Intervention Protocol

Antipsychotic drugs for anorexia nervosa

  1. Angélica M Claudino1,*,
  2. Phillipa J Hay2,
  3. Mauricio Silva de Lima3,
  4. Ulrike H Schmidt4,
  5. Josué Bacaltchuk5,
  6. Janet Treasure6

Editorial Group: Cochrane Depression, Anxiety and Neurosis Group

Published Online: 17 OCT 2007

DOI: 10.1002/14651858.CD006816


How to Cite

Claudino AM, Hay PJ, Silva de Lima M, Schmidt UH, Bacaltchuk J, Treasure J. Antipsychotic drugs for anorexia nervosa (Protocol). Cochrane Database of Systematic Reviews 2007, Issue 4. Art. No.: CD006816. DOI: 10.1002/14651858.CD006816.

Author Information

  1. 1

    Institute of Psychiatry, King's College London, Section of Eating Disorders, London, UK

  2. 2

    University of Western Sydney, School of Medicine, Penrith, New South Wales, Australia

  3. 3

    Genentech, US Medical Affairs, South San Francisco, California, USA

  4. 4

    King's College London, Institute of Psychiatry, Section of Eating Disorders, London, UK

  5. 5

    Universidade Federal de São Paulo, Department of Psychiatry, São Paulo, São Paulo, Brazil

  6. 6

    5th Floor Thomas Guy House, Department of Academic Psychiatry, London, UK

*Angélica M Claudino, Section of Eating Disorders, Institute of Psychiatry, King's College London, De Crespigny Park, PO Box 59, London, SE5 8AF, UK. angelica.claudino@uol.com.br.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 17 OCT 2007

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Abstract

  1. Top of page
  2. Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

1. The primary objective of this review is to determine if antipsychotic drugs are clinically effective in improving weight gain and reducing the core psychopathology of AN when compared to placebo.

2. Secondary objectives are:
(a) To investigate whether different classes/types of antipsychotics (eg. atypical versus typicals) differ in efficacy or acceptability for AN;
(b) To compare the efficacy and acceptability of treatments (e.g. inpatient programs, specific psychotherapies) for AN combined with an antipsychotic drug versus the same intervention(s) alone (i.e. without any drug);
(c) To investigate if antipsychotics may be effective in ameliorating the core psychopathology of AN (e.g. distorted body image, morbid preoccupation with weight and shape) independently of the effect in weight restoration;
(d) To identify factors (clinical, methodological) which predict response to treatment with antipsychotic drugs.