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Different corticosteroids and regimens for accelerating fetal lung maturation for women at risk of preterm birth

  1. Fiona C Brownfoot1,*,
  2. Daniela I Gagliardi2,
  3. Emily Bain2,
  4. Philippa Middleton2,
  5. Caroline A Crowther2,3

Editorial Group: Cochrane Pregnancy and Childbirth Group

Published Online: 29 AUG 2013

Assessed as up-to-date: 1 MAY 2013

DOI: 10.1002/14651858.CD006764.pub3


How to Cite

Brownfoot FC, Gagliardi DI, Bain E, Middleton P, Crowther CA. Different corticosteroids and regimens for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database of Systematic Reviews 2013, Issue 8. Art. No.: CD006764. DOI: 10.1002/14651858.CD006764.pub3.

Author Information

  1. 1

    Mercy Hospital for Women, Heidelberg, Australia

  2. 2

    The University of Adelaide, ARCH: Australian Research Centre for Health of Women and Babies, The Robinson Institute, Discipline of Obstetrics and Gynaecology, Adelaide, Australia

  3. 3

    The University of Auckland, Liggins Institute, Auckland, New Zealand

*Fiona C Brownfoot, Mercy Hospital for Women, Heidelberg, Australia. fiona.brownfoot@gmail.com.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 29 AUG 2013

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[Figure 1]
Figure 1. 'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
[Figure 2]
Figure 2. 'Risk of bias' summary: review authors' judgements about each risk of bias item for each included study.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Dexamethasone versus betamethasone, Outcome 1 Neonatal death.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Dexamethasone versus betamethasone, Outcome 2 Respiratory distress syndrome.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Dexamethasone versus betamethasone, Outcome 3 Intraventricular haemorrhage.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Dexamethasone versus betamethasone, Outcome 4 Neurosensory disability as a child (18 months).
[Analysis 1.5]
Analysis 1.5. Comparison 1 Dexamethasone versus betamethasone, Outcome 5 Apgar score < 7 at 5 minutes.
[Analysis 1.6]
Analysis 1.6. Comparison 1 Dexamethasone versus betamethasone, Outcome 6 Apgar score at 5 minutes.
[Analysis 1.7]
Analysis 1.7. Comparison 1 Dexamethasone versus betamethasone, Outcome 7 Apgar score at 5 minutes.
[Analysis 1.8]
Analysis 1.8. Comparison 1 Dexamethasone versus betamethasone, Outcome 8 Birthweight (kg).
[Analysis 1.9]
Analysis 1.9. Comparison 1 Dexamethasone versus betamethasone, Outcome 9 Birthweight (kg).
[Analysis 1.10]
Analysis 1.10. Comparison 1 Dexamethasone versus betamethasone, Outcome 10 Low birthweight.
[Analysis 1.11]
Analysis 1.11. Comparison 1 Dexamethasone versus betamethasone, Outcome 11 Head circumference (cm).
[Analysis 1.12]
Analysis 1.12. Comparison 1 Dexamethasone versus betamethasone, Outcome 12 Neonatal intensive care unit admission.
[Analysis 1.13]
Analysis 1.13. Comparison 1 Dexamethasone versus betamethasone, Outcome 13 Vasopressor use.
[Analysis 1.14]
Analysis 1.14. Comparison 1 Dexamethasone versus betamethasone, Outcome 14 Bronchopulmonary dysplasia.
[Analysis 1.15]
Analysis 1.15. Comparison 1 Dexamethasone versus betamethasone, Outcome 15 Severe intraventricular haemorrhage.
[Analysis 1.16]
Analysis 1.16. Comparison 1 Dexamethasone versus betamethasone, Outcome 16 Periventricular leukomalacia.
[Analysis 1.17]
Analysis 1.17. Comparison 1 Dexamethasone versus betamethasone, Outcome 17 Neonatal sepsis.
[Analysis 1.18]
Analysis 1.18. Comparison 1 Dexamethasone versus betamethasone, Outcome 18 Necrotising enterocolitis.
[Analysis 1.19]
Analysis 1.19. Comparison 1 Dexamethasone versus betamethasone, Outcome 19 Retinopathy of prematurity.
[Analysis 1.20]
Analysis 1.20. Comparison 1 Dexamethasone versus betamethasone, Outcome 20 Patent ductus arteriosus.
[Analysis 1.21]
Analysis 1.21. Comparison 1 Dexamethasone versus betamethasone, Outcome 21 Fetal heart rate, bpm (day 2).
[Analysis 1.22]
Analysis 1.22. Comparison 1 Dexamethasone versus betamethasone, Outcome 22 Fetal heart rate (day 2).
[Analysis 1.23]
Analysis 1.23. Comparison 1 Dexamethasone versus betamethasone, Outcome 23 Accelerations per hour.
[Analysis 1.24]
Analysis 1.24. Comparison 1 Dexamethasone versus betamethasone, Outcome 24 Accelerations per hour.
[Analysis 1.25]
Analysis 1.25. Comparison 1 Dexamethasone versus betamethasone, Outcome 25 Fetal movements in 30 minutes.
[Analysis 1.26]
Analysis 1.26. Comparison 1 Dexamethasone versus betamethasone, Outcome 26 Fetal movements per hour (maternal perception).
[Analysis 1.27]
Analysis 1.27. Comparison 1 Dexamethasone versus betamethasone, Outcome 27 Fetal movements per hour (ultrasound).
[Analysis 1.28]
Analysis 1.28. Comparison 1 Dexamethasone versus betamethasone, Outcome 28 Fetal movements per hour.
[Analysis 1.29]
Analysis 1.29. Comparison 1 Dexamethasone versus betamethasone, Outcome 29 Fetal breathing movements per hour.
[Analysis 1.30]
Analysis 1.30. Comparison 1 Dexamethasone versus betamethasone, Outcome 30 Duration of breathing time at 2 days (seconds in 30 minutes).
[Analysis 1.31]
Analysis 1.31. Comparison 1 Dexamethasone versus betamethasone, Outcome 31 Length of admission to birth (days).
[Analysis 1.32]
Analysis 1.32. Comparison 1 Dexamethasone versus betamethasone, Outcome 32 Neonatal intensive care unit stay (days).
[Analysis 2.1]
Analysis 2.1. Comparison 2 Dexamethasone: oral versus intramuscular, Outcome 1 Neonatal death.
[Analysis 2.2]
Analysis 2.2. Comparison 2 Dexamethasone: oral versus intramuscular, Outcome 2 Respiratory distress syndrome.
[Analysis 2.3]
Analysis 2.3. Comparison 2 Dexamethasone: oral versus intramuscular, Outcome 3 Intraventricular haemorrhage.
[Analysis 2.4]
Analysis 2.4. Comparison 2 Dexamethasone: oral versus intramuscular, Outcome 4 Birthweight (kg).
[Analysis 2.5]
Analysis 2.5. Comparison 2 Dexamethasone: oral versus intramuscular, Outcome 5 Neonatal sepsis.
[Analysis 2.6]
Analysis 2.6. Comparison 2 Dexamethasone: oral versus intramuscular, Outcome 6 Necrotising enterocolitis.
[Analysis 3.1]
Analysis 3.1. Comparison 3 Betamethasone acetate + phosphate versus betamethasone phosphate, Outcome 1 Neonatal death.
[Analysis 3.2]
Analysis 3.2. Comparison 3 Betamethasone acetate + phosphate versus betamethasone phosphate, Outcome 2 Respiratory distress syndrome.
[Analysis 3.3]
Analysis 3.3. Comparison 3 Betamethasone acetate + phosphate versus betamethasone phosphate, Outcome 3 Intraventricular haemorrhage.
[Analysis 3.4]
Analysis 3.4. Comparison 3 Betamethasone acetate + phosphate versus betamethasone phosphate, Outcome 4 Neurodevelopmental disability.
[Analysis 3.5]
Analysis 3.5. Comparison 3 Betamethasone acetate + phosphate versus betamethasone phosphate, Outcome 5 Birthweight (kg).
[Analysis 3.6]
Analysis 3.6. Comparison 3 Betamethasone acetate + phosphate versus betamethasone phosphate, Outcome 6 Low birthweight.
[Analysis 3.7]
Analysis 3.7. Comparison 3 Betamethasone acetate + phosphate versus betamethasone phosphate, Outcome 7 Neonatal intensive care unit admission.
[Analysis 3.8]
Analysis 3.8. Comparison 3 Betamethasone acetate + phosphate versus betamethasone phosphate, Outcome 8 Bronchopulmonary dysplasia.
[Analysis 3.9]
Analysis 3.9. Comparison 3 Betamethasone acetate + phosphate versus betamethasone phosphate, Outcome 9 Periventricular leukomalacia.
[Analysis 4.1]
Analysis 4.1. Comparison 4 Betamethasone 12 hour versus 24 hour dosing, Outcome 1 Perinatal death.
[Analysis 4.2]
Analysis 4.2. Comparison 4 Betamethasone 12 hour versus 24 hour dosing, Outcome 2 Respiratory distress syndrome.
[Analysis 4.3]
Analysis 4.3. Comparison 4 Betamethasone 12 hour versus 24 hour dosing, Outcome 3 Intraventricular hemorrhage.
[Analysis 4.4]
Analysis 4.4. Comparison 4 Betamethasone 12 hour versus 24 hour dosing, Outcome 4 Maternal fever > 100.4 F.
[Analysis 4.5]
Analysis 4.5. Comparison 4 Betamethasone 12 hour versus 24 hour dosing, Outcome 5 Birthweight (g).
[Analysis 4.6]
Analysis 4.6. Comparison 4 Betamethasone 12 hour versus 24 hour dosing, Outcome 6 Small-for-gestational age.
[Analysis 4.7]
Analysis 4.7. Comparison 4 Betamethasone 12 hour versus 24 hour dosing, Outcome 7 Neonatal intensive care unit admission.
[Analysis 4.8]
Analysis 4.8. Comparison 4 Betamethasone 12 hour versus 24 hour dosing, Outcome 8 Chronic lung disease.
[Analysis 4.9]
Analysis 4.9. Comparison 4 Betamethasone 12 hour versus 24 hour dosing, Outcome 9 Neonatal sepsis.
[Analysis 4.10]
Analysis 4.10. Comparison 4 Betamethasone 12 hour versus 24 hour dosing, Outcome 10 Neonatal antibiotic use (> 5 days).
[Analysis 4.11]
Analysis 4.11. Comparison 4 Betamethasone 12 hour versus 24 hour dosing, Outcome 11 Necrotising enterocolitis.
[Analysis 4.12]
Analysis 4.12. Comparison 4 Betamethasone 12 hour versus 24 hour dosing, Outcome 12 Retinopathy of prematurity.
[Analysis 4.13]
Analysis 4.13. Comparison 4 Betamethasone 12 hour versus 24 hour dosing, Outcome 13 Postpartum maternal length of stay (days).