Cancer-related fatigue is now recognised as an important symptom associated with cancer and its treatment. A number of studies have investigated the effects of physical activity in reducing cancer-related fatigue with no definitive conclusions regarding its effectiveness.
To evaluate the effect of exercise on cancer-related fatigue both during and after cancer treatment.
The Cochrane Controlled Trials Register (CENTRAL/CCTR), MEDLINE (1966 to July 2007), EMBASE (1980 to July 2007), CINAHL (1982 to July 2007), British Nursing Index (January 1984 to July 2007), AMED (1985 to July 2007), SIGLE (1980 to July 2007), and Dissertation Abstracts International (1861 to July 2007) were all searched using key words. Reference lists off all studies identified for inclusion and relevant reviews were also searched. In addition, relevant journals were hand searched and experts in the field of cancer-related fatigue were contacted.
Randomised controlled trials (RCTs) that investigated the effect of exercise on cancer-related fatigue in adults were included.
Data collection and analysis
Two review authors independently assessed the methodological quality of studies and extracted data based upon predefined criteria. Where data were available meta-analyses were performed for fatigue using a random-effects model.
Twenty-eight studies were identified for inclusion (n = 2083 participants), with the majority carried out on participants with breast cancer (n = 16 studies; n = 1172 participants). A meta-analysis of all fatigue data, incorporating 22 comparisons provided data for 920 participants who received an exercise intervention and 742 control participants. At the end of the intervention period exercise was statistically more effective than the control intervention (SMD -0.23, 95% Confidence Interval (CIs) -0.33 to -0.13).
Exercise can be regarded as beneficial for individuals with cancer-related fatigue during and post cancer therapy. Further research is required to determine the optimal type, intensity and timing of an exercise intervention.
我們使用關鍵字搜尋了The Cochrane Controlled Trials Register (CENTRAL/CCTR), MEDLINE (1966 to July 2007), EMBASE(1980 to July 2007), CINAHL (1982 to July 2007), British Nursing Index (January1984 to July 2007), AMED (1985 to July 2007), SIGLE (1980 to July 2007), and Dissertation Abstracts International (1861 to July 2007) 。進一步搜尋已被挑選出來的研究之參考文獻與相關的文獻回顧。此外也人工搜尋看相關的期刊及諮詢癌症相關疲憊領域的專家們。
共有28個研究(包括2083名受試者)納入本研究，絕大多數受試者是乳癌患者(16個研究;包括1172名受試者) 。 多項研究統合分析所有的數據，共有22個研究，包括920受試者有介入性運動治療，另外742人為對照組。評估結果是運動優於對照組，可以有效的改善疲憊(SMD −0.23 ， 95 ％的CI為 −0.33至−0.13) 。
此翻譯計畫由臺灣國家衛生研究院(National Health Research Institutes, Taiwan)統籌。