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Acupuncture and assisted reproductive technology

  1. Ying C Cheong1,*,
  2. Sarah Dix2,
  3. Ernest Hung Yu Ng3,
  4. William L Ledger4,
  5. Cindy Farquhar5

Editorial Group: Cochrane Gynaecology and Fertility Group

Published Online: 26 JUL 2013

Assessed as up-to-date: 22 JUL 2013

DOI: 10.1002/14651858.CD006920.pub3


How to Cite

Cheong YC, Dix S, Hung Yu Ng E, Ledger WL, Farquhar C. Acupuncture and assisted reproductive technology. Cochrane Database of Systematic Reviews 2013, Issue 7. Art. No.: CD006920. DOI: 10.1002/14651858.CD006920.pub3.

Author Information

  1. 1

    University of Southampton, Obstetrics and Gynaecology, Southampton, UK

  2. 2

    Princess Anne Hospital, Obstetrics and Gynaecology, Southampton, UK

  3. 3

    University of Hong Kong, Queen Mary Hospital, Department of Obstetrics and Gynaecology, Hong Kong, Hong Kong, Hong Kong

  4. 4

    University of New South Wales, School of Women's & Children's Health, Randwick, NSW, Australia

  5. 5

    University of Auckland, Obstetrics and Gynaecology, Auckland, New Zealand

*Ying C Cheong, Obstetrics and Gynaecology, University of Southampton, Level F, Princess Anne Hospital, Coxford Road, Southampton, SO16 5YA, UK. yingcheong@hotmail.com. Y.Cheong@soton.ac.uk.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 26 JUL 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Andersen 2010 {published data only}
  • Andersen D, Lossl K, Nyboe Andersen A, Furbringer J, Bach H, Simonsen J, et al. Acupuncture on the day of embryo transfer: a randomized controlled trial of 635 patients. Reproductive Biomedicine Online 2010;21(3):366-72.
Benson 2006 {published data only}
  • Benson MR, Elkind-Hirsch KE, Theall A, Fong K, Hogan RB, Scott RT. Impact of acupuncture before and after embryo transfer on the outcome of in vitro fertilization cycles: A prospective single blind randomized study. Fertility and Sterility 2006;86(3 Suppl):135.
Craig 2007 {published data only (unpublished sought but not used)}
  • Craig LB, Criniti AR, Hansen KR, Marshall LA, Soules MR. Acupuncture lowers pregnancy rates when performed before and after embryo transfer. Fertility and Sterility 2007;88 Suppl 1:40.
Dieterle 2006 {published data only}
  • Dieterle S, Ying G, Hatzmann W, Neuer A. Effect of acupuncture on the outcome of in vitro fertilisation and intracytoplasmic sperm injection: a randomised, prospective, controlled clinical study. Fertility and Sterility 2006;85:1347-51.
Domar 2009 {published data only}
Fraterelli 2008 {published data only}
  • Fratterelli JL, Leondires MR, Fong K, Theall A, Locatelli S, Scott RT. Laser acupuncture before and after embryo transfer improves art delivery rates: results of a prospective randomized double-blinded placebo controlled five-armed trial involving 1000 patients. Fertility and Sterility 2008;90 Suppl 1:105.
Gejervall 2005 {published data only}
  • Gejervall A, Stener-Victorin E, Moller A, Janson PO, Werner C, Bergh C. Electro-acupuncture versus conventional analgesia: a comparison of pain levels during oocyte aspiration and patients’ experiences of well-being after surgery. Human Reproduction 2005;20:728-35.
Ho 2009 {published data only}
  • Ho M, Huang LC, Chang YY, Chen HY, Chang WC, Yang TC, Tsai HD. Electroacupuncture reduces uterine artery blood flow impedance in infertile women. Taiwanese Journal of Obstetrics and Gynecology 2009;48(2):148-51.
Humaidan 2004 {published data only}
  • Humaidan P, Stener-Victorin E. Pain relief during oocyte retrieval with a new short duration electro-acupuncture technique - an alternative to conventional analgesic methods. Human Reproduction 2004;19:1367-72.
Madaschi 2010 {published data only}
  • Madaschi C, Braga DP, Figueira Rde C, Iaconelli A Jr, Borges E Jr. Effect of acupuncture on assisted reproduction treatment outcomes. Acupuncture in Medicine 2010;28(4):180-4.
Moy 2011 {published data only}
  • Moy I, Milad MP, Barnes R, Confino E, Kazer RR, Zhang X. Randomized controlled trial: effects of acupuncture on pregnancy rates in women undergoing in vitro fertilization. Fertility and Sterility 2011;95(2):583-7.
Paulus 2002 {published data only}
  • Paulus WE, Zhang M, Strehler E, El-Danasouri I, Sterzik K. Influence of acupuncture on the pregnancy rate in patients who undergo assisted reproductive technology. Fertility and Sterility 2002;77:721-44.
Paulus 2003 {published data only}
  • Paulus WE, Zhang M, Strehler E, Seybold B, Sterzik K. Placebo-controlled trial acupuncture effects in assisted reproductive therapy. Human Reproduction 2003; Vol. 18 Suppl:18.
Sator-K 2006 {published data only}
  • Sator-Katzenschlager SM, Wölfler MM, Kozek-Langenecker SA, Sator K, Sator PG, Li B, et al. Auricular electro-acupuncture as an additional perioperative analgesic method during oocyte aspiration in IVF treatment. Human Reproduction 2006;21:2114-20.
Smith 2006 {published data only}
So 2009 {published data only}
So 2010 {published data only}
  • So EW, Ng EH, Wong YY, Yeong WS, Ho PC. Acupuncture for frozen-thawed embryo transfer cycles: a double-blind randomized controlled trial. Reproductive Biomedicine Online 2010;20(6):814-21.
Stener-Victorin 1999 {published data only}
  • Stener-Victorin E, Waldenstrom U, Andersson SA, Wikland M, Janson PO. A prospective randomised study of electro-acupuncture versus alfentanil as anaesthesia during oocyte aspiration in in-vitro fertilisation. Human Reproduction 1999;14:2480-4.
Stener-Victorin 2003 {published data only}
  • Stener-Victorin E, Waldenstrom U, Wikland M, Nilsson L, Hagglund L, Lundeberg T. Electro-acupuncture as a preoperative analgesic method and its effects on implantation rate and neuropeptide Y concentrations in follicular fluid. Human Reproduction 2003;18:1454-60.
Westergaard 2006 {published data only}
  • Westergaard LG, Mao QH, Krogslund M, Sandrini S, Lenz S, Grinsted J. Acupuncture on the day of embryo transfer significantly improves the reproductive outcome in infertile women: a prospective, randomised trial. Fertility and Sterility 2006;85:1341-6.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Chen 2004 {published data only}
  • Chen D, Shi XL, Cai MX. Clinical observation on treatment of functional anovulation by acupunctural prick. Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongxiyi Jiehe Zazhi 2004;27(8):735-7.
Chen 2009 {published data only (unpublished sought but not used)}
  • Chen J, Liu L, Cui W, Sun W. Effects of electro-acupuncture on in vitro fertilization-embryo transfer (IVF-ET) of patients with poor ovarian response. Zhongguo Zhen Jiu 2009;29(10):775-9.
Chen 2012 {published data only}
  • Chen QQ, Wei QL, Zhang XH. Effects of electroacupuncture on supplementary analgesia and improvement of adverse reactions induced by dolantin in oocyte retrieval. Zhongguo zhen jiu (Chinese acupuncture & moxibustion) 2012;32(12):1113-6.
Cui 2007 {published data only (unpublished sought but not used)}
  • Cui W, Sun W, Liu L, Wen J. Study of the effect of electro-acupuncture treatment on the patients undergoing in vitro-fertilisation and embryo transfer. Chinese Maternal and Child Health 2007;22:3403-5.
Cui 2011 {published data only}
  • Cui W, Li J, Sun W, Wen J. Effect of electroacupuncture on oocyte quality and pregnancy for patients with PCOS undergoing in vitro fertilization and embryo transfer. Chinese Acupuncture & Moxibustion 2011;31(8):687-91.
Evans 2005 {published data only}
  • Evans J. A pilot study to explore the effects of acupuncture in women with unexplained infertility. South Bro Tak R&D Consortium 2005.
Feliciani 2011 {published data only}
  • Feliciani E, Ferraretti A, Paesano C, Pellizzaro E, Magli M, Gianardi L. The role of acupuncture in ART: preliminary results of an ongoing prospective randomised study. Human Reproduction 2011;26 Suppl 1:281.
Li 2009 {published data only}
  • Li J, Cui W, Sun W. Effects of electroacupuncture of in vitro fertilisation-embryo transfer (IVF-ET) of patients with polycystic ovarian syndrome. Chinese Journal of Human Sexuality 2009;18(8):33-5.
Omodei 2010 {published data only}
  • Omodei U, Piccioni G, Tombesi S, Dordoni D, Fallo L, Ghilardi F. Effect of acupuncture on rates of pregnancy among women undergoing in vitro fertilisation. Fertility and Sterility 2010;94:Suppl 1.
Quintero 2004 {published data only}
  • Quintero R. A randomised controlled, double-blind, cross-over study evaluating acupuncture as an adjunct to IVF. Fertility and Sterility 2004;81 Suppl 3:11.

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
ACTRN12611000226909 {published data only}
  • Smith C. Acupuncture compared to sham acupuncture and standard care to improve live birth rates for women undergoing IVF: a randomised controlled trial [Acupuncture compared to sham acupuncture and standard care to improve live birth rates for women undergoing IVF: a randomised controlled trial]. http://www.anzctr.org.au/ACTRN12611000226909.aspx Registered 02/03/2011.
  • Smith CA, de Lacey S, Chapman M, Ratcliffe J, Norman RJ, Johnson N, Sacks G, Lyttleton J, Boothroyd C. Acupuncture to improve live birth rates for women undergoing in vitro fertilization: a protocol for a randomized controlled trial. Trials 2012;13:60.
IRCT201011275181N4 {published data only}
  • Batool R. Effects of acupuncture on outcome of in vitro fertilization and intracytoplasmic sperm injection (IVF/ICSI) in women with polycystic ovarian. http://www.irct.ir/searchresult.php?id=5181&number=4 Registered 13/04/2011.
NCT00317317 {published data only}
  • Zhang G. The Effect of Acupuncture on Infertility With In-Vitro Fertilization (IVF) Patients. http://clinicaltrials.gov/show/NCT00317317 Registered 20/04/2006.
NCT01449396 {published data only}
  • Romeu M. Chinese Traditional Medicine contribution to improve in-vitro fertilization (IVF) results: acupuncture in embryo transfer. http://clinicaltrials.gov/show/NCT01449396 Registered 04/10/2011.
NCT01608048 {unpublished data only}
  • Zheng CH. Transcutaneous Electrical Acupoint Stimulation to Improve Pregnancy Rates for Women Undergoing in Vitro Fertilization. http://www.clinicaltrials.gov/ct2/show/NCT01608048?term=acupuncture&type=Intr&outc=pregnancy&gndr=Female&age=1&rcv_s=10%2F01%2F2011&rcv_e=10%2F01%2F2013&rank=5 2012.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Anderson 2007
  • Anderson BJ, Haimovici F, Ginsburg ES, Schust DJ, Wayne PM. In vitro fertilization and acupuncture: clinical efficacy and mechanistic basis. Alternative Therapies in Health and Medicine 2007;13(3):38-48.
Boivin 2007
  • Boivin J, Bunting L, Collins JA, Nygren KG. International estimates of infertility prevalence and treatment-seeking: potential need and demand for infertility medical care. Human Reproduction 2007;22:1506-12.
Cheong 2010
  • Cheong Y, Nardo LG, Rutherford T, Ledger W. Acupuncture and herbal medicine in in vitro fertilisation: a review of the evidence for clinical practice. Human Fertility 2010;13(1):3-12.
Domar 2011
  • Domar AD, Rooney KL, Wiegand B, Orav EJ, Alper MM, Berger BM, et al. Impact of a group mind/body intervention on pregnancy rates in IVF patients. Fertility and Sterility 2011;95:2269-73.
El-Toukhy 2010
Fisher 1994
Garcia 2013
  • Garcia MK, McQuade J, Haddad R, Patel S, Lee R, Yang P, et al. Systematic review of acupuncture in cancer care: a synthesis of the evidence. Journal of Clinical Oncology 2013;31(7):952-60. doi: 10.1200/JCO.2012.43.5818.
He et al, 2012
  • Wenju He, Xue Zhao, Yanqi Li, Qiang Xi, Yi Guo. Adverse events following acupuncture: A systematic review of the Chinese literature for the years 1956–2010. The Journal of Alternative and Complementary Medicine 2012;18(10):892-901.
Higgins 2011
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Holmer 2012
  • Holmér Pettersson P, Wengström Y. Acupuncture prior to surgery to minimise postoperative nausea and vomiting: a systematic review. Journal of Clinical Nursing 2012;21(13-14):1799-805/ doi: 10.1111/j.1365-2702.2012.04114.x..
Huang 2011
  • Huang DM, Huang GY, Lu FE, Stefan D, Andreas N, Robert G. Acupuncture for infertility: is it an effective therapy?. Chinese Journal of Integrative Medicine 2011;17(5):386-95.
Klein 2012
  • Klein SD, Frei-Erb M, Wolf U. Usage of complementary medicine across Switzerland: results of the Swiss Health Survey 2007. Swiss Medical Weekly 2012;142:w13666.
MacPherson 2010
  • MacPherson H, Altman DG, Hammerschlag R, Youping L, Taixiang W, White A, et al. Revised STandards for Reporting Interventions in Clinical Trials of Acupuncture (STRICTA): Extending the CONSORT statement. Journal of Evidence-Based Medicine 2010;3(3):140-55.
Manheimer 2008
  • Manheimer E, Zhang G, Udoff L, Haramati A, Langenberg P, Berman BM. Effects of acupuncture on rates of pregnancy and live birth among women undergoing in vitro fertilisation: systematic review and meta-analysis. BMJ 2008;336(7643):545-9.
Meissner 2007
Meldrum 2013
  • Meldrum DR, Fisher AR, Butts SF, Su HI, Sammel MD. Acupuncture-help, harm, or placebo?. Fertility and Sterility 2013:doi:pii: S0015-0282(13)00008-3. 10.1016/j.fertnstert.2012.12.046..
NIH Consensus 1998
Schmidt 1995
Stener-Victorin 1996
  • Stener-Victorin E, Waldenstrom U, Andersson SA, Wikland M. Reduction of blood flow impedence in the uterine arteries of infertile women with electro-acupuncture. Human Reproduction 1996;11:1314-7.
Stener-Victorin 2000
  • Stener-Victorin E, Lundeberg T, Waldenstrom U, Tagnfors U, Lundeberg T, Lindstedt G, Janson P. Effects of electro-acupuncture on anovulation in women with polycystic ovary syndrome. Acta Obstetricia et Gynecologica Scandinavica 2000;79:180-8.
Stener-Victorin 2001
  • Stener-Victorin E, Lundeberg T, Waldenstrom U, Bileviciute-Lindstedt I, Janson P. Effects of acupuncture on corticotropin releasing factor (CRF) in rats with experimentally induced polycystic ovaries. Neuropeptides 2001;6:1-5.
Tan 2011
  • Tan CW, Sheehan P, Santos D. Discrimination accuracy between real and sham needles using the Park sham device in the upper and lower limbs. Acupuncture in Medicine 2011;29(3):208-14.
Thomas 2001
Vickers 1999
Zheng 2012
  • Zheng CH, Huang GY, Zhang MM, Wang W. Effects of acupuncture on pregnancy rates in women undergoing in vitro fertilization: a systematic review and meta-analysis. Fertility and Sterility 2012;97(3):599-611.