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Prebiotics in infants for prevention of allergic disease and food hypersensitivity

  1. David A Osborn1,*,
  2. John KH Sinn2

Editorial Group: Cochrane Neonatal Group

Published Online: 17 OCT 2007

Assessed as up-to-date: 30 MAY 2007

DOI: 10.1002/14651858.CD006474.pub2


How to Cite

Osborn DA, Sinn JKH. Prebiotics in infants for prevention of allergic disease and food hypersensitivity. Cochrane Database of Systematic Reviews 2007, Issue 4. Art. No.: CD006474. DOI: 10.1002/14651858.CD006474.pub2.

Author Information

  1. 1

    Royal Prince Alfred Hospital, RPA Newborn Care, Camperdown, New South Wales, Australia

  2. 2

    Royal North Shore Hospital, Neonatal Unit, St. Leonards, New South Wales, Australia

*David A Osborn, RPA Newborn Care, Royal Prince Alfred Hospital, Missenden Road, Camperdown, New South Wales, 2050, Australia. david.osborn@email.cs.nsw.gov.au.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 17 OCT 2007

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This is not the most recent version of the article. View current version (28 MAR 2013)

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Ben 2004 {published data only}
  • Ben XM, Zhou XY, Zhao WH, Yu WL, Pan W, Zhang WL, et al. Supplementation of milk formula with galacto-oligosaccharides improves intestinal micro-flora and fermentation in term infants. Chinese Medical Journal 2004;117:927-31.
Boehm 2002 {published data only}
  • Boehm G, Lidestri M, Casetta P, Jelinek J, Negretti F, Stahl B, Marini A. Supplementation of a bovine milk formula with an oligosaccharide mixture increases counts of faecal bifidobacteria in preterm infants. Archives of Disease in Childhood Fetal and Neonatal Edition 2002;86:F178-81.
  • Knol J, Boehm G, Lidestri M, Negretti F, Jelinek J, Agosti M, et al. Increase of faecal bifidobacteria due to dietary oligosaccharides induces a reduction of clinically relevant pathogen germs in the faeces of formula-fed preterm infants. Acta Paediatrica Supplement 2005;94:S449;31-3.
Brunser 2006b {published data only}
  • Brunser O, Figueroa G, Gotteland M, Haschke-Becher E, Magliola C, Rochat F, et al. Effects of probiotic or prebiotic supplemented milk formulas on fecal microbiota composition of infants. Asia Pacific Journal of Clinical Nutrition 2006;15:368-76.
Fanaro 2005 {published data only}
  • Fanaro S, Jelinek J, Stahl B, Boehm G, Kock R, Vigi V. Acidic oligosaccharides from pectin hydrolysate as new component for infant formulae: effect on intestinal flora, stool characteristics, and pH. Journal of Pediatric Gastroenterology and Nutrition 2005;41:186-90.
Kapiki 2007 {published data only}
  • Kapiki A, Costalos C, Oikonomidou C, Triantafyllidou A, Loukatou E, Pertrohilou V. The effect of a fructo-oligosaccharide supplemented formula on gut flora of preterm infants. Early Human Development 2007;83:335-9.
Moro 2006 {published data only}
  • Moro G, Arslanoglu S, Stahl B, Jelinek J, Wahn U, Boehm G. A mixture of prebiotic oligosaccharides reduces the incidence of atopic dermatitis during the first six months of age. Archives of Disease in Childhood 2006;91:814-9.
  • Moro GE, Stahl B, Fanaro S, Jelinek R, Boehm G, Coppa GV. Dietary prebiotic oligosaccharides are detectable in the faeces of formula-fed infants. Acta Pædiatrica 2005;94:S449; 27-30.
Ziegler 2007 {published and unpublished data}
  • Ziegler E, Vanderhoof JA, Petschow B, Mitmesser SH, Stolz SI, Harris CL, Berseth CL. Term infants fed formula supplemented with selected blends of prebiotics grow normally and have soft stools similar to those reported for breast-fed infants. Journal of Pediatric Gastroenterology and Nutrition 2007;44:359-64.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Bakker-Zierikzee {published data only}
  • Bakker-Zierikzee AM, Alles MS, Knol J, Kok FJ, Tolboom JJ, Bindels JG. Effects of infant formula containing a mixture of galacto- and fructo-oligosaccharides or viable Bifidobacterium animalis on the intestinal microflora during the first 4 months of life. British Journal of Nutrition 2005;94:783-90.
  • Bakker-Zierikzee AM, Tol EA, Kroes H, Alles MS, Kok FJ, Bindels JG. Faecal SIgA secretion in infants fed on pre- or probiotic infant formula. Pediatric Allergy and Immunology 2006;17:134-40.
Brunser 2006 {published data only}
  • Brunser O, Gotteland M, Cruchet S, Figueroa G, Garrido D, Steenhout P. Effect of a milk formula with prebiotics on the intestinal microbiota of infants after an antibiotic treatment. Pediatric Research 2006;59:451-6.
Decsi 2005 {published data only}
  • Decsi T, Arato A, Balogh M, Dolinay T, Kanjo AH, Szabo E, Varkonyi A. Prebiotikus hatasu oligoszacharidok egeszseges csecsemok szekletflorajara gyakorolt hatasanak randomizalt, placeboval kontrollalt vizsgalata. Orvosi Hetilap 2005;146:2445-50.
Euler 2005 {published data only}
  • Euler AR, Mitchell DK, Kline R, Pickering LK. Prebiotic effect of fructo-oligosaccharide supplemented term infant formula at two concentrations compared with unsupplemented formula and human milk. Journal of Pediatric Gastroenterology and Nutrition 2005;40:157-64.
Haarman 2005 {published data only}
  • Haarman M, Knol J. Quantitative real-time PCR assays to identify and quantify fecal Bifidobacterium species in infants receiving a prebiotic infant formula. Applied and Environmental Microbiology 2005;71:2318-24.
Knol 2005 {published data only}
  • Knol J, Scholtens P, Kafka C, Steenbakkers J, Gro S, Helm K, et al. Colon microflora in infants fed formula with galacto- and fructo-oligosaccharides: more like breast-fed infants. Journal of Pediatric Gastroenterology and Nutrition 2005;40:36-42.
Scholtens 2006 {published data only}
  • Scholtens PA, Alles MS, Willemsen LE, van den Braak C, Bindels JG, Boehm G, Govers MJ. Dietary fructo-oligosaccharides in healthy adults do not negatively affect faecal cytotoxicity: a randomised, double-blind, placebo-controlled crossover trial. British Journal of Nutrition. 95 2006;95:1143-9.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Agostoni 2004
  • Agostoni C, Axelsson I, Goulet O, Koletzko B, Michaelsen KF, Puntis JW, et al. Prebiotic oligosaccharides in dietetic products for infants: a commentary by the ESPGHAN Committee on Nutrition. Journal of Pediatric Gastroenterology and Nutrition 2004;39:465-73.
Arshad 2005
Asher 2004
  • Asher I, Baena-Cagnani C, Boner A, Canonica GW, Chuchalin A, Custovic A, et al. World Allergy Organization guidelines for prevention of allergy and allergic asthma. International Archives of Allergy and Immunology 2004;135:83-92.
Bergmann 1997
Bernsen 2005
Bjorksten 2001
Burr 1989
  • Burr ML, Butland BK, King S, Vaughan-Williams E. Changes in asthma prevalence: two surveys 15 years apart. Archives of Disease in Childhood 1989;64:1452-6.
Halken 2004
  • Halken S. Prevention of allergic disease in childhood: clinical and epidemiological aspects of primary and secondary allergy prevention. Pediatric Allergy and Immunology 2004;15 Suppl 16:4-5.
Hansen 1993
  • Hansen LG, Halken S, Host A, Moller K, Osterballe O. Prediction of allergy from family history and cord blood IgE levels. A follow-up at the age of 5 years. Cord blood IgE. IV. Pediatric Allergy and Immunology 1993;4:34-40.
Holt 1997
Jaakkola 2004
Johansson 2004
  • Johansson SG, Bieber T, Dahl R, Friedmann PS, Lanier BQ, Lockey RF, et al. Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003. Journal of Allergy and Clinical Immunology 2004;113:832-6.
Kalliomaki 2001
  • Kalliomaki M, Kirjavainen P, Eerola E, Kero P, Salminen S, Isolauri E. Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing. Journal of Allergy and Clinical Immunology 2001;107:129-34.
Kjellman 1977
Moro 2002
  • Moro G, Minoli I, Mosca M, Fanaro S, Jelinek J, Stahl B, Boehm G. Dosage-related bifidogenic effects of galacto- and fructooligosaccharides in formula-fed term infants. Journal of Pediatric Gastroenterology and Nutrition 2002;34:291-5.
Murray 2005
Osborn 2007
  • Osborn DA, Sinn JK. Probiotics in infants for prevention of allergy and food hypersensitivity. Cochrane Database of Systematic Reviews 2007, Issue 4. [DOI: 10.1002/14651858.CD006475.pub2]
Osterballe 2005
Prescott 2005
  • Prescott SL, Tang ML, Australasian Society of Clinical Immunology and Allergy. The Australasian Society of Clinical Immunology and Allergy position statement: Summary of allergy prevention in children. Medical Journal of Australia 2005;182:464-7.
Probert 2004
  • Probert HM, Apajalahti JH, Rautonen N, Stowell J, Gibson GR. Polydextrose, lactitol, and fructo-oligosaccharide fermentation by colonic bacteria in a three-stage continuous culture system. Applied and environmental microbiology 2004;70:4505-11.
Raby 2004
Sampson 2004
Schmelzle 2003
  • Schmelzle H, Wirth S, Skopnik H, Radke M, Knol J, Bockler HM. Randomized double-blind study of the nutritional efficacy and bifidogenicity of a new infant formula containing partially hydrolyzed protein, a high beta-palmitic acid level, and nondigestible oligosaccharides. Journal of Pediatric Gastroenterology and Nutrition 2003;36:343-51.
Schultz Larsen 1996
Sudo 1997
  • Sudo N, Sawamura S, Tanaka K, Aiba Y, Kubo C, Koga Y. The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction. Journal of Immunology 1997;159:1739-45.