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Flavonoids for treating venous leg ulcers

  1. Christopher Scallon1,*,
  2. Sally EM Bell-Syer2,
  3. Zoriah Aziz3

Editorial Group: Cochrane Wounds Group

Published Online: 31 MAY 2013

Assessed as up-to-date: 11 FEB 2013

DOI: 10.1002/14651858.CD006477.pub2


How to Cite

Scallon C, Bell-Syer SEM, Aziz Z. Flavonoids for treating venous leg ulcers. Cochrane Database of Systematic Reviews 2013, Issue 5. Art. No.: CD006477. DOI: 10.1002/14651858.CD006477.pub2.

Author Information

  1. 1

    Epsom, Surrey, UK

  2. 2

    University of York, Department of Health Sciences, York, North Yorkshire, UK

  3. 3

    University of Malaya, Department of Pharmacy, Faculty of Medicine, Kuala Lumpur, Malaysia

*Christopher Scallon, 298 Fir Tree Road, Epsom Downs, Epsom, Surrey, KT17 3NN, UK. chris.scallon@hotmail.co.uk.

Publication History

  1. Publication Status: New
  2. Published Online: 31 MAY 2013

SEARCH

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Glinski 1999 {published data only}
  • Glinski W, Chodynicka B, Roszkiewicz J, Boydanowski T, Lecewicz-Torun B, Kaszuba A, et al. The beneficial augmentative effect of micronized purified flavonoid fraction (MPFF) on the healing of leg ulcers: a multicenter controlled study. Phlebology 1999;14(4):151-7.
Guilhou 1997 {published data only}
  • Dereure O, Guilhou JJ, Marzin L, Ouvry P, Zuccarelli F, Debure C, et al. Leg ulcer healing with Daflon 500 mg treatment. Phlebology 1995;Suppl 1:1113-5.
  • Guilhou JJ, Dereure O, Marzin L, Ouvry P, Zuccarelli F, Debure C, et al. Efficacy of Daflon 500 mg in venous leg ulcer healing: a double-blind, controlled versus placebo trial in 107 patients. Angiology 1997;48(1):77-85.
Roztocil 2002 {published data only}
  • Roztocil K, Stvrtinova V, Strejcek J. Efficacy of a 6-month treatment with Daflon 500 mg in patients with venous leg ulcers associated with chronic venous insufficiency. International Angiology 2003;22(1):24-31.
Saveljev 2002 {published and unpublished data}
  • Saveljev VS, Pokrovsky AV, Kirienko AI, Bogachev VU, Bogdanetz LI, Sapelkin SV, et al. Analysis report of an open, randomised, multicentre comparative study of efficiency and safety of Detralex in complementary treatment of complications of chronic venous insufficiency of lower extremities (trophic ulcers). Lab Servier, France 2002.
Schultz-Ehrenburg 1993a {published data only}
  • Schultz-Ehrenburg U, Muller B. Two multicentre clinical trials of two different dosages of O-(B-Hydroxyethyl)-Rutosides in the treatment of leg ulcers. Phlebology 1993;8(Suppl. 1):29-30.
Schultz-Ehrenburg 1993b {published data only}
  • Schultz-Ehrenburg U, Muller B. Two multicentre clinical trials of two different dosages of O-(B-Hydroxyethyl)-Rutosides in the treatment of leg ulcers. Phlebology 1993;8(Supp1.1):29-30.
Stegmann 1986 {published data only}
  • Stegmann WAE, Deichmann B, Hubner K, Muller B. Therapeutic benefit of hydroxyethylrutosides (HR) in venous ulcer treatment. A controlled multicentre study. Phlebology. John Libby & Co Ltd, 1986:617-20.
Zuccarelli 1996 {published data only}
  • Zuccarelli F, Taccoen A, Coget JM, Furderer CR. Treatment of venous ulcers with Troxerutin: a randomised double-blind, controlled study. International Angiology 1996;15(Suppl 1 to No 2):53.
Zuccarelli 2004 {unpublished data only}
  • Zuccarelli F, Rieger H. Effect of Daflon® 500 mg (2 tablets daily) on venous leg ulcers healing in 160 patients treated over a 6-month period. A multicentre, double-blind, randomised, controlled versus placebo, parallel group study. Clinical Report (Lab Servier, France).

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Balmer 1980 {published data only}
  • Balmer A, Limoni C. [Clinical, placebo-controlled double-blind study of venoruton in the treatment of chronic venous insufficiency. Importance of the selection of patients] [Klinische, plazebokontrollierte Doppelblindprufung von Venoruton bei der Behandlung der chronisch-venosen Insuffizienz. Die Bedeutung der Patientenauswahl]. VASA 1980;9(1):76-82.
Belcaro 2005 {published data only}
  • Belcaro G, Cesarone MR, Errichi BM, Ledda A, Di Renzo A, Stuard S, et al. Venous ulcers: microcirculatory improvement and faster healing with local use of Pycnogenol. Angiology 2005;56(6):699-705.
Gilly 1994 {published data only}
  • Gilly R, Pillion G, Frileux C. Evaluation of a new venoactive micronized flavonoid fraction (S 5682) in symptomatic disturbances of the venolymphatic circulation of the lower limb: A double-blind, placebo-controlled study. Phlebology 1994;9:67-70.
Mann 1981 {published data only}
Neumann 1996 {published data only}
  • Neumann HAM, van den Broek MJThB, Crombach NH. Evaluation of O-(beta-Hydroxyethyl-) Rutosides in the prevention of the breakdown of venous ulcers a long-term international multicentre controlled clinical trial. Scripta Phlebologica 1996;4:55-62.
Shrivastava 2011 {published data only}
  • Shrivastava R . Clinical evidence to demonstrate that simultaneous growth of epithelial and fibroblast cells is essential for deep wound healing. Diabetes Research and Clinical Practice 2011;92(1):92-9.
Wright 1991 {published data only}

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
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Baker 1991
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  • Bradley M, Cullum N, Nelson EA, Petticrew M, Sheldon T, Torgerson D. Systematic reviews of wound care management: (2) Dressings and topical agents used in the healing of chronic wounds. Health Technology Assessment 1999;3(Pt 2):1-35.
Callam 1987
Coleridge-Smith 2003
  • Coleridge-Smith P. From skin disorders to venous leg ulcers: pathophysiology and efficacy of Daflon 500 mg in ulcer healing. Angiology 2003;54(Suppl 1):S45-50.
Coleridge-Smith 2005
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Cornwall 1986
Dale 1995
  • Dale J. The aetiology of leg ulceration. In: Cullum N editor(s). Leg ulcers: nursing management - a research-based guide. Scutari Press, 1995.
Dickersin 1993
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Easterbrook 1991
Graham 2003
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Hammerstone 2000
Hasanoglu 2001
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Manach 2004
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Pascarella 2005
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