Intervention Review

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Interventions for preventing late postnatal mother-to-child transmission of HIV

  1. Tara Horvath1,*,
  2. Banyana C Madi2,
  3. Irene M Iuppa1,
  4. Gail E Kennedy1,
  5. George W Rutherford1,
  6. Jennifer S. Read3

Editorial Group: Cochrane HIV/AIDS Group

Published Online: 21 JAN 2009

Assessed as up-to-date: 19 SEP 2008

DOI: 10.1002/14651858.CD006734.pub2

How to Cite

Horvath T, Madi BC, Iuppa IM, Kennedy GE, Rutherford GW, Read JS. Interventions for preventing late postnatal mother-to-child transmission of HIV. Cochrane Database of Systematic Reviews 2009, Issue 1. Art. No.: CD006734. DOI: 10.1002/14651858.CD006734.pub2.

Author Information

  1. 1

    University of California, San Francisco, Global Health Sciences, San Francisco, California, USA

  2. 2

    SADC secretariat, HIV and AIDS Unit, Gaborone, Botswana

  3. 3

    Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Pediatric, Adolescent, and Maternal AIDS Branch, Center for Research for Mothers and Children, Bethesda, MD, USA

*Tara Horvath, Global Health Sciences, University of California, San Francisco, 50 Beale Street, Suite 1200, San Francisco, California, 94105, USA. thorvath@psg.ucsf.edu.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 21 JAN 2009

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Coovadia 2007 {published data only}
  • Coovadia HM, Rollins NC, Bland RM, Little K, Coutsoudis A, Bennish ML, et al. Mother-to-child transmission of HIV-1 infection during exclusive breastfeeding in the first 6 months of life: an intervention cohort study. Lancet 2007;369(9567):1107-16. [PUBMED: 17398310]
Fawzi 2002 {published data only}
  • Fawzi WW, Msamanga GI, Hunter D, Renjifo B, Antelman G, Bang H, et al. Randomized trial of vitamin supplements in relation to transmission of HIV-1 through breastfeeding and early child mortality. AIDS 2002;16(14):1935-44. [PUBMED: 12351954]
Kuhn 2008 {published data only}
  • Kuhn L, Aldrovandi GM, Sinkala M, Kankasa C, Semrau K, Mwiya M, et al. Effects of early, abrupt weaning on HIV-free survival of children in Zambia. N Engl J Med 2008;359(2):130-41. [PUBMED: 18525036]
Kumwenda 2008 {published data only}
  • Kumwenda NI, Hoover DR, Mofenson LM, Thigpen MC, Kafulafula G, Li Q, et al. Extended antiretroviral prophylaxis to reduce breast-milk HIV-1 transmission. N Engl J Med 2008;359(2):119-29. [PUBMED: 18525035]
Nduati 2000 {published data only}
  • Nduati R, John G, Mbori-Ngacha D, Richardson B, Overbaugh J, Mwatha A, et al. Effect of breastfeeding and formula feeding on transmission of HIV-1: a randomized clinical trial. JAMA 2000;283(9):1167-74. [PUBMED: 10703779]
SWEN 2008 {published data only}
  • Bedri A, Gudetta B, Isehak A, Kumbi S, Lulseged S, Mengistu Y, et al. Extended-dose nevirapine to 6 weeks of age for infants to prevent HIV transmission via breastfeeding in Ethiopia, India, and Uganda: an analysis of three randomized controlled trials. Lancet 2008;372(9635):300-13. [PUBMED: 18657709]
Thior 2006 {published data only}
  • Thior I, Lockman S, Smeaton LM, Shapiro RL, Wester C, Heymann SJ, et al. Breastfeeding plus infant zidovudine prophylaxis for 6 months vs formula feeding plus infant zidovudine for 1 month to reduce mother-to-child HIV transmission in Botswana: a randomized trial: the Mashi Study. JAMA 2006;296(7):794-805. [PUBMED: 16905785]

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Becquet 2006 {published data only}
  • Becquet R, Leroy V, Ekouevi DK, Viho I, Castetbon K, Fassinou P, et al. Complementary feeding adequacy in relation to nutritional status among early weaned breastfed children who are born to HIV-infected mothers: ANRS 1201/1202 Ditrame Plus, Abidjan, Cote d'Ivoire. Pediatrics 2006;117(4):e701-10.
Becquet 2008 {published data only}
  • Becquet R, Ekouevi DK, Menan H, Amani-Bosse C, Bequet L, Viho I, et al. Early mixed feeding and breastfeeding beyond 6 months increase the risk of postnatal HIV transmission: ANRS 1201/1202 Ditrame Plus, Abidjan, Cote d'Ivoire. Preventive Medicine 2008;47(1):27-33. [PUBMED: 18190955]
Bobat 1997 {published data only}
Dabis 1999 {published data only}
  • Dabis F, Msellati P, Meda N, Welffens-Ekra C, You B, Manigart O, et al. 6-month efficacy, tolerance, and acceptability of a short regimen of oral zidovudine to reduce vertical transmission of HIV in breastfed children in Cote d'Ivoire and Burkina Faso: a double-blind placebo-controlled multicentre trial. DITRAME Study Group. DIminution de la Transmission Mere-Enfant. Lancet 1999;353(9155):786-92.
Embree 2000 {published data only}
Gray 2005 {published data only}
  • Gray GE, Urban M, Chersich MF, Bolton C, van Niekerk R, Violari A, et al. A randomized trial of two postexposure prophylaxis regimens to reduce mother-to-child HIV-1 transmission in infants of untreated mothers. AIDS 2005;19(12):1289-97.
Guay 1999 {published data only}
  • Guay LA, Musoke P, Fleming T, et al. Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomized trial. Lancet 1999;354(9181):795-802.
Iliff 2005 {published data only}
  • Iliff PJ, Piwoz EG, Tavengwa NV, Zunguza CD, Marinda ET, Nathoo KJ, et al. Early exclusive breastfeeding reduces the risk of postnatal HIV-1 transmission and increases HIV-free survival. AIDS 2005;19(7):699-708.
Kilewo 2008 {published data only}
  • Kilewo C, Karlsson K, Massawe A, Lyamuya E, Swai A, Mhalu F, et al. Prevention of mother-to-child transmission of HIV-1 through breast-feeding by treating infants prophylactically with lamivudine in Dar es Salaam, Tanzania: the Mitra Study. J Acquir Immune Defic Syndr 2008;48(3):315-23. [PUBMED: 18344879]
Miotti 1999 {published data only}
SIMBA 2003 {published data only}
  • Vyankandondera J, Luchters S, Hassink E, et al. Reducing risk of HIV-1 transmission from mother to infant through breastfeeding using antiretroviral prophylaxis in infants (SIMBA study) [abstract # LB7]. Paper presented at: the 2nd International AIDS Society Conference on HIV Pathogenesis and Treatment; 2003.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
AAP 1995
  • American Academy of Pediatrics, Committee on Pediatric AIDS. Human milk, breastfeeding, and transmission of human immunodeficiency virus in the United States. Pediatrics 1995;96 977 –979.
Arendt 2007
  • Arendt V, Ndimubanzi P, Ndayabisa G, Muganda J, Courteille O, Rudanga C, et al. AMATA Study: effectiveness of antiretroviral therapy in breastfeeding mothers to prevent post-natal vertical transmission in Rwanda [Abstract TuAX102]. Paper presented at the 4th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention, 2007.
Arrive 2007
  • Arrivé E, Newell ML, Ekouevi DK, Chaix ML, Thiebaut R, Masquelier B, et al. Prevalence of resistance to nevirapine in mothers and children after single-dose exposure to prevent vertical transmission of HIV-1: a meta-analysis. Int J Epidemiol 2007 Oct;36(5):1009-21.
Becquart 1999
  • Becquart P, Gressenguet G, Hocini H, Kazatchkine MD, Belec L. Secretory leukocyte protease inhibitor in colostrum and breast milk is not a major determinant of the protection of early postnatal transmission of HIV. AIDS 1999;13 2599–2602.
Becquart 2000
  • Becquart P, Hocini H, Levy M, Sepou A, Kazatchkine MD, Belec L. Secretory anti-human immunodeficiency virus (HIV) antibodies in colostrum and breast milk are not a major determinant of the protection of early postnatal transmission of HIV. J Infect Dis 2000;181 532 –539.
BHITS 2004
  • Breastfeeding and HIV International Transmission Study Group. Late postnatal transmission of HIV-1 in breast-fed children: An individual patient data meta-analysis. J Infect Dis 2004;189:2154-2166.
Bland 2008
  • Bland RM, Little KE, Coovadia HM, Coutsoudis A, Rollins NC, Newell ML. Intervention to promote exclusive breast-feeding for the first 6 months of life in a high HIV prevalence area. AIDS 2008;22(7):883-91. [PUBMED: 18427207]
Bond 2007
  • Bond K, Horváth T, Harvey K, Wiysonge CS, Read JS. The Cochrane Library and mother-to-child transmission of HIV: an umbrella review. Evidence-Based Child Health: A Cochrane Review Journal 2007;2(1):4-24.
Catassi 1995
  • Catassi C, Bonucci A, Coppa GV, Carlucci A, Giorgi PL. Intestinal permeability changes during the first month: effect of natural versus artificial feeding. J Pediatr Gastroenterol Nutr 1995 Nov;21(4):383-86.
Cesar 1999
  • Cesar JA, Victora CG, Barros FC, Santos IS, Flores JA. Impact of breast feeding on admission for pneumonia during postneonatal period in Brazil nested case-control study. BMJ 1999;318 1316 –1320.
Coovadia 2007
  • Coovadia HM, Rollins NC, Bland RM, Little K, Coutsoudis A, Bennish ML, Newell ML. Mother-to-child transmission of HIV-1 infection during exclusive breastfeeding in the first 6 months of life: an intervention cohort study. Lancet 2007;369:1107-16.
Coutsoudis 1999
  • Coutsoudis A, Pillay K, Spooner E, Kuhn L, Coovadia HM. Influence of infant-feeding patterns on early mother-to-child transmission of HIV in Durban, South Africa a prospective cohort study. South African Vitamin A Study Group. Lancet 1999;354 471 –476.
Coutsoudis 2001
  • Coutsoudis A, Pillay K, Kuhn L, Spooner E, Tsai WY, Coovadia HM. Method of feeding and transmission of HIV from mothers to children by 15 months of age prospective cohort study from Durban, South Africa. South African Vitamin A Study Group. AIDS 2001;15 379 –387.
de Vincenzi 2008
  • de Vincenzi I and the Kesho Bora Study Group. HIV-free survival at 12 months among children born to HIV-infected women receiving antiretrovirals from 34-36 weeks of pregnancy [abstract # 638]. Paper presented at the15th Conference on Retroviruses and Opportunistic Infections (CROI), 2008.
Desmond 2008
  • Desmond C, Bland RM, Boyce G, Coovadia HM, Coutsoudis A, Rollins N, et al. Scaling-up exclusive breastfeeding support programmes: the example of KwaZulu-Natal. PLoS ONE 2008;3(6):e2454. [PUBMED: 18560596]
Donovan 1994
  • Donovan SM, Odle J. Growth factors in milk as mediators of infant development. Annu Rev Nutr 1994;14 147 –167.
Ekpini 1997
  • Ekpini ER, Wiktor SZ, Satten GA, et al. Late postnatal mother-to-child transmission of HIV in Abidjan, Côte d’Ivoire. Lancet 1997;349 1054 –1059.
Embree 2000
Fawzi 1998
  • Fawzi WW, Msamanga GI, Spiegelman D, Urassa EJ, McGrath N, Mwakagile D, et al. Randomised trial of effects of vitamin supplements on pregnancy outcomes and T cell counts in HIV-1-infected women in Tanzania. Lancet 1998;351(9114):1477-82. [PUBMED: 9605804]
Fawzi 1999
  • Fawzi WW, Msamanga GI, Spiegelman D, Urassa EJ, Hunter DJ. Rationale and design of the Tanzania Vitamin and HIV Infection Trial. Controlled Clinical Trials 1999;20(1):75-90. [PUBMED: 10027501]
Fawzi 2000
  • Fawzi WW, Msamanga G, Hunter D, Urassa E, Renjifo B, Mwakagile D, et al. Randomized trial of vitamin supplements in relation to vertical transmission of HIV-1 in Tanzania. J Acquir Immune Defic Syndr 2000;23(3):246-54. [PUBMED: 10839660]
Giuliano 2007
  • Giuliano M, Guidotti G, Andreotti M, Pirillo MF, Villani P, Liotta G, et al. Triple antiretroviral prophylaxis administered during pregnancy and after delivery significantly reduces breast milk viral load: a study within the Drug Resource Enhancement Against AIDS and Malnutrition Program. J Acquir Immune Defic Syndr 2007;44(3):286-91. [PUBMED: 17146372]
Goto 1999
  • Goto K, Chew F, Torún B, Peerson JM, Brown KH. Epidemiology of altered intestinal permeability to lactulose and mannitol in Guatemalan infants. Pediatr Gastroenterol Nutr 1999 Mar;28;3:282-90.
Handbook 2008
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions. Chichester (UK): Wiley-Blackwell, 2008.
Harmsen 1995
  • Harmsen MC, Swart RJ, de Bethune MP, et al. Antiviral effects of plasma and milk proteins lactoferrin shows potent activity against both human immunodeficiency virus and human cytomegalovirus replication in vitro. J Infect Dis 1995;172 380 –388.
Hocini 2000
  • Hocini H, Becquart P, Bouhlal H, Adle-Biassette H, Kazatchkine MD, Belec L. Secretory leukocyte protease inhibitor inhibits infection of monocytes and lymphocytes with human immunodeficiency virus type 1 but does not interfere with transcytosis of cell-associated virus across tight epithelial barriers. Clin Diagn Lab Immunol 2000;7:515 –518.
Israel-Ballard 2005
  • Israel-Ballard K, Chantry C, Dewey K, Lonnerdal B, Sheppard H, Donovan R, et al. Viral, nutritional, and bacterial safety of flash-heated and pretoria-pasteurized breast milk to prevent mother-to-child transmission of HIV in resource-poor countries: a pilot study. J Acquir Immune Defic Syndr 2005;40(2):175-81. [PUBMED: 16186735]
Israel-Ballard 2007
  • Israel-Ballard K, Donovan R, Chantry C, Coutsoudis A, Sheppard H, Sibeko L, et al. Flash-heat inactivation of HIV-1 in human milk: a potential method to reduce postnatal transmission in developing countries. J Acquir Immune Defic Syndr 2007;45(3):318-23. [PUBMED: 17514015]
Israel-Ballard 2008
  • Israel-Ballard KA, Abrams BF, Coutsoudis A, Sibeko LN, Cheryk LA, Chantry CJ. Vitamin content of breast milk from HIV-1-infected mothers before and after flash-heat treatment. J Acquir Immune Defic Syndr 2008;48(4):444-9. [PUBMED: 18614920]
John 2001
  • John GC, Richardson BA, Nduati RW, Mbori-Ngacha D, Kreiss JK. Timing of breast milk HIV transmission a meta-analysis. East Afr Med J. 2001;78 75 –79.
Kafulafula 2007
  • Kafulafula G, Thigpen M, Hoover D, et al. Post-weaning gastroenteritis and mortality in HIV-uninfected African infants receiving antiretroviral prophylaxis to prevent MTCT of HIV-1 [abstract # 773]. Paper presented at the 14th Conference on Retroviruses and Opportunistic Infections (CROI), 2007.
Kourtis 2007
  • Kourtis A, et al. Diarrhea in Uninfected Infants of HIV-infected Mothers Who Stop Breastfeeding at 6 Months: The BAN Study Experience [abstract #772]. Paper presented at presented at the 14th Conference on Retroviruses and Opportunistic Infections (CROI), 2007.
Kramer 2001
  • Kramer MS, Chalmers B, Hodnett ED, et al. Promotion of Breastfeeding Intervention Trial (PROBIT) a randomized trial in the Republic of Belarus. JAMA. 2001;285 413 –420.
Kumwenda 2008 Supplement
  • Supplement to: Kumwenda NI, Hoover DR, Mofenson LM, et al. Extended antiretroviral prophylaxis to reducebreast-milk HIV-1 transmission.. N Engl J Med 2008; Vol. 359:119-29.
Lindegren 1999
  • Lindegren ML, Byers RH Jr, Thomas P, et al. Trends in perinatal transmission of HIVAIDS in the United States. JAMA. 1999;282 531 –538.
Mbori-Ngacha 2001
  • Mbori-Ngacha D, Nduati R, John G, Reilly M, Richardson B, Mwatha A, et al. Morbidity and mortality in breastfed and formula-fed infants of HIV-1-infected women: A randomized clinical trial. JAMA 2001;286(19):2413-20. [PUBMED: 11712936]
Miotti 1999
  • Miotti PG, Taha TE, Kumwenda NI, et al. HIV transmission through breastfeeding a study in Malawi. JAMA. 1999; 282;744 –749.
MMWR 1985
  • Centers for Disease Control and Prevention. Recommendations for assisting in the prevention of perinatal transmission of human T-lymphotropic virus type IIIlymphadenopathy-associated virus and acquired immunodeficiency syndrome. MMWR Morb Mortal Wkly Rep. 1985; Vol. 34 721 –726, 731–732.
Newell 2004
  • Newell ML, Coovadia H, Cortina-Borja M, Rollins N, Gaillard P, Dabis F, Ghent International AIDS Society (IAS) Working Group on HIV Infection in Women and Children. Mortality of infected and uninfected infants born to HIV-infected mothers in Africa: a pooled analysis. Lancet. 2004 Oct 2-8;364(9441):1236-43.
Onyango 2007
  • Onyango C, et al. Early Breastfeeding Cessation among HIV-exposed Negative Infants and Risk of Serious Gastroenteritis: Findings from a Perinatal Prevention Trial in Kampala, Uganda [abstract # 775]. Paper presented at the 14th Conference on Retroviruses and Opportunistic Infections (CROI) 2007.
Pebley 1986
  • Pebley AR, Millman S. Birthspacing and child survival. Int Fam Plann Perspect. 1986;12 71 –79.
Pillay 2000
  • Pillay K, Coutsoudis A, York D, Kuhn L, Coovadia HM. Cell-free virus in breast milk of HIV -seropositive women. J Acquir Immune Defic Syndr. 2000;24 330 –336.
Rankin 2005
Read 1999
  • Read JS. Preventing mother-to-child transmission of HIV the USA experience. Prenat Neonatal Med. 1999;4 391 –397.
Read 2003
  • Read JS. American Academy of Pediatrics Committee on Pediatric AIDS. Human milk, breastfeeding, and transmission of human immunodeficiency virus type 1 in the United States. Pediatrics 2003; 112;1196-1205.
Read 2005a
  • Read JS. Prevention of mother-to-child transmission of HIV. In: Zeichner SL, Read JS editor(s). Textbook of Pediatric HIV Care. Cambridge, England: Cambridge University Press, 2005.
Read 2005b
Richardson 2003
  • Richardson BA, John-Steward GC, Hughes JP, et al. Breast-milk infectivity in human immunodeficiency virus type 1-infected mothers. J Infect Dis. 2003;187 736 –740.
Safrit 2004
  • Safrit JT, Ruprecht R, Ferrantelli F, Xu W, Kitabwalla M, Van Rompay K, et al. Immunoprophylaxis to prevent mother-to-child transmission of HIV-1. J Acquir Immune Defic Syndr 2004 Feb 1;35(2):169-77.
Semba 1999a
  • Semba RD, Kumwenda N, Hoover DR, et al. Human immunodeficiency virus load in breast milk, mastitis, and mother-to-child transmission of human immunodeficiency virus type 1. J Infect Dis 1999;180:93-98.
Semba 1999b
  • Semba RD, Kumwenda N, Taha TE, et al. Mastitis and immunological factors in breast milk of human immunodeficiency virus-infected women.. J Hum Lact 1999;15 301 –306.
Swart 1996
  • Swart PJ, Kuipers ME, Smit C, et al. Antiviral effects of milk proteins acylation results in polyanionic compounds with potent activity against human immunodeficiency virus types 1 and 2 in vitro. AIDS Res Hum Retroviruses. 1996;12 769 –775.
Thapa 1988
Thomas 2008
  • Thomas T, et al. Rates of diarrhea associated with early weaning among infants in Kisumu, Kenya [abstract # 774]. Paper presented at the 15th Conference on Retroviruses and Opportunistic Infections (CROI) 2008.
UNAIDS 2008
  • Joint United Nations Programme on HIV/AIDS. 2007 AIDS Epidemic Update. Geneva, Geneva: 2008.
Urdaneta 2005
  • Urdaneta S, Wigdahl B, Neely EB, Berlin CM Jr, Schengrund CL, Lin HM, Howett MK. Inactivation of HIV-1 in breast milk by treatment with the alkyl sulfate microbicide sodium dodecyl sulfate (SDS). Retrovirology 2005 Apr 29;2(28).
Van de Perre 1992
Van de Perre 1993
  • Van de Perre P, Simonon A, Hitimana DG, et al. Infective and anti-infective properties of breastmilk from HIV-infected women.. Lancet 1993;341 914 –918.
Van der Horst 2003
  • Van der Horst C, Fiscus S, Piwoz E, Corneli A, Moses A, Jones D, et al. Prevention of mother to infant transmission of HIV through breastfeeding and reduction of morbidity and mortality of the breastfeeding mothers: a study in Malawi. Antiviral Therapy 2003;8 (Suppl 1):S4777.
VanDerslice 1994
  • VanDerslice J, Popkin B, Briscoe J. Drinking-water quality, sanitation, and breast-feeding: their interactive effects on infant health.. Bull World Health Organ 1994;72:589–601.
Volmink 2007
  • Volmink J, Siegfried NL, van der Merwe L, Brocklehurst P. Antiretrovirals for reducing the risk of mother-to-child transmission of HIV infection. Cochrane Database Syst Rev 2007;1.
WHO 2006
  • WHO HIV, Infant Feeding Technical Consultation. held on behalf of the Inter-agency Task Team (IATT) on Prevention of HIV Infections in Pregnant Women, Mothers, their Infants. Geneva, October 25-27, 2006.
WHO Team 2000
  • WHO Collaborative Study Team on the Role of Breastfeeding on the Prevention of Infant Mortality. Effect of breastfeeding on infant and child mortality due to infectious diseases in less developed countries: a pooled analysis. Lancet 2000;355:451-455.
Yoon 1996
  • Yoon PW, Black RE, Moulton LH, Becker S. Effect of not breastfeeding on the risk of diarrheal and respiratory mortality in children under 2 years of age in Metro Cebu, The Philippines.. Am J Epidemiol 1996;143 1142 –1148.
Ziegler 1985
  • Ziegler JB, Cooper DA, Johnson RO, Gold J. Postnatal transmission of AIDS-associated retrovirus from mother to infant. Lancet 1985;1 896 –898.