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Azithromycin for treating uncomplicated malaria

  1. Anna M van Eijk*,
  2. Dianne J Terlouw

Editorial Group: Cochrane Infectious Diseases Group

Published Online: 16 FEB 2011

Assessed as up-to-date: 6 DEC 2010

DOI: 10.1002/14651858.CD006688.pub2


How to Cite

van Eijk AM, Terlouw DJ. Azithromycin for treating uncomplicated malaria. Cochrane Database of Systematic Reviews 2011, Issue 2. Art. No.: CD006688. DOI: 10.1002/14651858.CD006688.pub2.

Author Information

  1. Liverpool School of Tropical Medicine, Child & Reproductive Health Group, Liverpool, UK

*Anna M van Eijk, Child & Reproductive Health Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK. amvaneijk@yahoo.com.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 16 FEB 2011

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to ongoing studies
  3. Additional references
Dunne 2005a {published data only}
  • Dunne MW, Singh N, Shukla M, Valecha N, Bhattacharyya PC, Patel K, et al. A double-blind, randomized study of azithromycin compared to chloroquine for the treatment of Plasmodium vivax malaria in India. American Journal of Tropical Medicine and Hygiene 2005;73(6):1108-11.
Dunne 2005b {published data only}
  • Dunne MW, Singh N, Shukla M, Valecha N, Bhattacharyya PC, Dev V, et al. A multicenter study of azithromycin, alone and in combination with chloroquine, for the treatment of acute uncomplicated Plasmodium falciparum malaria in India. Journal of Infectious Diseases 2005;191(10):1582-8.
Krudsood 2000 {published data only}
  • Krudsood S, Silachamroon U, Wilairatana P, Singhasivanon P, Phumratanaprapin W, Chalermrut K, et al. A randomized clinical trial of combinations of artesunate and azithromycin for treatment of uncomplicated Plasmodium falciparum malaria in Thailand. Southeast Asian Journal of Tropical Medicine and Public Health 2000;31(4):801-7.
Krudsood 2002 {published data only}
  • Krudsood S, Buchachart K, Chalermut K, Charusabha C, Treepasertsuk S, Haoharn O, et al. A comparative clinical trial of combinations of dihydroartemisinin plus azithromycin and dihydroartemisinin plus mefloquine for treatment of multidrug resistant falciparum malaria. Southeast Asian Journal of Tropical Medicine and Public Health 2002;33(3):525-31.
Miller 2006 {published data only}
  • Miller RS, Wongsrichanalai C, Buathong N, McDaniel P, Walsh DS, Knirsch C, et al. Effective treatment of uncomplicated Plasmodium falciparum malaria with azithromycin-quinine combinations: a randomized, dose ranging study. American Journal of Tropical Medicine and Hygiene 2006;74(3):401-6.
Na-Bangchang 1996 {published data only}
  • Na-Bangchang K, Kanda T, Tipawangso P, Thanavibul A, Suprakob K, Ibrahim M, et al. Activity of artemether-azithromycin versus artemether-doxycycline in the treatment of multiple drug resistant falciparum malaria. Southeast Asian Journal of Tropical Medicine and Public Health 1996;27(3):522-5.
Noedl 2006 {published and unpublished data}
  • Noedl H, Krudsood S, Chalermratana K, Silachamroon U, Leowattana W, Tangpukdee N, et al. Azithromycin combination therapy with artesunate or quinine for the treatment of uncomplicated Plasmodium falciparum malaria in adults: A randomized, phase 2 clinical trial in Thailand. Clinical Infectious Diseases 2006;43:1264-71.
Pfizer 282919 {published and unpublished data}
  • Pfizer Inc. A three day trial of azithromycin plus chloroquine for the treatment of uncomplicated Plasmodium falciparum malaria. http://www.clinicaltrials.gov/ct/show/NCT00282919 2008.
Pfizer 367653 {published and unpublished data}
  • Pfizer Inc. A phase-3, randomized, open-label, comparative trial of azithromycin plus chloroquine versus mefloquine for the treatment of uncomplicated Plasmodium falciparum malaria in Africa. http://pdf.clinicalstudyresults.org/documents/company-study_4619_0.pdf 2008.
Pfizer 74841 {published and unpublished data}
  • Pfizer Inc. A phase 2/3 randomized, comparative trial of azithromycin plus chloroquine for the treatment of uncomplicated Plasmodium falciparum malaria in India. http://pdf.clinicalstudyresults.org/documents/company-study_1101_0.pdf 2007.
Pfizer 82563 {published and unpublished data}
  • Pfizer Inc. A phase 2, double blind, randomized, comparative trial of azithromycin in combination with chloroquine versus chloroquine in the eradication of asymptomatic Plasmodium falciparum infection in semi-immune adults. http://pdf.clinicalstudyresults.org/documents/company-study_1764_0.pdf 2007.
Pfizer 82576 {published and unpublished data}
  • Pfizer Inc. A phase 2/3, randomized, double-blind, comparative trial of azithromycin plus chloroquine versus mefloquine for the treatment of uncomplicated Plasmodium falciparum malaria in Africa. http://pdf.clinicalstudyresults.org/documents/company-study_2362_0.pdf 2007.
Pfizer 84227 {published and unpublished data}
  • Pfizer Inc. A phase 2/3, randomized, double blind, comparative trial of azithromycin plus chloroquine versus atovaquone-proguanil for the treatment of uncomplicated Plasmodium falciparum malaria in South America. http://pdf.clinicalstudyresults.org/documents/company-study_1770_0.pdf 2007.
Pfizer 84240 {published and unpublished data}
  • Pfizer Inc. A phase 2/3, randomized, comparative, double blind trial of azithromycin plus chloroquine versus sulfadoxine-pyrimethamine plus chloroquine for the treatment of uncomplicated, symptomatic falciparum malaria in Southeast Asia. http://pdf.clinicalstudyresults.org/documents/company-study_1765_0.pdf 2007.
Pukrittayakamee 2001 {published data only}
  • Pukrittayakamee A, Clemens R, Chantra A, Nontprasert A, Luknam T, Looareesuwan S, et al. Therapeutic responses to antibacterial drugs in vivax malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene 2001;95:524-8.
Sykes 2009 {published and unpublished data}
  • Sykes A, Hendriksen I, Mtove G, Mandea V, Mrema H, Rutta B, et al. Azithromycin plus artesunate versus artemether-lumefantrine for treatment of uncomplications malaria in Tanzanian children: a randomized, controlled trial. Clinical Infectious Diseases 2009;49:1195-1201.
Thriemer 2010 {published and unpublished data}
  • Thriemer K, Starzengruber P, Khan WA, Haque R, Marma ASP, Ley B, et al. Azithromycin combination therapy for the treatment of uncomplicated falciparum malaria in Bangladesh: an open-label randomized controlled clinical trial. Journal of Infectious Diseases 2010;202(3).

References to ongoing studies

  1. References to studies included in this review
  2. References to ongoing studies
  3. Additional references
NIAID 379821 {published and unpublished data}
  • National Institute of Allergy and Infectious Diseases. Chloroquine alone or in combination for malaria in children in Malawi. http://www.clinicaltrials.gov/ct/show/NCT00379821. 2006.
Pfizer 677833 {published data only}
  • Pfizer Inc. Azithromycin plus chloroquine versus artemether-lumefantrine for the treatment of uncomplicated P. falciparum malaria in children in Africa. http://www.clinicaltrials.gov/ct/show/NCT00677833. 2008.

Additional references

  1. References to studies included in this review
  2. References to ongoing studies
  3. Additional references
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Andersen 1998
  • Andersen SL, Oloo AJ, Gordon DM, Ragama OB, Aleman GM, Bermand JD, et al. Successful double-blinded, randomized, placebo-controlled field trial of azithromycin and doxycycline as prophylaxis for malaria in Western Kenya. Clinical Infectious Diseases 1998;26:146-50.
Barnes 2008
Biswas 2001
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Bloland 2003
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Gingras 1992
  • Gingras BA, Jensen JB. Activity of azithromycin (CP-62,993) and erythromycin against chloroquine-sensitive and chloroquine resistant strains of Plasmodium falciparum in vitro. American Journal of Tropical Medicine and Hygiene 1992;47(3):378-82.
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Gray 2001
  • Gray RH, Wabwire-Mangen F, Kigozi G, Sewankambo NK, Serwadda D, Moulton LH, et al. Randomized trial of presumptive sexually transmitted disease therapy during pregnancy in Rakai, Uganda. American Journal of Obstetrics and Gynecology 2001;185(5):1209-17.
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Kalilani 2007
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Neerja 2004
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Noedl 2001
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Noedl 2007
  • Noedl H, Krudsood S, Leowattana W, Tangpukdee N, Thanachartwet W, Looareesuwan S, et al. In vitro antimalarial activity of azithromycin, artesunate, and quinine in combination and correlation with clinical outcome. Antimicrobial Agents and Chemotherapy 2007;51(2):651-6.
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Taylor 2004
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