Intervention Review

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Interventions for erythropoietin-resistant anaemia in dialysis patients

  1. Sunil V Badve1,*,
  2. Elaine M Beller2,
  3. Alan Cass3,
  4. Daniel P Francis4,
  5. Carmel Hawley1,
  6. Iain C Macdougall5,
  7. Vlado Perkovic3,
  8. David W Johnson1

Editorial Group: Cochrane Kidney and Transplant Group

Published Online: 26 AUG 2013

Assessed as up-to-date: 4 APR 2013

DOI: 10.1002/14651858.CD006861.pub3


How to Cite

Badve SV, Beller EM, Cass A, Francis DP, Hawley C, Macdougall IC, Perkovic V, Johnson DW. Interventions for erythropoietin-resistant anaemia in dialysis patients. Cochrane Database of Systematic Reviews 2013, Issue 8. Art. No.: CD006861. DOI: 10.1002/14651858.CD006861.pub3.

Author Information

  1. 1

    Princess Alexandra Hospital, Department of Nephrology, Woolloongabba, QLD, Australia

  2. 2

    Bond University, Faculty of Health Sciences and Medicine, Gold Coast, QLD, Australia

  3. 3

    The George Institute for Global Health, Renal and Metabolic Division, Camperdown, NSW, Australia

  4. 4

    Queensland Health, Central Regional Services, Division of the CHO, Stafford DC, QLD, Australia

  5. 5

    King's College Hospital, Renal Unit, London, UK

*Sunil V Badve, Department of Nephrology, Princess Alexandra Hospital, Woolloongabba, QLD, 4102, Australia. sunil_badve@health.qld.gov.au.

Publication History

  1. Publication Status: New
  2. Published Online: 26 AUG 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Attallah 2006 {published data only}
  • Attallah N, Osman-Malik Y, Adams B, Frinak S, Besarab A. Effect of intravenous ascorbic acid in hemodialysis patients with erythropoietin-hyporesponsive anemia and hyperferritenemia [abstract]. Journal of the American Society of Nephrology 2005;16:488A.
  • Attallah N, Osman-Malik Y, Frinak S, Besarab A. Effect of intravenous ascorbic acid in hemodialysis patients with EPO-hyporesponsive anemia and hyperferritinemia. American Journal of Kidney Diseases 2006;47(4):644-54. [MEDLINE: 16564942]
Ayli 2004 {published data only}

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Abe 2010 {published data only}
  • Abe M, Okada K, Maruyama T, Maruyama N, Soma M, Matsumoto K. Clinical effectiveness and safety evaluation of long-term pioglitazone treatment for erythropoietin responsiveness and insulin resistance in type 2 diabetic patients on hemodialysis. Expert Opinion on Pharmacotherapy 2010;11(10):1611-20. [MEDLINE: 20540652]
Acchiardo 1989 {published data only}
  • Acchiardo SR, Quinn BP, Burk LB, Moore LW. Are high flux dialysis and erythropoietin treatment in a collision course?. ASAIO Transactions 1989;35(3):308-10. [MEDLINE: 2688711]
Aliev 1997 {published data only}
  • Aliev MA, Ismagilov RZ, Tsoy GM, Yusumbaeva AS. Influence of Eprex in combination with antihistamine drugs on correction of anemia in haemodialysis patients [abstract]. 34th Congress European Renal Association/European Dialysis and Transplantation Association; Geneva, Switzerland. 1997:236.
Andrulli 2010 {published data only}
  • Andrulli S, Di Filippo S, Manzoni C, Stefanelli L, Floridi A, Galli F, et al. Effect of synthetic vitamin E-bonded membrane on responsiveness to erythropoiesis-stimulating agents in hemodialysis patients: a pilot study. Nephron 2010;115(1):c82-9. [MEDLINE: 20215781]
Ballal 1991 {published data only}
  • Ballal SH, Domoto DT, Polack DC, Marciulonis P, Martin KJ. Androgens potentiate the effects of erythropoietin in the treatment of anemia of end-stage renal disease. American Journal of Kidney Diseases 1991;17(1):29-33. [MEDLINE: 1986567]
Barany 1998 {published data only}
  • Barany P. Treatment of anemia in hemodialysis patients to a normal hemoglobin concentration - results of an open randomized clinical trial of epoetin beta [abstract]. Journal of the American Society of Nephrology 1998;9:243A.
Berns 1992 {published data only}
  • Berns JS, Rudnick MR, Cohen RM. A controlled trial of recombinant human erythropoietin and nandrolone decanoate in the treatment of anemia in patients on chronic hemodialysis. Clinical Nephrology 1992;37(5):264-7. [MEDLINE: 1606777]
Brockenbrough 2006 {published data only}
  • Brockenbrough AT, Dittrich MO, Page ST, Smith T, Stivelman JC, Bremner WJ. Transdermal androgen therapy to augment EPO in the treatment of anemia of chronic renal disease. American Journal of Kidney Diseases 2006;47(2):251-62. [MEDLINE: 16431254]
Buchwald 1977 {published data only}
Cao 2010 {published data only}
  • Cao W, Liu JH, Zhang H, Zhang L, Zhang LY, Pan MM. Effect of acupoint injection on erythropoietin resistance in patients with chronic renal failure. Zhongguo Zhenjiu [Chinese Acupuncture & Moxibustion] 2010;30(11):891-5. [MEDLINE: 21246842]
Caruso 1998 {published data only}
  • Caruso U, Leone L, Cravotto E, Nava D. Effects of L-carnitine on anemia in aged hemodialysis patients treated with recombinant human erythropoietin: A pilot study. Dialysis & Transplantation 1998;27(8):498-506. [EMBASE: 1998284168]
Cerulli 2000 {published data only}
  • The effect of hemodiafiltration with on-line endogenous reinfusion (on-line HFR) on anemia: design of a European, open, randomised, multicentre trial. European Collaborative Study. Journal of Nephrology 2000;13(1):34-42. [MEDLINE: 10720212]
Chan 2005 {published data only}
  • Chan D, Irish A, Croft KD, Dogra G. Effect of ascorbic acid supplementation on plasma isoprostanes in haemodialysis patients. Nephrology Dialysis Transplantation 2006;21(1):234-5. [MEDLINE: 16204285]
  • Chan D, Irish A, Dogra G. Efficacy and safety of oral compared with intravenous ascorbic acid in improving anaemia in erythropoietin hyporesponsive, iron overloaded, haemodialysis patients - a randomised open-label study [abstract]. Nephrology 2003;8 Suppl 3:A80-1.
  • Chan D, Irish A, Dogra G. Efficacy and safety of oral versus intravenous ascorbic acid for anaemia in haemodialysis patients. Nephrology 2005;10(4):336-40. [MEDLINE: 16109077]
Chen 2003 {published data only}
  • Chen WT, Lin YF, Yu FC, Kao WY, Huang WH, Yan HC. Effect of ascorbic acid administration in hemodialysis patients on in vitro oxidative stress parameters: influence of serum ferritin levels. American Journal of Kidney Diseases 2003;42(1):158-66. [MEDLINE: 12830468]
Cruz 2008 {published data only}
  • Cruz DN, De Cal M, Garzotto F, Brendolan A, Nalesso F, Corradi V, et al. Effect of vitamin E-coated dialysis membranes on anemia in patients with chronic kidney disease: an Italian multicenter study. International Journal of Artificial Organs 2008;31(6):545-52. [MEDLINE: 18609507]
Culleton 2007 {published data only}
  • Culleton BF, Walsh M, Klarenbach SW, Mortis G, Scott-Douglas N, Quinn RR, et al. Effect of frequent nocturnal hemodialysis vs conventional hemodialysis on left ventricular mass and quality of life: a randomized controlled trial. JAMA 2007;298(11):1291-9. [MEDLINE: 17878421]
  • Culleton BF, Walsh M, Klarenbach SW, Mortis G, Scott-Douglas N, Quinn RR, et al. Nocturnal hemodialysis lowers blood pressure and reduces left ventricular mass: results of a randomized controlled trial [abstract]. Journal of the American Society of Nephrology 2007;18(Abstracts):67A-8A.
  • Khangura J, Culleton BF, Manns BJ, Zhang J, Barnieh L, Walsh M, et al. Association between routine and standardized blood pressure measurements and left ventricular hypertrophy among patients on hemodialysis. BMC Nephrology 2010;11:13. [MEDLINE: 20576127]
  • Manns BJ, Klarenbach S, Walsh M, Quinn R, Tonelli M, Scott-Douglas N, et al. The impact of nocturnal hemodialysis on quality of life: results of a randomized controlled trial [abstract]. Journal of the American Society of Nephrology 2007;18(Abstracts):298A-9A.
  • Manns BJ, Walsh MW, Culleton BF, Hemmelgarn B, Tonelli M, Schorr M, et al. Nocturnal hemodialysis does not improve overall measures of quality of life compared to conventional hemodialysis. Kidney International 2009;75(5):542-9. [MEDLINE: 19109588]
  • Schorr M, Manns BJ, Culleton B, Walsh M, Klarenbach S, Tonelli M, et al. The effect of nocturnal and conventional hemodialysis on markers of nutritional status: results from a randomized trial. Journal of Renal Nutrition 2011;21(3):271-6. [MEDLINE: 20650654]
  • Walsh M, Manns B, Tonelli M, Quinn R, Culleton B. Description of a randomized controlled trial on the effects of nocturnal hemodialysis on left ventricular hypertrophy compared to conventional hemodialysis [abstract]. Journal of the American Society of Nephrology 2005;16:734A-5A.
  • Walsh M, Manns BJ, Klarenbach S, Quinn R, Tonelli M, Culleton BF. The effects of nocturnal hemodialysis compared to conventional hemodialysis on change in left ventricular mass: rationale and study design of a randomized controlled pilot study. BMC Nephrology 2006;7:2. [MEDLINE: 16504054]
  • Walsh M, Manns BJ, Klarenbach S, Tonelli M, Hemmelgarn B, Culleton B. The effects of nocturnal compared with conventional hemodialysis on mineral metabolism: a randomized-controlled trial. Hemodialysis International 2010;14(2):174-81. [MEDLINE: 20041960]
Deira 2003 {published data only}
  • Deira J, Diego J, Martinez R, Oyarbide A, Gonzalez A, Diaz H, et al. Comparative study of intravenous ascorbic acid versus low-dose desferroxamine in patients on hemodialysis with hyperferritinemia. Journal of Nephrology 2003;16(5):703-9. [MEDLINE: 14733417]
Di Iorio 2003 {published data only}
  • Di Iorio BR, Bellizzi V, Minutolo R, De Nicola L, Iodice C, Conte G. Supplemented very low-protein diet in advanced CRF: is it money saving?. Kidney International 2004;65(2):742. [MEDLINE: 14717953]
  • Di Iorio BR, Minutolo R, De Nicola L, Bellizzi V, Catapano F, Iodice C, et al. Supplemented very low protein diet ameliorates responsiveness to erythropoietin in chronic renal failure. Kidney International 2003;64(5):1822-8. [MEDLINE: 14531817]
ECAP Study 2006 {published data only}
  • Rossert J, Gassmann-Mayer C, Frei D, McClellan W. Prevalence and predictors of epoetin hyporesponsiveness in chronic kidney disease patients. Nephrology Dialysis Transplantation 2007;22(3):794-800. [MEDLINE: 17210593]
  • Rossert J, Gassmann-Mayer C, Frei D, McClellan W. Prevalence and risk factors for erythropoetin hyporesponsiveness in chronic kidney disease: analysis of the ECAP study [abstract]. Journal of the American Society of Nephrology 2004;15(Oct):141A.
  • Rossert J, Levin A, Roger S, Horl W, Gassman-Mayer C, Frei D, et al. Effect of early correction of anemia on the progression of chronic kidney disease: final results ECAP study [abstract]. Journal of the American Society of Nephrology 2004;15(Oct):546A.
  • Rossert J, Levin A, Roger SD, Horl WH, Fouqueray B, Gassmann-Mayer C, et al. Effect of early correction of anemia on the progression of CKD. American Journal of Kidney Diseases 2006;47(5):738-50. [MEDLINE: 16632012]
  • Rossert J, Roger S, Levin A, Horl W, McClellan W. Effect on early correction of anemia on the progression of chronic kidney disease (ECAP) [abstract]. Journal of the American Society of Nephrology 2003;14(Nov):811A.
Eiselt 2000 {published data only}
Garcia Cortes 1999 {published data only}
  • Garcia Cortes MJ, Sanchez Pearles MC, Perez del Barrio MP, Borrego Utiel FJ, Liebana A, Borrego Hinojosa J, et al. Effects of biocompatible membranes on uremic anemia in hemodialysis patients [abstract]. Nephrology Dialysis Transplantation 1999;14(9):A260.
  • Garcia Cortes MJ, Sanchez Perales MC, Liebana A, Gil JM, Borrego FJ, Borrego J, et al. Beneficial effect of AN69 membranes on anemia in hemodialyzed patients. Nefrologia 2001;21(4):370-5. [MEDLINE: 11816513]
Garrote 2009 {published data only}
  • Garrote N, Guinsburg M, Garcia L, Boubee S, Moretto H, Canale R, et al. Vitamin C improves HB levels and reduce EPO resistance in hemodialysis (HD) patients with functional iron deficiency (FID). A randomized, open label, controlled multicentric trial [abstract SA778]. World Congress of Nephrology; 2009 May 22-26; Milan (Italy). 2009.
Gastaldello 1995 {published data only}
  • Gastaldello K, Vereerstraeten A, Nzame-Nze T, Vanherweghem JL, Tielemans C. Resistance to erythropoietin in iron-overloaded haemodialysis patients can be overcome by ascorbic acid administration. Nephrology Dialysis Transplantation 1995;10(Suppl 6):44-7. [MEDLINE: 8524494]
Gaughan 1997 {published data only}
  • Gaughan WJ, Liss KA, Dunn SR, Mangold AM, Buhsmer JP, Michael B, et al. A 6-month study of low-dose recombinant human erythropoietin alone and in combination with androgens for the treatment of anemia in chronic hemodialysis patients. American Journal of Kidney Diseases 1997;30(4):495-500. [MEDLINE: 9328363]
  • Liss KA, Gaughan WJ, Dunn SR, Michael B, Goldman JM, Armenti VT, et al. A six month study of low-dose recombinant human erythropoietin alone and in combination with androgen for the treatment of anemia in chronic hemodialysis patients [abstract]. Journal of the American Society of Nephrology 1996;7(9):1490.
Giancaspro 2000 {published data only}
  • Giancaspro V, Nuzziello M, Pallotta G, Sacchetti A, Petrarulo F. Intravenous ascorbic acid in hemodialysis patients with functional iron deficiency: a clinical trial. Journal of Nephrology 2000;13(6):444-9. [MEDLINE: 11132761]
Hakemi 2005 {published data only}
  • Hakemi MS, Ganji MR, Najafi I, Shekarchi M. Intravenous ascorbic acid in comparison to intravenous iron in erythropoietin resistant anemia with iron overload in hemodialysis patients [abstract]. Nephrology 2005;10(Suppl):A314.
Hsu 2004 {published data only}
  • Hsu PY, Lin CL, Yu CC, Chien CC, Hsiau TG, Sun TH, et al. Ultrapure dialysate improves iron utilization and erythropoietin response in chronic hemodialysis patients - a prospective cross-over study. Journal of Nephrology 2004;17(5):693-700. [MEDLINE: 15593037]
Hung 2005 {published data only}
  • Hung SC, Tung TY, Yang CS, Tarng DC. High-calorie supplementation increases serum leptin levels and improves response to rHuEPO in long-term hemodialysis patients. American Journal of Kidney Diseases 2005;45(6):1073-83. [MEDLINE: 15957137]
Imada 2001 {published data only}
  • Imada A, Yoshimoto S, Ohno T, Takahashi K, Imada T, Iida N. Effect of Vitamin C on recombinant human erythropoietin refractory anemia in patients with chronic hemodialysis [abstract]. Journal of the American Society of Nephrology 2001;12(Program & Abstracts):332A.
ISRCTN96315193 {published data only}
  • Comparison of the effect of erythropoietin, L-carnitine and erythropoietin plus L-carnitine in correction of anemia in chronic hemodialysis patients. http://www.controlled-trials.com/ISRCTN96315193/ISRCTN96315193 (accessed 11th March 2013).
Jacobs 2006 {published data only}
Janssen 1995 {published data only}
  • Janssen MJ, van der Kuy A, ter Wee PM, van Boven WP. Calcium acetate versus calcium carbonate and erythropoietin dosages in haemodialysis patients. Nephrology Dialysis Transplantation 1995;10(12):2321-4. [MEDLINE: 8808233]
Kato 2000 {published data only}
Keven 2003 {published data only}
  • Deicher R, Horl WH. Vitamin C for hyporesponsiveness to EPO: a cure for all?. American Journal of Kidney Diseases 2003;42(4):848-9. [MEDLINE: 14520639]
  • Keven K, Kutlay S, Nergizoglu G, Duman N, Erturk S. The effect of intravenous vitamin C on erythropoietin response in haemodialysis patients [abstract]. Nephrology Dialysis Transplantation 2002;17(Suppl 1):229.
  • Keven K, Kutlay S, Nergizoglu G, Erturk S. Randomized, crossover study of the effect of vitamin C on EPO response in hemodialysis patients. American Journal of Kidney Diseases 2003;41(6):1233-9. [MEDLINE: 12776276]
  • Keven K, Kutlay S, Nergizoglu G, Erturk S. The effect of Vitamin C on erythropoietin response in hemodialysis patients [abstract]. Journal of the American Society of Nephrology 2001;12(Program & Abstracts):357A-8A.
Klarenbach 2002 {published data only}
  • Klarenbach S, Heidenheim AP, Leitch R, Lindsay RM, Daily/Nocturnal Dialysis Study Group. Reduced requirement for erythropoietin with quotidian hemodialysis therapy. ASAIO Journal 2002;48(1):57-61. [MEDLINE: 11814098]
Kletzmayr 1999 {published data only}
  • Kletzmayr J, Mayer G, Legenstein E, Heinz-Peer G, Leitha T, Horl WH, et al. Anemia and carnitine supplementation in hemodialyzed patients. Kidney International - Supplement 1999;55(Suppl 69):S93-S106. [MEDLINE: 10084293]
Koronis 2000 {published data only}
  • Koronis C, Makris F, Stavroulaki E, Lambropoulou A, Orthopoulos V. Combination of low-dose recombinant human erythropoietin with androgens for the treatment of anaemia in hemodialysis patients [abstract]. 37th Congress. European Renal Association. European Dialysis and Transplantation Association. European Kidney Research Organisation; Nice (France). 2000:235.
Labonia 1995 {published data only}
Lee 2001 {published data only}
  • Lee M, Ahn S, Song J. Effects of adjuvant androgen on anemia and nutritional parameters in chronic hemodialysis patients using low-dose recombinant human erythropoietin [abstract]. Journal of the American Society of Nephrology 2001;12(Program & Abstracts):358A-9A.
Locatelli 1999 {published data only}
Locatelli 2000 {published data only}
Malegos 2000 {published data only}
  • Malegos I, Kaloheretis P, Drouzas A, Papadakis I. Does haemodialysis membrane's biocompatibility affect recombinant human erythropoietin (rHuEPO) effect on the anemia of hemodialyzed patients? [abstract]. Nephrology Dialysis Transplantation 2000;15(9):A156.
Miyahara 1990 {published data only}
  • Miyahara S, Motomori T, Miyazaki F, Noda S, Eto K, Nakamura Y, et al. Clinical studies of mepitiostane for treatment of anemia associated with chronic renal failure. Kiso to Rinsho (The Clinical Report) 1990;24(5):2963-8.
Mydlík 2003 {published data only}
Nakamoto 2008 {published data only}
Navarro 2002 {published data only}
  • Navarro JF, Mora C, Macia M, Chahin J, Gallego E, Mendez ML, et al. Effects of androgen therapy on hematologic and nutritional parameters in elderly peritoneal dialysis patients [abstract]. International Urology & Nephrology 2001;33(4):715-6.
  • Navarro JF, Mora C, Macia ML, Gallego E, Chahin J, Mendez ML, et al. Prospective comparison between rHuEPO and androgens in CAPD patients: impact on hematologic and nutritional parameters [abstract]. Journal of the American Society of Nephrology 2001;12(Program & Abstracts):436A.
  • Navarro JF,  Mora C,  Macía M,  García J. Randomized prospective comparison between erythropoietin and androgens in CAPD patients. Kidney International 2002;61(4):1537-44. [MEDLINE: 11918762]
Odabas 2003 {published data only}
  • Odabas AR, Cetinkaya R, Selcuk Y, Keles S, Bilen H. The effect of high dose losartan on erythropoietin resistance in patients undergoing haemodialysis. Panminerva medica 2003;45(1):59-62. [MEDLINE: 12682621]
Ono 1992 {published data only}
Onoyama 1989 {published data only}
  • Onoyama K, Sanai T, Motomura K, Fujishima M. Worsening of anemia by angiotensin converting enzyme inhibitors and its prevention by antiestrogenic steroid in chronic hemodialysis patients. Journal of Cardiovascular Pharmacology 1989;13(Suppl 3):S27-S30. [MEDLINE: 2474097]
Opatrnì 1998 {published data only}
Panichi 2011 {published data only}
  • Panichi V, Barattini M, Angelini D, Petrone I, Ferrandello FP, Grazi G, et al. A vitamin E-coated polysulfone membrane reduces inflammatory markers and EPO requirement in haemodialysis patients [abstract SA413]. World Congress of Nephrology; 2009 May 22-26; Milan (Italy). 2009.
  • Panichi V, Rosati A, Paoletti S, Ferrandello P, Migliori M, Beati S, et al. A vitamin E-coated polysulfone membrane reduces serum levels of inflammatory markers and resistance to erythropoietin-stimulating agents in hemodialysis patients: results of a randomized cross-over multicenter trial. Blood Purification 2011;32(1):7-14. [MEDLINE: 21242686]
Rao 2003 {published data only}
Richardson 2003 {published data only}
  • Richardson D, Lindley E, Bartlett C, Will EJ. Biocompatibility and erythropoiesis: - a randomised controlled, single center study of modified cellulose and polysulfone dialysers in a large hemodialysis cohort (n = 177) [abstract]. Journal of the American Society of Nephrology 2001;12(Program & Abstracts):240A.
  • Richardson D, Lindley EJ, Bartlett C, Will EJ. A randomized, controlled study of the consequences of hemodialysis membrane composition on erythropoietic response. American Journal of Kidney Diseases 2003;42(3):551-60. [MEDLINE: 12955684]
Saxena 1997 {published data only}
  • Saxena S, Dash SC, Tiwari SC, Agarwal SK, Jain PK, Aslam J. Effect of nandrolone deconoate on response to low dose erythropoietin (EPO) in anemia of end stage renal disease (ESRD) patients on maintenance hemodialysis (MHD) [abstract]. Nephrology 1997;3(Suppl 1):S310.
Sezer 2002 {published data only}
Shahrbanoo 2008 {published data only}
  • Shahrbanoo K, Taziki O. Effect of intravenous ascorbic acid in hemodialysis patients with anemia and hyperferritinemia. Saudi Journal of Kidney Diseases & Transplantation 2008;19(6):933-6. [MEDLINE: 18974579]
Sheashaa 2005 {published data only}
  • Sheashaa H, Abdel-Razek W, El Husseini A, Selim A, Hassan N, Abbas T, et al. Use of nandrolone decanoate as an adjuvant for erythropoietin dose reduction in treating anemia in patients on hemodialysis. Nephron 2005;99(4):c102-6. [MEDLINE: 15703460]
Sorge-Haedicke 2001 {published data only}
  • Sorge-Haedicke B, Goncalves-Marques M, Loew L, Samizadeh A. Routine intravenous l-carnitine-supplementation does not reduce erythropoietin (RH-EPO)- requirement in chronic hemodialysis (CHD) patients (P) with renal anemia (RA). Nephrology Dialysis Transplantation 2001;16(6):A135.
Taji 2004 {published data only}
  • Taji Y, Morimoto T, Okada K, Fukuhara S, Fukui T, Kuwahara T. Effects of intravenous ascorbic acid on erythropoiesis and quality of life in unselected hemodialysis patients. Journal of Nephrology 2004;17(4):537-43. [MEDLINE: 15372416]
Tarng 1998 {published data only}
  • Tarng DC, Huang TP. A parallel, comparative study of intravenous iron versus intravenous ascorbic acid for erythropoietin-hyporesponsive anaemia in haemodialysis patients with iron overload. Nephrology Dialysis Transplantation 1998;13(11):2867-72. [MEDLINE: 9829492]
Tarng 1999 {published data only}
  • Tarng DC, Wei YH, Huang TP, Kuo BI, Yang WC. Intravenous ascorbic acid as an adjuvant therapy for recombinant erythropoietin in hemodialysis patients with hyperferritinemia. Kidney International 1999;55(6):2477-86. [MEDLINE: 10354297]
Tarng 2004 {published data only}
  • Tarng DC, Hung SC, Huang TP. Effect of intravenous ascorbic acid medication on serum levels of soluble transferrin receptor in hemodialysis patients. Journal of the American Society of Nephrology 2004;15(9):2486-93. [MEDLINE: 15339999]
Ursea 1995 {published data only}
  • Ursea N, Capsa D. Faster improvement of the anemia in chronic hemodialysed patients with combined treatment with erythropoetin and essential amino acids ketoanalogues [abstract]. Nephrology Dialysis Transplantation 1995;10(6):1051.
Usberti 2002a {published data only}
  • Usberti M, Gerardi G, Bufano G, Tira P, Micheli A, Albertini A, et al. Effects of erythropoietin and vitamin E-modified membrane on plasma oxidative stress markers and anemia of hemodialyzed patients. American Journal of Kidney Diseases 2002;40(3):590-9. [MEDLINE: 12200812]
Usberti 2002b {published data only}
  • Usberti M, Gerardi G, Micheli A, Tira P, Bufano G, Gaggia P, et al. Effects of a vitamin E-bonded membrane and of glutathione on anemia and erythropoietin requirements in hemodialysis patients. Journal of Nephrology 2002;15(5):558-64. [MEDLINE: 12455724]
Vaslaki 2006 {published data only}
  • Vaslaki L, Berta K, Ladanyi E, Pethoe F, Karatson A, Misz M, et al. Less need for erythropoietin in on-line haemodiafiltration compared to haemodialysis [abstract]. Nephrology Dialysis Transplantation 2005;20(Suppl 5):v336.
  • Vaslaki L, Major L, Berta K, Karatson A, Misz M, Pethoe F, et al. On-line haemodiafiltration versus haemodialysis: stable haematocrit with less erythropoietin and improvement of other relevant blood parameters. Blood Purification 2006;24(2):163-73. [MEDLINE: 16352871]
Wang 2000 {published data only}
  • Wang M-C, Huang J-J, Liao L-H, Ruaan M-K, Sung J-M, Lan R-R. Effect of high-dose folic acid on hemodialysis patients with poor erythropoietin response. Dialysis & Transplantation 2000;29(11):710-7. [EMBASE: 2000401292]
Yang 2006 {published data only}

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Johnson 2008 {published data only}
  • Johnson DW, Hawley CM, Rosser B, Beller E, Thompson C, Fassett RG, et al. Oxpentifylline versus placebo in the treatment of erythropoietin-resistant anaemia: a randomized controlled trial. BMC Nephrology 2008;9:8. [MEDLINE: 18671885]
NCT01526798 {published data only}
  • Improvement of EPO-resistance in hemodialysis patients with chronic inflammation by high cut-off hemodialysis (CIEPO-PILOT). http://www.clinicaltrials.gov/ct2/results?term=NCT01526798 (accessed 18th March 2013).

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Badve 2011
Benz 1999
  • Benz RL, Pressman MR, Hovick ET, Peterson DD. A preliminary study of the effects of correction of anemia with recombinant human erythropoietin therapy on sleep, sleep disorders, and daytime sleepiness in hemodialysis patients (The SLEEPO study). American Journal of Kidney Diseases 1999;34(6):1089-95. [MEDLINE: 10585319]
Besarab 1998
  • Besarab A, Bolton WK, Browne JK, Egrie JC, Nissenson AR, Okamoto DM, et al. The effects of normal as compared with low hematocrit values in patients with cardiac disease who are receiving hemodialysis and epoetin. New England Journal of Medicine 1998;339(9):584-90. [MEDLINE: 9718377]
Brookhart 2010
  • Brookhart MA, Schneeweiss S, Avorn J, Bradbury BD, Liu J, Winkelmayer WC. Comparative mortality risk of anemia management practices in incident hemodialysis patients. JAMA 2010;303(9):857-64. [MEDLINE: 20197532]
Eschbach 1989
Gandra 2010
  • Gandra SR, Finkelstein FO, Bennett AV, Lewis EF, Brazg T, Martin ML. Impact of erythropoiesis-stimulating agents on energy and physical function in nondialysis CKD patients with anemia: a systematic review. American Journal of Kidney Diseases 2010;55(3):519-34. [MEDLINE: 20031287]
Higgins 2003
Higgins 2011
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References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Badve 2010