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Pelargonium sidoides extract for treating acute respiratory tract infections

  1. Antje Timmer1,*,
  2. Judith Günther2,
  3. Edith Motschall3,
  4. Gerta Rücker3,
  5. Gerd Antes3,
  6. Winfried V Kern4

Editorial Group: Cochrane Acute Respiratory Infections Group

Published Online: 22 OCT 2013

Assessed as up-to-date: 23 APR 2013

DOI: 10.1002/14651858.CD006323.pub3


How to Cite

Timmer A, Günther J, Motschall E, Rücker G, Antes G, Kern WV. Pelargonium sidoides extract for treating acute respiratory tract infections. Cochrane Database of Systematic Reviews 2013, Issue 10. Art. No.: CD006323. DOI: 10.1002/14651858.CD006323.pub3.

Author Information

  1. 1

    Leibniz Institute for Prevention Research and Epidemiology - BIPS GmbH, Clinical Epidemiology, Bremen, Germany

  2. 2

    Pharmafacts GmbH - Research and Consulting in Drug Care, Freiburg, Germany

  3. 3

    Institute of Medical Biometry and Medical Informatics, University Medical Center Freiburg, German Cochrane Centre, Freiburg, Germany

  4. 4

    Center for Infectious Diseases and Travel Medicine, University Hospital, Department of Medicine, Freiburg, Germany

*Antje Timmer, Clinical Epidemiology, Leibniz Institute for Prevention Research and Epidemiology - BIPS GmbH, Achterstrasse 30, Bremen, 28359, Germany. timmer@bips.uni-bremen.de.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 22 OCT 2013

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[Figure 1]
Figure 1. Study flow diagram.
[Figure 2]
Figure 2. 'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
[Figure 3]
Figure 3. 'Risk of bias' summary: review authors' judgements about each risk of bias item for each included study.
[Figure 4]
Figure 4. Forest plot of comparison: 1 P. sidoides versus placebo, acute bronchitis in adults, outcome: 1.2 Failure to recover by day seven (complete resolution of all symptoms).
[Figure 5]
Figure 5. Forest plot of comparison: 2 P. sidoides versus placebo, acute bronchitis in children, outcome: 2.2 Failure to recover by day seven (complete resolution of all symptoms).
[Figure 6]
Figure 6. Forest plot of comparison: 3 P. sidoides versus placebo, acute sinusitis in adults, outcome: 3.1 Failure to recover by day 21 (complete resolution of all symptoms).
[Figure 7]
Figure 7. Forest plot of comparison: 4 P. sidoides versus placebo, the common cold in adults, outcome: 4.1 Failure to recover by day 5 (complete resolution of all symptoms).
[Figure 8]
Figure 8. Forest plot of comparison: 4 P. sidoides versus placebo, the common cold in adults, outcome: 4.5 Failure to recover by day 10 (complete resolution of all symptoms).
[Figure 9]
Figure 9. Forest plot of comparison: 5 P. sidoides versus placebo, any indication, outcome: 5.1 Patients with adverse events.
[Figure 10]
Figure 10. Funnel plot of comparison: 5 P. sidoides versus placebo, any indication, outcome: 5.3 Failure to resolve all symptoms at prespecified day - publication bias.
[Analysis 1.1]
Analysis 1.1. Comparison 1 P. sidoides versus placebo, acute bronchitis in adults, Outcome 1 Failure to recover by day seven (complete resolution of all symptoms).
[Analysis 1.2]
Analysis 1.2. Comparison 1 P. sidoides versus placebo, acute bronchitis in adults, Outcome 2 Failure to resolve key symptom by day seven: cough.
[Analysis 1.3]
Analysis 1.3. Comparison 1 P. sidoides versus placebo, acute bronchitis in adults, Outcome 3 Failure to resolve key symptom by day seven: sputum.
[Analysis 2.1]
Analysis 2.1. Comparison 2 P. sidoides versus placebo, acute bronchitis in children, Outcome 1 Failure to recover by day seven (complete resolution of all symptoms).
[Analysis 2.2]
Analysis 2.2. Comparison 2 P. sidoides versus placebo, acute bronchitis in children, Outcome 2 Failure to resolve key symptom by day seven: cough.
[Analysis 2.3]
Analysis 2.3. Comparison 2 P. sidoides versus placebo, acute bronchitis in children, Outcome 3 Failure to resolve key symptom by day seven: sputum.
[Analysis 3.1]
Analysis 3.1. Comparison 3 P. sidoides versus placebo, acute sinusitis in adults, Outcome 1 Failure to recover by day 21 (complete resolution of all symptoms).
[Analysis 3.2]
Analysis 3.2. Comparison 3 P. sidoides versus placebo, acute sinusitis in adults, Outcome 2 Failure to resolve key symptom by day 21: nasal discharge.
[Analysis 3.3]
Analysis 3.3. Comparison 3 P. sidoides versus placebo, acute sinusitis in adults, Outcome 3 Failure to resolve key symptom by day 21: headache.
[Analysis 4.1]
Analysis 4.1. Comparison 4 P. sidoides versus placebo, the common cold in adults, Outcome 1 Failure to recover by day 5 (complete resolution of all symptoms).
[Analysis 4.2]
Analysis 4.2. Comparison 4 P. sidoides versus placebo, the common cold in adults, Outcome 2 Failure to resolve key symptom by day 5: sore throat.
[Analysis 4.3]
Analysis 4.3. Comparison 4 P. sidoides versus placebo, the common cold in adults, Outcome 3 Failure to resolve key symptom by day 5: nasal drainage.
[Analysis 4.4]
Analysis 4.4. Comparison 4 P. sidoides versus placebo, the common cold in adults, Outcome 4 Failure to resolve key symptom by day 5: nasal congestion.
[Analysis 4.5]
Analysis 4.5. Comparison 4 P. sidoides versus placebo, the common cold in adults, Outcome 5 Failure to recover by day 10 (complete resolution of all symptoms).
[Analysis 4.6]
Analysis 4.6. Comparison 4 P. sidoides versus placebo, the common cold in adults, Outcome 6 Failure to resolve key symptom by day 10: sore throat.
[Analysis 4.7]
Analysis 4.7. Comparison 4 P. sidoides versus placebo, the common cold in adults, Outcome 7 Failure to resolve key symptom by day 10: nasal drainage.
[Analysis 4.8]
Analysis 4.8. Comparison 4 P. sidoides versus placebo, the common cold in adults, Outcome 8 Failure to resolve key symptom by day 10: nasal congestion.
[Analysis 4.9]
Analysis 4.9. Comparison 4 P. sidoides versus placebo, the common cold in adults, Outcome 9 Days off work.
[Analysis 5.1]
Analysis 5.1. Comparison 5 P. sidoides versus placebo, any indication, Outcome 1 Patients with adverse events.
[Analysis 5.2]
Analysis 5.2. Comparison 5 P. sidoides versus placebo, any indication, Outcome 2 Adverse events leading to withdrawal.
[Analysis 5.3]
Analysis 5.3. Comparison 5 P. sidoides versus placebo, any indication, Outcome 3 Failure to resolve all symptoms at prespecified day - publication bias.