Intervention Review

Interventions for treating AIDS-associated Hodgkin´s lymphoma in treatment-naive adults

  1. Arturo J Martí-Carvajal1,*,
  2. Andrés Felipe Cardona2,
  3. Myriam Lucía Rodríguez3

Editorial Group: Cochrane HIV/AIDS Group

Published Online: 21 JAN 2009

Assessed as up-to-date: 18 FEB 2007

DOI: 10.1002/14651858.CD006149.pub2

Database Title

Additional Information

How to Cite

Martí-Carvajal AJ, Cardona AF, Rodríguez ML. Interventions for treating AIDS-associated Hodgkin´s lymphoma in treatment-naive adults. Cochrane Database of Systematic Reviews 2007, Issue 2. Art. No.: CD006149. DOI: 10.1002/14651858.CD006149.pub2.

Author Information

  1. 1

    Universidad de Carabobo and Iberoamerican Cochrane Network, Valencia, Edo. Carabobo, Venezuela

  2. 2

    Institute of Oncology, Fundación Santa Fe de Bogotá, Clinical and Translational Oncology Group, Bogotá, Cundinamarca, Colombia

  3. 3

    National Cancer Institute of Colombia, Hematology and Bone Marrow Transplantation Department, Bogota, Colombia

*Arturo J Martí-Carvajal, Universidad de Carabobo and Iberoamerican Cochrane Network, Valencia, Edo. Carabobo, Venezuela. arturo.marti.carvajal@gmail.com.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 21 JAN 2009

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Abstract

  1. Top of page
  2. Abstract
  3. Plain language summary
  4. 摘要

Background

Hodgkin's disease (HD) is the most common non-AIDS-defining malignancy in HIV-infected patients. Its unusually aggressive tumour behaviour includes a higher frequency of unfavourable histologic subtypes, high-stage and extranodal involvement by the time of presentation (anal canal, stomach), and poor therapeutic outcome, in comparison with HD outside the HIV setting. The optimal therapeutic strategy is still controversial, and median overall survival is short, ranging from 12 to 18 months. Thus, there is a need to identify the efficacy and safety of different interventions for AIDS-associated HD on overall survival and disease-free survival in treatment-naive adults with AIDS.

Objectives

To assess the effects of different interventions for treating AIDS-associated Hodgkin's disease including chemotherapy, bone marrow transplantation (BMT), and gene therapy on overall survival and disease-free survival in treatment-naive adults with AIDS.

Search methods

We searched The Cochrane HIV/AIDS Group Trials Register (September 2006), which comprises references identified from comprehensive electronic database searches and handsearching of relevant journals and abstract books of conference proceedings. We also searched the Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library (Issue 3, 2006), MEDLINE (1966 to September 2006), EMBASE (1974 to September 2006) LILACS (1982 to September 2006), ISI Web of Knowledge (1993 to September 2006), and AIDSearch (1980 to December 2006).

Date of most recent search: December 2006.

Selection criteria

We searched for published or unpublished randomised controlled trials.

Data collection and analysis

We intended to summarise data by standard Cochrane Collaboration methodologies, but no eligible randomised controlled trials were identified.

Main results

We were unable to find any randomised controlled trials of interventions for treating AIDS-associated HD in treatment-naive adults with AIDS.

Authors' conclusions

Randomised controlled trials are needed to establish the efficacy and safety of interventions for treating AIDS-associated HD in treatment-naive adults with AIDS.

 

Plain language summary

  1. Top of page
  2. Abstract
  3. Plain language summary
  4. 摘要

Interventions for previously untreated AIDS-associated Hodgkin´s lymphoma in adults

There is a lack of evidence from randomised controlled trials for the efficacy and safety of different interventions for treating AIDS-associated Hodgkin's disease, regarding both overall survival and disease-free survival in treatment-naive adults with AIDS. Lymphoma is a cancer of the lymphatic system. Lymphomas are classified into two general types: Hodgkin's disease and non-Hodgkin's lymphomas. Hodgkin's disease is the most common non-AIDS-defining malignancy in HIV-infected patients. Randomised controlled trials for the efficacy and safety of different interventions for treating AIDS-associated Hodgkin's disease on overall survival and disease-free survival in treatment-naive adults with AIDS could not be found.

 

摘要

  1. Top of page
  2. Abstract
  3. Plain language summary
  4. 摘要

背景

未曾接受治療之愛滋病成人患者，其何杰金氏症及急性淋巴瘤之處理與治療

在那些感染人類免疫缺陷病毒的病人當中，何杰金氏症是最常見的“非定義後天免疫缺乏症候群”之惡性腫瘤。該腫瘤具有非比尋常的侵犯性，包括了較惡性的組織型態、高腫瘤分期、第一次就診就呈現淋巴結外侵犯(肛管、胃)，以及不良的治療結果。何謂最佳治療方式仍存在爭議，平均存活期相當短約12至18個月。因此，在那些未曾接受治療之愛滋病成人患者，若是要處理愛滋病相關之何杰金氏症，我們有必要去確認不同治療方式對於整體存活率以及無病存活期的效果和安全性。

目標

評估各種治療愛滋病相關何杰金氏症方法的不同效果，包括化學治療、骨髓移植，以及基因療法。分析那些未曾接受治療的愛滋病成人之整體存活率及無復發存活期。

搜尋策略

我們蒐尋了Cochrane HIV/AIDS Group Trials Register(2006年9月)，它包含了廣泛的電子資料庫參考書目，並且手動查尋期刊和各式會議資料之摘要。我們也在考科藍圖書館蒐尋了考科藍控制試驗登記的資料(2006年，第三冊)，醫學期刊(1966年至2006年九月)，生物醫學與藥理學資料庫(1974年至2006年九月)，拉丁美洲加勒比海健康科學資料庫(1982年至2006九月)，整合科學期刊(1993年至2006年九月)，以及愛滋病蒐尋資料庫(1980年至2006年九月)。 最近期蒐尋：2006年12月。

選擇標準

我們蒐尋了已出版及未出版的隨機對照試驗。

資料收集與分析

我們試著利用考科藍組織之方式學來統整資料，但無相關合格之隨機對照試驗。

主要結論

對於未曾接受過治療的愛滋病成人患者，在處理愛滋病相關何杰金氏症方面，我們目前仍找不到任何的隨機對照試驗。

作者結論

對於未曾接受過治療的愛滋病成人患者，處理愛滋病相關何杰金氏症，仍需要隨機對照試驗來確定治療的成效與安全性。

翻譯人

本摘要由臺北榮民總醫院楊宗霖翻譯。

此翻譯計畫由臺灣國家衛生研究院(National Health Research Institutes, Taiwan)統籌。

總結

在未曾接受過治療的愛滋病患者當中，關於整體存活率以及無病存活期，目前缺乏隨機對照試驗來證明不同的治療愛滋病相關何杰金氏症治療方式的功效以及安全性。淋巴瘤是一種淋巴系統的癌症。淋巴瘤大體上分為兩大類：何杰金氏症以及非何杰金氏症。在非愛滋病定義惡性腫瘤當中，何杰金氏症是最常見的腫瘤。關於未曾接受治療的愛滋病成人，目前尚未找到隨機對照試驗來驗證各種不同治療方式治療愛滋病相關何杰金氏症其整體存活率以及無病存活期的效果和安全性。

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