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First-line allogeneic hematopoietic stem cell transplantation of HLA-matched sibling donors compared with first-line ciclosporin and/or antithymocyte or antilymphocyte globulin for acquired severe aplastic anemia

  1. Frank Peinemann1,*,
  2. Carmen Bartel2,
  3. Ulrich Grouven3

Editorial Group: Cochrane Haematological Malignancies Group

Published Online: 23 JUL 2013

Assessed as up-to-date: 22 APR 2013

DOI: 10.1002/14651858.CD006407.pub2


How to Cite

Peinemann F, Bartel C, Grouven U. First-line allogeneic hematopoietic stem cell transplantation of HLA-matched sibling donors compared with first-line ciclosporin and/or antithymocyte or antilymphocyte globulin for acquired severe aplastic anemia. Cochrane Database of Systematic Reviews 2013, Issue 7. Art. No.: CD006407. DOI: 10.1002/14651858.CD006407.pub2.

Author Information

  1. 1

    Children's Hospital, University of Cologne, Cologne, NW, Germany

  2. 2

    Cologne, Germany

  3. 3

    Hannover Medical School, Hannover, Germany

*Frank Peinemann, Children's Hospital, University of Cologne, Kerpener Str. 62, Cologne, NW, 50937, Germany. pubmedprjournal@gmail.com.

Publication History

  1. Publication Status: New
  2. Published Online: 23 JUL 2013

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[Figure 1]
Figure 1. MSD-HSCT: first-line allogeneic hematopoietic stem cell transplantation from HLA-matched (identical) sibling donor; IST: immunosuppressive therapy; "MR": 'Mendelian randomization'; SAA: severe aplastic anemia
[Figure 2]
Figure 2. 'Risk of bias' summary: review authors' judgements about each risk of bias item for each included study.
[Figure 3]
Figure 3. 'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
[Figure 4]
Figure 4. Mortality (HSCT vs. IST); effect: hazard ratio; random-effects model. Standard error calculated from data presented in the Kaplan-Meier graph of the article or deduced from it by the method of Parmar 1998 and the applicable tool by Tierney 2007. Data from the study Führer 1998 are taken from the article Führer 1998 (114 participants) because results in the article by Führer 2005 (213 participants) were not sufficient to allow calculation of the respective standard error. We included the data for 203 participants in the meta-analysis. We were not able to include the data for the additional 99 participants of the update.

Abbreviations: CI: confidence interval; MSD-HSCT: first-line allogeneic hematopoietic stem cell transplantation of bone marrow of HLA-matched sibling donors; log: logarithm; IST: first-line immunosuppressive therapy; IV: inverse variance; SE: standard error
[Figure 5]
Figure 5. Forest plot of comparison: 1 MSD-HSCT vs. IST - all patients, outcome: 1.2 Secondary clonal disease or malignancies.

Abbreviations: CI: confidence interval; MSD-HSCT: first-line allogeneic hematopoietic stem cell transplantation of bone marrow of HLA-matched sibling donors; IST: first-line immunosuppressive therapy
[Analysis 1.1]
Analysis 1.1. Comparison 1 MSD-HSCT versus IST - all patients, Outcome 1 Mortality.
[Analysis 1.2]
Analysis 1.2. Comparison 1 MSD-HSCT versus IST - all patients, Outcome 2 Secondary clonal disease or malignancies.