This is the protocol for a review and there is no abstract. The objectives are as follows:
To determine the effect of allopurinol on mortality and morbidity in term and near-term newborn infants with suspected hypoxic-ischaemic encephalopathy.
The following subgroup analyses are planned:
1. Trials that assessed allopurinol as a sole therapy.
2. Trials of allopurinol as an adjunct to an another therapy.
2. Trials where participants were predominantly (more than 80%) infants with moderate or severe encephalopathy (Sarnat 1976).