Intervention Review

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Interventions for preventing critical illness polyneuropathy and critical illness myopathy

  1. Greet Hermans1,
  2. Bernard De Jonghe2,
  3. Frans Bruyninckx3,
  4. Greet Van den Berghe4,*

Editorial Group: Cochrane Neuromuscular Group

Published Online: 30 JAN 2014

Assessed as up-to-date: 4 OCT 2011

DOI: 10.1002/14651858.CD006832.pub3


How to Cite

Hermans G, De Jonghe B, Bruyninckx F, Van den Berghe G. Interventions for preventing critical illness polyneuropathy and critical illness myopathy. Cochrane Database of Systematic Reviews 2014, Issue 1. Art. No.: CD006832. DOI: 10.1002/14651858.CD006832.pub3.

Author Information

  1. 1

    KU Leuven, Department of Cellular and Molecular Medicine, Leuven, Belgium

  2. 2

    Centre Hospitalier de Poissy-Saint-Germain, Réanimation Médico-Chirurgicale, Poissy, France

  3. 3

    KU Leuven, University Hospitals, Physical Medicine and Rehabilitation, Leuven, Belgium

  4. 4

    KU Leuven, University Hospitals, Department of Intensive Care Medicine, Leuven, Belgium

*Greet Van den Berghe, Department of Intensive Care Medicine, KU Leuven, University Hospitals, Herestraat 49,3000, Leuven, Belgium. Greta.vandenberghe@med.kuleuven.be.

Publication History

  1. Publication Status: New search for studies and content updated (conclusions changed)
  2. Published Online: 30 JAN 2014

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
Hermans 2007 {published and unpublished data}
  • Hermans G, Wilmer A, Meersseman W, Milants I, Wouters PJ, Bobbaers H, et al. Impact of intensive insulin therapy on neuromuscular complications and ventilator-dependency in MICU. American Journal of Respiratory Critical Care Medicine 2007;175(5):480-9. [PUBMED: 17138955]
Routsi 2010 {published data only}
  • Routsi C, Gerovasili V, Vasileiadis I, Karatzanos E, Pitsolis T, Tripodaki E, et al. Electrical muscle stimulation prevents critical illness polyneuromyopathy: a randomized parallel intervention trial. Critical Care (London, England) 2010;14(2):R74. [PUBMED: 20426834]
Schweickert 2009 {published and unpublished data}
  • Schweickert WD, Pohlman MC, Pohlman AS, Nigos C, Pawlik AJ, Esbrook CL, et al. Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet 2009;373(9678):1874-82. [PUBMED: 19446324]
Steinberg 2006 {published data only (unpublished sought but not used)}
  • Steinberg KP, Hudson LD, Goodman RB, Hough CL, Lanken PN, Hyzy R, et al. Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome. New England Journal of Medicine 2006;354(16):1671-84. [PUBMED: 16625008]
Van den Berghe 2005 {published and unpublished data}
  • Van den Berghe G, Schoonheydt K, Becx P, Bruyninckx F, Wouters PJ. Insulin therapy protects the central and peripheral nervous system of intensive care patients. Neurology 2005;64(8):1348-53. [PUBMED: 15851721]

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
Berard 2000 {published data only}
  • Bérard MP, Zazzo JF, Condat P, Vasson MP, Cynober L. Total parenteral nutrition enriched with arginine and glutamate generates glutamine and limits protein catabolism in surgical patients hospitalized in intensive care units. Critical Care Medicine 2000;28(11):3637-44. [PUBMED: 11098966]
Bouletreau 1985 {published data only}
  • Bouletreau P, Patricot MC, Saudin F, Guiraud M, Mathian B. Effects of intermittent electrical stimulations on muscle catabolism intensive care patients. JPEN. Journal of Parenteral and Enteral Nutrition 1987;11(6):552-5. [PUBMED: 3501482]
Brunello 2010 {published data only}
  • Brunello AG, Haenggi M, Wigger O, Porta F, Takala J, Jakob SM. Usefulness of a clinical diagnosis of ICU-acquired paresis to predict outcome in patients with SIRS and acute respiratory failure. Intensive Care Medicine 2010;36(1):66-74. [PUBMED: 19760204]
Burtin 2009 {published and unpublished data}
  • Burtin C, Clerckx B, Robbeets C, Ferdinande P, Langer D, Troosters T, et al. Early exercise in critically ill patients enhances short-term functional recovery. Critical Care Medicine 2009;37(9):2499-505. [PUBMED: 19623052]
Caruso 2005 {published and unpublished data}
  • Caruso P, Denari SD, Ruiz SA, Bernal KG, Manfrin GM, Friedrich C, et al. Inspiratory muscle training is ineffective in mechanically ventilated critically ill patients. Clinics (Sao Paulo, Brazil) 2005;60(6):479-84. [PUBMED: 16358138]
Chen 2011 {published data only}
  • Chen F, Wang J, Jiang Y. Influence of different routes of nutrition on the respiratory muscle strength and outcome of elderly patients in respiratory intensive care unit. Chinese Journal of Clinical Nutrition 2011;19(1):7-11.
Chiang 2006 {published data only}
  • Chiang LL, Wang LY, Wu CP, Wu HD, Wu YT. Effects of physical training on functional status in patients with prolonged mechanical ventilation. Physical Therapy 2006;86(9):1271-81. [PUBMED: 16959675]
Fläring 2003 {published data only}
Gamrin 2000 {published data only}
  • Gamrin L, Essén P, Hultman E, McNurlan MA, Garlick PJ, Wernerman J. Protein-sparing effect in skeletal muscle of growth hormone treatment in critically ill patients. Annals of Surgery 2000;231(4):577-86. [PUBMED: 10749620]
Gerovasili 2009a {published data only}
  • Gerovasili V, Tripodaki E, Karatzanos E, Pitsolis T, Markaki V, Zervakis D, et al. Short-term systemic effect of electrical muscle stimulation in critically ill patients. Chest 2009;136(5):1249-56. [PUBMED: 19710290]
Gerovasili 2009b {published data only}
  • Gerovasili V, Stefanidis K, Vitzilaios K, Karatzanos E, Politis P, Koroneos A, et al. Electrical muscle stimulation preserves the muscle mass of critically ill patients: a randomized study. Critical Care (London, England) 2009;13(5):R161. [PUBMED: 19814793]
Gruther 2010 {published data only}
  • Gruther W, Kainberger F, Fialka-Moser V, Paternostro-Sluga T, Quittan M, Spiss C, et al. Effects of neuromuscular electrical stimulation on muscle layer thickness of knee extensor muscles in intensive care unit patients: a pilot study. Journal of Rehabilitation Medicine 2010;42(6):593-7. [PUBMED: 20549166]
Hsieh 2006 {published data only}
  • Hsieh LC, Chien SL, Huang MS, Tseng HF, Chang CK. Anti-inflammatory and anticatabolic effects of short-term beta-hydroxy-beta-methylbutyrate supplementation on chronic obstructive pulmonary disease patients in intensive care unit. Asia Pacific Journal of Clinical Nutrition 2006;15(4):544-50. [PUBMED: 17077073]
Huang 2006 {published data only}
  • Huang CJ, Lin HC. Association between adrenal insufficiency and ventilator weaning. American Journal of Respiratory and Critical Care Medicine 2006;173(3):276-80. [PUBMED: 16272449]
Johnson 1993 {published data only (unpublished sought but not used)}
  • Johnson D, Gallagher C, Cavanaugh M, Yip R, Mayers I. The lack of effect of routine magnesium administration on respiratory function in mechanically ventilated patients. Chest 1993;104(2):536-41. [PUBMED: 8339645]
Karatzanos 2012 {published data only}
  • Karatzanos E, Gerovasili V, Zervakis D, Tripodaki ES, Apostolou K, Vasileiadis I, et al. Electrical muscle stimulation: an effective form of exercise and early mobilization to preserve muscle strength in critically ill patients. Critical Care Research and Practice 2012;2012:432752. [PUBMED: 22545212]
Knox 1996 {published data only}
Kuhls 2007 {published data only}
  • Kuhls DA, Rathmacher JA, Musngi MD, Frisch DA, Nielson J, Barber A, et al. Beta-hydroxy-beta-methylbutyrate supplementation in critically ill trauma patients. Journal of Trauma 2007;62(1):125-31. [PUBMED: 17215743]
Martin 2011 {published and unpublished data}
  • Martin AD, Smith BK, Davenport PD, Harman E, Gonzalez-Rothi RJ, Baz M, et al. Inspiratory muscle strength training improves weaning outcome in failure to wean patients: a randomized trial. Critical Care (London, England) 2011;15(2):R84. [PUBMED: 21385346]
Menadue 2010 {published data only}
  • Menadue C, Alison JA, Piper AJ, Flunt D, Ellis ER. Bilevel ventilation during exercise in acute on chronic respiratory failure: a preliminary study. Respiratory Medicine 2010;104(2):219-27. [PUBMED: 19804963]
Miao 2005 {published data only}
  • Miao LJ, Wang J, Liu H, Cheng Z. Role of enteral nutrition combined with parenteral nutrition in supporting mechanical ventilation of patients with chronic obstructive pulmonary disease accompanied by respiratory failure. Chinese Journal of Clinical Rehabilitation 2005;9(31):27-9.
Mohr 1997 {published data only}
  • Mohr M, Englisch L, Roth A, Burchardi H, Zielmann S. Effects of early treatment with immunoglobulin on critical illness polyneuropathy following multiple organ failure and gram-negative sepsis. Intensive Care Medicine 1997;23(11):1144-9. [PUBMED: 9434920]
Morris 2008 {published data only}
  • Morris PE, Goad A, Thompson C, Taylor K, Harry B, Passmore L, et al. Early intensive care unit mobility therapy in the treatment of acute respiratory failure. Critical Care Medicine 2008;36(8):2238-43. [PUBMED: 18596631]
Nava 1998 {published data only}
Paddon-Jones 2005 {published data only}
  • Paddon-Jones D, Wolfe RR, Ferrando AA. Amino acid supplementation for reversing bed rest and steroid myopathies. Journal of Nutrition 2005;135(7):1809-12S. [PUBMED: 15987870]
Pichard 1996 {published data only (unpublished sought but not used)}
  • Pichard C, Kyle U, Chevrolet JC, Jolliet P, Slosman D, Mensi N. Lack of effects of recombinant growth hormone on muscle function in patients requiring prolonged mechanical ventilation: a prospective, randomized, controlled study. Critical Care Medicine 1996;24(3):403-13. [PUBMED: 8625627]
Porta 2005 {published data only}
  • Porta R, Vitacca M, Gilè LS, Clini E, Bianchi L, Zanotti E, et al. Supported arm training in patients recently weaned from mechanical ventilation. Chest 2005;128(4):2511-20. [PUBMED: 16236917]
Rodriguez 2012 {published and unpublished data}
  • Rodriguez PO, Setten M, Maskin LP, Bonelli I, Vidomlansky SR, Attie S, et al. Muscle weakness in septic patients requiring mechanical ventilation: protective effect of transcutaneous neuromuscular electrical stimulation. Journal of Critical Care 2012;27(3):319 e1-8. [PUBMED: 21715139]
Routsi 2009 {published data only}
  • Routsi C, Gerovasili V, Zevakis D, Karatzanos E, Papadopoulos E, Pitsolis T, et al. Electrical muscle stimulation prevents critical illness polyneuromyopathy in ICU patients. Intensive Care Medicine. Conference: 22nd Annual Congress of the European Society of Intensive Care Medicine, ESICM Vienna, Austria 2009;35:s133.
Salisbury 2010 {published data only}
Sevette 2005 {published data only}
  • Sevette A, Smith RC, Aslani A, Kee AJ, Hansen R, Barratt SM, et al. Does growth hormone allow more efficient nitrogen sparing in postoperative patients requiring parental nutrition? A double-blind placebo-controlled randomised trial. Clinical Nutrition 2005;24(6):943-55. [PUBMED: 16083996]
Takala 1999a {published and unpublished data}
  • Takala J, Ruokonen E, Webster NR, Nielsen MS, Zandstra DF, Vundelinckx G, et al. Increased mortality associated with growth hormone treatment in critically ill adults. New England Journal of Medicine 1999;341(11):785-92. [PUBMED: 10477776]
Takala 1999b {published and unpublished data}
  • Takala J, Ruokonen E, Webster NR, Nielsen MS, Zandstra DF, Vundelinckx G, et al. Increased mortality associated with growth hormone treatment in critically ill adults. New England Journal of Medicine 1999;341(11):785-92. [PUBMED: 10477776]
Tjäder 2004 {published data only}
  • Tjäder I, Rooyackers O, Forsberg AM, Vesali RF, Garlick PJ, Wernerman J. Effects on skeletal muscle of intravenous glutamine supplementation to ICU patients. Intensive Care Medicine 2004;30(2):266-75. [PUBMED: 14722645]
Toledo 2007 {published data only}
  • Toledo A, Borghi-Silva A, Sampaio LM, Ribeiro KP, Baldissera V, Costa D. The impact of noninvasive ventilation during the physical training in patients with moderate-to-severe chronic obstructive pulmonary disease (COPD). Clinics (Sao Paulo, Brazil) 2007;62(2):113-20. [PUBMED: 17505694]
Vivodtzev 2006 {published data only}
  • Vivodtzev I, Pépin JL, Vottero G, Mayer V, Porsin B, Lévy P, et al. Improvement in quadriceps strength and dyspnea in daily tasks after 1 month of electrical stimulation in severely deconditioned and malnourished COPD. Chest 2006;129(6):1540-8. [PUBMED: 16778272]
Watters 1997 {published data only (unpublished sought but not used)}
  • Watters JM, Kirkpatrick SM, Norris SB, Sharmji FM, Wells GA. Immediate postoperative enteral feeding results in impaired respiratory mechanics and decreased mobility. Annals of Surgery 1997;226(3):369-77. [PUBMED: 9339943]
Zanotti 2003 {published data only (unpublished sought but not used)}
  • Zanotti E, Felicetti G, Maini M, Fracchia C. Peripheral muscle strength training in bed-bound patients with COPD receiving mechanical ventilation: effect of electrical stimulation. Chest 2003;124(1):292-6. [PUBMED: 12853536]
Ziegler 1990 {published data only}
  • Ziegler TR, Young LS, Ferrari-Baliviera E, Demling RH, Wilmore DW. Use of human growth hormone combined with nutritional support in a critical care unit. JPEN. Journal of Parenteral and Enteral Nutrition 1990;14(6):574-81. [PUBMED: 2273531]

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
Abokhabar 2012 {published data only}
  • Abokhabar H, Abouelela A, Abdelkarim I. Effect of electrical muscle stimulation in prevention of ICU acquired muscle weakness and facilitation of weaning from mechanical ventilation. Intensive Care Medicine. 2012; Vol. 38:S132.
Alia 2011 {published data only}
  • Alía I, de la Cal MA, Esteban A, Abella A, Ferrer R, Molina FJ, et al. Efficacy of corticosteroid therapy in patients with an acute exacerbation of chronic obstructive pulmonary disease receiving ventilatory support. Archives of Internal Medicine 2011;171(21):1939-46. [PUBMED: 22123804]
Brunner 2013 {published data only}
  • Brunner R, Rinner W, Haberler C, Kitzberger R, Sycha T, Herkner H, et al. Early treatment with IgM-enriched intravenous immunoglobulin does not mitigate critical illness polyneuropathy and/or myopathy in patients with multiple organ failure and SIRS/sepsis: a prospective, randomized, placebo-controlled, double-blinded trial. Critical Care (London, England) 2013;17(5):R213. [PUBMED: 24088271]
Devost 2011 {published data only}
  • Devost A-A, Boilard G, Vovodtzev, Saey D, Mainguy V, Maltais F, et al. Efficiency of neuromuscular electrical stimulation to prevent ICU-acquired weakness in mechanically ventilated patients. Intensive Care Medicine. 2011:S13.
Files 2013 {published data only}
  • Files D, Morris P, Shrestha S, Dhar S, Young M, Hauser J, et al. Randomized, controlled pilot study of early rehabilitation strategies in acute respiratory failure. Critical Care 2013;17(Suppl 2):P540.
Gerovasili 2011 {published data only}
  • Gerovasili V,  Karatzanos L,   Zervakis D, Dimopoulos S, Tripodaki E-S, Pitsolis T,  et al. Electrical muscle simulation is an effective form of excercise and early rehabilitation in ICU patients. American Journal of Respiratory and Critical Care Medicine. 2011; Vol. 183:A3740.
Hermans 2013 {published data only}
  • Hermans G, Casaer MP, Clerckx B, Güiza F, Vanhullebusch T, Derde S, et al. Effect of tolerating macronutrient deficit on the development of intensive-care unit acquired weakness: a subanalysis of the EPaNIC trial. The Lancet Respiratory Medicine 2013;1(8):621-9.
Mikaeili 2012 {published data only}
  • Mikaeili H, Yazdchi M, Barazandeh F, Ansarin K. Euglycemic state reduces the incidence of critical illness polyneuropathy and duration of ventilator dependency in medical intensive care unit. Bratislavské Lekárske Listy 2012;113(10):616-9. [PUBMED: 23094903]
Paternostro-Sluga 2012 {published data only}
  • Paternostro-Sluga T, Hiesmayr M, Janda D, Senekowitsch S. Early neuromuscular electrical stimulation for intensive care unit patients: effect on muscle strength and urinary nitrogen excretion. The Journal of Injury, Function, and Rehabilitation 2012;4(10 Suppl):S310.

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
Kho 2012 {published data only}
  • Kho ME, Truong AD, Brower RG, Palmer JB, Fan E, Zanni JM, et al. Neuromuscular electrical stimulation for intensive care unit-acquired weakness: protocol and methodological implications for a randomized, sham-controlled, phase II trial. Physical Therapy 2012;92(12):1564-79. [PUBMED: 22421734]
Parry 2012 {published data only}
  • Parry SM, Berney S, Koopman R, Bryant A, El-Ansary D, Puthucheary Z, et al. Early rehabilitation in critical care (eRiCC): functional electrical stimulation with cycling protocol for a randomised controlled trial. BMJ Open 2012;2(5):e001891. [PUBMED: 22983782]

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
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References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
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