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Peri-operative glycaemic control regimens for preventing surgical site infections in adults

  1. Lillian S Kao1,*,
  2. Derek Meeks1,
  3. Virginia A Moyer2,
  4. Kevin P Lally3

Editorial Group: Cochrane Wounds Group

Published Online: 8 JUL 2009

Assessed as up-to-date: 24 MAR 2009

DOI: 10.1002/14651858.CD006806.pub2


How to Cite

Kao LS, Meeks D, Moyer VA, Lally KP. Peri-operative glycaemic control regimens for preventing surgical site infections in adults. Cochrane Database of Systematic Reviews 2009, Issue 3. Art. No.: CD006806. DOI: 10.1002/14651858.CD006806.pub2.

Author Information

  1. 1

    University of Texas Health Science Center at Houston, Department of Surgery, Houston, Texas, USA

  2. 2

    Baylor College of Medicine and Texas Children's Hospital, Academic General Pediatrics, Houston, Texas, USA

  3. 3

    University of Texas at Houston, Houston, Texas, USA

*Lillian S Kao, Department of Surgery, University of Texas Health Science Center at Houston, 5656 Kelley Street, Suite 30S 62008, Houston, Texas, TX 77026, USA. Lillian.S.Kao@uth.tmc.edu.

Publication History

  1. Publication Status: New
  2. Published Online: 8 JUL 2009

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Bilotta 2007 {published and unpublished data}
  • Bilotta F, Spinelli A, Giovannini F, Doronzio A, Delfini R, Rosa G. The effect of intensive insulin therapy on infection rate, vasospasm, neurologic outcome, and mortality in neurointensive care unit after intracranial aneurysm clipping in patients with acute subarachnoid hemorrhage: a randomized prospective pilot trial. Journal Neurosurgical Anesthesiology 2007;19(3):156-60.
Gandhi 2007 {published data only}
  • Gandhi GY, Nuttall GA, Abel MD, Mullany CJ, Schaff HV, O'Brien PC, et al. Intensive intraoperative insulin therapy versus conventional glucose management during cardiac surgery. Annals of Internal Medicine 2007;146(4):235-43.
Grey 2004 {published data only}
  • Grey NJ, Perdrizet GA. Reduction of Nosocomial Infections in the Surgical Intensive-Care Unit by Strict Glycemic Control. Endocrine Practice 2004;10:46-52.
Lazar 2004 {published data only}
  • Lazar HL, Chipkin SR, Fitzgerald CA, Bao Y, Cabral H, Apstein CS. Tight glycemic control in diabetic coronary artery bypass graft patients improves perioperative outcomes and decreases recurrent ischemic events. Circulation 2004;109(12):1497-502.
Li 2006 {published data only}
  • Li JY, Sun S, Wu SJ. Continuous insulin infusion improves postoperative glucose control in patients with diabetes mellitus undergoing coronary artery bypass surgery. Texas Heart Institute Journal 2006;33(4):445-51.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Bilotta 2008 {published data only}
  • Bilotta F, Caramia R, Bernak I, Paoloni FP, Doronzio A, Cuzzone V, et al. Intensive insulin therapy after severe traumatic brain injury: a randomized clinical trial. Neurocritical Care 2008;9(2):159-66.
De La Rosa 2008 {published data only}
  • De La Rosa G, Donado JH, Restrepo AH, Quintero AM, Gonzalez LG, Saldarriaga NE, et al. Strict glycaemic control in patients hospitalised in a mixed medical and surgical intensive care unit: a randomised clinical trial. Critical Care 2008;12(5):R120.
He 2008 {published data only}
  • He ZY, Li N, Xing J, Xie XH, Wu Y. Effect of intensive insulin therapy on short-term outcome in critically ill patients. Chinese Journal of Clinical Nutrition 2008;16(4):220-2.
Quinn 2006 {published data only}
  • Quinn DW, Pagano D, Bonser RS, Rooney SJ, Graham TR, Wilson IC, et al. Improved myocardial protection during coronary artery surgery with glucose-insulin-potassium: a randomized controlled trial. Journal of Thoracic and Cardiovascular Surgery 2006;131(1):34-42.
Wang 2006 {published data only}
  • Wang LC, Lei S, Wu JN, Wang LF, Guan TR, Jiang HF, et al. Intensive insulin therapy in critically ill patients. Chinese Critical Care Medicine 2006;18(12):748-50.

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Arabi 2008 {published data only}
  • Arabi YM, Dabbagh OC, Tamim HM, Al Shimemeri AA, Memish ZA, Haddad SH, Syed SJ, Gridhar HR, Rishu AH, Al Daker MO, Kahoul SH, Britts RJ, Sakkijha MH. Intensive versus conventional insulin therapy: a randomized controlled trial in medical and surgical critically ill patients. Critical Care Medicine 2008;36(12):3190-7.
Barcellos 2007 {published data only}
  • Barcellos Cda S, Wender OC, Azambuja PC. Clinical and hemodynamic outcome following coronary artery bypass surgery in diabetic patients using glucose-insulin potassium (GIK) solution: a randomized clinical trial. Revista brasileira de cirurgia cardiovascular: orgao oficial da Sociedade Brasileira de Cirurgia Cardiovascular 2007;22(3):275-84.
Bilotta 2009 {published data only}
He 2007 {published data only}
  • He W, Zhang TY, Zhou H, Li T, Zhao JY, Zhao D, Liu XH, Hous J, Wang C, Xu Y. Impact of intensive insulin therapy on surgical critically ill patients. Zhonghua wai ke za zhi 2007;45(15):1052-4.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Bhatia 2006
Brunkhorst 2008
  • Brunkhorst FM, Engel C, Bloos F, Meier-Hellmann A, Ragaller M, Weiler N, et al. Intensive insulin therapy and pentastarch resuscitation in severe sepsis. New England Journal of Medicine 2008;358(2):125-39.
Cavaillon 2001
  • Cavaillon JM, Adib-Conquy M, Cloez-Tayarani I, Fitting C. Immunodepression in sepsis and SIRS assessed by ex vivo cytokine production is not a generalized phenomenon: a review. Journal of Endotoxin Research 2001;7:85-93.
Delamaire 1997
Devos 2007
  • Devos P, Preiser JC, Melot C on behalf of the Glucontrol Steering Committee. Impact of tight glucose control by intensive insulin therapy on ICU mortality and the rate of hypoglycaemia: results of the Glucontrol study [abstract]. Intensive Care Medicine 2007;33:S189.
Estrada 2003
  • Estrada CA, Young JA, Nifong LW, Chitwood WR Jr. Outcomes and perioperative hyperglycemia in patients with or without diabetes mellitus undergoing coronary artery bypass grafting. Annals of Thoracic Surgery 2003;75(5):1392-9.
Fry 2002
  • Fry DE. The economic costs of surgical site infection. Surgical Infections 2002;3 Suppl 1:S37-43.
Furnary 2004
  • Furnary AP, Wu Y, Bookin SO. Effect of hyperglycemia and continuous intravenous insulin infusions on outcomes of cardiac surgical procedures: the Portland Diabetic Project. Endocrine Practice 2004;10 Suppl 2:21-33.
Higgins 2003
Higgins 2008
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.1 [updated September 2008]. The Cochrane Collaboration, 2008. Available from www.cochrane-handbook.org.
Kennedy 1994
  • Kennedy DJ, Butterworth JFt. Clinical review 57: Endocrine function during and after cardiopulmonary bypass: recent observations. The Journal of Clinical Endocrinology and Metabolism 1994;78(5):997-1002.
Kirkland 1999
  • Kirkland KB, Briggs JP, Trivette SL, Wilkinson WE, Sexton DJ. The impact of surgical-site infections in the 1990s: attributable mortality, excess length of hospitalization, and extra costs. Infection Control and Hospital Epidemiology 1999;20(11):725-30.
Latham 2001
  • Latham R, Lancaster AD, Covington JF, Pirolo JS, Thomas CS. The association of diabetes and glucose control with surgical-site infections among cardiothoracic surgery patients. Infection Control and Hospital Epidemiology 2001;22(10):607-12.
Lefebvre 2008
  • Lefebvre C, Manheimer E, Glanville J. Chapter 6: Searching for studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.0 (updated February 2008). The Cochrane Collaboration. Available from www.cochrane-handbook.org 2008.
Ljungqvist 2005
Mangram 1999
  • Mangram AJ, Horan TC, Pearson ML, Silver LC, Jarvis WR. Guideline for Prevention of Surgical Site Infection, 1999. Centers for Disease Control and Prevention (CDC) Hospital Infection Control Practices Advisory Committee.  American Journal of Infection Control 1999;27(2):97-132.
Mazaki 2008
  • Mazaki T, Ebisawa K. Enteral versus parenteral nutrition after gastrointestinal surgery: a systematic review and meta-analysis of randomized controlled trials in the English literature. Journal of Gastrointestinal Surgery 2008;12(4):739-55.
Pomposelli 1998
  • Pomposelli JJ, Baxter JK 3rd, Babineau TJ, Pomfret EA, Driscoll DF, Forse RA, et al. Early postoperative glucose control predicts nosocomial infection rate in diabetic patients. JPEN Journal of Parenteral and Enteral Nutrition 1998;22(2):77-81.
SIGN 2009
  • Scottish Intercollegiate Guidelines Network (SIGN). Search filters. Available from http://www.sign.ac.uk/methodology/filters.html#random (accessed March 2009).
Stephan 2002
  • Stephan F, Yang K, Tankovic J, Soussy CJ, Dhonneur G, Duvaldestin P, et al. Impairment of polymorphonuclear neutrophil functions precedes nosocomial infections in critically ill patients. Critical Care Medicine 2002;30(2):315-22.
Trick 2000
  • Trick WE, Scheckler WE, Tokars JI, Jones KC, Reppen ML, Smith EM, et al. Modifiable risk factors associated with deep sternal site infection after coronary artery bypass grafting. The Journal of Thoracic and Cardiovascular Surgery 2000;119(1):108-14.
Van den Berghe 2001
  • van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, et al. Intensive insulin therapy in the critically ill patients. New England Journal of Medicine 2001;345(19):1359-67.
Zerr 1997
  • Zerr KJ, Furnary AP, Grunkemeier GL, Bookin S, Kanhere V, Starr A. Glucose control lowers the risk of wound infection in diabetics after open heart operations. Annals of Thoracic Surgery 1997;63(2):356-61.