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Oral iron supplements for children in malaria-endemic areas

  1. Joseph U Okebe2,
  2. Dafna Yahav3,
  3. Rana Shbita3,
  4. Mical Paul1,*

Editorial Group: Cochrane Infectious Diseases Group

Published Online: 5 OCT 2011

Assessed as up-to-date: 29 JUN 2011

DOI: 10.1002/14651858.CD006589.pub3


How to Cite

Okebe JU, Yahav D, Shbita R, Paul M. Oral iron supplements for children in malaria-endemic areas. Cochrane Database of Systematic Reviews 2011, Issue 10. Art. No.: CD006589. DOI: 10.1002/14651858.CD006589.pub3.

Author Information

  1. 1

    Sackler Faculty of Medicine, Infectious Diseases Unit, Tel Aviv, Israel

  2. 2

    Medical Research Council Unit, Banjul, Gambia

  3. 3

    Beilinson Hospital, Rabin Medical Center, Department of Medicine E, Petah Tikva, Israel

*Mical Paul, Infectious Diseases Unit, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 49100, Israel. paulm@post.tau.ac.il. mica@zahav.net.il; MichalP2@clalit.org.il; paulm@post.tau.ac.il.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 5 OCT 2011

SEARCH

[Figure 1]
Figure 1. Methodological quality graph: review authors' judgements about each methodological quality item presented as percentages across all included studies. The unclear category for incomplete outcome data represents studies that did not report this outcome, thus the relevant percentages are only those of yes or no.
[Figure 2]
Figure 2. Methodological quality summary: review authors' judgements about each methodological quality item for each included study. The unclear category for incomplete outcome data represents studies that did not report this outcome, thus the relevant percentages are only those of yes or no.
[Figure 3]
Figure 3. Funnel plot of comparison: 1 Iron versus placebo or no treatment, outcome: 1.1 Clinical malaria (by anaemia at baseline).
[Analysis 1.1]
Analysis 1.1. Comparison 1 Iron versus placebo or no treatment, Outcome 1 Clinical malaria (by anaemia at baseline).
[Analysis 1.2]
Analysis 1.2. Comparison 1 Iron versus placebo or no treatment, Outcome 2 Clinical malaria (by age).
[Analysis 1.3]
Analysis 1.3. Comparison 1 Iron versus placebo or no treatment, Outcome 3 Clinical malaria (P. falciparum only).
[Analysis 1.4]
Analysis 1.4. Comparison 1 Iron versus placebo or no treatment, Outcome 4 Severe malaria (clinical malaria with high-grade parasitaemia or requiring admission).
[Analysis 1.5]
Analysis 1.5. Comparison 1 Iron versus placebo or no treatment, Outcome 5 All-cause mortality (by location).
[Analysis 1.6]
Analysis 1.6. Comparison 1 Iron versus placebo or no treatment, Outcome 6 Any parasitaemia, end of treatment (by anaemia at baseline).
[Analysis 1.7]
Analysis 1.7. Comparison 1 Iron versus placebo or no treatment, Outcome 7 Any parasitaemia, end of treatment ( by age).
[Analysis 1.8]
Analysis 1.8. Comparison 1 Iron versus placebo or no treatment, Outcome 8 Any parasitaemia, end of treatment (P. falciparum only).
[Analysis 1.9]
Analysis 1.9. Comparison 1 Iron versus placebo or no treatment, Outcome 9 Any parasitaemia, end of treatment (by allocation concealment).
[Analysis 1.10]
Analysis 1.10. Comparison 1 Iron versus placebo or no treatment, Outcome 10 High-grade parasitaemia.
[Analysis 1.11]
Analysis 1.11. Comparison 1 Iron versus placebo or no treatment, Outcome 11 Any parasitaemia, end of follow up.
[Analysis 1.12]
Analysis 1.12. Comparison 1 Iron versus placebo or no treatment, Outcome 12 Hospitalizations and clinic visits.
[Analysis 1.13]
Analysis 1.13. Comparison 1 Iron versus placebo or no treatment, Outcome 13 Haemoglobin, end of treatment (by anaemia at baseline).
[Analysis 1.14]
Analysis 1.14. Comparison 1 Iron versus placebo or no treatment, Outcome 14 Haemoglobin, end of treatment (by location).
[Analysis 1.15]
Analysis 1.15. Comparison 1 Iron versus placebo or no treatment, Outcome 15 Haemoglobin, change from baseline, end of treatment.
[Analysis 1.16]
Analysis 1.16. Comparison 1 Iron versus placebo or no treatment, Outcome 16 Anaemia, end of treatment (by location).
[Analysis 1.17]
Analysis 1.17. Comparison 1 Iron versus placebo or no treatment, Outcome 17 URTI/pneumonia episodes per patient-month (by location).
[Analysis 1.18]
Analysis 1.18. Comparison 1 Iron versus placebo or no treatment, Outcome 18 Diarrhoeal episodes per patient-month (by location).
[Analysis 1.19]
Analysis 1.19. Comparison 1 Iron versus placebo or no treatment, Outcome 19 Infections per patient-month.
[Analysis 1.20]
Analysis 1.20. Comparison 1 Iron versus placebo or no treatment, Outcome 20 Weight, end value.
[Analysis 1.21]
Analysis 1.21. Comparison 1 Iron versus placebo or no treatment, Outcome 21 Weight, change from baseline.
[Analysis 1.22]
Analysis 1.22. Comparison 1 Iron versus placebo or no treatment, Outcome 22 Height, end value.
[Analysis 1.23]
Analysis 1.23. Comparison 1 Iron versus placebo or no treatment, Outcome 23 Height, change from baseline.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Iron + folic acid versus placebo or no treatment, Outcome 1 Severe malaria (malaria requiring admission).
[Analysis 2.2]
Analysis 2.2. Comparison 2 Iron + folic acid versus placebo or no treatment, Outcome 2 Severe malaria (cerebral malaria).
[Analysis 2.3]
Analysis 2.3. Comparison 2 Iron + folic acid versus placebo or no treatment, Outcome 3 Clinical malaria (by malaria management, including iron + folate).
[Analysis 2.4]
Analysis 2.4. Comparison 2 Iron + folic acid versus placebo or no treatment, Outcome 4 All-cause mortality.
[Analysis 2.5]
Analysis 2.5. Comparison 2 Iron + folic acid versus placebo or no treatment, Outcome 5 Any hospitalization.
[Analysis 2.6]
Analysis 2.6. Comparison 2 Iron + folic acid versus placebo or no treatment, Outcome 6 Haemoglobin, end of treatment (by anaemia at baseline).
[Analysis 2.7]
Analysis 2.7. Comparison 2 Iron + folic acid versus placebo or no treatment, Outcome 7 Haemoglobin, end of treatment (by location).
[Analysis 2.8]
Analysis 2.8. Comparison 2 Iron + folic acid versus placebo or no treatment, Outcome 8 Anaemia, end of treatment ( by location).
[Analysis 2.9]
Analysis 2.9. Comparison 2 Iron + folic acid versus placebo or no treatment, Outcome 9 Weight, end value.
[Analysis 2.10]
Analysis 2.10. Comparison 2 Iron + folic acid versus placebo or no treatment, Outcome 10 Height, end value.
[Analysis 3.1]
Analysis 3.1. Comparison 3 Iron + antimalarial versus placebo, Outcome 1 Clinical malaria.
[Analysis 3.2]
Analysis 3.2. Comparison 3 Iron + antimalarial versus placebo, Outcome 2 All-cause mortality.
[Analysis 3.3]
Analysis 3.3. Comparison 3 Iron + antimalarial versus placebo, Outcome 3 Hospitalizations and clinic visits.
[Analysis 3.4]
Analysis 3.4. Comparison 3 Iron + antimalarial versus placebo, Outcome 4 Haemoglobin at end of treatment.
[Analysis 3.5]
Analysis 3.5. Comparison 3 Iron + antimalarial versus placebo, Outcome 5 Anaemia.
[Analysis 4.1]
Analysis 4.1. Comparison 4 Iron versus control in the treatment of proven malaria, Outcome 1 All-cause mortality.
[Analysis 4.2]
Analysis 4.2. Comparison 4 Iron versus control in the treatment of proven malaria, Outcome 2 Parasitological failure.
[Analysis 4.3]
Analysis 4.3. Comparison 4 Iron versus control in the treatment of proven malaria, Outcome 3 Hospitalizations and clinic visits.
[Analysis 4.4]
Analysis 4.4. Comparison 4 Iron versus control in the treatment of proven malaria, Outcome 4 Haemoglobin at end of treatment.
[Analysis 4.5]
Analysis 4.5. Comparison 4 Iron versus control in the treatment of proven malaria, Outcome 5 Anaemia.
[Analysis 4.6]
Analysis 4.6. Comparison 4 Iron versus control in the treatment of proven malaria, Outcome 6 Infections (pneumonia).