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Iron supplementation for reducing morbidity and mortality in children with HIV

  1. Ifedayo Adetifa1,*,
  2. Uduak Okomo2

Editorial Group: Cochrane HIV/AIDS Group

Published Online: 15 APR 2009

Assessed as up-to-date: 28 SEP 2008

DOI: 10.1002/14651858.CD006736.pub2

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How to Cite

Adetifa I, Okomo U. Iron supplementation for reducing morbidity and mortality in children with HIV. Cochrane Database of Systematic Reviews 2009, Issue 1. Art. No.: CD006736. DOI: 10.1002/14651858.CD006736.pub2.

Author Information

  1. 1

    Medical Research Council (UK) Laboratories, Bacterial Diseases Programme, Banjul, Gambia

  2. 2

    Medical Research Council Laboratories, Clinical Services, Fajara, Gambia

*Ifedayo Adetifa, Bacterial Diseases Programme, Medical Research Council (UK) Laboratories, Atlantic Boulevard, Fajara, PO Box 273, Banjul, Gambia. iadetifa@mrc.gm. ifedayoadetifa@yahoo.com.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 15 APR 2009

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References

References to studies excluded from this review

  1. References to studies excluded from this review
  2. Additional references
Jacobus 1996 {published data only}
  • Jacobus DP. Randomization to iron supplementation of patients with advanced human immunodeficiency virus disease-an inadvertent but controlled study with results important for patient care. J Infect Dis 1996;173:1044-5.
Olsen 2004 {published data only}
Olsen 2006 {published data only}
  • Olsen A, Nawiri J, Magnussen P, Krarup H, Friis H. Failure of twice-weekly iron supplementation to increase blood haemoglobin and serum ferritin concentrations: results of a randomized controlled trial. Annals of Tropical Medicine and Parasitology 2006;100(3):251-263.
Semba 2007 {published data only}
  • Semba RD, Ricketts EP, Mehta S, Netski D, Thomas D, Kirk G. Eefect of micronutrients and iron supplementation on haemoglobin, iron status, and plasma hepatitis C and HIV RNA levels in female injection drug users: a controlled clinical trial. J Acquir Immune Defic Syndr 2007;45:298-303.

Additional references

  1. References to studies excluded from this review
  2. Additional references
Adetifa 2006
Adewuyi 1994
  • Adewuyi J, Chitsike I. Haematologic features of the human immunodeficiency virus (HIV) infection in black children in Harare. Central Africa Journal of Medicine 1994;40:333-336.
Afacan 2002
  • Afacan YE, Hasan MS, Omene JA. Iron deficiency anaemia in HIV infection: immunologic and virologic response. Journal of the National Medical Association 2002;94(2):73-7.
Allen 1998
Berhane 2004
  • Berhane K, Karim R, Cohen MH, Masri-Lavine L, Young M, Anastos K, Augenbraun M, WattsDH, Levine AM. Impact of highly active antiretroviral therapy on anaemia and relationship between anaemia and survival in a large cohort of HIV-infected women: Women's Interagency HIV Study. J Acquir Immune Defic Syndr 2004;37:1245-52.
Boelaert 1996
  • Boelaert JR, Weinberg GA, Weinberg ED. Altered iron metabolism in HIV infection:mechanisms, possible consequences, and proposals for management. Infect Agents Dis 1996;5:36-46.
Butler 1991
Carr 1998
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CDC 1994
  • Centres for Disease Control and Prevention. 1994 revised classification for human immunodeficiency virus infection in children less than 13 years of age.. Morbidity and Mortality Weekly Review 1994;43(RR-12):1-10.
Clark 2001
Clark 2002
  • Clark TD, Mmiro F, Ndugwa C, et al. Risk factors and cummulative incidence of anaemia among human immunodeficiency virus-infected children in Uganda. Annals of Tropical Paediatrics 2002;22:11-17.
Costagliola 1994
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Coyle 1997
De Monye 1999
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Delanghe 1998
  • Delanghe JR, Langlois MR, Boelaert JR. Haptoglobin polymorphism, iron metabolism and mortality in HIV infection. Acquired Immune Deficiency Syndrome 1998;12:1027-1032.
Eley 2002
  • Eley BS, Sive AA, Shuttleworth M, Hussey GD. A prospective, cross-sectional study of anaemia and peripheral iron status in antiretroviral naive, HIV-1 infected children in Cape Town, South Africa. BMC Infectious Diseases 2002;2(3).
Ellaurie 1990
Feelders 1999
Forsyth 1996
Fraser 2006
  • Fraser A, Bilenko N, Paul M, Leibovici L, Fraser D. Supplementation with two or more micronutrients versus single micronutrient supplementation or placebo in young children. Cochrane Database of Systematic Reviews 2006, Issue 2. [Art. No.: CD005977. DOI: ]
Friis 2005
  • Friis H. Micronutrients and HIV infection: a review of current evidence. Consultation on Nutrition and HIV/AIDS in Africa: evidence, lessons and recommedations for action. World Health Organization. Department of Nutrition for Health and Development. World Health Organization. Geneva, 2005:1-28.
Geissler 1991
  • Geissler RG, Ottman OG, Eder M, Kojouharoff G, Hoelzer D, Ganser A. Effect of recombinant human transforming growth factor beta and tumour necrosis factor alpha on bone marrow progenitor cells of HIV-infected persons. Ann Hematol 1991;62:151-155.
Gordeuk 2006
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Gordeux 2001
Iannotti 2006
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Kupka 2007
  • Kupka R, Msamanga GI, Mugusi F, Petraro P, Hunter DJ, Fawzi WW. Iron status is an important cause of anaemia in HIV infected Tanzanian women but is not related to accelerated HIV disease progression. J Nutr 2007;137:2317-23.
Martins 2001
  • Martins S, Logan S, Gilbert R. Iron supplementation for improving psychomotor development and cognitive function in infants under the age of one. Cochrane Database of Systematic Reviews 2001, Issue 2. [Art. No.: CD003016. DOI: ]
McDermid 2007
  • McDermid JM, Jaye A, Schim van der Loeff MF, Todd J, Austin S, Jeffries D, Awasana AA, Whittlex AA, Prentice AA. Elevated iron status strongly predicts mortality in West African adults with HIV infection. J Acquir Immune Defic Syndrom 2007;46:498-507.
Moore 1999
Moses 1996
  • Moses AV, Williams S, Heneveld ML. Human immunodeficiency virus infection of the bone marrow epithelium reduces induction of stromal hematopoietic growth factors. Blood 1996;87:919-925.
Ojukwu 2007
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Olsen 2004
Pizzo 1988
Richman 1987
Sahli 1998
  • Sahli Y, Costagliola DG, Rebulla P, et al. Serum ferritin, desferrioxamine, and evolution of HIV-1 infection in thalassemic patients.. J Acquir Immune Defic Syndr Hum Retrovirol 1998;18:473-8.
Salmon-Ceron 1995
  • Salmon-Ceron D, Fontbonne A, Saba J. Lower survival in AIDS patients receiving dapsone compared with aerosolized pentamidine for secondary prophylaxis of Pneumocystis carinii pneumonia. J Infect Dis 1995;172:656-664.
Savarino 1999
  • Savarino A, Pescarmona GP, Boelaert JR. Iron metabolism and HIV infection:reciprocal interactions with potentially harmful consequences?. Cell Biochem Funct 1999;17:279-287.
    Direct Link:
Schwartz 1994
  • Schwartz GN, Kessler SW, Rothwell SW. Inhibitory effects of HIV-1-infected stromal cell layers on production of myeloid progenitor cels in human long-term bone marrow cultures. Exp Hematol 1994;22:1288-1296.
Semba 2003
Semba 2000
  • Semba RD, Kumwenda N, Hoover DR, Taha TE, Mtimavalye L, Broadhead R, Eisinger W, Miotti PG, Chiphangwi JD. Assessment of iron status using plasma transferrin receptor in pregnant women with and without human immunodeficiency virus infection in Malawi. Eur J Clin Nutr 2000;54:872-7.
Semba 2001
Semba 2007
  • Semba RD, Ricketts EP, Mehta S, Netski D, Thomas D, Kirk G, Wu AW, Vlahov D. Effect of micronutrients and riron supplementation on haemoglobin, iron status, and plasma hepatitis C and HIV RNA levels in female injection drug users: a controlled clinical trial. J Acquir Immune Defic Syndr 2007;45:298-303.
Totin 2002
  • Totin D, Ndugwa C, Mmiro F, Perry RT, Jackson JB, Semba RD. Iron deficiency anaemia is highly prevalent among human immunodeficiency virus-infected and uninfected infants in Uganda. J Nutr 2002;132:423-9.
UNICEF 1998
  • UNICEF/UNU/WHO/MI. Preventing iron deficiency in women and children: background and consensus on key technical issues and resources for advocacy, planning, and implementing national programs. UNICEF/UNU/WHO/MI Technical Workshop, 1998. Geneva.
Volberding 2000
Vorster 2004
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Weinberg 1996
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Weinberg 2001
WHO 2001
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Zauli 1996
  • Zauli G, Vitale M, Gibellini D, Capitani S. Inhibition of purified CD34+ hematopoietic progenitor cells by human immunodeficiency virus-1 or gp120 mediated by endogenous transforig growth factor beta-1. J Exp Med 1996;183:99-108.
Zauli 1994
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Zon 1988
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