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Vitamin C for preventing and treating tetanus

  1. Harri Hemilä*,
  2. Teija Koivula

Editorial Group: Cochrane Wounds Group

Published Online: 13 NOV 2013

Assessed as up-to-date: 16 JUN 2013

DOI: 10.1002/14651858.CD006665.pub3


How to Cite

Hemilä H, Koivula T. Vitamin C for preventing and treating tetanus. Cochrane Database of Systematic Reviews 2013, Issue 11. Art. No.: CD006665. DOI: 10.1002/14651858.CD006665.pub3.

Author Information

  1. University of Helsinki, Department of Public Health, POB 41, Helsinki, Finland

*Harri Hemilä, Department of Public Health, POB 41, University of Helsinki, Mannerheimintie 172, Helsinki, FIN-00014, Finland. harri.hemila@helsinki.fi.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 13 NOV 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. Additional references
  3. References to other published versions of this review
Jahan 1984 {published data only}
  • Jahan K. Letter from Professor Khursheed Jahan. 9 July 2007.
  • Jahan K, Ahmad K, Ali MA. Effect of ascorbic acid in the treatment of tetanus. Bangladesh Medical Research Council Bulletin 1984;10(1):24-8. [: http://www.mv.helsinki.fi/home/hemila/CT/Jahan1984.pdf; PUBMED: 6466264]

Additional references

  1. References to studies included in this review
  2. Additional references
  3. References to other published versions of this review
Afshar 2011
Ataro 2011
Bjorndahl 2012
Briggs 1984
  • Briggs M. Vitamin C and infectious disease: a review of the literature and the results of a randomized, double-blind, prospective study over 8 years. In: Briggs MH editor(s). Recent Vitamin Research. Boca Raton, FL: CRC Press, 1984:39-82.
Büller Souto 1939
  • Büller Souto A, Lima C. Effect of vitamin C on Bacillus perfringensis toxin (see data extracted and analysed in Clemetson 2002 and in Hemilä 2006:115) [Action de la vitamine C sur la toxine du Bacillus perfringens]. Memorias do Instituto Butantan 1939;12:265-95 [in Portuguese]; 297-311 [in French; same data]. [: http://www.mv.helsinki.fi/home/hemila/CT/Buller1939.pdf]
Cameron 1976
Campbell 1975
  • Campbell GD, Steinberg MH, Bower JD. Ascorbic acid-induced hemolysis in G-6-PD deficiency. Annals of Internal Medicine 1975;82(6):810. [: http://www.mv.helsinki.fi/home/hemila/CC/Campbell1975.pdf; PUBMED: 1138591]
Carpenter 1986
  • Carpenter KJ. The History of Scurvy and Vitamin C. Cambridge: Cambridge University Press, 1986.
Cathcart 1981
CDC 2013
  • CDC (Centers for Disease Control and Prevention). Tetanus. http://www.cdc.gov/vaccines/pubs/pinkbook/downloads/tetanus.pdf 2013.
Chakrabarti 1955
  • Chakrabarti B, Banerjee S. Dehydroascorbic acid level in blood of patients suffering from various infectious diseases. Proceedings of the Society for Experimental Biology and Medicine 1955;88(4):581-3. [: http://www.mv.helsinki.fi/home/hemila/CT/Chakrabarti1955.pdf; PUBMED: 14371706]
Clemetson 2002
Cook 2007
  • Cook NR, Albert CM, Gaziano JM, Zaharris E, MacFadyen J, Danielson E, et al. A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: results from the Women's Antioxidant Cardiovascular Study. Archives of Internal Medicine 2007;167(15):1610-8. [DOI: 10.1001/archinte.167.15.1610; PUBMED: 17698683]
Daher 1997
  • Daher EF, Abdulkader RC, Motti E, Marcondes M, Sabbaga E, Burdmann EA. Prospective study of tetanus-induced acute renal dysfunction: role of adrenergic overactivity. American Journal of Tropical Medicine and Hygiene 1997;57(5):610-4. [PUBMED: 9392604]
Demicheli 2013
Dey 1966
  • Dey PK. Efficacy of vitamin C in counteracting tetanus toxin toxicity. Naturwissenschaften 1966;53(12):310. [PUBMED: 5986216]
Diliberto 1991
  • Diliberto EJ Jr, Daniels AJ, Viveros OH. Multicompartmental secretion of ascorbate and its dual role in dopamine beta-hydroxylation. American Journal of Clinical Nutrition 1991;54(Suppl 6):1163S-72S. [PUBMED: 1962565]
Gergen 1995
Gibson 2009
Glasziou 2007
Hathcock 2005
  • Hathcock JN, Azzi A, Blumberg J, Bray T, Dickinson A, Frei B, et al. Vitamins E and C are safe across a broad range of intakes. American Journal of Clinical Nutrition 2005;81(4):736-45. [PUBMED: 15817846]
Hemilä 2006
  • Hemilä H. Do vitamins C and E affect respiratory infections?. [Dissertation] University of Helsinki, Helsinki, Finland 2006:5-9,62-63,112,115.
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Higgins 2011
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1 [updated March 2011]. Vol. section 8.3.3, The Cochrane Collaboration, 2011.
Hrobjartsson 2010
IOM 2000
  • IOM (Institute of Medicine). Vitamin C. Dietary reference intakes for vitamin C, vitamin E, selenium and carotenoids. Washington DC: National Academy Press, 2000:95-185.
Kato 2006
Khan 2013
Klenner 1954
  • Klenner FR. Recent discoveries in the treatment of lockjaw with vitamin C and tolserol. Tri-State Medical Journal 1954;2(July):7-11. [: http://www.mv.helsinki.fi/home/hemila/CT/Klenner1954.pdf]
Levine 1996
Levy 2002
  • Levy TE. Vitamin C, Infectious Diseases, and Toxins. Xlibris, 2002.
Nathens 2002
  • Nathens AB, Neff MJ, Jurkovich GJ, Klotz P, Farver K, Ruzinski JT, et al. Randomized, prospective trial of antioxidant supplementation in critically ill surgical patients. Annals of Surgery 2002;236(6):814-22. [: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1422648/]
Padayatty 2004
Padayatty 2006
Padayatty 2010
Papoulidis 2011
  • Papoulidis P, Ananiadou O, Chalvatzoulis E, Ampatzidou F, Koutsogiannidis C, Karaiskos T, et al. The role of ascorbic acid in the prevention of atrial fibrillation after elective on-pump myocardial revascularization surgery: a single-center experience--a pilot study. Interactive Cardiovascular and Thoracic Surgery 2011;12(2):121-4. [DOI: 10.1510/icvts.2010.240473; PUBMED: 21098510]
Patak 2004
Qin 2001
R-Project 2013
  • http://www.r-project.org/. The R Project for Statistical Computing. http://www.r-project.org/, 2013.
Reddy 2010
  • Reddy P, Bleck TP. Clostridium tetani (tetanus). In: Mandell GL, Bennett JE, Dolin R editor(s). Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 7th Edition. Vol. 2, Philadelphia: Elsevier Churchill Livingstone, 2010:3091-6.
RevMan 2012
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager. 5.2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2012.
Rice 2000
Rothman 1998
  • Rothman KJ, Greenland S. Small sample statistics for pure count data. Modern Epidemiology. 2nd Edition. London: Lippincott, Williams, Wilkins, 1998:250-2.
Sesso 2008
Stone 1972
  • Stone I. The Healing Factor. Vitamin C Against Disease. New York, NY: Grosset & Dunlap, 1972.
Tanaka 2000
Thwaites 2006
Thwaites 2006a
Wasay 2005
Webb 2007
WHO 1999
  • WHO. Recent outbreaks of scurvy. Scurvy and its prevention and control in major emergencies. WHO/NHD/99.11. WHO, 1999:1-4 (Table 2). [: http://whqlibdoc.who.int/hq/1999/WHO_NHD_99.11.pdf]
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WHO 2013
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Yuan 1997
  • Yuan L, Lau W, Thipphawong J, Kasenda M, Xie F, Bevilacqua J. Diphtheria and tetanus immunity among blood donors in Toronto. CMAJ 1997;156(7):985-90. [PUBMED: 9099166]

References to other published versions of this review

  1. References to studies included in this review
  2. Additional references
  3. References to other published versions of this review
Hemilä 2008
Hemilä 2010
  • Hemilä H, Koivula T. Vitamin C for preventing and treating tetanus. Cochrane Database of Systematic Reviews 2010, Issue 2. [DOI: 10.1002/14651858.CD006665.pub2]
Hemilä 2011
  • Hemilä H, Koivula T. Vitamin C for preventing and treating tetanus. Cochrane Database of Systematic Reviews 2011, Issue 10. [DOI: 10.1002/14651858.CD006665.pub2]