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Topical silver for preventing wound infection

  1. Marja N Storm-Versloot1,*,
  2. Cornelis G Vos1,
  3. Dirk T Ubbink2,
  4. Hester Vermeulen2

Editorial Group: Cochrane Wounds Group

Published Online: 17 MAR 2010

Assessed as up-to-date: 1 NOV 2009

DOI: 10.1002/14651858.CD006478.pub2


How to Cite

Storm-Versloot MN, Vos CG, Ubbink DT, Vermeulen H. Topical silver for preventing wound infection. Cochrane Database of Systematic Reviews 2010, Issue 3. Art. No.: CD006478. DOI: 10.1002/14651858.CD006478.pub2.

Author Information

  1. 1

    Academic Medical Centre at the University of Amsterdam, Department of Surgery, Amsterdam, Netherlands

  2. 2

    Academic Medical Centre, University of Amsterdam, Quality Assurance & Process Innovation, Amsterdam, Netherlands

*Marja N Storm-Versloot, Department of Surgery, Academic Medical Centre at the University of Amsterdam, Meibergdreef 9, Amsterdam, 1105 AZ, Netherlands. m.n.storm@amc.uva.nl.

Publication History

  1. Publication Status: New
  2. Published Online: 17 MAR 2010

SEARCH

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Afilalo 1992 {published data only}
  • Afilalo M, Dankoff J, Guttman A, Lloyd J. DuoDERM hydroactive dressing versus silver sulphadiazine/Bactigras in the emergency treatment of partial skin thickness burns. Burns 1992;18(4):313-6.
Carneiro 2002 {published data only}
  • Carneiro PM, Rwanyuma LR, Mkony CA. A comparison of topical Phenytoin with Silverex in the treatment of superficial dermal burn wounds. Central African Journal of Medicine 2002;48(9/10):105-8.
Caruso 2006 {published data only}
  • Caruso DM, Foster KN, Blome-Eberwein SA, Twomey JA, Herndon DN, Luterman A, et al. Randomized clinical study of Hydrofiber dressing with silver or silver sulfadiazine in the management of partial-thickness burns. Journal of Burn Care and Research 2006;27(3):298-309.
De Gracia 2001 {published data only}
  • De Gracia CG. An open study comparing topical silver sulfadiazine and topical silver sulfadiazine-cerium nitrate in the treatment of moderate and severe burns. Burns 2001;27(1):67-74.
Dire 1995 {published data only}
  • Dire DJ, Coppola M, Dwyer DA, Lorette JJ, Karr JL. Prospective evaluation of topical antibiotics for preventing infections in uncomplicated soft-tissue wounds repaired in the ED. Academic Emergency Medicine 1995;2(1):4-10.
Fang 1987 {published data only}
  • Fang CH, Nathan P, Robb EC, Alexander JW, MacMillan BG. Prospective clinical study of Hydron, a synthetic dressing, in delivery of an antimicrobial drug to second-degree burns. Journal of Burn Care and Rehabilitation 1987;8(3):206-9.
Gerding 1988 {published data only}
  • Gerding RL, Imbembo AL, Fratianne RB. Biosynthetic Skin Substitute vs. 1% Silver Sulfadiazine for Treatment of Inpatient Partial-thickness Thermal Burns. The Journal of Trauma 1988;28(8):1265-9.
Gerding 1990 {published data only}
  • Gerding RL, Emerman CL, Effron D, Lukens T, Imbembo AL, Fratianne RB. Outpatient management of partial-thickness burns: Biobrane versus 1% silver sulfadiazine. Annals of Emergency Medicine 1990;19(2):121-4.
Hansbrough 1995 {published data only}
  • Hansbrough JF, Achauer B, Dawson J, Himel H, Luterman A, Slater H, et al. Wound healing in partial-thickness burn wounds treated with collagenase ointment versus silver sulfadiazine cream. The Journal of Burn Care and Rehabilitation 1995;16(3 Pt 1):241-7.
Homann 2007 {published data only}
  • Hauser J, Rossbach O, Langer S, Vogt P, Germann G, Steinau HU, et al. Local therapy of grade IIa burns: Efficacy and tolerability of a new hydrosome wound gel for the local treatment of grade IIa burns as compared with silver sulfadiazine ointment [Lokale Behandlung von Grad-IIa-Verbrennungen. Wirksamkeit und Verträglichkeit eines neuartigen hydrosomalen Wundgels im Vergleich zu Silbersulfadiazin-Creme]. Unfallchirurg  2007 2007;110(11):988-94.
  • Homann HH, Rosbach O, Moll W, Vogt PM, Germann G, Hopp M, et al. A liposome hydrogel with polyvinyl-pyrrolidone iodine in the local treatment of partial-thickness burn wounds. Annals of Plastic Surgery 2007;59(4):423-7.
  • Rossbach O, Vogt P, Germann G, et al. Repithel® in comparison with Flammazine® for IIa degree burns. European Wound Management Association Conference; 2005, 15-17 September; Stuttgart, Germany. 2005.
Hutchinson 1993 {published data only}
  • Allen RB, Kerstein M, Klassen H, Friedmann PS, Pryce DW, Lawrence JC, et al. Prospective study of clinical infections in wounds dressed with occlusive versus conventional dressings. 9th Annual Symposium on Advanced Wound Care and 6th Annual Medical Research Forum on Wound Repair; April 20-24; Atlanta. 1996.
  • Hutchinson JJ. A prospective clinical trial of wound dressings to investigate the rate of infection under occlusion. 3rd European Conference on Advances in Wound Management; 19-22 October; Harrogate, UK. 1993.
  • Hutchinson JT. Influence of occlusive dressings on wound microbiology - interim results of a multi-centre clinical trial of an occlusive hydrocolloid dressing. 1st European Conference on Advances in Wound Management; 4-6 September; Cardiff, UK. 1992.
Inman 1984 {published data only}
  • Inman RJ, Snelling CF, Roberts FJ, Shaw K, Boyle JC. Prospective comparison of silver sulfadiazine 1 per cent plus chlorhexidine digluconate 0.2 per cent (Silvazine) and silver sulfadiazine 1 per cent (Flamazine) as prophylaxis against burn wound infection. Burns 1984;11(1):35-40.
Innes 2001 {published data only}
Jacobs 2008 {published data only}
  • Jacobs AM, Tomczak R. Evaluation of Bensal HP for the treatment of diabetic foot ulcers. Advances in Skin and Wound Care 2008;21(10):461-5.
Jude 2007 {published data only}
  • Jude E. Non-ischemic diabetic foot ulcers: Effects of Aquacel Ag with hydrofiber versus alginate dressing. 2nd World Union of Wound Healing Societies Meeting, 8-13 July, Paris. 2004.
  • Jude E, Apelqvist J, Spraul M, Martini J. Randomized controlled study of diabetic foot ulcers dressed with hydrofiber® containing ionic silver or calcium alginate dressings. European Wound Management Association Conference,15-17 September, Stuttgart, Germany. 2005.
  • Jude EB, Apelqvist J, Spraul M, Martini J, and the Silver Dressing Study Group. Prospective randomized controlled study of Hydrofiber dressing containing ionic silver or calcium alginate dressings in non-ischaemic diabetic foot ulcers. Diabetic Medicine 2007;24(3):280-8.
Jurczak 2007 {published data only}
  • Dugré T, Jurczak F, Offori T, et al. Randomized multi-center study comparing open surgical wound outcomes using silver or iodine dressings. European Wound Management Association Conference,15-17 September, Stuttgart, Germany. 2005.
  • Jurczak F, Dugré T, Johnstone A, Offori T, Vujovic Z, Hollander D, on behalf of the AQUACEL Ag Surgical/Trauma Wound Study Group. Randomised clinical trial of Hydrofiber dressing with silver versus povidone-iodine gauze in the management of open surgical and traumatic wounds. International Wound Journal 2007;4(1):66-76.
Livingston 1990 {published data only}
  • Livingston DH, Cryer HG, Miller FB, Malangoni MA, Polk HC, Weiner LJ. A randomized prospective study of topical antimicrobial agents on skin grafts after thermal injury. Plastic and Reconstructive Surgery 1990;86(6):1059-64.
Mashhood 2006 {published data only}
  • Mashhood AA, Khan TA, Sami AN. Honey compared with 1% silver sulfadiazine cream in the treatment of superficial and partial thickness burns. Journal of Pakistan Association of Dermatologists 2006;16:14-9.
Miller 1990 {published data only}
  • Miller L, Hansbrough J, Slater H, Goldfarb IW, Kealey P, Saffle J, et al. Sildimac: a new delivery system for silver sulfadiazine in the treatment of full-thickness burn injuries. Journal of Burn Care & Rehabilitation 1990;11(1):35-41.
Muangman 2006 {published data only}
  • Muangman P, Chuntrasakul C, Silthram S, Suvanchote S, Benjathanung R, Kittidacha S, et al. Comparison of efficacy of 1% silver sulfadiazine and Acticoat for treatment of partial-thickness burn wounds. Journal of the Medical Association of Thailand 2006;89(7):953-8.
Noordenbos 1999 {published data only}
Soroff 1994 {published data only}
  • Soroff HS, Sasvary DH. Collagenase ointment and polymyxin B sulfate/bacitracin spray versus silver sulfadiazine cream in partial-thickness burns: a pilot study. Journal of Burn Care and Rehabilitation 1994;15(1):13-7.
Subrahmanyam 1998 {published data only}
Tredget 1998 {published data only}
  • Tredget EE, Shankowsky HA, Groeneveld A, Burrell R. A matched-pair, randomized study evaluating the efficacy and safety of Acticoat silver-coated dressing for the treatment of burn wounds. Journal of Burn Care and Rehabilitation 1998;19(6):531-7.
Wunderlich 1991 {published data only}
  • Wunderlich U, Orfanos CE. Treatment of venous ulcera cruris with dry wound dressings Phase overlapping use of silver impregnated activated charcoal xero-dressing. Hautarzt 1991;42(7):446-50.
Wyatt 1990 {published data only}
  • Wyatt D, McGowan DN, Najarian MP. Comparison of a hydrocolloid dressing and silver sulfadiazine cream in the outpatient management of second-degree burns. The Journal of Trauma 1990;30(7):857-65.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
De Boer 1981 {published data only}
  • De Boer P, Collinson PO. The use of silver sulphadiazine occlusive dressings for finger-tip injuries. Journal of Bone and Joint Surgery 1981;63-B(4):545-47.
Ganai 2002 {published data only}
  • Ganai AA, Darzi MA, Chowdri NA, Iqbal S, Zaroo MI. Prospective randomized comparative study of early surgical excision and conservative treatment for deep burns of hand. JK Practitioner 2002;9(1):24-7.
Guilbaud 1993 {published data only}
  • Guilbaud J, Honde C. Multicentre comparative clinical study of a new wound dressing: PA286 (Inerpan). European Journal of Plastic Surgery 1993;16(2):73-6.
Hadjiiski 1999 {published data only}
  • Hadjiiski OG, Lesseva MI. Comparison of four drugs for local treatment of burn wounds. European Journal of Emergency Medicine 1999;6(1):41-7.
Huang 2007 {published data only}
  • Huang Y, Li X, Liao Z, Zhang G, Liu Q, Tang J, et al. A randomized comparative trial between Acticoat and SD-Ag in the treatment of residual burn wounds, including safety analysis. Burns 2007;33(2):161-6.
Jorgensen 2006 {published data only}
  • Ivins N, Harding KG, Price P, Jurgensen B, Lohmann M, Gottrup F, et al. Safety and efficacy in long-term use of a sustained silver-releasing foam dressing: a randomized, controlled trial on venous leg ulcers. SAWC 2006 April 30-May 3, 2006 San Antonio, Texas. 2006.
  • Jorgensen B, Bech Thomsen N, Grenov B, Gottrup F. Effect of a new silver dressing on chronic venous leg ulcers with signs of critical colonisation. International Wound Journal 2005;2(1):64-73.
Lanzara 2008 {published data only}
  • Lanzara S, Tacconi G, Gianesini S, Menegatti E, Federici F, Liboni A, et al. A pilot randomized trial to determine the effects of a new active dressing on wound healing of venous leg ulcers [Abstract no. 114]. EWMA Journal 2008;8(2):76.
Molnar 2004 {published data only}
  • Molnar JA, Heimbach DM, Tredgett EE, Mozingo DW. Prospective, randomized, controlled, multicenter trial applying subatmospheric pressure to acute hand burns: an interim report. 2nd World Union of Wound Healing Societies Meeting, 8-13 July, Paris. 2004.
Munster 1980 {published data only}
  • Helvig EI, Munster AM, Su CT, Oppel W. Cerium nitrate-silver sulfadiazine cream in the treatment of burns: a prospective, randomized study. American Surgeon 1979; Vol. 45, issue 4:270-2.
  • Munster AM, Helvig E, Rowland S. Cerium nitrate-silver sulfadiazine cream in the treatment of burns: a prospective evaluation. Surgery 1980;88(5):658-60.
Münter 2006 {published data only}
  • Münter KC, Beele H,   Russell L, Crespi A, Grochenig E, Basse P, et al. Effect of a sustained silver-releasing dressing on ulcers with delayed healing: the CONTOP study. Journal of Wound Care 2006;15(5):199-206.
Planinsek 2007 {published data only}
  • Planinsek Rucigaj T. Comparative effects of honey based and silver/charcoal based dressings on the healing of venous leg ulcers: a randomized clinical study [Oral presentation no: 78]. 17th Conference of the European Wound Management Association; 2007, 2-4 May; Glasgow, Scotland. 2007.
Riesinger 2006 {published data only}
  • Riesinger T, Gubish ER. Clinical evaluation of the efficacy and safety of an innovative moist wound dressing (IWD), containing a nanolayer of metallic silver in patients following an extensive surgical procedure for pectus excavatum. SAWC April 30 - May 3, 2006 San Antonio, Texas. 2006.
Silver 2007 {published data only}
  • Silver GM, Robertson SW, Halerz MM, Conrad P, Supple KG, Gamelli RL. A silver-coated antimicrobial barrier dressing used postoperatively on meshed autografts: A dressing comparison study. Journal of Burn Care and Research 2007;28(5):715-9.
Stair 1986 {published data only}
  • Stair TO, D'Orta J, Altieri MF, Lippe MS. Polyurethane and silver sulfadiazene dressings in treatment of partial-thickness burns and abrasions. American Journal of Emergency Medicine 1986;4(3):214-7.
Subrahmanyam 1991 {published data only}
Terrill 1991 {published data only}
Verdú 2004 {published data only}
  • Verdú SJ, Rueda LJ, Martinez CF, Soldevilla AJ. Effects of an activated charcoal silver dressing on chronic wounds with no clinical signs of infection. Journal of Wound Care 2004;13(10):419, 421-3.
Yue Seng 2005 {published data only}
  • Yue Seng C, Bin Sofiyan M, Bin Mohd Hashim AS. The role of nanocrystalline silver in complicated wounds in the orthopaedic ward. European Wound Management Association Conference; 2005, 15-17 September; Stuttgart, Germany. 2005.

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Chen 2006 {published data only}
  • Chen J, Han CM, Lin XW, Tang ZJ, Su SJ. Effect of silver nanoparticle dressing on second degree burn wound. Chung-Hua Wai Ko Tsa Chih 2006;44(1):50-2.
Hirsch 2008 {published data only}
  • Hirsch T, Ashkar W, Schumacher O, Steinstraesser L, Ingianni G, Cedidi CC. Moist Exposed Burn Ointment (MEBO) in partial thickness burns - a randomized, comparative open mono-center study on the efficacy of dermaheal (MEBO) ointment on thermal 2nd degree burns compared to conventional therapy. European Journal of Medical Research 2008;13(11):505-10.
Li 2006 {published data only}
  • Li XL, Huang YS, Peng YZ, Liao ZJ, Zhang GA, Liu Q, et al. Multi-center clinical study of acticoat (nanocrystalline silver dressing) for the management of residual burn wounds. Zhonghua Shao Shang Za Zhi [Chinese Journal of Burns] 2006;22(1):15-8.
Wang 2008 {published data only}
  • Wang J-W, Teng Y-J. Efficacy of ionic silver dressing and gel in local treatment of dog bite III wounds: A randomized control study. Journal of Clinical Rehabilitative Tissue Engineering Research 2008;12(14):2659-62.

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Serena 2008 {published data only}
  • Hanft J, Serena T, Snyder R. Evaluation of the clinical effectiveness of a collagen-orc antimicrobial matrix in venous leg ulcers. 16th Conference of the European Wound Management Association May 2006 Prague. 2006.
  • Serena TE, Hanft JR, Snyder R. The lack of reliability of clinical examination in the diagnosis of wound infection: preliminary communication. The International Journal of Lower Extremity Wounds 2008;7(1):32-5.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Abedon 1998
  • Abedon ST. Supplemental lecture, 1998. Available from: http://www.mansfield.ohio-state.edu/∼sabedon/biol2007.htm (accessed 10 January 2010).
Adeyemo 2005
Arrowsmith 2001
  • Arrowsmith VA, Maunder JA, Sargent RJ, Taylor R. Removal of nail polish and finger rings to prevent surgical infection. Cochrane Database of Systematic Reviews 2001, Issue 4. [DOI: 10.1002/14651858.CD003325]
Atiyeh 2007
Ballard 2002
  • Ballard K, McGregor F. Product Focus. Avance: silver hydropolymer dressing for critically colonised wounds. British Journal of Nursing 2002;11(3):208-11.
Balthazar 1982
Bergin 2006
Brett 2006
Brooks 2001
  • Brooks RA, Hollinghurst D, Ribbans WJ, Severn M. Bacterial recolonization during foot surgery: a prospective randomized study of toe preparation techniques. Foot & Ankle International 2001;22(4):347-50.
Cooper 2004
  • Cooper R. A review of the evidence for the use of topical antimicrobials agents in wound care. World Wide Wounds. 2004:http://www.worldwidewounds.com/2004/february/Cooper/Topical–Antimicrobial-Agents.html (accessed October 19, 2008).
Cutting 2005
Dowsett 2004
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Dunn 2004
Edwards 2004
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Egger 1997
Fernandez 2008
Fuller 1994
  • Fuller FW, Parrish M, Nance FC. A review of the dosimetry of 1% silver sulfadiazine cream in burn wound treatment. Journal of Burn Care and Rehabilitation 1994;15(3):213-23.
Hartford 1981
Higgins 2003
Higgins 2008
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Hussain 2006
Jakobsen 1993
  • Jakobsen BW, Bach A, Kristensen K, Sorensen TS, Staehr H. Finger tip injuries. A comparative study of silver sulfadiazine and fucidin gauze. Ugeskrift for Laeger 1993;155(45):3654-6.
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Karlsmark 2003
  • Karlsmark T, Agerslev RH, Bendz SH, Larsen JR, Roed-Petersen J, Andersen KE. Clinical performance of a new silver dressing, Contreet Foam, for chronic exuding venous leg ulcers. Journal of Wound Care 2003;12(9):351-4.
Kucan 1981
  • Kucan JO, Robson MC, Heggers JP, Ko F. Comparison of silver sulfadiazine, povidone-iodine and physiologic saline in the treatment of chronic pressure ulcers. Journal of the American Geriatrics Society 1981;29(5):232-5.
Lammers 1990
  • Lammers RL, Fourré M, Callaham ML, Boone T. Effect of povidone-iodine and saline soaking on bacterial counts in acute, traumatic, contaminated wounds. Annals of Emergency Medicine 1990;19(6):709-14.
Lansdown 2002
  • Lansdown AB. Silver. I: Its antibacterial properties and mechanism of action. Journal of Wound Care 2002;11(4):125-30.
Lawson 2003
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Lefebvre 2008
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Lethaby 2008
Mangram 1999
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McLaws 2000
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Nagl 2003
O'Meara 2001
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Ovington 2001
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Ovington 2003
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Peinemann 2008
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Perelman 2004
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Rossoff 1995
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Sibbald 2005
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Stotts 1997
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Tang 2001
Tanner 2006
Tanner 2008
Vermeulen 2007
Vogt 2001
Wasiak 2006
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Wasiak 2008
Wilson 1986
Wilson 2004
  • Wilson AP, Gibbons C, Reeves BC, Hodgson B, Liu M, Plummer D, Krukowski ZH, Bruce J, Wilson J, Pearson A. Surgical wound infection as a performance indicator: agreement of common definitions of wound infection in 4773 patients. BMJ 2004;329(7468):720.