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Omega 3 fatty acids (fish oil) for maintenance of remission in Crohn's disease

  1. Raffi Lev-Tzion1,*,
  2. Anne Marie Griffiths2,
  3. Oren Ledder1,
  4. Dan Turner1

Editorial Group: Cochrane IBD Group

Published Online: 28 FEB 2014

Assessed as up-to-date: 22 NOV 2013

DOI: 10.1002/14651858.CD006320.pub4


How to Cite

Lev-Tzion R, Griffiths AM, Ledder O, Turner D. Omega 3 fatty acids (fish oil) for maintenance of remission in Crohn's disease. Cochrane Database of Systematic Reviews 2014, Issue 2. Art. No.: CD006320. DOI: 10.1002/14651858.CD006320.pub4.

Author Information

  1. 1

    Shaare Zedek Medical Center, Pediatric Gastroenterology Unit, Jerusalem, Israel

  2. 2

    The Hospital for Sick Children, Division of Gastroenterology, Hepatology & Nutrition, Toronto, ON, Canada

*Raffi Lev-Tzion, Pediatric Gastroenterology Unit, Shaare Zedek Medical Center, Jerusalem, Israel. raffilv@szmc.org.il.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 28 FEB 2014

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Belluzzi 1996 {published data only}
  • Belluzzi A, Brignola C, Campieri M, Pera A, Boschi S, Miglioli M. Effect of an enteric-coated fish-oil preparation on relapses in Crohn's disease. New England Journal of Medicine 1996;334(24):1557-60.
Belluzzi 1997 {published data only}
  • Belluzzi A, Campieri M, Belloli C, Boschi S, Cottone M, Rizzello F, et al. A new enteric coated preparation of omega-3 fatty acids for preventing post-surgical recurrence in Crohn's disease. Gastroenterology 1997;112(4):A494.
Feagan 2008a {published data only}
  • Feagan BG, Sandborn WJ, Mittmann U, Bar-Meir S, D'Haens G, Bradette M, et al. Omega-3 free fatty acids for the maintenance of remission in Crohn disease: the EPIC Randomized Controlled Trials. JAMA 2008;299(14):1690-7.
Feagan 2008b {published data only}
  • Feagan BG, Sandborn WJ, Mittmann U, Bar-Meir S, D'Haens G, Bradette M, et al. Omega-3 free fatty acids for the maintenance of remission in Crohn disease: the EPIC Randomized Controlled Trials. JAMA 2008;299(14):1690-7.
Lorenz-Meyer 1996 {published data only}
  • Lorenz-Meyer H, Bauer P, Nicolay C, Schulz B, Purrmann J, Fleig WE, et al. Omega-3 fatty acids and low carbohydrate diet for maintenance of remission in Crohn's disease. A randomized controlled multicenter trial. Study Group Members (German Crohn's Disease Study Group). Scandinavian Journal of Gastroenterology 1996;31(8):778-85.
Romano 2005 {published data only}
  • Romano C, Cucchiara S, Barabino A, Annese V, Sferlazzas C. Usefulness of omega-3 fatty acid supplementation in addition to mesalazine in maintaining remission in pediatric Crohn's disease: a double-blind, randomized, placebo-controlled study. World Journal of Gastroenterology 2005;11(45):7118-21.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Bamba 2003 {published data only}
  • Bamba T, Shimoyama T, Sasaki M, Tsujikawa T, Fukuda Y, Koganei K, et al. Dietary fat attenuates the benefits of an elemental diet in active Crohn's disease: a randomized, controlled trial. European Journal of Gastroenterology and Hepatology 2003;15(2):151-7.
Bjorkkjaer 2004 {published data only}
  • Bjorkkjaer T, Brunborg LA, Arslan G, Lind RA, Brun JG, Valen M, et al. Reduced joint pain after short-term duodenal administration of seal oil in patients with inflammatory bowel disease: comparison with soy oil. Scandinavian Journal of Gastroenterology 2004;39(11):1088-94.
Eivindson 2005 {published data only}
  • Eivindson M, Gronbaek H, Nielsen JN, Frystyk J, Flyvbjerg A, Jorgensen L, et al. Insulin-like growth factors (IGFs) and IGF binding proteins in active Crohn's disease treated with omega-3 or omega-6 fatty acids and corticosteroids. Scandinavian Journal of Gastroenterology 2005;40(10):1214-21.
Geerling 2000 {published data only}
  • Geerling BJ, Badart-Smook A, van Deursen C, van Houwelingen AC, Russel MG, Stockbrugger RW, et al. Nutritional supplementation with N-3 fatty acids and antioxidants in patients with Crohn's disease in remission: effects on antioxidant status and fatty acid profile. Inflammatory Bowel Diseases 2000;6(2):77-84.
Lorenz 1989 {published data only}
  • Lorenz R, Weber PC, Szimnau P, Heldwein W, Strasser T, Loeschke K. Supplementation with n-3 fatty acids from fish oil in chronic inflammatory bowel disease--a randomized, placebo-controlled, double-blind cross-over trial. Journal of Internal Medicine. Supplement 1989;731:225-32.
Mate 1991 {published data only}
  • Mate J, Castanos R, Garcia-Samaniego J, Pajares JM. Does dietary fish oil maintain the remission of Crohn's disease (CD): A case control study. Gastroenterology 1991;100(5):A228.
Nielsen 2005 {published data only}
Sakurai 2002 {published data only}
  • Sakurai T, Matsui T, Yao T, Takagi Y, Hirai F, Aoyagi K, et al. Short-term efficacy of enteral nutrition in the treatment of active Crohn's disease: a randomized, controlled trial comparing nutrient formulas. JPEN. Journal of Parenteral and Enteral Nutrition 2002;26(2):98-103.
Seidman 2003 {published data only}
  • Seidman E, Bouthillier L, Thibault L, Lepage G, Chartre M, Deslandres C, et al. Clinical and nutritional parameters in Crohn's disease patients treated with either an n-3 PUFA-enriched semi-elemental or a polymeric diet. Results of a randomized controlled trial. Journal of Pediatric Gastroenterology and Nutrition 2003;37(3):393.
Socha 2002 {published data only}
  • Socha P, Ryzko J, Koletzko B, Czubkowski P, Korszynska D, Celinska-Cedro D, et al. The influence of fish oil therapy in children with inflammatory bowel disease on the fatty acid status. Pediatria Wspolczesna 2002;4(3):413-6.
Trebble 2004 {published data only}
  • Trebble TM, Arden NK, Wootton SA, Calder PC, Mullee MA, Fine DR, et al. Fish oil and antioxidants alter the composition and function of circulating mononuclear cells in Crohn disease. American Journal of Clinical Nutrition 2004;80(5):1137-44.
Trebble 2005 {published data only}
  • Trebble TM. Bone turnover and nutritional status in Crohn's disease: relationship to circulating mononuclear cell function and response to fish oil and antioxidants. Proceedings of the Nutrition Society 2005;64(2):183-91.
Tsujikawa 2000 {published data only}
  • Tsujikawa T, Satoh J, Uda K, Ihara T, Okamoto T, Araki Y, et al. Clinical importance of n-3 fatty acid-rich diet and nutritional education for the maintenance of remission in Crohn's disease. Journal of Gastroenterology 2000;35(2):99-104.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Akabas 2006
  • Akabas SR, Deckelbaum RJ. Summary of a workshop on n-3 fatty acids: current status of recommendations and future directions. American Journal of Clinical Nutrition 2006;83(6 Suppl):1536S-8S.
Arterburn 2006
  • Arterburn LM, Hall EB, Oken H. Distribution, interconversion, and dose response of n-3 fatty acids in humans. American Journal of Clinical Nutrition 2006;83(6 Suppl):1467S-76S.
Bassaganya-Riera 2006
  • Bassaganya-Riera J, Hontecillas R. CLA and n-3 PUFA differentially modulate clinical activity and colonic PPAR-responsive gene expression in a pig model of experimental IBD. Clinical Nutrition 2006;25(3):454-65.
Belluzzi 1994
  • Belluzzi A, Brignola C, Campieri M, Camporesi EP, Gionchetti P, Rizzello F, et al. Effects of new fish oil derivative on fatty acid phospholipid-membrane pattern in a group of Crohn's disease patients. Digestive Diseases and Sciences 1994;39(12):2589-94.
Belluzzi 2002
Best 1976
  • Best WR, Becktel JM, Singleton JW, Kern F Jr. Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study. Gastroenterology 1976;70(3):439-44.
Deckelbaum 2006
el Boustani 1987
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Ergas 2002
Figler 2007
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Harvey 1980
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Hokari 2013
Hooper 2004
  • Hooper L, Thompson RL, Harrison RA, Summerbell CD, Moore H, Worthington HV, et al. Omega 3 fatty acids for prevention and treatment of cardiovascular disease. Cochrane Database of Systematic Reviews 2004, Issue 4. [DOI: 10.1002/14651858.CD003177.pub2]
Hyams 1991
  • Hyams JS, Ferry GD, Mandel FS, Gryboski JD, Kibort PM, Kirschner BS, et al. Development and validation of a pediatric Crohn's disease activity index. Journal of Pediatric Gastroenterology and Nutrition 1991;14(4):439-47.
Kandiel 2005
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Kim 1996
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Lawson 1988
Lee 1985
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MacLean 2005
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Marion-Letellier 2013
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Matsunaga 2008
Meister 2005
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Melanson 2005
  • Melanson SF, Lewandrowski EL, Flood JG, Lewandrowski KB. Measurement of organochlorines in commercial over-the-counter fish oil preparations: implications for dietary and therapeutic recommendations for omega-3 fatty acids and a review of the literature. Archives of Pathology and Laboratory Medicine 2005;129(1):74-7.
Nakazawa 2000
Nieto 2002
  • Nieto N, Torres MI, Rios A, Gil A. Dietary polyunsaturated fatty acids improve histological and biochemical alterations in rats with experimental ulcerative colitis. Journal of Nutrition 2002;132(1):11-9.
Oh 2005
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Roy 2007
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Ruxton 2004
Schünemann 2011
  • Schünemann HJ, Oxman AD, Vist GE, Higgins JPT, Deeks JJ, Glasziou P, et al. Chapter 12: Interpreting results and drawing conclusions. In: Higgins JPT, Green S editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Siguel 1996
Simopoulos 2002
Socha 2005
  • Socha P, Ryzko J, Koletzko B, Celinska-Cedro D, Woynarowski M, Czubkowski P, et al. Essential fatty acid depletion in children with inflammatory bowel disease. Scandinavian Journal of Gastroenterology 2005;40(5):573-7.
Thayu 2005
  • Thayu M, Markowitz JE, Mamula P, Russo PA, Muinos WI, Baldassano RN. Hepatosplenic T-cell lymphoma in an adolescent patient after immunomodulator and biologic therapy for Crohn disease. Journal of Pediatric Gastroenterology and Nutrition 2005;40(2):220-2.
Turner 2012
Vilaseca 1990
  • Vilaseca J, Salas A, Guarner F, Rodriguez R, Martinez M, Malagelada JR. Dietary fish oil reduces progression of chronic inflammatory lesions in a rat model of granulomatous colitis. Gut 1990;31(5):539-44.
Woodworth 2010
  • Woodworth HL, McCaskey SJ, Duriancik DM, Clinthorne JF, Langohr IM, Gardner EM, et al. Dietary fish oil alters T lymphocyte cell populations and exacerbates disease in a mouse model of inflammatory colitis. Cancer Research 2010;70(20):7690-9.
Zachos 2007

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Turner 2007
Turner 2009