Intervention Review

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Heliox for croup in children

  1. Irene Moraa1,*,
  2. Nancy Sturman2,
  3. Treasure McGuire3,
  4. Mieke L van Driel2,4,5

Editorial Group: Cochrane Acute Respiratory Infections Group

Published Online: 7 DEC 2013

Assessed as up-to-date: 12 NOV 2013

DOI: 10.1002/14651858.CD006822.pub4


How to Cite

Moraa I, Sturman N, McGuire T, van Driel ML. Heliox for croup in children. Cochrane Database of Systematic Reviews 2013, Issue 12. Art. No.: CD006822. DOI: 10.1002/14651858.CD006822.pub4.

Author Information

  1. 1

    Pharmacy Australia Centre of Excellence, School of Pharmacy, Woolloongabba, Australia

  2. 2

    The University of Queensland, Discipline of General Practice, School of Medicine, Brisbane, Queensland, Australia

  3. 3

    Bond University, Faculty of Health Sciences and Medicine, Gold Coast, Queensland, Australia

  4. 4

    Bond University, Centre for Research in Evidence-Based Practice, Gold Coast, QLD, Australia

  5. 5

    Ghent University, Department of General Practice and Primary Health Care, Ghent, Belgium

*Irene Moraa, School of Pharmacy, Pharmacy Australia Centre of Excellence, 20 Cornwall Street, Woolloongabba, Australia. imoraa@yahoo.com.

Publication History

  1. Publication Status: New search for studies and content updated (conclusions changed)
  2. Published Online: 7 DEC 2013

SEARCH

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Pardillo 2009 {published data only}
  • Pardillo MR, Citores AP, Navarro CM, Soler MG, Lopez VP. Heliox as mild treatment for croup [Heliox como tratamiento del crup moderado]. Acta Pediatrica Espanola 2009;67(9):432-4.
Terregino 1998 {published data only}
Weber 2001 {published data only}
  • Weber JE, Chudnofsky CR, Younger JG, Larkin GL, Boczar M, Wilkerson MD, et al. A randomized comparison of helium-oxygen mixture (Heliox) and racemic epinephrine for the treatment of moderate to severe croup. Pediatrics 2001;107:E96.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Beckmann 2000 {published data only}
Brown 2002 {published data only}
Choi 2012 {published data only}
DiCecco 2004 {published data only}
  • DiCecco RJ, Rega PP. The application of heliox in the management of croup by an air ambulance service. Air Medical Journal 2004;23(2):33-5.
Duncan 1979 {published data only}
Frazier 2010 {published data only}
Gupta 2005 {published data only}
  • Gupta VK, Cheifetz IM. Heliox administration in the pediatric intensive care unit: an evidence-based review. Pediatric Critical Care Medicine 2005;6(2):204-11.
Iglesias 2007 {published data only}
  • Iglesias FC, Lopez-Herce CJ, Mencia BS, Santiago LMJ, Moral TR, Carrillo AA. Efficacy of heliox therapy in respiratory insufficiency in infants and children. Anales de Pediatrica 2007;66(3):240-7.
Johnson 2009 {published data only}
  • Johnson DW. Croup. Clinical Evidence (http://clinicalevidence.bmj.com/ceweb/conditions/chd/0321/0321.jsp) (accessed June 2009) 2009.
Kaditis 1998 {published data only}
Kline-Krammes 2012 {published data only}
  • Kline-Krammes S, Reed C, Giuliano JS Jr, Schwartz HP, Forbes M, Pope J, et al. Heliox in children with croup: a strategy to hasten improvement. Air Medical Journal 2012;31(3):131-7.
Myers 2004 {published data only}
  • Myers TR. Therapeutic gases for neonatal and pediatric respiratory care. Respiratory Care 2004;48(4):399-422.
Myers 2006 {published data only}
Nelson 1982 {published data only}
  • Nelson DS, McClellan L. Helium-oxygen mixtures as adjunctive support for refractory viral croup. Ohio State Medical Journal 1982;78(10):729-30.
Nicolai 2012 {published data only}
  • Nicolai T. Infection-associated acute airway obstruction in children [Infektiös Bedingte Akute Atemwegsobstruktion bei Kindern]. Notfall und Rettungsmedizin 2012;15(2):103-10.
Pitluk 2011 {published data only}
Rosekrans 1998 {published data only}
Smith 1999 {published data only}
Wald 2010 {published data only}
Wright 2005 {published data only}

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Barach 1935
  • Barach AL. Use of helium in the treatment of asthma and obstructive lesions in the larynx and trachea. Annals of Internal Medicine 1935;9:739-65.
Barach 1936
  • Barach AL. The therapeutic use of helium. Journal of the American Medical Association 1936;107:1273-80.
Bjornson 2011
Cambonie 2006
  • Cambonie G, Milesi C, Fournier-Favre S, Council F, Jaber S, Picaud JP, et al. Clinical effects of heliox administration for acute bronchiolitis in young infants. Chest 2006;129:676-82.
Denny 1983
Fitzgerald 1996
  • Fitzgerald D, Mellis C, Johnson M, Allen H, Cooper P, Van Asperen P. Nebulized budesonide is as effective as nebulized adrenaline in moderately severe croup. Pediatrics 1996;97:722-5.
Glauser 1969
Grozs 2001
Higgins 2011
  • Higgins JPT, Altman DG (editors). Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.1 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Hollman 1998
  • Hollman G, Shen G, Zeng L, Yngsdal-Krenz R, Perloff W, Zimmerman J, et al. Helium-oxygen improves clinical asthma scores in children with acute bronchiolitis. Critical Care Medicine 1998;26:1731-6.
Houck 1990
Katz 2001
  • Katz A, Gentile MA, Craig DM, Quick G, Meliones JN, Cheifetz IM. Heliox improves gas exchange during high-frequency ventilation in a pediatric model of acute lung injury. American Journal of Respiratory Critical Care Medicine 2001;164:260-4.
Katz 2003
  • Katz AL, Gentile MA, Craig DM, Quick G, Cheifetz IM. Heliox does not affect gas exchange during high-frequency oscillatory ventilation if tidal volume is held constant. Critical Care Medicine 2003;31:2006-9.
Klassen 1998
Liet 2010
Martinon-Torres 2002
Martinon-Torres 2003
  • Martinon-Torres F, Rodriguez-Nunez A, Martinon-Sanchez JM, Ball J, Grounds M, Waddell A, et al. Heliox questions. Pediatrics 2003;111:411-3.
Marx 1997
  • Marx A, Torok TJ, Holman RC, Clarke MJ, Anderson LJ. Pediatric hospitalizations for croup (laryngotracheobronchitis): biennial increases associated with human influenza virus 1 epidemics. Journal of Infectious Diseases 1997;176:1423-7.
Papamoschou 1995
Rittichier 2000
Robin 1988
Rodrigo 2010
  • Rodrigo GJ, Pollack CV, Rodrigo C, Rowe BH. Heliox for non-intubated acute asthma patients. Cochrane Database of Systematic Reviews 2010, Issue 10. [DOI: 10.1002/14651858.CD002884.pub2]
Russell 2012
  • Russell KF, Liang Y, O'Gorman K, Johnson DW, Klassen TP. Glucocorticoids for croup. Cochrane Database of Systematic Reviews 2012, Issue 1. [DOI: 10.1002/14651858.CD001955.pub3]
Segal 2005
Stillwell 1989
Taussig 1975
  • Taussig L, Castro O, Beaudry PH. Treatment of laryngotracheobronchitis (croup). Use of intermittent positive-pressure breathing and racemic epinephrine. American Journal of Diseases of Children 1975;129:790-3.
Vorwerk 2008
Westley 1978

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Vorwerk 2010