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Pelargonium sidoides extract for treating acute respiratory tract infections

  1. Antje Timmer1,*,
  2. Judith Günther2,
  3. Edith Motschall3,
  4. Gerta Rücker3,
  5. Gerd Antes3,
  6. Winfried V Kern4

Editorial Group: Cochrane Acute Respiratory Infections Group

Published Online: 22 OCT 2013

Assessed as up-to-date: 23 APR 2013

DOI: 10.1002/14651858.CD006323.pub3


How to Cite

Timmer A, Günther J, Motschall E, Rücker G, Antes G, Kern WV. Pelargonium sidoides extract for treating acute respiratory tract infections. Cochrane Database of Systematic Reviews 2013, Issue 10. Art. No.: CD006323. DOI: 10.1002/14651858.CD006323.pub3.

Author Information

  1. 1

    Leibniz Institute for Prevention Research and Epidemiology - BIPS GmbH, Clinical Epidemiology, Bremen, Germany

  2. 2

    Pharmafacts GmbH - Research and Consulting in Drug Care, Freiburg, Germany

  3. 3

    Institute of Medical Biometry and Medical Informatics, University Medical Center Freiburg, German Cochrane Centre, Freiburg, Germany

  4. 4

    Center for Infectious Diseases and Travel Medicine, University Hospital, Department of Medicine, Freiburg, Germany

*Antje Timmer, Clinical Epidemiology, Leibniz Institute for Prevention Research and Epidemiology - BIPS GmbH, Achterstrasse 30, Bremen, 28359, Germany. timmer@bips.uni-bremen.de.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 22 OCT 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
Bachert 2009 {published and unpublished data}
  • Bachert C, Schapowal A, Funk P, Kieser M. Treatment of acute rhinosinusitis with the preparation from Pelargonium sidoides EPs 7630: a randomized, double-blind, placebo-controlled trial. Rhinology 2009;47(1):51-8.
  • Bachert C, Schapowal A, Kieser M, Malek F. Treatment of acute bacterial maxillary sinusitis with EPs 7630-solution: a randomised, double-blind, placebo-controlled trial. Focus on Alternative Complementary Therapy. 2006; Vol. 11:4.
Chuchalin 2005 {published and unpublished data}
  • Chuchalin AG, Berman B, Lehmacher W. Treatment of acute bronchitis in adults with a pelargonium sidoides preparation (EPs 7630): a randomized, double blind, placebo-controlled trial. Explore 2005;1(6):437-45.
  • Golovatiouk A, Chuchalin AG. Efficacy of Pelargonium sidoides preparation (Eps (R) 7630) in adults with acute bronchitis [Wirksamkeit eines Extraktes aus Pelargonium sidoides (EPs 7630) im Vergleich zu Placebo bei Patienten mit akuter Bronchitis]. Phytopharmaka 2002;7:3-12.
  • Schulz V. Liquid herbal drug preparation from the root of Pelargonium sidoides is effective against acute bronchitis: results of a double-blind study with 124 patients. Phytomedicine 2007;14(Suppl 6):74-5.
  • Schulz V. Pelargonium sidoides extract for the treatment of acute bronchitis. [German] [Pelargonium sidoides-Extrakt bei akuter Bronchitis]. Komplementäre und Integrative Medizin 2007;48(4):35-9.
Kamin 2010a {published and unpublished data}
  • Anonymous. Efficacy and tolerability of Pelargonium sidoides extract EPs 7630 in patients (1 to 18 years old) with acute bronchitis: a randomized, double-blind, placebo-controlled clinical trial. Study No. 701003.01.001. Summary of design, methods and results.
  • Anonymous. Efficacy and tolerability of Pelargonium sidoides extract EPs 7630 in patients (1 to 18 years old) with acute bronchitis: a randomized, double-blind, placebo-controlled clinical trial. Study No. 701003.01.001. Supplement to the clinical study report (subgroup of patients less than 7 years old) 2007.
  • Huntley A, Kamin W. Encouraging results for herbal treatment of acute bronchitis in children and adolescents. Focus on Alternative and Complementary Therapies 2010;15(3):238-9.
  • Kamin W, Maydannik V, Malek FA, Kieser M. Efficacy and tolerability of EPs 7630 in children and adolescents with acute bronchitis - a randomized, double-blind, placebo-controlled multicenter trial with a herbal drug preparation from Pelargonium sidoides roots. International Journal of Clinical Pharmacology and Therapeutics 2010;48(3):184-91.
Kamin 2010b {published and unpublished data}
  • Anonymous. Efficacy and tolerability of Pelargonium sidoides extract EPs 7630 in patients (6 to 18 years old) with acute bronchitis. Study No. 701003.01.002. Biostatistical Short Report of the Interim Analysis 2007.
  • Kamin W, Maydannik VG, Malek FA, Kieser M. Efficacy and tolerability of EPs 7630 in patients (aged 6-18 years old) with acute bronchitis. Acta Paediatrica 2010;99(4):537-43.
Kamin 2010b - 10 mg {published and unpublished data}
  • Anonymous. Efficacy and tolerability of Pelargonium sidoides extract EPs 7630 in patients (6 to 18 years old) with acute bronchitis. Study No. 701003.01.002. Biostatistical short report of the Interim Analysis 2007.
  • Kamin W, Maydannik VG, Malek FA, Kieser M. Efficacy and tolerability of EPs 7630 in patients (aged 6-18 years old) with acute bronchitis. Acta Paediatrica 2010;99(4):537-43.
Kamin 2010b - 20 mg {unpublished data only}
  • Anonymous. Efficacy and tolerability of Pelargonium sidoides extract EPs 7630 in patients (6 to 18 years old) with acute bronchitis. Study No. 701003.01.002. Biostatistical Short Report of the Interim Analysis 2007.
  • Kamin W, Maydannik VG, Malek FA, Kieser M. Efficacy and tolerability of EPs 7630 in patients (aged 6-18 years old) with acute bronchitis. Acta Paediatrica 2010;99(4):537-43.
Kamin 2010b - 30 mg {unpublished data only}
  • Anonymous. Efficacy and tolerability of Pelargonium sidoides extract EPs 7630 in patients (6 to 18 years old) with acute bronchitis. Study No. 701003.01.002. Biostatistical Short Report of the Interim Analysis 2007.
  • Kamin W, Maydannik VG, Malek FA, Kieser M. Efficacy and tolerability of EPs 7630 in patients (aged 6-18 years old) with acute bronchitis. Acta Paediatrica 2010;99(4):537-43.
Kamin 2012 {published and unpublished data}
  • Anonymous. Efficacy and tolerability of EPs 7630, a liquid herbal drug preparation from Pelargonium sidoides in patients (1-18 years old) suffering from acute bronchitis: a randomized, double-blind, placebo-controlled trial. Study No. 701003.01.004. Summary of Design, Methods and Results.
  • Anonymous. Efficacy and tolerability of Pelargonium sidoides extract EPs 7630 in patients (1 to 18 years old) with acute bronchitis: a randomized, double-blind, placebo-controlled clinical trial. Study No. 701003.01.004. Supplement to the Clinical Study Report (subgroup of patients less than 7 years old).
  • Kamin W, Ilyenko LI, Malek FA, Kieser M. Treatment of acute bronchitis with EPs 7630: randomized, controlled trial in children and adolescents. Pediatrics International: Official Journal of the Japan Pediatric Society 2012;54(2):219-26. [PUBMED: 22360575]
Lizogub 2007 {published data only}
  • Lizogub VG, Riley DS, Heger M. Efficacy of Pelargonium sidoides preparation in patients with the common cold: a randomized, double blind, placebo-controlled clinical trial. Explore 2007;3(6):573-84.
Matthys 2007a {published and unpublished data}
  • Matthys H, Funk P. EPs 7630 improves acute bronchitic symptoms and shortens time to remission. Results of a randomised, double-blind, placebo-controlled, multicentre trial. Planta Medica 2008;74(6):686-92.
  • Matthys H, Heger M. Treatment of acute bronchitis with a liquid herbal drug preparation from Pelargonium sidoides (EPs 7630): a randomised, multicentre, double-blind, placebo-controlled study. Current Medical Research and Opinion 2007;23(2):323-31.
  • Schulz V. Pelargonium sidoides extract EPs for the treatment of 217 patients with acute bronchitis: Publication of an additional double-blind study. [German] [Pelargonium sidoides-Extrakt EPs 7630 bei 217 Patienten mit akuter Bronchitis: Weitere zulassungsrelevante Doppelblindstudie publiziert]. Zeitschrift für Phytotherapie 2007;28(4):169-70.
Matthys 2010 {published and unpublished data}
  • Anonymous. Efficacy and tolerability of Pelargonium sidoides extract EPs 7630 in patients (older than 18 years) with acute bronchitis. Study No. 701003.01.003. Biostatistical Short Report of the Interim Analysis 2007.
  • Ernst E. Instead of antibiotics: Pelargonium sidoides in acute bronchitis. [German] [Statt Antibiotika: Pelargonium sidoides bei akuter Bronchitis]. Munchener Medizinische Wochenschrift 2010;152(41):32.
  • Matthys H, Lizogub VG, Funk P, Malek FA. Health-related quality of life and patient-reported outcome in patients with acute bronchitis receiving EPs 7630 treatment. Respiration 2011;82(1):100.
  • Matthys H, Lizogub VG, Funk P, Malek FA. Pelargonium sidoides in acute bronchitis - Health-related quality of life and patient-reported outcome in adults receiving EPs 7630 treatment [Pelargonium sidoides bei akuter Bronchitis - Gesundheitsbezogene Lebensqualitat und Therapiebeurteilung aus Patientensicht unter Behandlung mit EPs 7630]. Wiener Medizinische Wochenschrift 2010;160(21-2):564-70. [PUBMED: 21170697]
  • Matthys H, Lizogub VG, Malek FA, Kieser M. Efficacy and tolerability of EPs 7630 tablets in patients with acute bronchitis: a randomised, double-blind, placebo-controlled dose-finding study with a herbal drug preparation from Pelargonium sidoides. Current Medical Research Opinion 2010;26(6):1413-22.
  • Schulz V. Assessment of the success of treatment from the patient's point of view: Study of Pelargonium sidoides in acute bronchitis breaks the mold. [German] [Beurteilung des Behandlungserfolges aus Patientensicht: Studie mit Pelargonium sidoides bei akuter Bronchitis geht neue Wege]. Zeitschrift für Phytotherapie 2011;32(1):21-2.
  • Schulz V. Dose finding study on the efficacy of Pelargonium sidoides extract (EPs 7630 in new tablet form) in 405 adults with acute bronchitis. [German] [Dosisfindungsstudie zur Wirksamkeit von Pelargonium-sidoides-extrakt (EPs 7630 in neuer Tablettenform) bei 405 Erwachsenen mit akuter Bronchitis]. Zeitschrift für Phytotherapie 2008;29(1):37-8.
Matthys 2010 - 10 mg {published and unpublished data}
  • Anonymous. Efficacy and tolerability of Pelargonium sidoides extract EPs 7630 in patients (older than 18 years) with acute bronchitis. Study No. 701003.01.003. Biostatistical Short Report of the Interim Analysis 2007.
  • Matthys H, Lizogub VG, Funk P, Malek FA. Pelargonium sidoides in acute bronchitis - Health-related quality of life and patient-reported outcome in adults receiving EPs 7630 treatment [Pelargonium sidoides bei akuter Bronchitis - Gesundheitsbezogene Lebensqualitat und Therapiebeurteilung aus Patientensicht unter Behandlung mit EPs 7630]. Wiener Medizinische Wochenschrift 2010;160(21-2):564-70. [PUBMED: 21170697]
  • Matthys H, Lizogub VG, Malek FA, Kieser M. Efficacy and tolerability of EPs 7630 tablets in patients with acute bronchitis: a randomised, double-blind, placebo-controlled dose-finding study with a herbal drug preparation from Pelargonium sidoides. Current Medical Research Opinion 2010;26(6):1413-22.
Matthys 2010 - 20 mg {published and unpublished data}
  • Anonymous. Efficacy and tolerability of Pelargonium sidoides extract EPs 7630 in patients (older than 18 years) with acute bronchitis. Study No. 701003.01.003. Biostatistical Short Report of the Interim Analysis 2007.
  • Matthys H, Lizogub VG, Funk P, Malek FA. Pelargonium sidoides in acute bronchitis - Health-related quality of life and patient-reported outcome in adults receiving EPs 7630 treatment [Pelargonium sidoides bei akuter Bronchitis - Gesundheitsbezogene Lebensqualitat und Therapiebeurteilung aus Patientensicht unter Behandlung mit EPs 7630]. Wiener Medizinische Wochenschrift 2010;160(21-2):564-70. [PUBMED: 21170697]
  • Matthys H, Lizogub VG, Malek FA, Kieser M. Efficacy and tolerability of EPs 7630 tablets in patients with acute bronchitis: a randomised, double-blind, placebo-controlled dose-finding study with a herbal drug preparation from Pelargonium sidoides. Current Medical Research Opinion 2010;26(6):1413-22.
Matthys 2010 - 30 mg {published and unpublished data}
  • Anonymous. Efficacy and tolerability of Pelargonium sidoides extract EPs 7630 in patients (older than 18 years) with acute bronchitis. Study No. 701003.01.003. Biostatistical Short Report of the Interim Analysis 2007.
  • Matthys H, Lizogub VG, Funk P, Malek FA. Pelargonium sidoides in acute bronchitis - Health-related quality of life and patient-reported outcome in adults receiving EPs 7630 treatment [Pelargonium sidoides bei akuter Bronchitis - Gesundheitsbezogene Lebensqualitat und Therapiebeurteilung aus Patientensicht unter Behandlung mit EPs 7630]. Wiener Medizinische Wochenschrift 2010;160(21-2):564-70. [PUBMED: 21170697]
  • Matthys H, Lizogub VG, Malek FA, Kieser M. Efficacy and tolerability of EPs 7630 tablets in patients with acute bronchitis: a randomised, double-blind, placebo-controlled dose-finding study with a herbal drug preparation from Pelargonium sidoides. Current Medical Research Opinion 2010;26(6):1413-22.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
Bachert 2005 {published data only (unpublished sought but not used)}
  • Bachert C, Schapowal A. EPs 7630 (Extract from Pelargonium sidoides) is effective in the treatment of acute maxillary sinusitis - results from two randomized double blind placebo controlled trials [EPs 7630 (Extrakt aus Pelargonium sidoides) ist wirksam in der Behandlung der akuten Sinusitis maxillaris - Ergebnisse zweier doppelblinder placebokontrollierter Studien]. Kongressband Phytopharmaka Phytotherapie; S4. 2005.
Bereznoj 2009 {published data only}
  • Bereznoj VV, Heger M, Iljenko LJ, Tischko FA. EPs 7630 in adults and children with acute tonsillitis [German] [EPs 7630 bei Erwachsenen und Kindern mit Angina tonsillaris]. Zeitschrift für Phytotherapie 2009;30(1):6-12.
Bereznoy 2003 {published data only}
  • Bereznoy VV, Riley DS, Wassmer G, Heger M. Efficacy of extract of pelargonium sidoides in children with acute non-group a beta-hemolytic streptococcus tonsillopharyngitis: a randomized, double blind, placebo-controlled trial. Alternative Therapies 2003;9(5):68-79.
  • Heger M, Bereznoy VV. Non streptococcal tonsillopharyngitis in children: efficacy of an extract of Pelargonium sidoides (EPs 7630) as compared to placebo [Nicht-streptokokkenbedingte Tonsillopharyngitis bei Kindern: Wirksamkeit eines Extraktes aus Pelargonium sidoides (EPs 7630) im Vergleich zu Placebo]. Phytopharmaka. Vol. 7, Darmstadt: Steinkopff, 2002:13-25.
Blochin 1999 {published data only}
  • Blochin B, Haidvogel M, Heger M. Umckaloabo vs. acetylcysteine in the treatment of acute bronchitis in children [Umckaloabo im Vergleich mit Acetylcystein bei Kindern mit akuter Bronchitis]. Der Kassenarzt 1999;49:46-9.
Blochin 2000 {published data only}
  • Blochin B, Heger M. Umckaloabo vs. symptomatic therapy for the treatment of acute non streptococcal tonsillitis [Umckaloabo vs. symptomatische. Therapie in der Behandlung der akuten Angina catarrhalis]. Päd 2000;6:2-8.
Dome 1996 {published data only}
  • Dome L, Schuster R. Umckaloabo - a phytotherapeutic alternative for acute bronchitis in childhood? [Umckaloabo - eine phytotherapeutische Alternative bei akuter Bronchitis im Kindesalter]. Ärztezeitschrift für Naturheilverfahren 1996;37(3):216-22.
  • Haidvogl M, Heger M. Treatment effect and safety of EPs 7630-solution in acute bronchitis in childhood: report of a multicentre observational study. Phytomedicine 2007;14(Suppl 6):60-4.
Haidvogl 1996 {published data only}
  • Haidvogl M, Schuster R, Heger M. Acute bronchitis in childhood. Multicenter study on the effectiveness and safety of the phytotherapeutic preparation Umckaloabo [Akute Bronchitis im Kindesalter. Multi-zenter Studie zur Wirksamkeit und Verträglichkeit des Phytotherapeutikums Umckaloabo]. Zeitschrift für Phytotherapie 1996;17:300-13.
Koenig 1995 {published data only}
  • König I. Natural respiratory tract therapy: from Umckaloabo drug to therapy of respiratory tract infections [Naturnahe Atemwegstherapie: von der Umckaloabo-Droge zur Therapie von Atemwegsinfekten]. Therapiewoche 1995;45(19):1123-6.
Luna 2011 {published data only}
  • Luna LA Jr, Bachi AL, Novaes e Brito RR, Eid RG, Suguri VM, Oliveira PW, et al. Immune responses induced by Pelargonium sidoides extract in serum and nasal mucosa of athletes after exhaustive exercise: modulation of secretory IgA, IL-6 and IL-15. Phytomedicine 2011;18(4):303-8. [PUBMED: 20850953]
Martins Kirk 2007 {published data only}
  • Martins Kirk K. Post marketing surveillance of Pelargonium sidoides for treatment of presumably viral acute community acquired tonsillopharyngitis [Vigilancia Pos-Comercializacao do Pelargonium sidoides no tratamento das tonsilofaringites comunitarias agudas de origem presumidamente viral]. Revista Panamericana de Infectología 2007;9(1):15-24.
Matthys 2003 {published data only}
  • Matthys H, Eisebitt R, Seith B, Heger M. Efficacy and safety of an extract of Pelargonium sidoides (EPs 7630) in adults with acute bronchitis. A randomised, double-blind, placebo-controlled trial. Phytomedicine 2003;10(Suppl IV):7-17.
Matthys 2007b {unpublished data only}
  • Matthys H, Heger M. EPs 7630-solution--an effective therapeutic option in acute and exacerbating bronchitis. Phytomedicine 2007;14 Suppl 6:65-8.
Matthys 2007c {published data only}
  • Matthys H, Kamin W, Funk P, Heger M. Pelargonium sidoides preparation (EPs 7630) in the treatment of acute bronchitis in adults and children. Phytomedicine 2007;14(Suppl 6):69-73. [PUBMED: 17184981]
Matthys 2013 {published data only}
  • Matthys H, Pliskevich DA, Bondarchuk OM, Malek FA, Tribanek M, Kieser M. Randomised, double blind, placebo-controlled trials of EPs 7673 in adults with COP. Respiratory Medicine 2013;107:691-701.
Patiroglu 2012 {published data only}
  • Patiroglu T, Tunc A, Eke Gungor H, Unal E. The efficacy of Pelargonium sidoides in the treatment of upper respiratory tract infections in children with transient hypogammaglobulinemia of infancy. Phytomedicine 2012;19(11):958-61. [PUBMED: 22809962]
Perez 2011 {published data only}
  • Perez G, Rodriguez N, Castro H, Silva O, Pabbou D, Maestracci F, et al. Evaluation of the effectiveness of Renikan [Extracto del Pelargonium sidoides estandarizado en el tratamiento de las infecciones de las vias respiratorias superiores de etilogia viral]. Archivas Venezolanos de Farmacologia y Terapeutica 2011;30(4):79-85.
Roots 2004 {unpublished data only}
  • Roots I, Arold G, Dienel A, Meng G, Wollny A, Bauer S. Placebo controlled double blind study of interaction of Pelargonium sidoides with penicillin in healthy volunteers [Placebokontrollierte doppelblinde Interaktionsstudie mit Pelargonium sidoides Extrakt und Penicillin V bei gesunden Probanden]. Phytopharmaka und Phytotherapie - Forschung und Praxis. 2004:22.
Schapowal 2007 {published data only}
  • Schapowal A, Heger M. EPs 7630 solution (Umckaloabo) in the treatment of sinusitis. [German] [EPs 7630 losung (Umckaloabo) bei sinusitis]. Zeitschrift für Phytotherapie 2007;28(2):58-65.
Tahan 2013 {published data only}
  • Tahan F, Yaman M. Can the Pelargonium sidoides root extract EPs(R) 7630 prevent asthma attacks during viral infections of the upper respiratory tract in children?. Phytomedicine 2013;20(2):148-50. [PUBMED: 23142309]

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
Bachert 2004 {unpublished data only}

 

Beck 2001 {unpublished data only}

 

Heger 2002 {unpublished data only}

 

Heger 2003 {unpublished data only}

 

ISRCTN86579667 {unpublished data only}

 

Wolf 2011 {unpublished data only}

 

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
EUCTR2007-004923-39-DE {unpublished data only}
  • Efficacy and tolerability of EPs® 7630 film-coated tablets in patients (>=18 years old) with Acute Rhinopharyngitis (ARP). Ongoing study November 2007 (first enrolment).
EUCTR2007-005579-33-BG {unpublished data only}
  • Efficacy and tolerability of EPs® 7630 film-coated tablets in patients (>=18 years old) with Acute Rhinopharyngitis (ARP). Ongoing study August 2008 (first enrolment).
EUCTR2007-005797-31-BG {unpublished data only}
  • Efficacy and tolerability of EPs® 7630 film-coated tablets in patients (>=18 years old) with Acute Rhinopharyngitis (ARP). Ongoing study August 2008 (first enrolment).
EUCTR2011-002652-14-DE {unpublished data only}
  • Safety and tolerability of Pelargonium sidoides extract EPs® 7630 in children (1 to 5 years old) suffering from acute bronchitis: a randomized controlled trial. Ongoing study 1 October 2011 (first enrolment).
ISRCTN77419032 {unpublished data only}
  • (Schwabe Pharmaceuticals). Safety and tolerability of Pelargonium sidoides extract EPs® 7630 in children (1 to 5 years old) suffering from acute bronchitis: a randomised controlled trial. International Clinical Trials Platform (WHO - ICTRP) 2012.
JPRN-UMIN000003815 {unpublished data only}
  • Efficacy of a Pelargonium sidoides preparation in patients with the upper respiratory infection. Ongoing study July 2010 (first enrolment).
NCT01420445 {unpublished data only}
  • (Yuhan Corporation). Safety/Tolerability and Efficacy of YHD001 in Patients With Acute and Chronic Bronchitis. http://www.clinicaltrials.gov 2011.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
Agbabiaka 2008
Ah-See 2007
AKDÄ 2011
  • Arzneimittelkommission der deutschen Ärzteschaft. Hepatitis linked to Umckaloabo ® (from the UAW database; 29.07.2011). Deutsches Ärzteblatt 2011;108:30.
Becker 2011
Bent 1999
Bucher 2003
  • Bucher HC, Tschudi P, Young J, Périat P, Welge-Lüussen A, Züst H, et al. Effect of amoxicillin-clavulanate in clinically diagnosed acute rhinosinusitis: a placebo-controlled, double-blind, randomized trial in general practice. Archives of Internal Medicine 2003;163(15):1793-8.
Chalumeau 2013
  • Chalumeau M, Duijvestijn YC. Acetylcysteine and carbocysteine for acute upper and lower respiratory tract infections in paediatric patients without chronic broncho-pulmonary disease. Cochrane Database of Systematic Reviews 2013, Issue 5. [DOI: 10.1002/14651858.CD003124.pub4; PUBMED: 23728642]
CKS Guideline 2009
  • NHS. CKS-Guideline: Sinusitis. Online document. http://cks.nice.org.uk/sinusitis#!background. Last revised March 2009.
CKS Guideline 2010
  • NHS. CKS Guideline: Cough. Online document. http://cks.nice.org.uk/cough#!backgroundsub. Last revised September 2010.
CKS Guideline 2011
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Conrad 2007a
  • Conrad A, Jung I, Tioua D, Lallemand C, Carrapatoso F, Engels I, et al. Extract of Pelargonium sidoides (EPs((R)) 7630) inhibits the interactions of group A-streptococci and host epithelia in vitro. Phytomedicine 2007;14(Suppl 6):52-9.
Conrad 2007b
  • Conrad A, Hansmann C, Engels I, Daschner FD, Frank U. Extract of Pelargonium sidoides (EPs 7630) improves phagocytosis, oxidative burst, and intracellular killing of human peripheral blood phagocytes in vitro. Phytomedicine 2007;14(Suppl 6):46-51.
Conrad 2007c
  • Conrad A, Kolodziej H, Schulz V. Pelargonium sidoides-extract (EPs((R)) 7630): registration confirms efficacy and safety. Wiener Klinische Wochenschrift 2007;157(13-14):331-6.
de Boer 2007
EMA 2012
  • European Medicines Agency (EMA). Committee on Herbal Medicinal Products (HMPC). Assessment report on Pelargonium sidoides DC and/or Pelargonium reniforme Curt., radix. 20 November 2012, EMA/HMPC/560962/2010. www.ema.europa.eu.
Fahey 1998
Fintelmann 2012
  • Fintelmann V, Albrecht U, Schmitz G, Schnitker J. Efficacy and safety of a combination herbal medicinal product containing Tropaeoli majoris herba and Armoraciae rusticanae radix for the prophylactic treatment of patients with respiratory tract diseases: a randomised, prospective, double-blind, placebo-controlled phase III trial. Current Medical Research Opinion 2012;28:1799-807.
Gonzales 2000
Gonzales 2001
  • Gonzales R, Bartlett JG, Besser RE, Cooper RJ, Hickner JM, Hoffman JR, et al. Principles of appropriate antibiotic use for treatment of acute respiratory tract infections in adults: background, specific aims, and methods. Annals of Internal Medicine 2001;37(6):690-7.
Goos 2006
  • Goos KH, Albrecht U, Schneider B. Efficacy and safety profile of a herbal drug containing nasturtium herb and horseradish root in acute sinusitis, acute bronchitis and acute urinary tract infection in comparison with other treatments in the daily practice/results of a prospective cohort study. Arzneimittelforschung 2006;56(3):249-57.
Goos 2007
  • Goos KH, Albrecht U, Schneider B. On-going investigations on efficacy and safety profile of a herbal drug containing nasturtium herb and horseradish root in acute sinusitis, acute bronchitis and acute urinary tract infection in children in comparison with other antibiotic treatments. Arzneimittelforschung 2007;57(4):238-46.
Gruenwald 2005
  • Gruenwald J, Graubaum HJ, Busch R. Efficacy and tolerability of a fixed combination of thyme and primrose root in patients with acute bronchitis. A double-blind, randomized, placebo-controlled clinical trial. Arzneimittelforschung 2005;55(11):669-76.
Higgins 2011
  • Higgins JPT, Altman DG, Sterne JAC (editors). Chapter 8: Assessing risk of bias in included studies. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org. Chichester: Wiley-Blackwell.
Jiang 2012
Kayser 1997
Kayser 2001
Kemmerich 2006
  • Kemmerich B, Eberhardt R, Stammer H. Efficacy and tolerability of a fluid extract combination of thyme herb and ivy leaves and matched placebo in adults suffering from acute bronchitis with productive cough. A prospective, double-blind, placebo-controlled clinical trial. Arzneimittelforschung 2006;56:652-60.
Kemmerich 2007
  • Kemmerich B. Evaluation of efficacy and tolerability of a fixed combination of dry extracts of thyme herb and primrose root in adults suffering from acute bronchitis with productive cough. A prospective, double-blind, placebo-controlled multicenter clinical trial. Arzneimittelforschung 2007;57:607-15.
Kenealy 2013
Kolodziej 2003
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References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
Timmer 2008