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Benzodiazepines for delirium

  • Protocol
  • Intervention


  • ET Lonergan,

  • J Luxenberg,

  • A Areosa Sastre,

  • T Wyller

Prof Edmund Lonergan, 4 Captain Drive, Apt 215, Emeryville, CA, 94608, USA.


This is the protocol for a review and there is no abstract. The objectives are as follows:

Primary Objective
To determine the effect of benzodiazepines on hospitalised adults with delirium

Secondary Objectives

  • To examine the incidence and types of adverse effects of benzodiazepines

  • To examine the number of withdrawals among benzodiazepine treated and control patients

  • To examine the number of patients withdrawing from treatment because of adverse effects of benzodiazepines

  • To examine adverse drug effects of benzodiazepines as they confound the evaluation of the response of delirium to treatment

  • To examine the effect of benzodiazepines of different classes (eg, short-acting, intermediate acting, long acting) on the course of delirium.

To determine if response to benzodiazepines is influenced by:

  • The cause of delirium: surgery, infection, stroke, drugs

  • The character of delirium: hypoactive, hyperactive

  • The presence of previous cognitive impairment

  • Dose of drug

  • Duration of treatment

  • Age of the patient.