Intervention Review

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Psychological and behavioural treatments for adults with non-epileptic attack disorder

  1. Jayne Martlew1,*,
  2. Jennifer Pulman2,
  3. Anthony G Marson2

Editorial Group: Cochrane Epilepsy Group

Published Online: 11 FEB 2014

Assessed as up-to-date: 7 FEB 2014

DOI: 10.1002/14651858.CD006370.pub2


How to Cite

Martlew J, Pulman J, Marson AG. Psychological and behavioural treatments for adults with non-epileptic attack disorder. Cochrane Database of Systematic Reviews 2014, Issue 2. Art. No.: CD006370. DOI: 10.1002/14651858.CD006370.pub2.

Author Information

  1. 1

    The Walton Centre, Department of Neuropsychology, Liverpool, Mersyside, UK

  2. 2

    Institute of Translational Medicine, University of Liverpool, Department of Molecular and Clinical Pharmacology, Liverpool, Merseyside, UK

*Jayne Martlew, Department of Neuropsychology, The Walton Centre, Jubilee House, 10th Avenue, Fazakerley, Liverpool, Mersyside, L9 7AL, UK. Jayne.Martlew@thewaltoncentre.nhs.uk. jayneg1nxs@googlemail.com.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 11 FEB 2014

SEARCH

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
  5. References to other published versions of this review
Ataoglu 2003 {published data only}
Barry 2008 {published data only}
Goldstein 2004 {published data only}
  • Goldstein LH, Deale AC, Mitchell-O'Malley SJ, Toone BK, Mellers JDC. An evaluation of cognitive behavioral therapy as a treatment for dissociative seizures: a pilot study. Cognitive and Behavioral Neurology 2004;17(1):41-9.
Goldstein 2010 {published data only}
Kuyk 2008 {published data only}
LaFrance 2009 {published data only}
  • LaFrance WC Jr, Miller IW, Ryan CE, Blum AS, Solomon DA, Kelley JE, et al. Cognitive behavioural therapy for psychogenic nonepileptic seizures. Epilepsy and Behavior 2009;14(4):591-6.
Moene 2002 {published data only}
  • Moene FC, Spinhoven P, Hoogduin KA, van Dyck R. A randomised controlled clinical trial on the additional effect of hypnosis in a comprehensive treatment programme for in-patients with conversion disorder of the motor type. Psychotherapy and Psychosomatics 2002;71(2):66-76.
Moene 2003 {published data only}
  • Moene FC, Spinhoven P, Hoogduin KA, van Dyck R. A randomized controlled clinical trial of a hypnosis-based treatment for patients with conversion disorder, motor type. International Journal of Clinical and Experimental Hypnosis 2003;51(1):29-50.
Prigatano 2002 {published data only}
  • Prigatano GP, Stonnington CM, Fisher RS. Psychological factors in the genesis and management of nonepileptic seizures: clinical observations. Epilepsy and Behavior 2002;3(4):343-9.
Ramani 1982 {published data only}
Rusch 2001 {published data only}
Zaroff 2004 {published data only}

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
  5. References to other published versions of this review
Allen 2006 {published data only}
  • Allen LA, Woolfolk RL, Escobar JI, Gara MA, Hamer RM. Cognitive-behavioral therapy for somatization disorder: a randomized controlled trial. Archives of Internal Medicine 2006;166(14):1512-8.
Betts 1992 {published data only}
  • Betts T, Boden S. Diagnosis, management and prognosis of a group of 128 patients with non-epileptic attack disorder. Part 1. Seizure: European Journal of Epilepsy 1992;1(1):19-26.
Bhatia 2005 {published data only}
Bleichhardt 2004 {published data only}
  • Bleichhardt G, Timmer B, Rief W. Cognitive-behavioural therapy for patients with multiple somatoform symptoms-a randomised controlled trial in tertiary care. Journal of Psychosomatic Research 2004;56(4):449-54.
Buchanan 1993 {published data only}
  • Buchanan N, Snars J. Pseudoseizures (non epileptic attack disorder)-clinical management and outcome in 50 patients. Seizure 1993;2(2):141-6.
Chinta 2008 {published data only}
  • Chinta S, Malhi P, Singhi P, Prabhakar S. Clinical and psychosocial characteristics of children with nonepileptic seizures. Annals of Indian Academy of Neurology 2008;11(3):159-63.
Elsas 2011 {published data only}
  • Elsas SM, Gregory WL, White G, Navarro G, Salinsky MC, Andrews DJ. Aura interruption: the Andrews/Reiter behavioral intervention may reduce seizures and improve quality of life: a pilot trial. Epilepsy and Behavior 2011;22(4):765-72.
Flom 1999 {published data only}
  • Flom J. The effects of psychotherapy on psychogenic seizures. ProQuest Dissertations and Theses. Seattle University, 1999.
Ghosh 2007 {published data only}
  • Ghosh JK, Majumder P, Pant P, Dutta R, Bhatia BD. Clinical profile and outcome of conversion disorder in children in a tertiary hospital of north India. Journal of Tropical Pediatrics 2007;53(3):213-4.
Gupta 2011 {published data only}
Hiller 2003 {published data only}
  • Hiller W, Fichter MM, Rief W. A controlled treatment study of somatoform disorders including analysis of healthcare utilization and cost-effectiveness. Journal of Psychosomatic Research 2003;54(4):369-80.
Hovorka 2007 {published data only}
  • Hovorka J, Nezadal T, Herman E, Nemcova I, Bajacek M. Psychogenic non-epileptic seizures, prospective clinical experience: diagnosis, clinical features, risk factors, psychiatric comorbidity, treatment outcome. Epileptic Disorders 2007;9(Suppl 1):S52-8.
Kashner 1995 {published data only}
Katsamanis 2011 {published data only}
  • Katsamanis M, Lehrer PM, Escobar JI, Gara MA, Kotay A, Liu R. Psychophysiologic treatment for patients with medically unexplained symptoms: a randomized controlled trial. Psychosomatics 2011;52(3):218-29.
Khattak 2006 {published data only}
  • Khattak T, Farooq S, Jan B. Behavior therapy in dissociative convulsions disorder. Journal of the College of Physicians and Surgeons Pakistan 2006;16(5):359-63.
Lidbeck 1997 {published data only}
Lidbeck 2003 {published data only}
Magallon 2008 {published data only}
  • Magallon R, Gili M, Moreno S, Bauza N, Garcia-Campayo J, Roca M, et al. Cognitive-behaviour therapy for patients with Abridged Somatization Disorder (SSI 4,6) in primary care: a randomized, controlled study. BMC Psychiatry 2008;8:47.
Martin 2007 {published data only}
  • Martin A, Rauh E, Fichter M, Rief W. A one-session treatment for patients suffering from medically unexplained symptoms in primary care: a randomized clinical trial. Psychosomatics 2007;48(4):294-303.
Mayor 2010 {published data only}
McDade 1992 {published data only}
  • McDade G, Brown SW. Non-epileptic seizures: management and predictive factors of outcome. Seizure 1992;1(1):7-10.
McLeod 1997 {published data only}
Miller 1983 {published data only}
Mims 1994 {published data only}
  • Mims J, Antonello JL. Treatment of nonepileptic psychogenic events in adolescent patients using the systems model for intervention. Journal of Neuroscience Nursing 1994;26(5):298-305.
Nanke 2000 {published data only}
Nanke 2003 {published data only}
Posse 2004 {published data only}
Schweickhardt 2007 {published data only}
  • Schweickhardt A, Larisch A, Wirsching M, Fritzsche K. Short-term psychotherapeutic interventions for somatizing patients in the general hospital: a randomized controlled study. Psychotherapy and Psychosomatics 2007;76(6):339-46.
Share 1996 {published data only}
Smith 1986 {published data only}
Smith 2009 {published data only}
Speckens 1996 {published data only}
  • Speckens AEM, Van HAM, Spinhoven P, Hawton KE, Bolk JH, Rooijmans HGM. Favourable effects of cognitive behavioural therapy on unexplained physical symptoms: a randomized trial. Nederlands Tijdschrift Voor Geneeskunde 1996;140(23):1227-32.
Timmer 2004 {published data only}
  • Timmer B, Bleichhardt G, Rief W. Effectiveness of a cognitive-behavioral group therapy for somatization: results of a randomized controlled trial in tertiary care. Zeitschrift fur Klinische Psychologie und Psychotherapie 2004;33(1):24-32.
Timmer 2006 {published data only}

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
  5. References to other published versions of this review
La France {unpublished data only}
  • LaFrance W, Webb A, Blum A, Keitner G, Barry J, Szaflarski J. Multi-center treatment trial pilot for psychogenic nonepileptic seizures. American Epilepsy Society. 2012.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
  5. References to other published versions of this review
Ataoglu 1998
  • Ataoglu A, Sir A, Ozkan, M. Paradoxical therapy in conversion disorder. Turkish Journal of Medical Sciences 1998;28:419-21.
Betts 1993
  • Betts T, Duffy N. Non-epileptic attack disorder (pseudoseizures) and sexual abuse: a review. In: Gram L, Johannessen SI, Osterman PO, Sillanpää M editor(s). Pseudo Epileptic Seizures. Petersfield: Wrightson Biomedical, 1993:55-65.
Bodde 2009
  • Bodde N, Brooks J, Baker G, Boon P, Hendriksen J, Mulder O, et al. Psychogenic non-epileptic seizures--definition, etiology, treatment and prognostic issues: a critical review. Seizure 2009;18:543-53.
Chemali 2004
Devinsky 1998
  • Devinsky O. Nonepileptic psychogenic seizures: quagmires of pathophysiology, diagnosis and treatment. Epilepsia 39;5:458-62.
Duncan 2011
  • Duncan R, Razvi S, Mulhern S. Newly presenting psychogenic nonepileptic seizures: incidence, population, characteristics and early outcome from a prospective audit of a first seizure clinic. Epilepsy and Behavior 2011;20:308-11.
Francis 1999a
Francis 1999b
Kirkham 2010
  • Kirkham J, Dwan K, Altman D, Gamble C, Dodd S, Smyth R, et al. The impact of outcome reporting bias in randomised controlled trials on a cohort of systematic reviews. BMJ 2010;340:365.
Lesser 2003
Martin 2003
  • Martin R, Bell B, Hermann B, Mennemeyer S. Non epileptic seizures and their costs: the role neuropsychology. In: Pritigano GP, Pliskin NH editor(s). Clinical Neuropsychology and Cost Outcome Research: a Beginning. NY, USA: Psychology Press, 2003:235-58.
Moene 1998
  • Moene FC, Hoogduin K AL, van Dyck R. The inpatient treatment of patients suffering from (motor) conversion symptoms: a description of eight cases. International Journal of Clinical and Experimental Hypnosis 1998;46(2):171-90.
NEAD Trust
  • NEAD Trust. Seizures and symptoms. http://www.neadtrust.co.uk/seizuressymptoms.html (accessed 2 November 2012).
Non-Epileptic Attacks
  • Non-epileptic attacks. http://www.nonepilepticattacks.info/2_common.html (accessed 2 November 2012).
Ramani 1993
  • Ramani V. Review of psychiatric treatment strategies in non-epileptic seizures. In: Rowan AJ, Gates JR editor(s). Non-Epileptic Seizures. MA, USA: Butterworth-Heinemann, 1993:259-67.
Reilly 1999
  • Reilly J, Baker GA, Rhodes J, Salmon P. The association of sexual and physical abuse with somatization: characteristics of patients presenting with irritable bowel syndrome and non-epileptic attack disorder. Psychological Medicine 1999;29:399-406.
Reuber 2005
  • Reuber M, Howlett S, Kemp S. Psychologic treatment of patients with psychogenic nonepileptic seizures. Expert Review in Neurotherapeutics 2005;5(6):737-52.
Sharpe 2011
  • Sharpe M, Walker J, Williams C, Stone J, Cavanagh J, Murray G, et al. Guided self-help for functional (psychogenic) symptoms: a randomized controlled efficacy trial. Neurology 2011;77:564-72.
Stone 2004
Szaflarski 2000

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
  5. References to other published versions of this review
Martlew 2009
  • Martlew J, Baker G, Goodfellow L, Bodde N, Aldenkamp A. Behavioural treatments for non-epileptic attack disorder. Cochrane Database of Systematic Reviews 2009, Issue 4. [DOI: 10.1002/14651858.CD006370]