Intervention Review

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Pharmacological interventions for preventing post-traumatic stress disorder (PTSD)

  1. Taryn Amos*,
  2. Dan J Stein,
  3. Jonathan C Ipser

Editorial Group: Cochrane Depression, Anxiety and Neurosis Group

Published Online: 8 JUL 2014

Assessed as up-to-date: 14 FEB 2014

DOI: 10.1002/14651858.CD006239.pub2


How to Cite

Amos T, Stein DJ, Ipser JC. Pharmacological interventions for preventing post-traumatic stress disorder (PTSD). Cochrane Database of Systematic Reviews 2014, Issue 7. Art. No.: CD006239. DOI: 10.1002/14651858.CD006239.pub2.

Author Information

  1. University of Cape Town, Department of Psychiatry and Mental Health, Cape Town, South Africa

*Taryn Amos, Department of Psychiatry and Mental Health, University of Cape Town, Education Centre, Valkenberg Hospital, Private Bage X1, Observatory, Cape Town, 7925, South Africa. tarynamos@gmail.com.

Publication History

  1. Publication Status: New
  2. Published Online: 8 JUL 2014

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Delahanty 2012 {published data only}
  • Delahanty DL, Gabert-Quillen C, Ostrowski SA, Nugent NR, Fischer B, Morris A, et al. The efficacy of initial hydrocortisone administration at preventing posttraumatic distress in adult trauma patients: a randomized trial. CNS Spectrums 2013;18:103-11.
  • Delahanty DL, Ostrowski S, Nugent N, Gabert C, Fallon W. Hydrocortisone as a secondary intervention to prevent subsequent PTSD symptoms [conference abstract]. Psychosomatic Medicine [abstracts from the 69th Annual Meeting of the American Psychosomatic Society; 2011 Mar 9-12; San Antonio, TX United States] 2011;73(3):A107.
Hoge 2012 {published data only}
Mellman 2002 {published data only}
Pitman 2002 {published data only}
  • Pitman RK, Sanders KM, Zusman RM, Healy AR, Cheema F, Lasko NB, et al. Pilot study of secondary prevention of posttraumatic stress disorder with propranolol. Biological Psychiatry 2002;51:189-92.
Schelling 2001 {published data only}
  • Schelling G, Briegal J, Roozendaal B, Stoll C, Rothenhausler H-B, Kapfhammer HP. The effect of stress doses of hydrocortisone during septic shock on post traumatic stress disorder in survivors. Biological Psychiatry 2001;50:978-85.
  • Schelling G, Stoll C, Kapfhammer HP, Rothenhäusler HB, Krauseneck T, Durst K, et al. The effect of stress doses of hydrocortisone during septic shock on posttraumatic stress disorder and health-related quality of life in survivors. Critical Care Medicine 1999;27(12):2678-83.
  • Schelling G, Stoll C, Wichmann A, Haller M, Schuffel W, Briegel J. The effect of hydrocortisone (HC) during septic shock on incidence and intensity of post-traumatic stress disorder (PTSD) in long term survivors. Critical Care Medicine 1998;26(1):131A.
Shalev 2012 {published data only}
  • Galatzer-Levy IR, Ankri Y, Freedman S, Israeli-Shalev Y, Roitman P, Gilad M, et al. Early PTSD symptom trajectories: persistence, recovery, and response to treatment: results from the Jerusalem trauma outreach and prevention study (J-TOPS). PloS One 2013;8(8):e70084.
  • Shalev AY, Ankri Y, Israeli-Shalev Y, Peleg T, Adessky R, Freedman S. Prevention of posttraumatic stress disorder by early treatment: results from the Jerusalem Trauma Outreach And Prevention study. Archives of General Psychiatry 2012;69(2):166-76.
  • Shalev AY, Ankri YL, Peleg T, Israeli-Shalev Y, Freedman S. Barriers to receiving early care for PTSD: results from the Jerusalem trauma outreach and prevention study. Psychiatric Services 2011;62:765–73.
Stein 2007 {published data only}
Weis 2006 {published data only}
  • Weis F, Kilger E, Roozendaal B, De Quervain D-F, Lamm P, Schmidt M, et al. Stress doses of hydrocortisone reduce chronic stress symptoms and improve health-related quality of life in high-risk patients after cardiac surgery: a randomized study. Cardiopulmonary Support and Physiology 2006;131:277-82.
Zohar 2011a {published data only}
  • Zohar J, Yahalom H, Kozlovsky N, Cwikel-Hamzany S, Matar MA, Kaplan Z, et al. High dose hydrocortisone immediately after trauma may alter the trajectory of PTSD: interplay between clinical and animal studies. European Neuropsychopharmacology 2011;21:796–809.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Davidson 2000 {published data only}
  • Davidson J, Londborg P, Pearlstein T, Rothbaum B, Brady K, Farfel G. Sertraline and posttraumatic stress disorder: results of 24 weeks of open-label sertraline followed by a 28-week discontinuation study. European Neuropsychopharmacology 2000;10(Suppl 3):S349.
Gelpin 1996 {published data only}
  • Gelpin E, Bonne O, Peri T, Brandes D, Shalev AY. Treatment of recent trauma survivors with benzodiazepines: a prospective study. Journal of Clinical Psychiatry 1996;57(9):390-4.
Martenyi 2002 {published data only}
  • Martenyi F, Brown EB, Zhang H, Koke SC, Prakash A. Fluoxetine v. placebo in prevention of relapse in post-traumatic stress disorder. British Journal of Psychiatry 2002;181:315-20.
Martenyi 2006 {published data only}
  • Martenyi F, Brown EB, Zhang H, Prakash A, Koke SC. Fluoxetine versus placebo in posttraumatic stress disorder. Journal of Clinical Psychiatry 2002;63(3):199-206.
  • Martenyi F, Soldatenkova V. Fluoxetine in the acute treatment and relapse prevention of combat-related post-traumatic stress disorder: analysis of the veteran group of a placebo-controlled randomized clinical trial. European Neuropsychopharmacology 2006;16(5):340-9.
Schelling 2004 {published data only}
  • Schelling G, Kilger E, Roozendaal B, de Quervain DJ-F, Briegel J, Dagge A, et al. Stress doses of hydrocortisone, traumatic memories, and symptoms of posttraumatic stress disorder in patients after cardiac surgery: a randomized study. Society of Biological Psychiatry 2004;55:627–33.
Vaiva 2003 {published data only}
  • Vaiva G, Ducrocq F, Jezequel K, Averland B, Lestavel P, Brunet A, et al. Immediate treatment with propranolol decreases posttraumatic stress disorder two months after trauma. Society of Biological Psychiatry 2003;54:947-9.

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Azad 2007 {unpublished data only}
  • Azad S, Shelling G. Influence of Hydrocortisone on Immunologic Markers and Health Care Related Quality of Life in Patients After Cardiac Surgery. http://clinicaltrials.gov/ct2/show/NCT00490828 2007 (accessed 12 March 2014).
  • Hauer D, Weis F, Campolongo P, Schopp M, Beiras-Fernandez A, Strewe C, et al. Glucocorticoid-endocannabinoid interaction in cardiac surgical patients: relationship to early cognitive dysfunction and late depression. Reviews in the Neurosciences 2012;23(5-6):681-90.
Marx 2006 {unpublished data only}
  • Marx CE. Secondary Prevention With Paroxetine vs. Placebo in Subthreshold Posttraumatic Stress Disorder (PTSD). http://clinicaltrials.gov/ct2/show/NCT00560612 2007 (accessed 12 March 2014).
Simon 2005 {unpublished data only}
  • Simon NM. SSRI Administration to Reduce Acute Stress Disorder Symptoms and Prevent Depression and PTSD in Physical Trauma Victims. http://clinicaltrials.gov/ct2/show/NCT00114374 2005 (accessed 12 March 2014).

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Zohar 2009 {unpublished data only}
  • Zohar J. PTSD Prevention Using Escitalopram. http://clinicaltrials.gov/ct2/show/NCT00300313 2006 (accessed 12 March 2014).
Zohar 2010 {unpublished data only}
  • Zohar J. The Efficacy of a Single Dose of Intranasal Oxytocin in the Prevention of Post Traumatic Stress Disorder (PTSD). http://clinicaltrials.gov/ct2/show/NCT01039766 2009, issue accessed 12 March 2014.
Zohar 2011b {published data only}
  • Zohar J. Efficacy of Single Dose IV Hydrocortisone in Post Traumatic Stress Disorder (PTSD) Prevention. http://clinicaltrials.gov/ct2/show/NCT00855270 2009 (accessed 12 March 2014).
  • Zohar J. Randomized placebo-controlled trial of hydrocortisone in PTSD prophylaxis. http://projectreporter.nih.gov; Project Number: 4R01MH086570-03 (accessed 12 March 2014).

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
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