Intervention Review

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Methods of preventing bacterial sepsis and wound complications after liver transplantation

  1. Kurinchi Selvan Gurusamy1,*,
  2. Myura Nagendran2,
  3. Brian R Davidson1

Editorial Group: Cochrane Hepato-Biliary Group

Published Online: 5 MAR 2014

Assessed as up-to-date: 9 FEB 2013

DOI: 10.1002/14651858.CD006660.pub3


How to Cite

Gurusamy KS, Nagendran M, Davidson BR. Methods of preventing bacterial sepsis and wound complications after liver transplantation. Cochrane Database of Systematic Reviews 2014, Issue 3. Art. No.: CD006660. DOI: 10.1002/14651858.CD006660.pub3.

Author Information

  1. 1

    Royal Free Campus, UCL Medical School, Department of Surgery, London, UK

  2. 2

    Department of Surgery, UCL Division of Surgery and Interventional Science, London, UK

*Kurinchi Selvan Gurusamy, Department of Surgery, Royal Free Campus, UCL Medical School, Royal Free Hospital, Rowland Hill Street, London, NW3 2PF, UK. k.gurusamy@ucl.ac.uk.

Publication History

  1. Publication Status: New search for studies and content updated (conclusions changed)
  2. Published Online: 5 MAR 2014

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Arnow 1996 {published data only}
  • Arnow PM, Carandang GC, Zabner R, Irwin ME. Randomized controlled trial of selective bowel decontamination for prevention of infections following liver transplantation. Clinical Infectious Diseases 1996;22(6):997-1003.
Bion 1994 {published data only}
  • Badger IL, Crosby HA, Kong KL, Baker JP, Hutchings P, Elliott TS, et al. Is selective decontamination of the digestive tract beneficial in liver transplant patients? Interim results of a prospective, randomized trial. Transplantation Proceedings 1991;23(1 Part 2):1460-1.
  • Bion JF, Badger I, Crosby HA, Hutchings P, Kong KL, Baker J, et al. Selective decontamination of the digestive tract reduces gram-negative pulmonary colonization but not systemic endotoxemia in patients undergoing elective liver transplantation. Critical Care Medicine 1994;22(1):40-9.
Hellinger 2002 {published and unpublished data}
  • Hellinger WC, Yao JD, Alvarez S, Blair JE, Cawley JJ, Paya CV, et al. A randomized, prospective, double-blinded evaluation of selective bowel decontamination in liver transplantation. Transplantation 2002;73(12):1904-9.
Rayes 2002 {published and unpublished data}
  • Rayes N, Brammer M, Hansen S, Mueller AR, Serke S, Seehofer D, et al. Early enteral supply of lactobacilli and fiber versus SBD - a prospective randomized trial in liver transplant recipients (abstract). Journal of Hepatology 2001;34(1):199.
  • Rayes N, Seehofer D, Hansen S, Boucsein K, Muller AR, Serke S, et al. Early enteral supply of lactobacillus and fiber versus selective bowel decontamination: a controlled trial in liver transplant recipients. Transplantation 2002;74(1):123-7.
  • Rayes N, Seehofer D, Muller AR, Hansen S, Bengmark S, Neuhaus P. Influence of probiotics and fibre on the incidence of bacterial infections following major abdominal surgery - results of a prospective trial. Zeitschrift für Gastroenterologie 2002;40(10):869-76.
Rayes 2005 {published and unpublished data}
Winston 1999 {published data only}
  • Winston DJ, Foster PF, Somberg KA, Busuttil RW, Levy MF, Sheiner PA, et al. Randomized, placebo-controlled, double-blind, multicenter trial of efficacy and safety of granulocyte colony-stimulating factor in liver transplant recipients. Transplantation 1999;68(9):1298-304.
Zwaveling 2002 {published data only}
  • Maring JK, Zwaveling JH, Klompmaker IJ, van der Meer J, Slooff MJ. Selective bowel decontamination in elective liver transplantation: no improvement in endotoxaemia, initial graft function and post-operative morbidity. Transplant International 2002;15(7):329-34.
  • Zwaveling JH, Maring JK, Klompmaker IJ, Haagsma EB, Bottema JT, Laseur M, et al. Selective decontamination of the digestive tract to prevent postoperative infection: a randomized placebo-controlled trial in liver transplant patients. Critical Care Medicine 2002;30(6):1204-9.
  • van Enckevort PJ, Zwaveling JH, Bottema JT, Maring JK, Klompmaker IJ, Slooff MJH, et al. Cost effectiveness of selective decontamination of the digestive tract in liver transplant patients. Pharmacoeconomics 2001;19(5):523-30.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Biasi 2002 {published data only}
  • Biasi F, Poli G, Salizzoni M, Cerutti E, Battista S, Mengozzi G, et al. Effect of perioperative infusion of antioxidants on neutrophil activation during liver transplantation in humans. Transplantation Proceedings 2002;34(3):755-8.
Cisneros 1993 {published data only}
  • Cisneros AC, Sanchez IRJA, Montejo GJC, Arribas LP, Martinez DLGA. Infections in the post-surgical period of liver transplantation. Comparison of two protocols with anti-infective prophylaxis. Revista Clinica Espanola 1993;192(3):112-5.
Decruyenaere 1995 {published data only}
  • Decruyenaere J, Colardyn F, Vogelaers D, Claeys G, Hesse U, De Deyne C, et al. Combined use of fluconazole and selective digestive decontamination in the prevention of fungal infection after adult liver transplantation. Transplantation Proceedings 1995;27(6):3515-6.
Hasse 1995 {published data only}
  • Hasse JM, Blue LS, Liepa GU, Goldstein RM, Jennings LW, Mor E, et al. Early enteral nutrition support in patients undergoing liver transplantation. Journal of Parenteral and Enteral Nutrition 1995;19(6):437-43.
Ott 2006 {published data only}
  • Ott R, Bussenius-Kammerer M, Reck T, Hering C, Muller V, Riese J, et al. Does the inactivation of leukocytes in blood transfusions during and following liver transplantation by gamma-irradiation have an impact on rejection and infection rate?. Medical Science Monitor 2006;12(12):514-20.
Philpott-Howard 2003 {published data only}
  • Philpott-Howard J, Burroughs A, Fisher N, Hastings M, Kibbler C, Mutimer D, et al. Piperacillin-tazobactam versus ciprofloxacin plus amoxicillin in the treatment of infective episodes after liver transplantation. Journal of Antimicrobial Chemotherapy 2003;52(6):993-1000.
Smith 1993 {published data only}
  • Smith SD, Jackson RJ, Hannakan CJ, Wadowsky RM, Tzakis AG, Rowe MI. Selective decontamination in pediatric liver transplants. A randomized prospective study. Transplantation 1993;55(6):1306-9.
van Saene 2003 {published data only}
  • van Saene HK, Silvestri L, Bams JL, van der Voort PH, Zandstra DF. Selective decontamination of the digestive tract: use in liver transplantation is evidence based. Critical Care Medicine 2003;31(5):1600-1.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Agopian 2013
  • Agopian VG, Petrowsky H, Kaldas FM, Zarrinpar A, Farmer DG, Yersiz H, et al. The evolution of liver transplantation during 3 decades: analysis of 5347 consecutive liver transplants at a single center. Annals of Surgery 2013;258(3):409-21.
Blair 2005
Bombuy 2004
  • Bombuy E, Fondevila C, Rodriguez-Laiz G, Ferrer J, Amador A, Valentini M, et al. Ischemic preconditioning in adult living donor liver transplantation, a pilot study [EASL abstract]. Journal of Hepatology 2004;40(Suppl 1):39.
Bonnel 2011
Bratzler 2013
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References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Gurusamy 2008