Allopurinol for preventing mortality and morbidity in newborn infants with suspected hypoxic-ischaemic encephalopathy

  • Protocol
  • Intervention


  • T Chaudhari,

  • Z Kecskes,

  • W McGuire

Dr William McGuire, Associate Professor of Neonatology, Department of Paediatrics and Child Health, Australian National University Medical School, Canberra Hospital Campus, Canberra, ACT 2606, AUSTRALIA.


This is the protocol for a review and there is no abstract. The objectives are as follows:

To determine the effect of allopurinol on mortality and morbidity in term and near-term newborn infants with suspected hypoxic-ischaemic encephalopathy.

The following subgroup analyses are planned:
1. Trials that assessed allopurinol as a sole therapy.
2. Trials of allopurinol as an adjunct to an another therapy.
2. Trials where participants were predominantly (more than 80%) infants with moderate or severe encephalopathy (Sarnat 1976).