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Allopurinol for preventing mortality and morbidity in newborn infants with suspected hypoxic-ischaemic encephalopathy

  • Protocol
  • Intervention

Authors

  • T Chaudhari,

  • Z Kecskes,

  • W McGuire


Dr William McGuire, Associate Professor of Neonatology, Department of Paediatrics and Child Health, Australian National University Medical School, Canberra Hospital Campus, Canberra, ACT 2606, AUSTRALIA. william.mcguire@act.gov.au.

Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

To determine the effect of allopurinol on mortality and morbidity in term and near-term newborn infants with suspected hypoxic-ischaemic encephalopathy.

The following subgroup analyses are planned:
1. Trials that assessed allopurinol as a sole therapy.
2. Trials of allopurinol as an adjunct to an another therapy.
2. Trials where participants were predominantly (more than 80%) infants with moderate or severe encephalopathy (Sarnat 1976).