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Treatment of helminth co-infection in HIV-1 infected individuals in resource-limited settings.

  1. Judd L Walson*,
  2. Grace John-Stewart

Editorial Group: Cochrane HIV/AIDS Group

Published Online: 15 APR 2009

Assessed as up-to-date: 13 SEP 2007

DOI: 10.1002/14651858.CD006419.pub2

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Walson JL, John-Stewart G. Treatment of helminth co-infection in HIV-1 infected individuals in resource-limited settings.. Cochrane Database of Systematic Reviews 2008, Issue 1. Art. No.: CD006419. DOI: 10.1002/14651858.CD006419.pub2.

Author Information

  1. University of Washington, Allergy and Infectious Diseases, Seattle, WA, USA

*Judd L Walson, Allergy and Infectious Diseases, University of Washington, Box 359909, University of Washington, 325 Ninth Avenue, Seattle, WA, 98104, USA. walson@u.washington.edu.

Publication History

  1. Publication Status: Unchanged
  2. Published Online: 15 APR 2009

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Brown 2004 {published and unpublished data}
  • Brown M, Kizza M, Watera C, Quigley MA, Rowland A, Highes P, et al. Helminth infection is not associated iwth faster progression of HIV disease in coinfected adults in Uganda. The Journal of Infectious Diseases 2004;190:1869-79.
Elliott 2003 {published and unpublished data}
  • Elliott AM, Mawwa PA, Joseph S, Namujju PB, Kizza M, Nakiyingi JS, et al. Associations between helminth infection and CD4+ T cell count, viral load and cytokine responses in HIV-1 infected Ugandan adults. Transactions of the Royal Society of Tropical Medicine and Hygiene 2003;97:103-8.
Kallestrup 2005 {published and unpublished data}
  • Kallestrup P, Zinyama R, Gomo E, Butterworth AE, Mudenge B, van Dam GJ, et al. Schistosomiasis and HIV-1 infection in rural Zimbabwe: effect of treatment of schistosomiasis on CD4 cell count and plasma HIV-1 RNA load. The Journal of Infectious Diseases 2005;192:1956-61.
Modjarrad 2005 {published data only}
  • Modjarrad K, Zulu I, Redden DT, Njobvu L, Lane HC, Bentwich Z, Vermund SH. Treatment of intestinal helminths does not reduce plasma concentrations of HIV-1 RNA in coinfected Zambian adults. The journal of infectious diseases 2005;192:1277-83.
Wolday 2002 {published data only (unpublished sought but not used)}
  • Wolday D, Mayaan S, Mariam ZG, Berhe N, Seboxa T, Britton S, Galai N, Landay A, Bentwich Z. Treatment of intestinal worms is associated with decreased HIV plasma viral load. Journal of acquired immune deficiency syndromes 2002;31:56-62.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Brown 2005 {published data only}
  • Brown M, Mawa PA, Joseph S, Bukusuba J, Watera C, Whitworth JAG, et al. Treatment of Schistosoma mansoni infection increases helminth-specific type 2 cytokine responses and HIV-1 loads in coinfected Ugandan adults. Journal of Infectious Diseases 2005;191:1648-57.
Gallagher 2005 {published data only}
  • Gallagher M, Malhotra I, Mungai PL, Wamachi AN, Kioko JM, Ouma JH, Muchiri E, King CL. The effects of maternal helminth and malaria infections on mother-to-child HIV transmission. AIDS 2005;19:1849-55.
Ganley-Leal 2006 {published data only}
  • Ganley-Leal LM, Mwinzi PN, Cetre-Sossah CB, Andove J, Hightower AW, Karanja DM, et al. Correlation between eosinophils and protection against reinfection with schistosoma mansoni and the effect of human immunodeficiency virus type 1 coinfection in humans. Infection and Immunity 2006;74(4):2169-76.
Hosseinipour 2007 {published data only}
  • Hosseinipour MC, Napravnik S, Joaki G, Gama S, Mbeye N, Banda B, et al. HIV and parasitic infection and the effect of treatment among adult outpatients in Malawi. The Journal of Infectious Diseases 2007;195:1278-82.
Kallestrup 2006 {published data only}
  • Kallestrup P, Zinyama R, Gomo E, Butterworth AE, van Dam GJ, Gerstoft J, et al. Schistosomiasis and HIV in rural Zimbabwe: efficacy of treatment of schistosomiasis in individuals with HIV coinfection. Clinical Infectious Diseases 2006;42:1781-9.
Kassu 2003 {published data only}
  • Kassu A, Tsegaye A, Wolday D, Petros B, Aklilu M, Fontanet AL, et al. Role of incidental and/or cured intestinal parasitic infections on profile of CD4 and CD8 T cell subsets and activation status in HIV-1 infected and uninfected adult Ethiopians. Clinical Experimental Immunology 2003;132:113-19.
Kelly 1996 {published data only}
  • Kelly P, Lungu F, Keane E, Baggaley R, Kazembe F, Pobee J, et al. Albendazole chemotherapy for treatment of diarrhoea in patients with AIDS in Zambia: a randomized double blind controlled trial. British Medical Journal 1996;312(7040):1187(5).
Lawn 2000 {published data only}
  • Lawn SD, Karanja MS, Mwinzi P, Andove J, Colley DG, Folks TM, et al. The effect of treatment of schistosomiasis on blood plasma HIV-1 RNA concentration in coinfected individuals. AIDS 2000;14(16):2437-43.
McElroy 2005 {published data only}
  • McElroy MD, Elrefaei M, Jones N, Ssali F, Mugyenyi P, Barugahare B, et al. Coinfection with schistosoma mansoni is associated with decreased HIV-specific cytolysis and increased IL-10 production. The Journal of Immunology 2005;174:5119-23.
Mwanakasale 2003 {published data only}
  • Mwanakasale V, Vounatsou P, Sukwa TY, Ziba M, Ernest A, Tanner M. Interactions between schistosoma haematobium and human immunodeficiency virus type 1: The effects of coinfection on treatment outcomes in rural Zambia. American Journal of Tropical Medicine and Hygiene 2003;69(4):420-8.

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Walson {unpublished data only}
  • Treatment of helminth co-infection; short term effects of HIV-1 progression markers and immune activation. Ongoing study March 2006.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Actor 1993
  • Actor JK, Shirai M, Kullberg MC, Buller RM, Sher A, Berzofsky JA. Helminth infection results in decreased virus-specific CD8+ cytotoxic T-cell and Th1 cytokine responses as well as delayed virus clearance. Proc Natl Acad Sci U S A. 1993 Feb 1;90(3):948-52.
Allen 1996
  • Allen JE, Lawrence RA, Maizels RM. APC from mice harbouring the filarial nematode, Brugia malayi, prevent cellular proliferation but not cytokine production. International immunology. 1996 Jan;8(1):143-51.
Bentwich 1995
  • [8] Bentwich Z, Kalinkovich A, Weisman Z. Immune activation is a dominant factor in the pathogenesis of African AIDS. Immunology today. 1995 Apr;16(4):187-91.
Bentwich 1996
  • Bentwich Z, Weisman Z, Moroz C, Bar-Yehuda S, et al. Immune dysregulation in Ethiopian immigrants in Israel: relevance to helminth infections. Clinical Experimental Immunology 1996;103:239-43.
Borkow 2006
  • Borkow G, Bentwich Z. HIV and helminth co-infection: is deworming necessary? Parasite Immunol. 2006 Nov;28(11):605-12.
Brown 2006
  • Brown M, Mawa PA, Kaleebu P, Elliott AM. Helminths and HIV infection: epidemiological observations on immunological hypotheses. Parasite Immunol. 2006 Nov;28(11):613-23.
Eggena 2005
  • Eggena MP, Barugahare B, Okello M, Mutyala S, Jones N, Ma Y, Kityo C, Mugyenyi P, Cao H. T cell activation in HIV-seropositive Ugandans: differential associations with viral load, CD4+ T cell depletion, and coinfection. The journal of infectious diseases 2005;191:694-701.
Fincham 2003
  • Fincham JE, Markus MB, Adams VJ. Could control of soil-transmitted helminthic infection influence the HIV/AIDS pandemic. Acta Tropica 2003;86:315-333.
Gomez-Escobar 2000
  • Gomez-Escobar N, Gregory WF, Maizels RM. Identification of tgh-2, a filarial nematode homolog of Caenorhabditis elegans daf-7 and human transforming growth factor beta, expressed in microfilarial and adult stages of Brugia malayi. Infect Immun. 2000 Nov;68(11):6402-10.
Goodridge 2001
  • Goodridge HS, Wilson EH, Harnett W, Campbell CC, Harnett MM, Liew FY. Modulation of macrophage cytokine production by ES-62, a secreted product of the filarial nematode Acanthocheilonema viteae. J Immunol. 2001 Jul 15;167(2):940-5.
Gupta 2007
  • Gupta SB, Jacobson LP, Margolick JB, Rinaldo CR, Phair JP, Jamieson BD, et al. Estimating the benefit of an HIV-1 vaccine that reduces viral load set point. The Journal of infectious diseases. 2007 Feb 15;195(4):546-50.
JPT 2005
  • JPT H. Effect measures for continuous outcomes. Cochrane Handbook for Systematic Reviews of Interventions 4.2.5 [updated May 2005]. The Cochrane Library 2005 [cited 25th May 2007]; Available from: http://www.cochrane.org/resources/handbook/hbook. Available from: http://www.cochrane.org/resources/handbook/hbook.htm.
Lawn 2001
  • Lawn SD, Butera ST, Folks TM. Contribution of immune activation to the pathogenesis and transmission of human immunodeficiency virus type 1 infection. Clinical Microbiology Reviews 2001;14(4):753-777.
Maizels 2003
  • Maizels RM, Yazdanbakhsh M. Immune regulation by helminth parasites: cellular and molecular mechanisms. Nature reviews. 2003 Sep;3(9):733-44.
Pastrana 1998
  • Pastrana DV, Raghavan N, FitzGerald P, Eisinger SW, Metz C, Bucala R, et al. Filarial nematode parasites secrete a homologue of the human cytokine macrophage migration inhibitory factor. Infect Immun. 1998 Dec;66(12):5955-63.
Shapira-Nahor 1998
  • Shapira-Nahor O, Kalinkovich A, Weisman Z, Greenberg Z, Nahmias J, Shapiro M, et al. Increased susceptibility to HIV-1 infection of peripheral blood mononuclear cells from chronically immune-activated individuals. Aids. 1998 Sep 10;12(13):1731-3.
UNAIDS 2004
  • 2004 report on the global AIDS epidemic. 4th global report. UNAIDS 2004.
van der Kleij 2002
  • van der Kleij D, Latz E, Brouwers JF, Kruize YC, Schmitz M, Kurt-Jones EA, et al. A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization. The Journal of biological chemistry. 2002 Dec 13;277(50):48122-9.
Wells et al
  • Wells GA, Shea B, O'Connell D, Peterson J, Welch V, Losos M, Tugwell P. The Newcastle_Ottawa Scale (NOW) for assessing teh quality of nonrandomized studies in meta-analyses. Department of Epidemiology and Community Medicine, University of Ottawa, Canada. [: http://www.lri.ca/programs/ceu/oxford.htm]

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Walson, in press
  • Walson JL, John-Stewart G. Treatment of helminth co-infection in HIV-1 infected individuals: a systematic review of the literature.. PLoS Neglected Tropical Diseases (In press: accepted for publication September 2007).
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