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Routine iron supplementation for preventing or treating iron-deficiency anaemia in children in malaria-endemic areas

  1. Juliana U Ojukwu1,*,
  2. Joseph U Okebe2

Editorial Group: Cochrane Infectious Diseases Group

Published Online: 18 JUL 2007

DOI: 10.1002/14651858.CD006589

How to Cite

Ojukwu JU, Okebe JU. Routine iron supplementation for preventing or treating iron-deficiency anaemia in children in malaria-endemic areas (Protocol). Cochrane Database of Systematic Reviews 2007, Issue 3. Art. No.: CD006589. DOI: 10.1002/14651858.CD006589.

Author Information

  1. 1

    Ebonyi State University, Department of Paediatrics, Abakaliki, Ebonyi State, Nigeria

  2. 2

    Medical Research Council Laboratories, Malaria Programme, Fajara , Banjul, Gambia

*Juliana U Ojukwu, Department of Paediatrics, Ebonyi State University, PMB 077, Abakaliki, Ebonyi State, Nigeria.

Publication History

  1. Publication Status: Unchanged
  2. Published Online: 18 JUL 2007


This is not the most recent version of the article. View current version (05 OCT 2011)


Additional references

Abdalla 1990
  • Abdalla SH. Iron and folate status in Gambian children with malaria. Annals of Tropical Paediatrics 1990;10(3):265-72.
Beard 2001
  • Beard JL. Iron biology in immune function, muscle metabolism and neurological functioning. The Journal of Nutrition 2001;131 Suppl 2(2):568-80.
Berger 2000
  • Berger J, Dyck JL, Galan P, Aplogan A, Schneider D, Traissac P, et al. Effect of daily iron supplementation on iron status, cell-mediated immunity, and incidence of infections in 6-36 month old Togolese children. European Journal of Clinical Nutrition 2000;54(1):29-35.
Biemba 2000
  • Biemba G, Dolmas D, Thuma PE, Weiss G, Gordeuk VR. Severe anaemia in Zambian children with Plasmodium falciparium malaria. Tropical Medicine and International Health 2000;5(1):9-16.
Bloland 1999
  • Bloland PB, Ruebush TK, McCormick JB, Ayisi J, Boriga DA, Oloo AT, et al. Longitudinal cohort study of the epidemiology of malaria infections in an area of intense malaria transmission II. Description of study site, general methodology and study population. American Journal of Tropical Medicine and Hygiene 1999;60(4):635-40.
Bojang 1997
  • Bojang KA, Palmer A, Boele van Hensbroek M, Banya WA, Greenwood BM. Management of severe malarial anaemia in Gambian children. Transactions of the Royal Society of Tropical Medicine and Hygiene 1997;91(5):557-61.
Breman 2001
  • Breman JG. The ears of the hippopotamus: manifestations, determinants, and estimates of the malaria burden. American Journal of Tropical Medicine and Hygiene 2001;64 Suppl 1-2:1-11.
Crawley 2004
  • Crawley J. Reducing the burden of anemia in infants and young children in malaria-endemic countries of Africa: from evidence to action. American Journal of Tropical Medicine and Hygiene 2004;71 Suppl 2:25-34.
Desai 2004
  • Desai MR, Dhar R, Rosen DH, Kariuki SK, Shi YP, Kager PA, et al. Daily iron supplementation is more efficacious than twice weekly iron supplementation for the treatment of childhood anemia in western Kenya. Journal of Nutrition 2004;134(5):1167-74.
Ekvall 2003
  • Ekvall H. Malaria and anaemia. Current Opinion in Haematology 2003;10(2):108-14.
FAO/WHO 2005
  • Joint FAO/WHO Expert Consultation on Human Vitamin, Mineral Requirements. Iron. Vitamin and mineral requirements in human nutrition. 2nd Edition. Geneva: World Health Organization, 2005:246-78.
Gera 2002
  • Gera T, Sachdev HP. Effect of iron supplementation on incidence of infectious illness in children: systematic review. BMJ 2002;325(7373):1142.
Grantham 2001
  • Grantham-McGregor S, Ani C. A review of studies on the effect of iron deficiency on cognitive development in children. Journal of Nutrition 2001;131 Suppl 2(2):649-66.
Greenwood 1997
  • Greenwood BM. The epidemiology of malaria. Annals of Tropical Medicine and Parasitology 1997;91(7):763-9.
Haas 2001
  • Haas JD, Brownlie T 4th. Iron deficiency and reduced work capacity: a critical review of the research to determine a causal relationship. Journal of Nutrition 2001;131 Suppl 2(2):676-88.
Harvey 1989
  • Harvey PWJ, Heywood PF, Nesheim MC, Galme K, Zegans M, Habicht JP, et al. The effect of iron therapy on malarial infection in Papua New Guinean schoolchildren. American Journal of Tropical Medicine and Hygiene 1989;40(1):12-8.
Hay 2004
  • Hay SI, Guerra CA, Snow RW. Report on agreement to perform work (APW). Determination of populations at malaria risks [Ref. M50/370/19]. 2004 (accessed 20 March 2007).
Higgins 2006
  • Higgins JPT, Green S, editors. Highly sensitive search strategies for identifying reports of randomized controlled trials in MEDLINE. Cochrane Handbook for Systematic Reviews of Interventions 4.2.6 [updated September]; Appendix 5b. handbook/hbook.htm (accessed 1 March 2007).
INACG 1999
  • International Nutritional Anemia Consultative Group (INACG). INACG consensus statement: Safety of iron supplementation programs in malaria-endemic regions. 1999 (accessed 7 February 2007).
Jüni 2001
  • Jüni P, Altman DG, Edder M. Systematic reviews in health care: Assessing the quality of controlled clinical trials. BMJ 2001;323(7303):42-6.
Kahigwa 2002
  • Kahigwa E, Schellenberg D, Sanz S, Aponte JJ, Wigayi J, Mshinda H, et al. Risk factors for presentation to hospital with severe anaemia in Tanzanian children: a case-control study. Tropical Medicine and International Health 2002;7(10):823-30.
Kochan 1973
  • Kochan I. The role of iron in bacterial infections with special consideration of host-tubercle bacillus interaction. Current Topics in Microbiology and Immunology 1973;60:1-30.
Lawless 1994
  • Lawless JW, Latham MC, Stephenson LS, Kinoti SN, Pertet AM. Iron supplementation improves appetite and growth in anaemic Kenyan school children. Journal of Nutrition 1994;124(5):645-54.
Martins 2001
  • Martins S, Logan S, Gilbert R. Iron therapy for improving psychomotor development and cognitive function in children under the age of three with iron deficiency anaemia. Cochrane Database of Systematic Reviews 2001, Issue 2. [DOI: DOI: 10.1002/14651858.CD001444]
Mebrahtu 2004
  • Mebrahtu T, Stoltzfus RJ, Chwaya HM, Jape JK, Savioli L, Montresor A, et al. Low-dose daily iron supplementation for 12 months does not increase the prevalence of malarial infection or density of parasites in young Zanzibari children. Journal of Nutrition 2004;134(11):3037-41.
Menendez 1997
  • Menendez C, Kahigwa E, Hirt R, Vounatsou P, Aponte JJ, Font F, et al. Randomized placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants. Lancet 1997;350(9081):844-50.
Menendez 2000
  • Menendez C, Fleming AF, Alonso PL. Malaria-related anaemia. Parasitology Today 2000;16(11):469-76.
Murray 1978
  • Murray MJ, Murray AB, Murray MB, Murray CJ. The adverse effect of iron repletion on the course of certain infections. British Medical Journal 1978;2(6145):1113-5.
Newton 1997
  • Newton CR, Warn PA, Winstanley PA, Peshu N, Snow RW, Pasvol G, et al. Severe anaemia in children living in a malaria endemic area of Kenya. Tropical Medicine and International Health 1997;2(1):165-78.
Nyakeriga 2004
  • Nyakeriga AM, Troye-Blomberg M, Dorfman JR, Alexander ND, Back R, Kortok M, et al. Iron deficiency and malaria among children living on the coast of Kenya. Journal of Infectious Diseases 2004;191(4):439-47.
Oppenheimer 1986
  • Oppenheimer SJ, Gibson FD, Macfarlane SB, Moody JB, Harrison C, Spencer A, et al. Iron supplementation increases prevalence and effects of malaria: report on clinical studies in Papua New Guinea. Transactions of the Royal Society of Tropical Medicine and Hygiene 1986;80(4):603-12.
Oppenheimer 2001
  • Oppenheimer SJ. Iron and its relation to immunity and infectious disease. Journal of Nutrition 2001;131 Suppl 2(2):616-33.
Parmar 1998
  • Parmar MK, Torri V, Steward L. Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. Statistics in Medicine 1998;17(24):2815-34.
Pollitt 1993
  • Pollitt E. Iron deficiency and cognitive function. Annual Review of Nutrition 1993;13:521-37.
Ramakrishnan 2004
  • Ramakrishnan U, Aburto N, McCabe G, Martorell R. Multimicronutrient Interventions but not vitamin A or iron interventions alone improve child growth: results of 3 meta-analyses. Journal of Nutrition 2004;134(10):2592-602.
Review Manager 5
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). 5.0. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2008.
Sachdev 2005
  • Sachdev H, Gera T, Nestel P. Effect of iron supplementation on mental and motor development in children: systematic review of randomised controlled trials. Public Health Nutrition 2005;8(2):117-32.
Sazawal 2006
  • Sazawal S, Black RE, Ramsan M, Chwaya HM, Stoltzfus RJ, Dutta A, et al. Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomized, placebo-controlled trial. Lancet 2006;367(9505):133-43.
Schellenberg 1999
  • Schellenberg D, Menendez C, Kahigwa E, Font F, Galindo C, Acosta C, et al. African children with malaria in an area of intense Plasmodium falciparum transmission: features on admission to the hospital and risk factors for death. American Journal of Tropical Medicine and Hygiene 1999;61(3):431-8.
Slutsker 1994
  • Slutsker L, Taylor TE, Wirima JJ, Steketee RW. In-hospital morbidity and mortality due to malaria-associated severe anaemia in two areas of Malawi with different patterns of malaria infection. Transactions of the Royal Society of Tropical Medicine and Hygiene 1994;88(5):548-51.
Smith 1989
  • Smith AW, Hendrickse RG, Harrison C, Hayes RJ, Greenwood BM. The effects on malaria of treatment of iron-deficiency anaemia with oral iron in Gambian children. Annals of Tropical Paediatrics 1989;9(1):17-23.
Stoltzfus 1997
  • Stoltzfus RJ, Dreyfuss ML, Chwaya HM, Albonico M. Hookworm control as a strategy to prevent iron deficiency. Nutrition Review 1997;55(6):223-32.
Stoltzfus 1998
  • Stoltzfus R, Dreyfuss ML, INACG, WHO, UNICEF. Guidelines for the use of iron supplements to prevent and treat iron deficiency anaemia. Washington, D. C.: ILSI Press, 1998.
Tielsch 2006
  • Tielsch JM, Khatry S, Stoltzfus R, Katz J, LeClerq S, Adhikan R, et al. Effect of routine prophylactic supplementation with iron and folic acid on preschool child mortality in Southern Nepal: community-based, cluster-randomized, placebo-controlled trial. Lancet 2006;367(9505):144-52.
  • UNICEF. Spotlight on iron. The state of the world's children 1998 []. Oxford and New York: Oxford University Press for UNICEF, 1998:78.
van Hensbroek 1995
  • van Hensbroek MB, Morris-Jones, Meisner S, Jaffar S, Bayo L, Dackour R, et al. Iron, but not folic acid, combined with effective antimalarial therapy promotes haematological recovery in African children after acute falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene 1995;89(5):672-9.
WHO 2001
  • World Health Organization. Dept. of Nutrition for Health and Development. Iron deficiency anaemia : assessment, prevention and control : a guide for programme managers [WHO/NHD/01.3]. Geneva: World Health Organization, 2001.
WHO 2003
  • World Health Organization, Malaria Control Unit. The Africa malaria report 2003 [WHO/CDS/MAL/2003.1093]. Geneva: World Health Organization, 2003.
WHO 2004
  • Stoltzfus RJ, Mullany L, Black RE. Iron deficiency anaemia. In: Ezzati M, Lopez AD, Rodgers A, Murray CJL editor(s). Comparative quantification of health risks: global and regional burden of disease attributable to selected major risk factors. Volume 1. Geneva: World Health Organization, 2004.