Intervention Review

You have free access to this content

High-dose chemotherapy and autologous haematopoietic stem cell rescue for children with high-risk neuroblastoma

  1. Bilgehan Yalçin1,*,
  2. Leontien CM Kremer2,
  3. Huib N Caron2,
  4. Elvira C van Dalen2

Editorial Group: Cochrane Childhood Cancer Group

Published Online: 22 AUG 2013

Assessed as up-to-date: 24 DEC 2012

DOI: 10.1002/14651858.CD006301.pub3


How to Cite

Yalçin B, Kremer LCM, Caron HN, van Dalen EC. High-dose chemotherapy and autologous haematopoietic stem cell rescue for children with high-risk neuroblastoma. Cochrane Database of Systematic Reviews 2013, Issue 8. Art. No.: CD006301. DOI: 10.1002/14651858.CD006301.pub3.

Author Information

  1. 1

    Hacettepe University Faculty of Medicine, Pediatric Oncology, Ankara, Turkey

  2. 2

    Emma Children's Hospital / Academic Medical Center, Department of Paediatric Oncology, Amsterdam, Netherlands

*Bilgehan Yalçin, Pediatric Oncology, Hacettepe University Faculty of Medicine, Ankara, 06100, Turkey. yalcinb@hacettepe.edu.tr. bilgehanyalcin@yahoo.com.

Publication History

  1. Publication Status: New search for studies and content updated (conclusions changed)
  2. Published Online: 22 AUG 2013

SEARCH

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
  5. References to other published versions of this review
Berthold 2005 {published data only}
  • Berthold F, Boos J, Burdach S, Erttmann R, Henze G, Hermann J, et al. Myeloablative megatherapy with autologous stem-cell rescue versus oral maintenance chemotherapy as consolidation treatment in patients with high-risk neuroblastoma: a randomised controlled trial. Lancet Oncology 2005;6:649-58.
Matthay 1999 {published data only}
  • Matthay KK, Reynolds CP, Seeger RC, Shimada H, Adkins ES, Haas-Kogan D, et al. Long-term results for children with high-risk neuroblastoma treated on a randomized trial of myeloablative therapy followed by 13-cis-retinoic acid: a children's oncology group study. Journal of Clinical Oncology 2009;27(7):1007-13.
  • Matthay KK, Villablanca JG, Seeger RC, Stram DO, Harris RE, Ramsay NK, et al. Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. Children's Cancer Group. New England Journal of Medicine 1999;341:1165-73.
Pritchard 2005 {published data only}

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
  5. References to other published versions of this review
Adkins 2004 {published data only}
  • Adkins ES, Sawin R, Gerbing RB, London WB, Matthay KK, Haase GM. Efficacy of complete resection for high-risk neuroblastoma: a Children's Cancer Group study. Journal of Pediatric Surgery 2004;39:931-6.
Berthold 1990 {published data only}
  • Berthold F, Burdach S, Kremens B, Lampert F, Niethammer D, Riehm H, et al. The role of chemotherapy in the treatment of children with neuroblastoma stage IV: the GPO (German Pediatric Oncology Society) experience. Klinische Pädiatrie 1990;202:262-9.
Castel 2001 {published data only}
  • Castel V, Cañete A, Navarro S, García-Miguel P, Melero C, Acha T, et al. Outcome of high-risk neuroblastoma using a dose intensity approach: improvement in initial but not in long-term results. Medical and Pediatric Oncology 2001;37:537-42.
Castel 2002 {published data only}
Dini 1989 {published data only}
  • Dini G, Philip T, Hartmann O, Pinkerton R, Chauvin F, Garaventa A, et al. Bone marrow transplantation for neuroblastoma: a review of 509 cases. EBMT Group. Bone Marrow Transplant 1989;4(Suppl 4):42-6.
Dini 1991a {published data only}
  • Dini G, Lanino E, Garaventa A, Paolucci P, Amici A, Locatelli F, et al. Unpurged ABMT for neuroblastoma: AIEOP-BMT experience. Bone Marrow Transplant 1991;7(Suppl 2):92.
Dini 1991b {published data only}
  • Dini G, Lanino E, Garaventa A, Paolucci P, Amici A, Locatelli F, et al. Unpurged autologous bone marrow transplantation for neuroblastoma: the AIEOP-BMT group experience. Bone Marrow Transplant 1991;7(Suppl 3):109-11.
Garaventa 1993 {published data only}
  • Garaventa A, Ladenstein R, Chauvin F, Lanino E, Philip I, Corciulo P, et al. High-dose chemotherapy with autologous bone marrow rescue in advanced stage IV neuroblastoma. European Journal of Cancer 1993;29A:487-91.
Haas-Kogan 2003 {published data only}
  • Haas-Kogan DA, Swift PS, Selch M, Haase GM, Seeger RC, Gerbing RB, et al. Impact of radiotherapy for high-risk neuroblastoma: a Children's Cancer Group study. International Journal of Radiation Oncology, Biology, Physics 2003;56:28-39.
Hartmann 1985 {published data only}
  • Hartmann O, Zucker JM, Pinkerton R, Philip T, Beaujean F, Bernard JL, et al. Metastatic neuroblastoma in children older than one year old at diagnosis. Treatment with intensive chemo-radiotherapy and autologous bone marrow transplant. Revue Française de Transfusion et Immuno-Hématologie 1985;28:539-46.
Kaneko 1999 {published data only}
  • Kaneko M, Tsuchida Y, Uchino J, Takeda T, Iwafuchi M, Ohnuma N, et al. Treatment results of advanced neuroblastoma with the first Japanese study group protocol. Study Group of Japan for Treatment of Advanced Neuroblastoma. Journal of Pediatric Hematology/Oncology 1999;21:190-7.
Klingebiel 1994 {published data only}
  • Klingebiel T, Handgretinger R, Herter M, Lang P, Dopfer R, Scheel-Walter H, et al. Peripheral stem cell transplantation in neuroblastoma stage 4 with the use of [131I-m]IBG. Progress in Clinical and Biological Research 1994;385:309-17.
Ladenstein 1991 {published data only}
  • Ladenstein R, Lasset C, Bouffet E, Brunat-Mentigny M, Biron P, Philip I, et al. A single center experience with bone marrow transplantation for high risk neuroblastoma. Bone Marrow Transplant 1991;7(Suppl 2):93.
Ladenstein 1996 {published data only}
Madon 1985 {published data only}
  • Madon E, Pastore G, Cordero di Montezemolo L, Brach del Prever A, Lanino E. Italian multicenter experience in the treatment of neuroblastoma and soft tissue sarcoma. Minerva Pediatrica 1985;37:603-10.
Matthay 1995 {published data only}
  • Matthay KK, O'Leary MC, Ramsay NK, Villablanca J, Reynolds CP, Atkinson JB, et al. Role of myeloablative therapy in improved outcome for high risk neuroblastoma: review of recent Children's Cancer Group results. European Journal of Cancer 1995;31A:572-5.
Matthay 1996 {published data only}
  • Matthay KK. Impact of myeloablative therapy with bone marrow transplantation in advanced neuroblastoma. Bone Marrow Transplant 1996;18(Suppl 3):S21-4.
Matthay 1998 {published data only}
  • Matthay KK, Perez C, Seeger RC, Brodeur GM, Shimada H, Atkinson JB, et al. Successful treatment of stage III neuroblastoma based on prospective biologic staging: a Children's Cancer Group study. Journal of Clinical Oncology 1998;16:1256-64.
Mugishima 1999 {published data only}
  • Mugishima H. High-dose chemotherapy and hematopoietic stem cell transplant in the treatment of advanced neuroblastoma. Gan To Kagaku Ryoho 1999;26:1056-67.
Ohnuma 1995 {published data only}
  • Ohnuma N, Takahashi H, Kaneko M, Uchino J, Takeda T, Iwafuchi M, et al. Treatment combined with bone marrow transplantation for advanced neuroblastoma: an analysis of patients who were pretreated intensively with the protocol of the Study Group of Japan. Medical and Pediatric Oncology 1995;24:181-7.
Olgun 2008 {published data only}
  • Olgun N, Gunes D, Aksoylar S, Varan A, Erbay A, Hazar V, et al. The Turkish Pediatric Oncology Group Neuroblastoma 2003 (TPOG-NB-2003): treatment results of the high risk group (abstract D110). Pediatric Blood and Cancer. 2008:140.
Paolucci 1989 {published data only}
  • Paolucci P, Mancini AF, Rosito P, Vecchi V, Vivarelli F, Granchi D, et al. Intensification of induction prior to intensification of consolidation and bone marrow rescue in disseminated neuroblastoma. Bone Marrow Transplant 1989;4(Suppl 4):151-2.
Philip 1991 {published data only}
  • Philip T, Zucker JM, Bernard JL, Lutz P, Bordigoni P, Plouvier E, et al. The LMCE1 unselected group of stage IV neuroblastoma revisited with a median follow up of 59 months after ABMT. Progress in Clinical and Biological Research 1991;366:517-25.
Pinkerton 1991 {published data only}
  • Pinkerton CR. ENSG 1-randomised study of high-dose melphalan in neuroblastoma. Bone Marrow Transplant 1991;7(Suppl 3):112-3.
Saarinen 1996 {published data only}
  • Saarinen UM, Wikström S, Mäkipernaa A, Lanning M, Perkkiö M, Hovi L, et al. In vivo purging of bone marrow in children with poor-risk neuroblastoma for marrow collection and autologous bone marrow transplantation. Journal of Clinical Oncology 1996;14:2791-802.
Sawaguchi 1989 {published data only}
  • Sawaguchi S, Kaneko M, Nakajo T, Sawada T, Takahashi H, Tsuchida Y. A preliminary treatment report of the Study Group of Japan for Advanced Neuroblastoma. Nippon Gan Chiryo Gakkai Shi 1989;24:1020-6.
Sawaguchi 1990 {published data only}
  • Sawaguchi S, Kaneko M, Uchino J, Takeda T, Iwafuchi M, Matsuyama S, et al. Treatment of advanced neuroblastoma with emphasis on intensive induction chemotherapy. A report from the Study Group of Japan. Cancer 1990;66:1879-87.
Schmidt 2005 {published data only}
  • Schmidt ML, Lal A, Seeger RC, Maris JM, Shimada H, O'Leary M, et al. Favorable prognosis for patients 12 to 18 months of age with stage 4 nonamplified MYCN neuroblastoma: a Children's Cancer Group Study. Journal of Clinical Oncology 2005;23:6474-80.
Seeger 1991 {published data only}
  • Seeger RC, Villablanca JG, Matthay KK, Harris R, Moss TJ, Feig SA, et al. Intensive chemoradiotherapy and autologous bone marrow transplantation for poor prognosis neuroblastoma. Progress in Clinical and Biological Research 1991;366:527-33.
Seeger 2000 {published data only}
  • Seeger RC, Reynolds CP, Gallego R, Stram DO, Gerbing RB, Matthay KK. Quantitative tumor cell content of bone marrow and blood as a predictor of outcome in stage IV neuroblastoma: a Children's Cancer Group Study. Journal of Clinical Oncology 2000;18:4067-76.
Shuster 1991 {published data only}
  • Shuster JJ, Cantor AB, McWilliams N, Pole JG, Castleberry RP, Marcus R, et al. The prognostic significance of autologous bone marrow transplant in advanced neuroblastoma. Journal of Clinical Oncology 1991;9:1045-9.
Stram 1994 {published data only}
  • Stram DO, Matthay KK, O'Leary M, Reynolds CP, Seeger RC. Myeloablative chemoradiotherapy versus continued chemotherapy for high risk neuroblastoma. Progress in Clinical and Biological Research 1994;385:287-91.
Stram 1996 {published data only}
  • Stram DO, Matthay KK, O'Leary M, Reynolds CP, Haase GM, Atkinson JB, et al. Consolidation chemoradiotherapy and autologous bone marrow transplantation versus continued chemotherapy for metastatic neuroblastoma: a report of two concurrent Children's Cancer Group studies. Journal of Clinical Oncology 1996;14:2417-26.
Zucker 1991 {published data only}
  • Zucker JM, Philip T, Bernard JL, Michon J, Bouffet E, Gentet JC, et al. Single or double consolidation treatment according to remission status after initial therapy in metastatic neuroblastoma: first results of LMCE 3 study in 40 patients. Bone Marrow Transplant 1991;7(Suppl 2):91.

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
  5. References to other published versions of this review
Hero 2010 {published data only}
  • Hero B, Thorsten S, Dillo D, Kremens B, Grigull L, Scheel-Walter HG, et al. Long term outcome: the price of treatment for surviving high-risk neuroblastoma. Advances in Neuroblastoma Research Association. 2010:105.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
  5. References to other published versions of this review
Aydin 2009
  • Aydin GB, Kutluk MT, Yalçin B, Büyükpamukçu M, Kale G, Varan A, et al. Neuroblastoma in Turkish children: experience of a single center. Journal of Pediatric Hematology and Oncology 2009;31:471-80.
Bollard 2006
  • Bollard CM, Krance RA, Heslop HE. Hematopoietic stem cell transplantation in pediatric oncology. In: Pizzo PA, Poplack DG editor(s). Principles and practice of pediatric oncology. 5th Edition. Philadelphia: Lippincott Williams & Wilkins, 2006:476-500.
Brodeur 1988
  • Brodeur GM, Seeger RC, Barrett A, Berthold F, Castleberry RP, D'Angio G, et al. International criteria for diagnosis, staging, and response to treatment in patients with neuroblastoma. Journal of Clinical Oncology 1988;6:1874-81.
Brodeur 1993
  • Brodeur GM, Pritchard J, Berthold F, Carlsen NL, Castel V, Castelberry RP, et al. Revisions of the international criteria for neuroblastoma diagnosis, staging, and response to treatment. Journal of Clinical Oncology 1993;11:1466-77.
Brodeur 2006
  • Brodeur GM, Maris JM. Neuroblastoma. In: Pizzo PA, Poplack DG editor(s). Principles and practice of pediatric oncology. 5th Edition. Philadelphia: Lippincott Williams & Wilkins, 2006:933-70.
Burchill 2004
Castel 1995
  • Castel V, García-Miguel P, Melero C, Navajas A, Navarro S, Molina J, et al. On behalf of the Spanish Neuroblastoma Study Group. The treatment of advanced neuroblastoma. Results of the Spanish Neuroblastoma Study Group (SNSG) Studies. European Journal of Cancer 1995;31A:642-5.
Cheung 1991
  • Cheung NK, Heller G. Chemotherapy dose intensity correlates strongly with response, median survival, and median progression-free survival in metastatic neuroblastoma. Journal of Clinical Oncology 1991;9:1050-8.
Cohn 1997
  • Cohn SL, Moss TJ, Hoover M, Katzenstein HM, Haut PR, Morgan ER, et al. Treatment of poor-risk neuroblastoma patients with high-dose chemotherapy and autologous peripheral stem cell rescue. Bone Marrow Transplantation 1997;20:543-51.
Cohn 2009
  • Cohn SL, Pearson AD, London WB, Monclair T, Ambros PF, Brodeur GM, et al. The International Neuroblastoma Risk Group (INRG) classification system: an INRG Task Force report. Journal of Clinical Oncology 2009;27(2):289-97.
De Bernardi 2003
  • De Bernardi B, Nicolas B, Boni L, Indolfi P, Carli M, di Montezemolo LC, et al. Disseminated neuroblastoma in children older than one year at diagnosis: comparable results with three consecutive high-dose protocols adopted by the Italian Co-Operative Group for Neuroblastoma. Journal of Clinical Oncology 2003;21:1592-601.
Di Caro 1994
  • Di Caro A, Bostrom B, Moss TJ, Neglia J, Ramsay NK, Smith J, et al. Autologous peripheral blood cell transplantation in the treatment of advanced neuroblastoma. American Journal of Pediatric Hematology/Oncology 1994;16:200-6.
Evans 1971
Goldsby 2004
  • Goldsby RE, Matthay KK. Neuroblastoma: evolving therapies for a disease with many faces. Paediatric Drugs 2004;6:107-22.
Higgins 2005
  • Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions [updated May 2005]. In: The Cochrane Library, Issue 3, 2006. John Wiley & Sons Ltd, Chichester (UK).
Higgins 2008
  • Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.0 [updated February 2008]. The Cochrane Collaboration, 2008. Available from www.cochrane-handbook.org.
Kaneko 2002
  • Kaneko M, Tsuchida Y, Mugishima H, Ohnuma N, Yamamoto K, Kawa K, et al. Intensified chemotherapy increases the survival rates in patients with stage 4 neuroblastoma with MYCN amplification. Journal of Pediatric Hematology/Oncology 2002;24:613-21.
Keshelava 1998
  • Keshelava N, Seeger RC, Groshen S, Reynolds CP. Drug resistance patterns of human neuroblastoma cell lines derived from patients at different phases of therapy. Cancer Research 1998;58:5396-405.
Kushner 2004
  • Kushner BH, Kramer K, LaQuaglia MP, Modak S, Yataghene K, Cheung NK. Reduction from seven to five cycles of intensive induction chemotherapy in children with high-risk neuroblastoma. Journal of Clinical Oncology 2004;22:4888-92.
Lachin 2000
Ladenstein 1994
  • Ladenstein R, Lasset C, Hartmann O, Klingebiel T, Bouffet E, Gadner H, et al. Comparison of auto versus allografting as consolidation of primary treatments in advanced neuroblastoma over one year of age at diagnosis: report from the European Group for Bone Marrow Transplantation. Bone Marrow Transplantation 1994;14:37-46.
Ladenstein 2004
  • Ladenstein R, Hartmann O, Koscielnak E, Philip T. Megatherapy with stem cell rescue in solid tumours. In: Pinkerton R, Plowman PN, Pieters R editor(s). Pediatric Oncology. 3rd Edition. London: Arnold Publishers, 2004:538-569.
Laprie 2004
  • Laprie A, Michon J, Hartmann O, Munzer C, Leclair MD, Coze C, et al. Neuroblastoma Study Group of the French Society of Pediatric Oncology. High-dose chemotherapy followed by locoregional irradiation improves the outcome of patients with international neuroblastoma staging system Stage II and III neuroblastoma with MYCN amplification. Cancer 2004;101:1081-9.
Lee 1991
Maris 2005
Maris 2007
Matthay 1993
  • Matthay KK, Atkinson JB, Stram DO, Selch M, Reynolds CP, Seeger RC. Patterns of relapse after autologous purged bone marrow transplantation for neuroblastoma: a Children's Cancer Group pilot study. Journal of Clinical Oncology 1993;11:2226-33.
Matthay 2009
  • Matthay KK, Reynolds CP, Seeger RC, Shimada H, Adkins ES, Haas-Kogan D, et al. Long-term results for children with high-risk neuroblastoma treated on a randomized trial of myeloablative therapy followed by 13-cis-retinoic acid: a children's oncology group study. Journal of Clinical Oncology 2009;27:1007-13.
Mertens 2001
  • Mertens AC, Yasui Y, Neglia JP, Potter JD, Nesbit ME Jr, Ruccione K, et al. Late mortality experience in five-year survivors of childhood and adolescent cancer: the Childhood Cancer Survivor Study. Journal of Clinical Oncology 2001;19:3163-72.
Parmar 1998
Philip 1997
  • Philip T, Ladenstein R, Lasset C, Hartmann O, Zucker JM, Pinkerton R, et al. 1070 myeloablative megatherapy procedures followed by stem cell rescue for neuroblastoma: 17 years of European experience and conclusions. European Group for Blood and Marrow Transplant Registry Solid Tumour Working Party. European Journal of Cancer 1997;33:2130-5.
Pritchard 1995
Reulen 2010
  • Reulen RC, Winter DL, Frobisher C, Lancashire ER, Stiller CA, Jenney ME, et al. Long-term cause-specific mortality among survivors of childhood cancer. Journal of American Medical Association 2010;304:172-9.
Reynolds 2001
  • Reynolds CP, Seeger RC. Detection of minimal residual disease in bone marrow during or after therapy as a prognostic marker for high-risk neuroblastoma. Journal of Pediatric Hematology/Oncology 2001;23:150-2.
Reynolds 2004
Shimada 1984
  • Shimada H, Chatten J, Newton WA Jr, Sachs N, Hamoudi AB, Chiba T, et al. Histopathologic prognostic factors in neuroblastic tumors: definition of subtypes of ganglioneuroblastoma and an age-linked classification of neuroblastomas. Journal of the National Cancer Institute 1984;73:405-16.
Trahair 2007
  • Trahair TN, Vowels MR, Johnston K, Cohn RJ, Russell SJ, Neville KA, et al. Long-term outcomes in children with high-risk neuroblastoma treated with autologous stem cell transplantation. Bone Marrow Transplantation 2007;40(8):741-6.
Verdeguer 2004
  • Verdeguer A, Munoz A, Canete A, Pardo N, Martinez A, Donat J, et al. Long-term results of high-dose chemotherapy and autologous stem cell rescue for high-risk neuroblastoma patients: a report of the Spanish working party for BMT in children (Getmon). Pediatric Hematology and Oncology 2004;21:495-504.
Weinstein 2003
Yoon 2012
  • Yoon U, Knobloch K. Assessment of reporting quality of conference abstracts in sports injury prevention according to CONSORT and STROBE criteria and their subsequent publication rate as full papers. BMC Medical Research Methodology 2012;12:47.
Yu 2010
  • Yu AL, Gilman AL, Ozkaynak MF, London WB, Kreissman SG, Chen HX, et al. Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma. New England Journal of Medicine 2010;363(14):1324-34.

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
  5. References to other published versions of this review
Yalçin 2006
  • Yalçin B, Kremer LC, Caron HN, van Dalen EC. High dose chemotherapy and autologous haematopoietic stem cell rescue for children with high-risk neuroblastoma. Cochrane Database of Systematic Reviews 2006, Issue 4. [DOI: 10.1002/14651858.CD006301]
Yalçin 2010
  • Yalçin B, Kremer LC, Caron HN, van Dalen EC. High-dose chemotherapy and autologous haematopoietic stem cell rescue for children with high-risk neuroblastoma. Cochrane Database of Systematic Reviews 2010, Issue 5. [DOI: 10.1002/14651858.CD006301.pub2]