treatment of major depressive disorder. Poster presented at the Annual Meeting of the American College of Neuropsychopharmacology, December, 2004.
Baca 2003 {published data only}
  • Baca E, Gonzalez de Chavez M, Garcia-Toro M, Perez-Arnau F, Porras-Chavarino A. Sertraline is more effective than imipramine in the treatment of non-melancholic depression: results from a multicentre, randomized study. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2003;27:493-500.
Behan 1995 {published data only}
  • Behan PO, Hannifah H. 5-HT reuptake inhibitors in CFS. EOS Rivista di Immunologia ed Immunofarmacologia 1995;15:66-9.
Behnke 2003 {published data only}
  • Behnke K, Sogaard J, Martin S, Bauml J, Ravindran AV, Agren H, Vester-Blokland ED. Mirtazapine orally disintegrating tablet versus sertraline: a prospective onset of action study. Journal of Clinical Psychopharmacology 2003;23:358-64.
Bennie 1995 {published data only}
  • Bennie EH, Mullin JM, Martindale JJ. A double-blind multicenter trial comparing sertraline and fluoxetine in outpatients with major depression. Journal of Clinical Psychiatry 1995;56:229-37.
Bersani 1994 {published and unpublished data}
Bondareff 2000 {published data only}
  • Bondareff W, Alpert M, Friedhoff AJ, Richter EM, Clary CM, Batzar E. Comparison of sertraline and nortriptyline in the treatment of major depressive disorder in late life. American Journal of Psychiatry 2000;157(5):729-36.
Boyer 1998 {published data only}
  • Boyer P, Danion JM, Bisserbe JC, Hotton JM, Troy S. Clinical and economic comparison of sertraline and fluoxetine in the treatment of depression A 6-month double-blind study in a primary-care setting in France. Pharmacoeconomics 1998;13:157-69.
Brenner 2000 {published data only}
  • Brenner R, Azbel V, Madhusoodanan S, Pawlowska M. Comparison of an extract of hypericum (LI 160) and sertraline in the treatment of depression: a double-blind, randomized pilot study. Clinical Therapeutics 2000;22:411-9.
Chen 2001 {published data only}
  • Chen ZM, Zhang JH, Li ZW, Zhang HM. Venlafaxine vs imipramine, sertraline in treating depression. Chinese Journal of New Drugs and Clinical Remedies 2001;20:109-11.
Cohn 1990 {published data only}
  • Cohn CK, Shrivastava R, Mendels J, Cohn JB, Fabre LF, Claghorn JL, Dessain EC, Itil TM, Lautin A. Double-blind, multicenter comparison of sertraline and amitriptyline in elderly depressed patients. Journal of Clinical Psychiatry 1990;51:28-33.
Coleman 1999 {published data only}
  • Coleman CC, Cunningham LA, Foster VJ, Batey SR, Donahue RMJ, Houser TL, Ascher JA. Sexual dysfunction associated with the treatment of depression: a placebo-controlled comparison of bupropion sustained release and sertraline treatment. Annals of Clinical Psychiatry 1999;11:205-15.
Croft 1999 {published data only}
  • Croft H, Settle Jr E, Houser T, Batey SR, Donahue RMJ, Ascher JA. A placebo-controlled comparison of the antidepressant efficacy and effects on sexual functioning of sustained-release bupropion and sertraline. Clinical Therapeutics 1999;21:643-58.
Davidson 2002 {published data only}
  • Davidson JR, Gadde KM, Fairbank JA, Rama Krishnan KR, Califf RM, Binanay C, et al. Effect of Hypericum perforatum (St John's Wort) in major depressive disorder: A randomized controlled trial. JAMA 2002;287:1807-14.
Doogan 1994 {published data only}
  • Doogan DP, Langdon CJ. A double-blind, placebo-controlled comparison of sertraline and dothiepin in the treatment of major depression in general practice. International Clinical Psychopharmacology 1994;9(2):95-100.
Edwards 1996 {published data only}
  • Edwards RA, Newburn GL. A double blind trial comparing clomipramine and sertraline in the treatment of major depression. Priory Lodge Education Limited www.cityscape.co.uk/users/ad88/sertrl.html 1996.
Eker 2005 {published data only}
  • Eker SS, Akkaya C, Akgoz S, Sarandol A, Kirli S. Comparison of reboxetine and sertraline in terms of efficacy and safety in major depressive disorder. Turk Psikiyatri Dergisi 2005;16(3):153-63.
Ekselius 1997 {published data only}
  • Ekselius L, von Knorring L, Eberhard G. A double-blind multicenter trial comparing sertraline and citalopram in patients with major depression treated in general-practice. International Clinical Psychopharmacology 1997;12:323-31.
Fava 2000 {published data only}
  • Fava M, Rosenbaum JF, Hoog SL, Tepner RG, Kopp JB, Nilsson ME. Fluoxetine versus sertraline and paroxetine in major depression: tolerability and efficacy in anxious depression. Journal of Affective Disorders 2000;59:119-26.
Fava 2002 {published data only}
  • Fava M, Hoog SL, Judge RA, Kopp JB, Nilsson ME, Gonzales JS. Acute efficacy of fluoxetine versus sertraline and paroxetine in major depressive disorder including effects of baseline insomnia. Journal of Clinical Psychopharmacolog 2002;22:137-47.
Feiger 1996 {published data only}
  • Feiger A, Kiev A, Shrivastava RK, Wisselink PG, Wilcox CS. Nefazodone versus sertraline in outpatients with major depression: Focus on efficacy, tolerability, and effects on sexual function and satisfaction. Journal of Clinical Psychiatry 1996;57:53-62.
Forlenza 2001 {published data only}
  • Forlenza OV, Almeida OP, Stoppe A Jr, Hirata ES, Ferreira RCR. Antidepressant efficacy and safety of low-dose sertraline and standard-dose imipramine for the treatment of depression in older adults: Results from a double-blind, randomized, controlled clinical trial. International Psychogeriatrics 2001;13:75-84.
Fournier 1997 {published data only}
Gastpar 2005 {published data only}
  • Gastpar M, Singer A, Zeller K. Efficacy and tolerability of hypericum extract STW3 in long-term treatment with a once-daily dosage in comparison with sertraline. Pharmacopsychiatry 2005;38:78-86.
Hegerl 1997 {published data only}
  • Hegerl U, Gallinat J, Moeller HJ, Arato M, Janka Z. Sertraline versus amitriptyline in hospitalized patients with major depression. Pharmacopsychiatry 1997;30:175.
Kamijima 1997 {published data only}
  • Kamijima K, Koyama T, Mita T, Yamauchi T, Asai M, Toru M, et al. A double-blind, group comparison study of sertraline by hydrochloride vs amitriptyline hydrochloride. Japanese Journal of Neuropsychopharmacology 1997;19:529-48.
Kavoussi 1997 {published data only}
  • Kavoussi RJ, Segraves RT, Hughes AR, Ascher JA, Johnston JA. Double-blind comparison of bupropion sustained release and sertraline in depressed outpatients. Journal of Clinical Psychiatry 1997;58:532-7.
Lee 1994 {published and unpublished data}
  • Lee MS, Kim SH, Suh KY, Kwak DI. Efficacy of sertraline in dysthymia. Neuropsychopharmacology 1994;10:222S.
Lepine 2000 {published data only}
  • Lepine JP, Goger J, Blashko C, Probst C, Moles MF, Kosolowski J, et al. A double-blind study of the efficacy and safety of sertraline and clomipramine in outpatients with severe major depression. International Clinical Psychopharmacology 2000;15:263-71.
Li 2001 {published data only}
  • Li JH, Kong QR, Li SM. A comparative study of sertraline and maprotiline in the treatment of depression. Shandong Journal of Psychological Medicine 2001;14:173-5.
Lydiard 1997 {published data only}
  • Lydiard RB, Stahl SM, Hertzman M, Harrison WM. A double-blind, placebo-controlled study comparing the effects of sertraline versus amitriptyline in the treatment of major depression. Journal of Clinical Psychiatry 1997;58:484-91.
Mehtonen 2000 {published data only}
  • Mehtonen OP, Sogaard J, Roponen P, Behnke K. Randomized, double-blind comparison of venlafaxine and sertraline in outpatients with major depressive disorder. Journal of Clinical Psychiatry 2000;61:95-100.
Moller 2000 {published data only}
  • Moller HJ, Glaser K, Leverkus F, Gobel C. Double-blind, multicenter comparative study of sertraline versus amitriptyline in outpatients with major depression. Pharmacopsychiatry 2000;33:206-12.
Moon 1994 {published data only}
  • Moon CA, Jago W, Wood K, Doogan DP. A double-blind comparison of sertraline and clomipramine in the treatment of major depressive disorder and associated anxiety in general-practice. Journal of Psychopharmacology 1994;8:171-6.
Munizza 2006 {published data only}
  • Munizza C. A Comparative, randomized, double-blind study of trazodone prolonged-release and sertraline in the treatment of major depressive disorder. Current medical research and opinion 2006;22:1703-1713.
Murasaki 1997 {published data only}
  • Murasaki M, Kamijima K, Yamashita I, Mita T, Yamauchi T, Asai M, et al. Clinical evaluation of sertraline hydrochloride, a selective serotonin reuptake inhibitor for depression and depressive state-A double-blind study compared with imipramine hydrochloride. Japanese Journal of Meuropsychopharmacology 1997;19:505-27.
Nemeroff 1995 {published data only}
  • Nemeroff CB, Ninan PT, Ballenger J, Lydiard RB, Feighner J, Patterson WM, Greist JH. Double-blind multicenter comparison of fluvoxamine versus sertraline in the treatment of depressed outpatients. Depression 1995;3:163-9.
Newhouse 2000 {published data only}
  • Newhouse PA, Krishnan KR, Doraiswamy PM. A double-blind comparison of sertraline and fluoxetine in depressed elderly outpatients. J Clin Psychiatry 2000;61:559-568.
Orsel Donbak 1995 {published data only}
  • Orsel Donbak S, Turkcapar MH, Ozturk Kilic EZ, Demirergi N, Akdemir A, Sirin A, Ozbay MH. Moclobemide and sertraline in the treatment of depressive disorders: a comparative study. Acta Psychiatrica Belgica 1995;95:139-51.
Oslin 2003 {published data only}
  • Oslin DW, Ten Have TR, Streim JE, Datto CJ, Weintraub D, DiFilippo S, Katz IR. Probing the safety of medications in the frail elderly: evidence from a randomized clinical trial of sertraline and venlafaxine in depressed nursing home residents. Journal of Clinical Psychiatry 2003;64:875-82.
Quednow 2004 {published data only}
  • Quednow BB, Kuhn KU, Stelzenmuelle R, Hoenig K, Maier W, Wagner M. Effects of serotonergic and noradrenergic antidepressants on auditory startle response in patients with major depression. Psychopharmacology 2004;175:399-406.
Ravindran 1995 {published data only}
Reimherr 1990 {published data only}
  • Reimherr FW, Chouinard G, Cohn CK, Cole JO, Itil TM, LaPierre YD, Masco HL, Mendels J. Antidepressant efficacy of sertraline: a double-blind, placebo- and amitriptyline-controlled, multicenter comparison study in outpatients with major depression. Journal of Clinical Psychiatry 1990;51:18-27.
Rossini 2005 {published data only}
  • Rossini D. Sertraline versus Fluvoxamine in the treatment of elderly patients with major depression a double-blind, randomized trial.. Journal of Clinical Psychopharmacology 2005;25:471-475.
Sechter 1999 {published data only}
  • Sechter D, Troy S, Paternetti S, Boyer P. A double-blind comparison of sertraline and fluoxetine in the treatment of major depressive episode in outpatients. European Psychiatry: the Journal of the Association of European Psychiatrists 1999;14:41-8.
Shelton 2006 {published data only}
Sir 2005 {published data only}
Sogaard 1999 {published data only}
  • Sogaard J, Lane R, Latimer P, Behnke K, Christiansens P.E, Nielsen B, Ravindran A.V, Reesal R.T, Goodwin D.P. A 12-week study comparing moclobemide and sertraline in the treatment of outpatients with atypical depression. Journal of Psychopharmacology 1999;13:406-14.
Stahl 2000 {published data only}
Suri 2000 {published data only}
  • Suri RA, Altshuler LL, Rasgon NL, Calcagno JL, Frye MA, Gitlin MJ, et al. Efficacy and response time to sertraline versus fluoxetine in the treatment of unipolar major depressive disorder. Journal of Clinical Psychiatry 2000;61:942-6.
Szadoczky 2002 {published data only}
Thase 2000 {published data only}
  • Thase M, Simmons J, Howland R, Fava M. Double-blind, Randomized Comparision of Mirtazapine and Sertraline in Depressed Patients who had not responded to SSRI treatment. 52nd Institute on Psychiatric Services - American Psychiatric Association Meeting. Philadelphia, PA, 2000.
Tsutsui 1997 {published data only}
  • Tsutsui S, Okuse S, Sasaki D. Clinical evaluation of sertraline hydrochloride, a selective serotonin reuptake inhibitor in the treatment of depression and depressive state: a double-blind, group comparison study of sertraline hydrochloride vs trazodone hydrochloride. Shinkeiseishinyakuri 1997;19:549-68.
Van Gurp 2002 {published data only}
  • Van Gurp G, Meterissian GB, Haiek LN, McCusker J, Bellavance F. St John's wort or sertraline? Randomized controlled trial in primary care. Canadian Family Physician 2002;48:905-12.
Van Moffaert 1995 {published data only}
Ventura 2007 {published and unpublished data}
  • Ventura D, Armstrong E P, Skrepnek GH, Erder MH. Escitalopram versus sertraline in the treatment of major depressive disorder: a randomized clinical trial. Current Medical Research and Opinion 2007;23(2):245-250.
Zanardi 1996 {published data only}
  • Zanardi R, Franchini L, Gasperini M, Perez J, Smeraldi E. Double-blind controlled trial of sertraline versus paroxetine in the treatment of delusional depression. American Journal of Psychiatry 1996;153:1631-3.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Davidson 2004 {unpublished data only}
  • Davidson J. A placebo controlled clinical trial of a standardized extract of hypericum perforatum in major depressive disorder. ClinicalTrials.gov 2004.
Fava 1997 {published data only}
  • Fava M, Nierenberg AA, Quitkin FM, Zisook S, Pearlstein T, Stone A, Rosenbaum JF. A preliminary study on the efficacy of sertraline and imipramine on anger attacks in atypical depression and dysthymia. Psychopharmacology Bulletin 1997;33(1):101-103.
Finkel 1995 {published data only}
  • Finkel S, Richter E. Double-blind comparison of sertraline and nortriptyline in late-life depression. 8th ECNP (European College of Neuropsychopharmacology) Congress. Venice, Italy. Utrecht: ECNP, 1995.
Gonul 1999 {unpublished data only}
  • Gonul AS, Yabanoglu I, Reyhancan M, Oguz A. Selective serotonin reuptake inhibitors: discontinuation rates due to side effects. European Neuropsychopharmacology 1999;9(Suppl 5):215.
Latimer 1996 {unpublished data only}
  • Latimer PR, Ravindran AV, Bernatchez JP, Fournier JP, Gojer JA, Barratt K, & Buttars J. A six month comparison of toleration and efficacy of sertraline and fluoxetine treatment of major depression. XXth Collegium Internationale Neuro psychopharmacologicum. Melbourne, Australia, 1996.
Vovin 1998 {unpublished data only}
  • Vovin R, Mazo G, Ivanov M. Treatment of major depression: Sertraline or amitriptyline. XXIst Collegium Internationale Neuro psychopharmacologicum. Glasgow, Scotland, 1998.

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Malt 1999 {published data only}
  • Malt UF, Robak OH, Madsbu HP, Bakke O, Loeb M. The Norwegian naturalistic treatment study of depression in general practice (NORDEP)-I: randomised double blind study. British Medical Journal 1999;318:1180-4.

Additional references

  1. References to studies included in this review
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  3. References to studies awaiting assessment
  4. Additional references
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