Intervention Review

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Interventions for the prevention of nutritional rickets in term born children

  1. Christian Lerch1,*,
  2. Thomas Meissner2

Editorial Group: Cochrane Metabolic and Endocrine Disorders Group

Published Online: 17 OCT 2007

Assessed as up-to-date: 21 AUG 2007

DOI: 10.1002/14651858.CD006164.pub2

How to Cite

Lerch C, Meissner T. Interventions for the prevention of nutritional rickets in term born children. Cochrane Database of Systematic Reviews 2007, Issue 4. Art. No.: CD006164. DOI: 10.1002/14651858.CD006164.pub2.

Author Information

  1. 1

    Universitaetsklinikum Duesseldorf, Heinrich-Heine University, Department of General Practice, Duesseldorf, Germany

  2. 2

    University Children's Hospital, Department of General Pediatrics, Düsseldorf, Germany

*Christian Lerch, Department of General Practice, Universitaetsklinikum Duesseldorf, Heinrich-Heine University, PO Box 101007, Duesseldorf, 40001, Germany.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 17 OCT 2007



References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Beser 1994 {published data only}
Du 2004 {published and unpublished data}
  • Du X, Zhu K, Trube A, Zhang Q, Ma G, Hu X, et al. School-milk intervention trial enhances growth and bone mineral accretion in Chinese girls aged 10-12 years in Beijing. British Jounral of Nutrition 2004;92:159-68.
Duhamel 2000 {published data only}
  • Duhamel JF, Zeghoud F, Sempé M, Boudailliez B, Odièvre M, Laurans M, et al. Prevention of vitamin D deficiency during adolescence: interventional multicenter study on the biological effects of repeated dosis of 100,000 IU of vitamin D3 [Prophylaxie de la carence en vitamine D chez l'adolscent et le préadolscent. Étude interventionnelle multicentrique sur les effets biologiques d'un apport répété de 100 000 UI de vitamine D3]. Archives de Pédiatrie 2000;7:148-53.
Strand 2002/2003 {published and unpublished data}
  • Strand MA, Peng G, Zhang P, Lee G. Preventing rickets in locally appropriate ways: a case report from north China. International Quarterly of Community Health Education 2002/2003;21:297-322.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Nguema-Asseko 2005 {published data only}
  • Nguema-Asseko B, Ganga-Zandzou PS, Ovono F, Lendoye E, Lemamy GJ, Akendengue B, et al. Vitamin D status in gabonese children [Statut et besoins en vitamine D chez le nourisson au Gabon]. Archives de pédiatrie 2005;12:1587-90.
Thacher {unpublished data only}
  • Thacher TD, Fischer PR, Isichei CO, Zoakah AI, Pettifor JM. Prevention of nutritional rickets in Nigerian children with dietary calcium supplementation. E-mail from Dr Thacher, 17.11.2004.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Bronner 2003
Callaghan 2006
Chesney 2001
  • Chesney RW. Vitamin D deficiency and rickets. Reviews in Endocrine & Metabolic Disorders 2001;2:145-51.
Cohen 1960
Cooke 1973
Deeks 2002
Deeks 2003
  • Deeks JJ, Dines J, D'Amico R, Sowden AJ, Sakarovitch C, Song F, et al. Evaluating non-randomised intervention studies. Health Technology Assessment 2003;7(27):iii-x, 1-173.
DerSimonian 1986
Downs 1998
  • Downs SH, Black N. The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. Journal of Epidemiology and Community Health 1998;52:377-84.
Dusso 2005
Harris 2001
Higgins 2002
Higgins 2003
Higgins 2006
  • Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions 4.2.6 [updated September 2006]. The Cochrane Library, Issue 4. Chichester, UK: John Wiley & Sons, Ltd, 2006.
Jadad 1996
  • Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary?. Controlled Clinical Trials 1996;17:1-12.
Jelliffe 1968
  • Jelliffe DB. Infant nutrition in the subtropics and tropics. 2nd Edition. Geneva: World Health Organization, 1968.
Lapatsanis 1968
Markestad 1987
  • Markestad T, Hesse V, Siebenhuner M, Jahreis G, Aksnes L, Plenert W, et al. Intermittent high-dose vitamin D prophylaxis during infancy: effect on vitamin D metabolites, calcium, and phosphorus. American Journal of Clinical Nutrition 1987;46:652-8.
Moher 1999
  • Moher D, Cook DJ, Eastwood S, Olkin I, Rennie D, Stroup DF. Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement. Quality of Reporting of Meta-analyses. Lancet 1999;354(9193):1896-900.
Peach 1984
  • Peach H. A critique of survey methods used to measure the occurence of osteomalacia and rickets in the United Kingdom. Community Medicine 1984;6:20-8.
Pettifor 2003
  • Pettifor JM. Nutritional rickets. In: Glorieux FH, Pettifor JM, Jüppner H editor(s). Pediatric Bone. Amsterdam: Academic Press, 2003:541-65.
Pettifor 2005
Pfitzner 1988
Rajakumar 2003
Richards 1968
Rönnefarth 2000
Schulz 1995
  • Schulz KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA 1995;273:408-12.
Shaw 2004
  • Shaw NJ, Kershaw M. Vitamin D deficiency in children. In: David TJ editor(s). Recent Advances in Paediatrics 21. London: Royal Society of Medicine Press, 2004:85-100.
Thacher 2003
  • Thacher TD. Calcium-deficiency rickets. Endocrine Development 2003;6:105-25.
Thacher 2006